{"id":"https://openalex.org/W2952826643","doi":"https://doi.org/10.24911/jbcgenetics/183-1554287386","title":"Collagen-specific chaperone, heat shock protein 47 kDa (HSP47)-pathway and expression patterns in cancer","display_name":"Collagen-specific chaperone, heat shock protein 47 kDa (HSP47)-pathway and expression patterns in cancer","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2952826643","doi":"https://doi.org/10.24911/jbcgenetics/183-1554287386","mag":"2952826643"},"language":"en","primary_location":{"id":"doi:10.24911/jbcgenetics/183-1554287386","doi":"https://doi.org/10.24911/jbcgenetics/183-1554287386","is_oa":true,"landing_page_url":"https://doi.org/10.24911/jbcgenetics/183-1554287386","pdf_url":null,"source":{"id":"https://openalex.org/S4210194563","display_name":"Journal of Biochemical and Clinical Genetics","issn_l":"1658-807X","issn":["1658-807X","1658-8088"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Clinical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.24911/jbcgenetics/183-1554287386","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035800986","display_name":"Alisha Parveen","orcid":"https://orcid.org/0000-0002-9236-6821","observed_orcids":["https://orcid.org/0000-0002-9236-6821"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alisha Parveen","raw_affiliation_strings":["Medical Research Center, University of Heidelberg, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Center, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723628","display_name":"Rajesh Kumar","orcid":"https://orcid.org/0000-0001-9346-8806","observed_orcids":["https://orcid.org/0000-0001-9346-8806"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rajesh Kumar","raw_affiliation_strings":["Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210151100"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009588266","display_name":"Sukant Khurana","orcid":"https://orcid.org/0000-0002-6665-6892","observed_orcids":["https://orcid.org/0000-0002-6665-6892"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sukant Khurana","raw_affiliation_strings":["Pharmacology Department, Central Drug Research Institute, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, Central Drug Research Institute, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":null,"display_name":"Abhishek Kumar","orcid":"https://orcid.org/0000-0003-4172-4059","observed_orcids":["https://orcid.org/0000-0003-4172-4059"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhishek Kumar","raw_affiliation_strings":["Pharmacology Department, Central Drug Research Institute, Lucknow, Uttar Pradesh, India"],"raw_orcid":"https://orcid.org/0000-0003-4172-4059","affiliations":[{"raw_affiliation_string":"Pharmacology Department, Central Drug Research Institute, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0728,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33073784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"1","first_page":"3","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp47","display_name":"HSP47","score":0.8040000200271606},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.48399999737739563},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7900000214576721},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.890999972820282},{"id":"https://openalex.org/keywords/hsp40","display_name":"Hsp40","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hsph1","display_name":"HSPH1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/fkbp4","display_name":"FKBP4","score":0.7680000066757202},{"id":"https://openalex.org/keywords/crtap","display_name":"CRTAP","score":0.6819999814033508},{"id":"https://openalex.org/keywords/protein-disulfide-isomerase","display_name":"protein disulfide isomerase","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tissue-expression","display_name":"tissue expression","score":0.4269999861717224},{"id":"https://openalex.org/keywords/normal-human-tissues","display_name":"normal human tissues","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2778965386","wikidata":"https://www.wikidata.org/wiki/Q420068","display_name":"Serpin","level":3,"score":0.8001996278762817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5770729780197144},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5607905983924866},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5345773696899414},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.49134936928749084},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.48217979073524475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4067692458629608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40543586015701294},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.4052257537841797},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3430898189544678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32986170053482056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08959183096885681},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.084522545337677}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.24911/jbcgenetics/183-1554287386","doi":"https://doi.org/10.24911/jbcgenetics/183-1554287386","is_oa":true,"landing_page_url":"https://doi.org/10.24911/jbcgenetics/183-1554287386","pdf_url":null,"source":{"id":"https://openalex.org/S4210194563","display_name":"Journal of Biochemical and Clinical Genetics","issn_l":"1658-807X","issn":["1658-807X","1658-8088"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Clinical Genetics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a12d4418fd274fbab1cca04c2323c388","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a12d4418fd274fbab1cca04c2323c388","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biochemical and Clinical Genetics, Vol 2, Iss 1, Pp 3-17 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.24911/jbcgenetics/183-1554287386","doi":"https://doi.org/10.24911/jbcgenetics/183-1554287386","is_oa":true,"landing_page_url":"https://doi.org/10.24911/jbcgenetics/183-1554287386","pdf_url":null,"source":{"id":"https://openalex.org/S4210194563","display_name":"Journal of Biochemical and Clinical Genetics","issn_l":"1658-807X","issn":["1658-807X","1658-8088"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Clinical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W595144989","https://openalex.org/W1965639209","https://openalex.org/W1972121275","https://openalex.org/W1985063313","https://openalex.org/W1990034546","https://openalex.org/W1997150574","https://openalex.org/W2014077633","https://openalex.org/W2023481820","https://openalex.org/W2040233624","https://openalex.org/W2041660879","https://openalex.org/W2042809289","https://openalex.org/W2044089985","https://openalex.org/W2076981817","https://openalex.org/W2084408578","https://openalex.org/W2095358593","https://openalex.org/W2096173332","https://openalex.org/W2122029850","https://openalex.org/W2130888576","https://openalex.org/W2135035906","https://openalex.org/W2136659618","https://openalex.org/W2138496162","https://openalex.org/W2139665091","https://openalex.org/W2171215167","https://openalex.org/W2238888716","https://openalex.org/W2416143757","https://openalex.org/W2522323574","https://openalex.org/W2551012893","https://openalex.org/W2747709233","https://openalex.org/W2753399420","https://openalex.org/W2794639511","https://openalex.org/W2936378180","https://openalex.org/W4210757594"],"related_works":["https://openalex.org/W2901638901","https://openalex.org/W2888354601","https://openalex.org/W3210995005","https://openalex.org/W1483255008","https://openalex.org/W2980717441","https://openalex.org/W2088901734","https://openalex.org/W2551012893","https://openalex.org/W4396730986","https://openalex.org/W2913301468","https://openalex.org/W2079442545"],"abstract_inverted_index":{"Background:":[0],"Human":[1],"serpin":[2,9],"gene":[3],"SERPINH1":[4],"encodes":[5],"for":[6,36,108],"a":[7,14,19,159,219],"non-inhibitory":[8],"shock":[10],"protein":[11,34,74,95,124,149,195,200],"47kDa":[12],"(HSP47)":[13],"client-specific":[15],"chaperone,":[16,54],"which":[17,169],"is":[18,28],"hallmark":[20],"in":[21,52,56,71,92,115,142,241,264,280],"the":[22,33,40,46,155,237,259,276],"collagen":[23],"biosynthesis.":[24],"Till":[25],"today,":[26],"there":[27],"no":[29],"comprehensive":[30],"study":[31,42,62,156,217,238],"on":[32,275],"network":[35],"human":[37,78,123,144,153,265,281],"HSP47.":[38,79,101],"Thus":[39],"current":[41],"aimed":[43],"at":[44,228],"studying":[45],"pathway":[47],"and":[48,132,188,209],"expression":[49,111,129,141,244,260],"patterns":[50,112,245],"observed":[51],"collagen-specific":[53],"HSP47":[55,114,140,243,263,279],"relation":[57],"to":[58,138,234],"cancer.":[59,117],"Methodology:":[60],"The":[61,102,216],"used":[63,91,107,137],"online":[64,120],"database":[65,81],"STRING":[66],"10":[67],"(website:":[68],"http://version10a.string-db.org":[69],"(7))":[70],"finding":[72,242],"putative":[73],"interaction":[75,165],"partners":[76,166],"of":[77,110,113,152,161,167,174,192,221,262,278],"Also,":[80],"HMMER3":[82],"(www.hmmer.org/)":[83],"with":[84,100,225],"Pfam":[85,94],"32.0":[86],"(Sept":[87],"2018)":[88],"dataset":[89],"was":[90,106,136,239],"identifying":[93],"domains":[96],"from":[97,232],"proteins":[98,187],"interacting":[99,224],"db":[103],"DEPC":[104],"3.0,":[105],"evaluation":[109],"different":[116,222,229,252],"Further":[118],"three":[119,251],"resources":[121],"namely,":[122],"atlas":[125],"(HPA,":[126],"https://www.proteinatlas.org/),":[127],"genotype-tissue":[128],"(GTEx":[130],"https://gtexportal.org)":[131],"FANTOM5":[133],"project":[134],"(http://fantom.gsc.riken.jp/5/)":[135],"examine":[139],"normal":[143,248],"tissues.":[145],"Results:":[146],"Upon":[147],"constructing":[148],"interactive":[150],"map":[151],"HSP47,":[154,168,226],"found":[157,218],"that":[158],"set":[160],"molecular":[162],"chaperones":[163,223],"as":[164],"included":[170],"two":[171],"copies":[172],"each":[173,191],"cAMP":[175],"response":[176],"element":[177],"binding":[178,180],"(CREB)":[179],"proteins,":[181],"HSP27,":[182],"HSP40,":[183],"HSP70,":[184],"HSP90,":[185],"ubiquitin":[186],"one":[189],"copy":[190],"cartilage":[193],"associated":[194],"(CRTAP),":[196],"HSPH1,":[197],"HSBP1,":[198],"FK506-binding":[199],"4":[201],"(FKBP4),":[202],"kruppel-like":[203],"factor":[204],"(KLF13),":[205],"peptidyl-prolyl":[206],"isomerase":[207],"PIPB":[208],"Prolyl":[210],"4-hydroxylase":[211],"beta":[212],"subunit":[213],"(P4HB).":[214],"Conclusion:":[215],"cocktail":[220],"originated":[227],"time":[230],"points":[231],"prokaryotes":[233],"eukaryotes.":[235],"Overall,":[236],"successful":[240],"among":[246],"several":[247],"tissues":[249],"using":[250],"publicly":[253],"available":[254],"datasets.":[255],"It":[256],"also":[257],"assessed":[258],"pattern":[261],"cancer":[266],"types.":[267],"These":[268],"findings":[269],"will":[270],"encourage":[271],"further":[272],"studies":[273],"focusing":[274],"role":[277],"diseases.":[282]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-06-27T00:00:00"}
