{"id":"https://openalex.org/W2953046832","doi":"https://doi.org/10.1021/acs.analchem.7b04713","title":"Accurate, Sensitive, and Precise Multiplexed Proteomics Using the Complement Reporter Ion Cluster","display_name":"Accurate, Sensitive, and Precise Multiplexed Proteomics Using the Complement Reporter Ion Cluster","publication_year":2018,"publication_date":"2018-03-09","ids":{"openalex":"https://openalex.org/W2953046832","doi":"https://doi.org/10.1021/acs.analchem.7b04713","mag":"2953046832","pmid":"https://pubmed.ncbi.nlm.nih.gov/29522331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6220677"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.7b04713","doi":"https://doi.org/10.1021/acs.analchem.7b04713","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b04713","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/08/205054.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019549929","display_name":"Matthew Sonnett","orcid":"https://orcid.org/0000-0002-6795-1308","observed_orcids":["https://orcid.org/0000-0002-6795-1308"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Sonnett","raw_affiliation_strings":["Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033661311","display_name":"Eyan Yeung","orcid":"https://orcid.org/0000-0002-2478-0879","observed_orcids":["https://orcid.org/0000-0002-2478-0879"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eyan Yeung","raw_affiliation_strings":["Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050912870","display_name":"Martin W\u00fchr","orcid":"https://orcid.org/0000-0002-0244-8947","observed_orcids":["https://orcid.org/0000-0002-0244-8947"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin W\u00fchr","raw_affiliation_strings":["Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States"],"raw_orcid":"https://orcid.org/0000-0002-0244-8947","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, United States","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050912870"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.724,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.98356415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"90","issue":"8","first_page":"5032","last_page":"5039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isobaric-tags","display_name":"isobaric tags","score":0.7239999771118164},{"id":"https://openalex.org/keywords/chemical-noise","display_name":"chemical noise","score":0.6010000109672546},{"id":"https://openalex.org/keywords/deconvolution-algorithm","display_name":"deconvolution algorithm","score":0.753000020980835},{"id":"https://openalex.org/keywords/measurement-precision","display_name":"measurement precision","score":0.7039999961853027},{"id":"https://openalex.org/keywords/measurement-accuracy","display_name":"measurement accuracy","score":0.48500001430511475},{"id":"https://openalex.org/keywords/label-free-proteomics","display_name":"label-free quantitative proteomics","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7059277296066284},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.5929775834083557},{"id":"https://openalex.org/C2780841973","wikidata":"https://www.wikidata.org/wiki/Q2607924","display_name":"Orbitrap","level":3,"score":0.5245628356933594},{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.5158876180648804},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.5003492832183838},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.48243317008018494},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.4784305691719055},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3767856955528259},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.310281366109848},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2374742329120636},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20842096209526062},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1275976300239563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1021/acs.analchem.7b04713","doi":"https://doi.org/10.1021/acs.analchem.7b04713","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b04713","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/205054","doi":"https://doi.org/10.1101/205054","is_oa":true,"landing_page_url":"https://doi.org/10.1101/205054","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/08/205054.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:29522331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29522331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5171031","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6220677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6220677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6220677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1436582","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1436582","pdf_url":"https://www.osti.gov/servlets/purl/1436582","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1101/205054","doi":"https://doi.org/10.1101/205054","is_oa":true,"landing_page_url":"https://doi.org/10.1101/205054","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/08/205054.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1877487381","display_name":"Predoctoral Training in Genetics and Molecular Biology","funder_award_id":"T32GM007388","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4015411069","display_name":"GENOME-SCALE DESIGN AND ENGINEERING OF NON-MODEL YEAST ORGANISMS FOR PRODUCTION OF BIOFUELS AND BIOPRODUCTS","funder_award_id":"DESC0018260","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6380751991","display_name":"CENTER FOR ADVANCED BIOENERGY AND BIOPRODUCTS INNOVATION","funder_award_id":"DESC0018420","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6482703748","display_name":"CENTER FOR ADVANCED BIOENERGY AND BIOPRODUCTS INNOVATION","funder_award_id":"DESC0018420","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G6538927617","display_name":"Using Quantitative Proteomics to Understand Mitotic Spindle Composition and Function","funder_award_id":"F31GM116451","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8264398363","display_name":null,"funder_award_id":"DE-SC0018420","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G83646676","display_name":null,"funder_award_id":"DE\u2010SC0018420","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953046832.pdf","grobid_xml":"https://content.openalex.org/works/W2953046832.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1480858518","https://openalex.org/W1859662172","https://openalex.org/W1988146323","https://openalex.org/W2006986579","https://openalex.org/W2012626734","https://openalex.org/W2033484454","https://openalex.org/W2041399392","https://openalex.org/W2044008548","https://openalex.org/W2048280438","https://openalex.org/W2050199432","https://openalex.org/W2054380602","https://openalex.org/W2080752012","https://openalex.org/W2087872380","https://openalex.org/W2108508103","https://openalex.org/W2120016245","https://openalex.org/W2126441851","https://openalex.org/W2137214758","https://openalex.org/W2147773057","https://openalex.org/W2170776626","https://openalex.org/W2185223450","https://openalex.org/W2231596876","https://openalex.org/W2565605558","https://openalex.org/W2571000140","https://openalex.org/W2772184539","https://openalex.org/W2783339637"],"related_works":["https://openalex.org/W2087872380","https://openalex.org/W3159334229","https://openalex.org/W2335262420","https://openalex.org/W2465149832","https://openalex.org/W4283168258","https://openalex.org/W1988146323","https://openalex.org/W4385476712","https://openalex.org/W4294761858","https://openalex.org/W2465975605","https://openalex.org/W4306875795"],"abstract_inverted_index":{"Quantitative":[0],"analysis":[1],"of":[2,23,33,48,115,132,194,218],"proteomes":[3],"across":[4,36],"multiple":[5],"time":[6],"points,":[7],"organelles,":[8],"and":[9,18,52,102,153,163,198,234],"perturbations":[10],"is":[11,103,174],"essential":[12],"for":[13],"understanding":[14],"both":[15],"fundamental":[16],"biology":[17],"disease":[19],"states.":[20],"The":[21,81,92,140,149],"development":[22],"isobaric":[24],"tags":[25],"(e.g.,":[26],"TMT)":[27],"has":[28],"enabled":[29],"the":[30,112,116,130,133,137,168,212,215],"simultaneous":[31],"measurement":[32,53,79,122],"peptide":[34],"abundances":[35],"several":[37],"different":[38],"conditions.":[39],"These":[40],"multiplexed":[41,236],"approaches":[42,60],"are":[43,71,143],"promising":[44],"in":[45,50,56,145,207],"principle":[46],"because":[47],"advantages":[49],"throughput":[51],"quality.":[54],"However,":[55,111],"practice,":[57],"existing":[58],"multiplexing":[59],"suffer":[61],"from":[62,180,221],"key":[63],"limitations.":[64],"In":[65],"its":[66],"simple":[67],"implementation":[68],"(TMT-MS2),":[69],"measurements":[70,101,142],"distorted":[72],"by":[73,230],"chemical":[74,181],"noise":[75,182],"leading":[76],"to":[77,120,147,177,190,223],"poor":[78,121],"accuracy.":[80],"current":[82],"state-of-the-art":[83],"(TMT-MS3)":[84],"addresses":[85],"this":[86],"but":[87],"requires":[88],"specialized":[89],"quadrupole-iontrap-Orbitrap":[90],"instrumentation.":[91],"complement":[93],"reporter":[94],"ion":[95],"approach":[96],"(TMTc)":[97],"produces":[98],"high":[99],"accuracy":[100],"compatible":[104],"with":[105,165],"many":[106],"more":[107,159,239],"instruments,":[108],"like":[109],"quadrupole-Orbitraps.":[110],"required":[113],"deconvolution":[114,138],"TMTc":[117],"cluster":[118],"leads":[119],"precision.":[123],"Here,":[124],"we":[125,187],"introduce":[126],"TMTc+,":[127],"which":[128],"adds":[129],"modeling":[131],"MS2-isolation":[134],"step":[135],"into":[136],"algorithm.":[139],"resulting":[141],"comparable":[144,164],"precision":[146],"TMT-MS3/MS2.":[148],"improved":[150],"duty":[151],"cycle":[152],"lower":[154],"filtering":[155],"requirements":[156],"make":[157],"TMTc+":[158,173,189,201,226],"sensitive":[160],"than":[161],"TMT-MS3":[162],"TMT-MS2.":[166],"At":[167,211],"same":[169,213],"time,":[170,214],"unlike":[171],"TMT-MS2,":[172],"exquisitely":[175],"able":[176],"distinguish":[178],"signal":[179],"even":[183],"outperforming":[184],"TMT-MS3.":[185],"Lastly,":[186],"compare":[188],"quantitative":[191,228],"label-free":[192],"proteomics":[193,229],"total":[195],"HeLa":[196],"lysate":[197],"find":[199],"that":[200],"quantifies":[202],"7.8k":[203],"versus":[204],"3.9k":[205],"proteins":[206],"a":[208],"5-plex":[209],"sample.":[210],"median":[216],"coefficient":[217],"variation":[219],"improves":[220],"13%":[222],"4%.":[224],"Thus,":[225],"advances":[227],"enabling":[231],"accurate,":[232],"sensitive,":[233],"precise":[235],"experiments":[237],"on":[238],"commonly":[240],"used":[241],"instruments.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-06-27T00:00:00"}