{"id":"https://openalex.org/W2952883374","doi":"https://doi.org/10.1016/s0040-4020(01)86495-4","title":"Genetic engineering of hybrid antibiotics - a progress report","display_name":"Genetic engineering of hybrid antibiotics - a progress report","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W2952883374","doi":"https://doi.org/10.1016/s0040-4020(01)86495-4","mag":"2952883374"},"language":"en","primary_location":{"id":"doi:10.1016/s0040-4020(01)86495-4","doi":"https://doi.org/10.1016/s0040-4020(01)86495-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0040-4020(01)86495-4","pdf_url":null,"source":{"id":"https://openalex.org/S205754296","display_name":"Tetrahedron","issn_l":"0040-4020","issn":["0040-4020","1464-5416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027410094","display_name":"Heinz G. Floss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heinz G. Floss","raw_affiliation_strings":["Department of Chemistry, University of Washington, Seattle, WA 98195 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Washington, Seattle, WA 98195 U.S.A","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044774669","display_name":"William R. Strohl","orcid":"https://orcid.org/0000-0002-8271-6875","observed_orcids":["https://orcid.org/0000-0002-8271-6875"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Strohl","raw_affiliation_strings":["Department of Microbiology, The Ohio State University, Columbus, OH 43210 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Ohio State University, Columbus, OH 43210 U.S.A","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":2.5201,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.90203477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"31","first_page":"6045","last_page":"6058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hybrid-antibiotics","display_name":"hybrid antibiotics","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antibiotic-biosynthesis-genes","display_name":"antibiotic biosynthesis genes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polyketides","display_name":"polyketides","score":0.8149999976158142},{"id":"https://openalex.org/keywords/thiopeptide-antibiotics","display_name":"thiopeptide antibiotics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.8044723272323608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7906918525695801},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7372227907180786},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.6945472955703735},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5547927021980286},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.5137375593185425},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4825727045536041},{"id":"https://openalex.org/C2777763344","wikidata":"https://www.wikidata.org/wiki/Q4369963","display_name":"Polyketide synthase","level":5,"score":0.4455999732017517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3701602518558502},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3534735441207886},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.3275233507156372},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.24926140904426575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1992672085762024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19245976209640503},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1873568892478943},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09814569354057312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07791489362716675},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06054568290710449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0040-4020(01)86495-4","doi":"https://doi.org/10.1016/s0040-4020(01)86495-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0040-4020(01)86495-4","pdf_url":null,"source":{"id":"https://openalex.org/S205754296","display_name":"Tetrahedron","issn_l":"0040-4020","issn":["0040-4020","1464-5416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W7247092","https://openalex.org/W20980533","https://openalex.org/W1243723833","https://openalex.org/W1581215757","https://openalex.org/W1810746252","https://openalex.org/W1995021414","https://openalex.org/W2004659858","https://openalex.org/W2006283042","https://openalex.org/W2006643920","https://openalex.org/W2007465209","https://openalex.org/W2009071736","https://openalex.org/W2011348472","https://openalex.org/W2026898360","https://openalex.org/W2040863283","https://openalex.org/W2042879430","https://openalex.org/W2049147489","https://openalex.org/W2049844183","https://openalex.org/W2054146451","https://openalex.org/W2069267492","https://openalex.org/W2070754043","https://openalex.org/W2077099415","https://openalex.org/W2087925087","https://openalex.org/W2088330573","https://openalex.org/W2107333144","https://openalex.org/W2119893355","https://openalex.org/W2135967789","https://openalex.org/W2141876341","https://openalex.org/W2150613482","https://openalex.org/W2316605418","https://openalex.org/W2330410040","https://openalex.org/W2335153963","https://openalex.org/W2615139755","https://openalex.org/W4244679105"],"related_works":["https://openalex.org/W2008622270","https://openalex.org/W2004659858","https://openalex.org/W2363237660","https://openalex.org/W2084411736","https://openalex.org/W1606418040","https://openalex.org/W3192321010","https://openalex.org/W1987950188","https://openalex.org/W2049147489","https://openalex.org/W1994881065","https://openalex.org/W2379691555"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-06-27T00:00:00"}
