{"id":"https://openalex.org/W2953058729","doi":"https://doi.org/10.1002/hon.130_2629","title":"PRIMARY ANALYSIS RESULTS OF THE SINGLE\u2010ARM PHASE II STUDY OF MOR208 PLUS LENALIDOMIDE IN PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B\u2010CELL LYMPHOMA (L\u2010MIND)","display_name":"PRIMARY ANALYSIS RESULTS OF THE SINGLE\u2010ARM PHASE II STUDY OF MOR208 PLUS LENALIDOMIDE IN PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B\u2010CELL LYMPHOMA (L\u2010MIND)","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2953058729","doi":"https://doi.org/10.1002/hon.130_2629","mag":"2953058729"},"language":"en","primary_location":{"id":"doi:10.1002/hon.130_2629","doi":"https://doi.org/10.1002/hon.130_2629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.130_2629","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086354986","display_name":"Gilles A. Salles","orcid":"https://orcid.org/0000-0002-9541-8666","observed_orcids":["https://orcid.org/0000-0002-9541-8666"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Salles","raw_affiliation_strings":["Hospices Civils de Lyon Centre Hospitalier Lyon Sud, Service d'H\u00e9matologie  Pierre\u2010B\u00e9nite France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospices Civils de Lyon Centre Hospitalier Lyon Sud, Service d'H\u00e9matologie  Pierre\u2010B\u00e9nite France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061317839","display_name":"Johannes Duell","orcid":"https://orcid.org/0000-0001-6935-7997","observed_orcids":["https://orcid.org/0000-0001-6935-7997"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Duell","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048566051","display_name":"Eva M. Gonz\u00e1lez-Barca","orcid":"https://orcid.org/0000-0002-1323-1508","observed_orcids":["https://orcid.org/0000-0002-1323-1508"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]},{"id":"https://openalex.org/I4210143012","display_name":"Duran i Reynals Hospital","ror":"https://ror.org/03qwghy04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210143012"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Gonz\u00e1lez Barca","raw_affiliation_strings":["Department of Hematology Institut Catal\u00e1 d'Oncolog\u00eda, Hospital Duran i Reynals, IDIBELL  Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Institut Catal\u00e1 d'Oncolog\u00eda, Hospital Duran i Reynals, IDIBELL  Barcelona Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147","https://openalex.org/I4210143012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788725","display_name":"Wojciech J. Jurczak","orcid":"https://orcid.org/0000-0003-1879-8084","observed_orcids":["https://orcid.org/0000-0003-1879-8084"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"W. Jurczak","raw_affiliation_strings":["Department of Hematology Jagiellonian University  Krak\u00f3w Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Jagiellonian University  Krak\u00f3w Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049135933","display_name":"A. M. Liberati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123105","display_name":"Azienda Ospedaliera S.Maria","ror":"https://ror.org/02t96cy48","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123105"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A.M. Liberati","raw_affiliation_strings":["SC Oncoematologia, Azienda Ospedaliera Santa Maria, Terni, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Oncoematologia, Azienda Ospedaliera Santa Maria, Terni, Italy","institution_ids":["https://openalex.org/I4210123105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865823","display_name":"Zsolt Nagy","orcid":"https://orcid.org/0000-0001-9756-5427","observed_orcids":["https://orcid.org/0000-0001-9756-5427"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Z. Nagy","raw_affiliation_strings":["First Department of Internal Medicine, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063710613","display_name":"Ale\u0161 Obr","orcid":"https://orcid.org/0000-0002-6758-3074","observed_orcids":["https://orcid.org/0000-0002-6758-3074"]},"institutions":[{"id":"https://openalex.org/I4210107161","display_name":"University Hospital Olomouc","ror":"https://ror.org/01jxtne23","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210107161"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"A. Obr","raw_affiliation_strings":["Department of Hemato\u2010Oncology Palack\u00fd University Olomouc and the University Hospital Olomouc  Olomouc Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemato\u2010Oncology Palack\u00fd University Olomouc and the University Hospital Olomouc  Olomouc Czech Republic","institution_ids":["https://openalex.org/I4210107161","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041745367","display_name":"Gianluca Ga\u00efdano","orcid":"https://orcid.org/0000-0002-4681-0151","observed_orcids":["https://orcid.org/0000-0002-4681-0151"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Gaidano","raw_affiliation_strings":["Division of Haematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077504536","display_name":"Marc P.E. Andr\u00e9","orcid":"https://orcid.org/0000-0001-7101-810X","observed_orcids":["https://orcid.org/0000-0001-7101-810X"]},"institutions":[{"id":"https://openalex.org/I4210093617","display_name":"CHU Dinant Godinne UCL Namur","ror":"https://ror.org/00ntbvq76","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210093617"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. Andre","raw_affiliation_strings":["Department of Hematology Universit\u00e9 catholique de Louvain, CHU UCL Namur  Yvoir Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology Universit\u00e9 catholique de Louvain, CHU UCL Namur  Yvoir Belgium","institution_ids":["https://openalex.org/I4210093617","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014125875","display_name":"Nagesh Kalakonda","orcid":"https://orcid.org/0000-0002-5300-1360","observed_orcids":["https://orcid.org/0000-0002-5300-1360"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I283776267","display_name":"Clatterbridge Cancer Centre NHS Foundation Trust","ror":"https://ror.org/05gcq4j10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I283776267"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Kalakonda","raw_affiliation_strings":["Department of Haemato-oncology, Clatterbridge Cancer Centre and University of Liverpool, Wirral, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haemato-oncology, Clatterbridge Cancer Centre and University of Liverpool, Wirral, United Kingdom","institution_ids":["https://openalex.org/I146655781","https://openalex.org/I283776267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046049357","display_name":"Martin H. Dreyling","orcid":"https://orcid.org/0000-0002-0358-5249","observed_orcids":["https://orcid.org/0000-0002-0358-5249"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Dreyling","raw_affiliation_strings":["Department of Medicine III University Hospital of Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III University Hospital of Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091882595","display_name":"Pier Luigi Zinzani","orcid":"https://orcid.org/0000-0002-2112-2651","observed_orcids":["https://orcid.org/0000-0002-2112-2651"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P.L. Zinzani","raw_affiliation_strings":["Institute of Hematology \u201cL. e A. Ser\u00e0gnoli\u201d University of Bologna  Bologna Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology \u201cL. e A. Ser\u00e0gnoli\u201d University of Bologna  Bologna Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050782079","display_name":"Maren Dirnberger\u2010Hertweck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144094060","display_name":"MorphoSys (Germany)","ror":"https://ror.org/00ew7rg06","country_code":"DE","type":"company","lineage":["https://openalex.org/I144094060"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Dirnberger\u2010Hertweck","raw_affiliation_strings":["Department of Drug Safety and Pharmacovigilance, MorphoSys AG, Planegg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Safety and Pharmacovigilance, MorphoSys AG, Planegg, Germany","institution_ids":["https://openalex.org/I144094060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007901103","display_name":"Johannes Weirather","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144094060","display_name":"MorphoSys (Germany)","ror":"https://ror.org/00ew7rg06","country_code":"DE","type":"company","lineage":["https://openalex.org/I144094060"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Weirather","raw_affiliation_strings":["Department of Biostatistics and Data Management, MorphoSys AG, Planneg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Data Management, MorphoSys AG, Planneg, Germany","institution_ids":["https://openalex.org/I144094060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007316044","display_name":"Sumeet Ambarkhane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144094060","display_name":"MorphoSys (Germany)","ror":"https://ror.org/00ew7rg06","country_code":"DE","type":"company","lineage":["https://openalex.org/I144094060"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Ambarkhane","raw_affiliation_strings":["Department of Clinical Development, MorphoSys AG, Planegg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Development, MorphoSys AG, Planegg, Germany","institution_ids":["https://openalex.org/I144094060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024389256","display_name":"Kami J. Maddocks","orcid":"https://orcid.org/0000-0001-8519-8404","observed_orcids":["https://orcid.org/0000-0001-8519-8404"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Maddocks","raw_affiliation_strings":["Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":20,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4284,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.82525843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"37","issue":"S2","first_page":"173","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/anti-cd19-monoclonal-antibody","display_name":"anti-CD19 monoclonal antibody","score":0.9929999709129333},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5879999995231628},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9850000143051147},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.75},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.7009999752044678},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.39500001072883606},{"id":"https://openalex.org/keywords/rituximab-refractory-disease","display_name":"rituximab-refractory disease","score":0.6980000138282776},{"id":"https://openalex.org/keywords/early-recurrence","display_name":"early recurrence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/ipi","display_name":"IPI","score":0.3569999933242798},{"id":"https://openalex.org/keywords/cd19-targeted-therapy","display_name":"CD19-targeted therapy","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.836654543876648},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.8178781270980835},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.678223729133606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6337937116622925},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.5787518620491028},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5747621655464172},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5548970699310303},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.5498530864715576},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5026102066040039},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4818626344203949},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4607587456703186},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4401395320892334},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4138139486312866},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40877565741539},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39029449224472046},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2721692621707916},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2531052827835083},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.23874202370643616},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/hon.130_2629","doi":"https://doi.org/10.1002/hon.130_2629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.130_2629","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899239653","https://openalex.org/W2735855342","https://openalex.org/W2959649660","https://openalex.org/W2950927135","https://openalex.org/W7053361791","https://openalex.org/W2763229989","https://openalex.org/W2988395771","https://openalex.org/W3037219498","https://openalex.org/W4246296409","https://openalex.org/W2556811747"],"abstract_inverted_index":{"Introduction:":[0],"CD19":[1],"is":[2],"an":[3,23,252],"important":[4],"target":[5],"for":[6,60,78,503,566,649],"the":[7,58,61,350,385,424],"treatment":[8],"of":[9,91,115,126,180,187,207,215,237,257,275,290,309,347,390,423],"B-cell":[10,18,39,447],"malignancies,":[11],"including":[12,93],"relapsed":[13],"or":[14,230,233],"refractory":[15,244],"diffuse":[16,445],"large":[17,446],"lymphoma":[19,40,448],"(R-R":[20],"DLBCL).":[21],"MOR208,":[22,116],"Fc-enhanced,":[24],"humanized,":[25],"anti-CD19":[26],"monoclonal":[27],"antibody,":[28],"has":[29,398],"shown":[30,399],"single":[31],"agent":[32],"activity":[33,52,401],"in":[34,53,288,293,297,300,303,307,384,406,505,568,651],"patients":[35],"(pts)":[36],"with":[37,47,74,408,426],"R-R":[38,409],"(Jurczak":[41],"et":[42,68],"al,":[43,69],"2018).":[44,71],"MOR208":[45,143,259,391],"combined":[46],"lenalidomide":[48],"(LEN)":[49],"demonstrated":[50],"synergistic":[51],"preclinical":[54],"models,":[55],"which":[56],"formed":[57],"basis":[59],"single-arm":[62],"phase":[63],"II":[64],"L-MIND":[65],"study":[66,425],"(Salles":[67],"ASH":[70],"Methods:":[72],"Patients":[73],"R/R":[75],"DLBCL,":[76,410],"ineligible":[77],"autologous":[79],"stem":[80],"cell":[81],"transplantation,":[82],"who":[83,411],"had":[84,100,217,251],"received":[85,142],"up":[86,108],"to":[87,109,245],"3":[88],"prior":[89,208,239],"lines":[90],"therapy,":[92,98,248],"at":[94,440],"least":[95],"one":[96],"anti-CD20":[97],"and":[99,128,183,249,266,305,316,322,334,339,355,372,392,397,402,415,433,471,485,498,513,517,522,534,543,553,560,593,601,608,614,620,634,644,663,692,699,706],"adequate":[101],"organ":[102],"function":[103],"were":[104,226,243,286,320,337,359,382],"eligible.":[105],"Treatment":[106],"comprised":[107],"12,":[110],"28-day":[111],"(d)":[112],"cycles":[113],"(C)":[114],"12":[117,348],"mg/kg":[118],"IV,":[119],"q1w":[120],"C1\u20133":[121],"(loading":[122],"dose":[123,274],"on":[124,271],"d4":[125],"C1),":[127],"q2w":[129,144],"C4\u201312":[130],"plus":[131,260],"LEN":[132,261,273,393],"25":[133],"mg":[134],"PO":[135],"d1\u201321,":[136],"C1\u201312.":[137],"Pts":[138],"progression-free":[139,176],"after":[140],"C12":[141],"until":[145],"progression.":[146],"The":[147,278,388],"primary":[148],"endpoint":[149],"was":[150,192,200,210,263,329,394],"independent":[151],"review":[152],"committee":[153],"(IRC)-assessed":[154],"overall":[155,173],"response":[156,181,229,314,318],"rate":[157],"(ORR)":[158],"as":[159,170,172,325],"per":[160],"Cheson":[161],"2007":[162],"criteria.":[163],"Secondary":[164],"endpoints":[165],"included":[166],"investigator":[167],"(INV)-assessed":[168,312],"ORR,":[169],"well":[171,264,395],"survival":[174,177],"(OS),":[175],"(PFS),":[178],"duration":[179],"(DoR),":[182],"safety.":[184],"Results:":[185],"As":[186],"June":[188],"5,":[189],"2018,":[190],"recruitment":[191],"complete":[193,313],"(n=81":[194],"pts).":[195],"At":[196,343],"baseline,":[197],"median":[198,205,345,352],"age":[199],"72":[201],"years":[202],"(range":[203,212],"41\u201387),":[204],"number":[206],"therapies":[209],"2":[211],"1\u20134),":[213],"23%":[214],"pts":[216,269,381,407],"early":[218],"relapse":[219],"(\u226412":[220],"months":[221,236,361],"from":[222,509,519,572,616,655],"initial":[223],"diagnosis),":[224],"40%":[225],"rituximab-refractory":[227],"(no":[228],"progression":[231],"during":[232],"within":[234],"6":[235],"a":[238,272,326,344,427,434,506,569,652],"rituximab":[240],"therapy),":[241],"42%":[242],"their":[246],"last":[247],"52%":[250],"International":[253],"Prognostic":[254],"Index":[255],"(IPI)":[256],"3\u20135.":[258],"therapy":[262],"tolerated,":[265],"58":[267],"(72%)":[268],"stayed":[270],"\u226520":[276],"mg/day.":[277],"most":[279],"common":[280],"grade":[281],"\u22653":[282],"treatment-emergent":[283],"adverse":[284],"events":[285],"neutropenia":[287,296],"43%":[289],"pts,":[291],"thrombocytopenia":[292],"17%,":[294],"febrile":[295],"12%,":[298],"anemia":[299],"9%,":[301],"leukopenia":[302],"7%,":[304],"hypokalemia":[306],"6%":[308],"pts.":[310],"Investigator":[311],"(CR)":[315],"partial":[317],"rates":[319,336],"33%":[321],"25%,":[323],"respectively;":[324],"result,":[327],"ORR":[328,333],"58%":[330],"(n=81).":[331],"IRC-assessed":[332],"CR":[335],"54%":[338],"32%,":[340],"respectively":[341],"(n=76).":[342],"follow-up":[346,436],"months,":[349],"INV-assessed":[351],"PFS,":[353],"OS":[354],"DoR":[356],"(intention-to-treat":[357],"analysis)":[358],"16.2":[360],"(95%":[362,368,375],"CI:":[363,369,376],"6.3":[364],"months\u2013NR),":[365,371],"not":[366,373],"reached":[367,374],"18.6":[370],"NR\u2013NR),":[377],"respectively.":[378],"Thirty-seven":[379],"(46%)":[380],"ongoing":[383],"study.":[386],"Conclusions:":[387],"combination":[389],"tolerated":[396],"encouraging":[400],"long":[403],"lasting":[404],"responses":[405],"have":[412],"poor":[413],"prognosis":[414],"urgently":[416],"need":[417],"effective":[418],"therapies.":[419],"Primary":[420],"analysis":[421],"results":[422],"recent":[428],"cut-off":[429],"(November":[430],"30,":[431],"2018)":[432],"longer":[435],"will":[437],"be":[438],"presented":[439],"this":[441],"conference.":[442],"Keywords:":[443],"CD19;":[444],"(DLBCL);":[449],"lenalidomide.":[450],"Disclosures:":[451],"Salles,":[452],"G:":[453,546],"Consultant":[454,490,526,547,581,624,685],"Advisory":[455,491,527,548,582,625,686],"Role:":[456,492,528,549,583,626,687],"Roche/Genentech,":[457,474],"Gilead":[458,479,495,530,588,598],"Sciences,":[459,480,496,531,589,599],"Janssen,":[460,476,494,510,521,551,558,590,600,606,618],"Celgene,":[461,477,542,587,597,605,617],"Novartis,":[462,481,591],"Merck,":[463,483],"Pfizer,":[464],"Acerta":[465,584],"Pharma,":[466,468,585],"Kite":[467],"SERVIER,":[469,478],"MorphoSys,":[470,538,552,559],"Epizyme;":[472],"Honoraria:":[473,556,595,636,694],"Amgen,":[475],"Abbvie,":[482,511,520,550,557],"Takeda,":[484,512],"MorphoSys.":[486,670,676,682],"Gonz\u00e1lez":[487],"Barca,":[488],"E:":[489],"Celltrion,":[493,541],"Sandoz,":[497],"Kowa;":[499],"Other":[500,563,610,646],"Remuneration:":[501,564,611,647],"Fees":[502,565,648],"participation":[504,567,650],"speakers'":[507,570,653],"bureau":[508,571,654],"Roche;":[514,602,609],"travel,":[515],"accommodations":[516,613],"expenses":[518,615],"Roche.":[523],"Jurczak,":[524],"W:":[525],"AstraZeneca,":[529,688,695],"Sandoz-Novartis,":[532,540],"Roche,":[533,539,592,619],"MorphoSys;":[535],"Research":[536,576,603,701],"Funding:":[537,577,604,702],"Janssen.":[544,573],"Gaidano,":[545],"Sunesis":[554,561],"Pharmaceuticals;":[555,562],"Kalakonda,":[574],"N:":[575],"Celgene.":[578],"Dreyling,":[579],"M:":[580,666],"Bayer,":[586,596,690,697],"Sandoz;":[594,693],"Mundipharma,":[607],"Travel,":[612],"Takeda.":[621],"Zinzani,":[622],"P:":[623],"Verastem,":[627,637,656],"BMS,":[628,638,657,704],"MSD,":[629,639,658],"Johnson":[630,640,659],"&":[631,641,660],"Johnson,":[632,642,661],"Servier,":[633,643,662],"Gilead;":[635,645],"Gilead.":[664],"Dirnberger-Hertweck,":[665],"Employment":[667,673,679],"Leadership":[668,674,680],"Position:":[669,675,681],"Weirather,":[671],"J:":[672],"Ambarkhane,":[677],"S:":[678],"Maddocks,":[683],"K:":[684],"Pharmacyclics,":[689,696,703],"Teva":[691],"Sandoz":[698],"Teva;":[700],"Novartis":[705],"Merck.":[707]},"counts_by_year":[{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-06-27T00:00:00"}
