{"id":"https://openalex.org/W2952829451","doi":"https://doi.org/10.1101/gr.227272.117","title":"Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures","display_name":"Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures","publication_year":2018,"publication_date":"2018-02-02","ids":{"openalex":"https://openalex.org/W2952829451","doi":"https://doi.org/10.1101/gr.227272.117","mag":"2952829451","pmid":"https://pubmed.ncbi.nlm.nih.gov/29429976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5848609"},"language":"en","primary_location":{"id":"doi:10.1101/gr.227272.117","doi":"https://doi.org/10.1101/gr.227272.117","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.227272.117","pdf_url":"http://genome.cshlp.org/content/28/3/295.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genome.cshlp.org/content/28/3/295.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036529265","display_name":"Federico Comoglio","orcid":"https://orcid.org/0000-0002-8970-6610","observed_orcids":["https://orcid.org/0000-0002-8970-6610"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Federico Comoglio","raw_affiliation_strings":["Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8970-6610","affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"raw_affiliation_string":"1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618576","display_name":"Hyun Jung Park","orcid":"https://orcid.org/0000-0002-8324-2624","observed_orcids":["https://orcid.org/0000-0002-8324-2624"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hyun Jung Park","raw_affiliation_strings":["Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"raw_affiliation_string":"1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090153306","display_name":"Stefan Schoenfelder","orcid":"https://orcid.org/0000-0002-3200-8133","observed_orcids":["https://orcid.org/0000-0002-3200-8133"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefan Schoenfelder","raw_affiliation_strings":["Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","2Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"2Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080587435","display_name":"Iros Barozzi","orcid":"https://orcid.org/0000-0003-0690-3473","observed_orcids":["https://orcid.org/0000-0003-0690-3473"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iros Barozzi","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA","3Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"3Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052368007","display_name":"Daniel Bode","orcid":"https://orcid.org/0000-0003-4415-7387","observed_orcids":["https://orcid.org/0000-0003-4415-7387"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Bode","raw_affiliation_strings":["Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"raw_affiliation_string":"1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049273208","display_name":"Peter Fraser","orcid":"https://orcid.org/0000-0002-0041-1227","observed_orcids":["https://orcid.org/0000-0002-0041-1227"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Peter Fraser","raw_affiliation_strings":["Department of Biological Science, Florida State University, Tallahassee, Florida 32301, USA","Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","2Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","4Department of Biological Science, Florida State University, Tallahassee, Florida 32301, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, Florida 32301, USA","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"2Nuclear Dynamics Programme, The Babraham Institute, Cambridge CB22 3AT, United Kingdom","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"4Department of Biological Science, Florida State University, Tallahassee, Florida 32301, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047637115","display_name":"Anthony Richard Green","orcid":"https://orcid.org/0000-0002-9795-0218","observed_orcids":["https://orcid.org/0000-0002-9795-0218"]},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony R. Green","raw_affiliation_strings":["Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom","1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","5Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I4210156194"]},{"raw_affiliation_string":"1Cambridge Institute for Medical Research, Medical Research Council/Wellcome Trust Stem Cell Institute, and Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I90344618"]},{"raw_affiliation_string":"5Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom","institution_ids":["https://openalex.org/I4210156194"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":{"value":4907,"currency":"EUR","value_usd":5292},"fwci":null,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"3","first_page":"295","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombopoietin-signaling","display_name":"thrombopoietin signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.7670000195503235},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.9490000009536743},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.6449999809265137},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9218969345092773},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.9011358618736267},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7875373363494873},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.7122583389282227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5566273927688599},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.43492555618286133},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4348376393318176},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.425857275724411},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.41455554962158203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38549506664276123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3714069128036499},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.31465792655944824},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11263260245323181},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11145293712615967},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10651472210884094},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.10555949807167053},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07147166132926941}],"mesh":[{"descriptor_ui":"D000081122","descriptor_name":"Epigenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013926","descriptor_name":"Thrombopoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1101/gr.227272.117","doi":"https://doi.org/10.1101/gr.227272.117","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.227272.117","pdf_url":"http://genome.cshlp.org/content/28/3/295.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5848609","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5848609","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Res","raw_type":"Text"},{"id":"pmid:29429976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29429976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:genome:28/3/295","doi":null,"is_oa":false,"landing_page_url":"http://genome.cshlp.org/cgi/content/short/28/3/295","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:osti.gov:1625636","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1625636","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:s-space.snu.ac.kr:10371/235573","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/235573","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/81256","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/81256","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"309","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gr.227272.117","doi":"https://doi.org/10.1101/gr.227272.117","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.227272.117","pdf_url":"http://genome.cshlp.org/content/28/3/295.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1324026023","display_name":"To study epigenetic mechanisms regulating lineage commitment and cell potency","funder_award_id":"BBS/E/B/000C0421","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2401687207","display_name":null,"funder_award_id":"13003","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G2537149883","display_name":null,"funder_award_id":"MC_PC_12009","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2992180400","display_name":null,"funder_award_id":"BB/J004480/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G34383514","display_name":null,"funder_award_id":"21762","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5111006549","display_name":"Supporting transnational mobility within the European life sciences by cofunding of the EMBO Fellowship Programme","funder_award_id":"609409","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5707549070","display_name":null,"funder_award_id":"13003","funder_id":"https://openalex.org/F4320324760","funder_display_name":"Bloodwise"},{"id":"https://openalex.org/G7567962354","display_name":null,"funder_award_id":"BBS/E/B/000C0421","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8617195224","display_name":"CALR mutations and human myeloproliferative neoplasms.","funder_award_id":"104710/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320104","display_name":"Kay Kendall Leukaemia Fund","ror":"https://ror.org/03j2wfg84"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320324760","display_name":"Bloodwise","ror":"https://ror.org/0055acf80"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952829451.pdf","grobid_xml":"https://content.openalex.org/works/W2952829451.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W655820313","https://openalex.org/W1579958344","https://openalex.org/W1606273823","https://openalex.org/W1776547251","https://openalex.org/W1965375035","https://openalex.org/W1970831058","https://openalex.org/W1970956961","https://openalex.org/W1971578941","https://openalex.org/W1972796654","https://openalex.org/W1979594866","https://openalex.org/W1981030303","https://openalex.org/W1981077232","https://openalex.org/W1983612778","https://openalex.org/W1985621639","https://openalex.org/W1986586739","https://openalex.org/W1990184382","https://openalex.org/W1996448420","https://openalex.org/W2004966039","https://openalex.org/W2008227324","https://openalex.org/W2011990150","https://openalex.org/W2016015848","https://openalex.org/W2017558718","https://openalex.org/W2017826121","https://openalex.org/W2018420076","https://openalex.org/W2018658338","https://openalex.org/W2021189802","https://openalex.org/W2030545812","https://openalex.org/W2035942502","https://openalex.org/W2039096008","https://openalex.org/W2044417243","https://openalex.org/W2045362835","https://openalex.org/W2056482755","https://openalex.org/W2062853747","https://openalex.org/W2065006553","https://openalex.org/W2069332674","https://openalex.org/W2070021921","https://openalex.org/W2072288967","https://openalex.org/W2079407198","https://openalex.org/W2090037139","https://openalex.org/W2091525085","https://openalex.org/W2091548199","https://openalex.org/W2103393606","https://openalex.org/W2103428287","https://openalex.org/W2104198848","https://openalex.org/W2105337489","https://openalex.org/W2116185766","https://openalex.org/W2116634411","https://openalex.org/W2123564569","https://openalex.org/W2131453083","https://openalex.org/W2132257972","https://openalex.org/W2135046866","https://openalex.org/W2137601569","https://openalex.org/W2139805763","https://openalex.org/W2143531841","https://openalex.org/W2145139769","https://openalex.org/W2149454526","https://openalex.org/W2152791321","https://openalex.org/W2160304959","https://openalex.org/W2160856280","https://openalex.org/W2161212572","https://openalex.org/W2162544653","https://openalex.org/W2167714308","https://openalex.org/W2168602111","https://openalex.org/W2176574121","https://openalex.org/W2185693210","https://openalex.org/W2187652773","https://openalex.org/W2252980137","https://openalex.org/W2259938310","https://openalex.org/W2261235911","https://openalex.org/W2263191133","https://openalex.org/W2268267797","https://openalex.org/W2295037017","https://openalex.org/W2295297857","https://openalex.org/W2300220838","https://openalex.org/W2325112174","https://openalex.org/W2337928212","https://openalex.org/W2461460074","https://openalex.org/W2475324019","https://openalex.org/W2530292798","https://openalex.org/W2536763320","https://openalex.org/W2556041461","https://openalex.org/W2568062379","https://openalex.org/W2575110262","https://openalex.org/W2594685900","https://openalex.org/W2602710346","https://openalex.org/W2614144400","https://openalex.org/W2757387674","https://openalex.org/W2761461280","https://openalex.org/W2775505403","https://openalex.org/W2782190517","https://openalex.org/W2894824533","https://openalex.org/W2911964244","https://openalex.org/W2950020758","https://openalex.org/W2965584346","https://openalex.org/W2988515069","https://openalex.org/W4211259900"],"related_works":["https://openalex.org/W6925149076","https://openalex.org/W2607265226","https://openalex.org/W3087675265","https://openalex.org/W2073123597","https://openalex.org/W4313354928","https://openalex.org/W1553025596","https://openalex.org/W6983059918","https://openalex.org/W2596505058","https://openalex.org/W3017287520","https://openalex.org/W2006993223"],"abstract_inverted_index":{"Thrombopoietin":[0],"(TPO)":[1],"is":[2,116,167],"a":[3],"critical":[4],"cytokine":[5,53],"regulating":[6],"hematopoietic":[7,44,80],"stem":[8],"cell":[9],"maintenance":[10],"and":[11,20,37,48,65,95,107,130,136,155,180],"differentiation":[12],"into":[13],"the":[14,18,33,59,74,149],"megakaryocytic":[15],"lineage.":[16],"However,":[17],"transcriptional":[19,36],"chromatin":[21,56,66,96,156,171],"dynamics":[22,94,154],"elicited":[23],"by":[24,105],"TPO":[25,42,71,144],"signaling":[26,54],"are":[27,103,127,140],"poorly":[28],"understood.":[29],"Here,":[30],"we":[31,98,158,175],"study":[32],"immediate":[34],"early":[35],"cis":[38,62,92,112,152,164,182,198],"-regulatory":[39,63,93,113,153,165,183,199],"responses":[40,200],"to":[41,55,57,143,201],"in":[43,132],"stem/progenitor":[45],"cells":[46],"(HSPCs)":[47],"use":[49],"this":[50],"paradigm":[51],"of":[52,76,88,111,163,170],"dissect":[58],"relationship":[60],"between":[61,151],"activity":[64,166],"architecture.":[67],"We":[68],"show":[69,159,176],"that":[70,100,115,139,160],"profoundly":[72],"alters":[73],"transcriptome":[75],"HSPCs,":[77],"with":[78],"key":[79],"regulators":[81],"being":[82],"transcriptionally":[83],"repressed":[84,181],"within":[85,119],"30":[86],"min":[87],"TPO.":[89,202],"By":[90,146],"examining":[91,148],"architectures,":[97],"demonstrate":[99],"these":[101],"changes":[102],"accompanied":[104],"rapid":[106,161,197],"extensive":[108],"epigenome":[109],"remodeling":[110],"landscapes":[114],"spatially":[117,128],"coordinated":[118],"topologically":[120],"associating":[121],"domains":[122],"(TADs).":[123],"Moreover,":[124],"TPO-responsive":[125],"enhancers":[126],"clustered":[129],"engage":[131],"preferential":[133],"homotypic":[134],"intra-":[135],"inter-TAD":[137],"interactions":[138],"largely":[141,168],"refractory":[142],"signaling.":[145],"further":[147],"link":[150],"looping,":[157],"modulation":[162],"independent":[169],"looping":[172],"dynamics.":[173],"Finally,":[174],"that,":[177],"although":[178],"activated":[179],"elements":[184],"share":[185],"remarkably":[186],"similar":[187],"DNA":[188],"sequence":[189],"compositions,":[190],"transcription":[191],"factor":[192],"binding":[193],"patterns":[194],"accurately":[195],"predict":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}
