{"id":"https://openalex.org/W2952800550","doi":"https://doi.org/10.1534/genetics.116.190462","title":"A Statistical Guide to the Design of Deep Mutational Scanning Experiments","display_name":"A Statistical Guide to the Design of Deep Mutational Scanning Experiments","publication_year":2016,"publication_date":"2016-07-14","ids":{"openalex":"https://openalex.org/W2952800550","doi":"https://doi.org/10.1534/genetics.116.190462","mag":"2952800550","pmid":"https://pubmed.ncbi.nlm.nih.gov/27412710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5012406"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.116.190462","doi":"https://doi.org/10.1534/genetics.116.190462","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.116.190462","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2016/06/29/048892.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037896866","display_name":"Sebastian Matuszewski","orcid":"https://orcid.org/0000-0002-4393-9283","observed_orcids":["https://orcid.org/0000-0002-4393-9283"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sebastian Matuszewski","raw_affiliation_strings":["School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics , Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4393-9283","affiliations":[{"raw_affiliation_string":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics , Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006443017","display_name":"Marcel E. Hildebrandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcel E. Hildebrandt","raw_affiliation_strings":["School of Basic Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","School of Basic Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Basic Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035262138","display_name":"Ana\u2010Hermina Ghenu","orcid":"https://orcid.org/0000-0002-9088-2232","observed_orcids":["https://orcid.org/0000-0002-9088-2232"]},"institutions":[{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana-Hermina Ghenu","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia , Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia , Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020301143","display_name":"Jeffrey D. Jensen","orcid":"https://orcid.org/0000-0002-4786-8064","observed_orcids":["https://orcid.org/0000-0002-4786-8064","https://orcid.org/0000-0003-1790-7453"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jeffrey D. Jensen","raw_affiliation_strings":["School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics , Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics , Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053742951","display_name":"Claudia Bank","orcid":"https://orcid.org/0000-0003-4730-758X","observed_orcids":["https://orcid.org/0000-0003-4730-758X"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH","PT"],"is_corresponding":true,"raw_author_name":"Claudia Bank","raw_affiliation_strings":["Instituto Gulbenkian de Ci\u00eancia , Oeiras, Portugal","Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal Email:","School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics , Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4730-758X","affiliations":[{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia , Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal Email:","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"School of Life Sciences, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"School of Life Sciences , \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics , Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053742951"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I48057805","https://openalex.org/I5124864"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.8862,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.91279849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"204","issue":"1","first_page":"77","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-mutational-scanning","display_name":"deep mutational scanning","score":0.996999979019165},{"id":"https://openalex.org/keywords/fitness-effects-of-mutations","display_name":"fitness effects of mutations","score":0.8240000009536743},{"id":"https://openalex.org/keywords/experimental-design-optimization","display_name":"experimental design optimization","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sequencing-depth","display_name":"sequencing depth","score":0.718999981880188},{"id":"https://openalex.org/keywords/selection-coefficients","display_name":"selection coefficients","score":0.6340000033378601},{"id":"https://openalex.org/keywords/measurement-precision","display_name":"measurement precision","score":0.5370000004768372},{"id":"https://openalex.org/keywords/confidence-intervals","display_name":"confidence intervals","score":0.7319999933242798},{"id":"https://openalex.org/keywords/approximate-analytical-solutions","display_name":"approximate analytical solutions","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5793318152427673},{"id":"https://openalex.org/C75553542","wikidata":"https://www.wikidata.org/wiki/Q178161","display_name":"A priori and a posteriori","level":2,"score":0.5651222467422485},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5504770874977112},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.5363314151763916},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.493103951215744},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.47679615020751953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46202975511550903},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.4591464698314667},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.44919607043266296},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.4490245580673218},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.4352148175239563},{"id":"https://openalex.org/C2778067643","wikidata":"https://www.wikidata.org/wiki/Q166507","display_name":"Interval (graph theory)","level":2,"score":0.4195360243320465},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3680117130279541},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2600850462913513},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2394249141216278},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23771223425865173},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1357266902923584},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0965941846370697},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1534/genetics.116.190462","doi":"https://doi.org/10.1534/genetics.116.190462","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.116.190462","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/048892","doi":"https://doi.org/10.1101/048892","is_oa":true,"landing_page_url":"https://doi.org/10.1101/048892","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2016/06/29/048892.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:4473525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5012406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27412710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27412710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5012406","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5012406/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmh:oai:infoscience.epfl.ch:223302","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/223302","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:223302","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/223302","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1101/048892","doi":"https://doi.org/10.1101/048892","is_oa":true,"landing_page_url":"https://doi.org/10.1101/048892","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2016/06/29/048892.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952800550.pdf","grobid_xml":"https://content.openalex.org/works/W2952800550.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W104370512","https://openalex.org/W1483736513","https://openalex.org/W1488166531","https://openalex.org/W1552511499","https://openalex.org/W1575552072","https://openalex.org/W1577451703","https://openalex.org/W1900500601","https://openalex.org/W1968075680","https://openalex.org/W1969012077","https://openalex.org/W1978781447","https://openalex.org/W1980032585","https://openalex.org/W1995369952","https://openalex.org/W2003393395","https://openalex.org/W2004671976","https://openalex.org/W2005869314","https://openalex.org/W2011343696","https://openalex.org/W2014470952","https://openalex.org/W2023205268","https://openalex.org/W2026597085","https://openalex.org/W2028599082","https://openalex.org/W2028800939","https://openalex.org/W2029423415","https://openalex.org/W2031460659","https://openalex.org/W2038522196","https://openalex.org/W2041380027","https://openalex.org/W2042750808","https://openalex.org/W2045435533","https://openalex.org/W2048945712","https://openalex.org/W2052120841","https://openalex.org/W2055346334","https://openalex.org/W2060588922","https://openalex.org/W2061184966","https://openalex.org/W2062210712","https://openalex.org/W2065395033","https://openalex.org/W2087808706","https://openalex.org/W2094223039","https://openalex.org/W2097955805","https://openalex.org/W2102795115","https://openalex.org/W2107996465","https://openalex.org/W2123850444","https://openalex.org/W2126263906","https://openalex.org/W2128023973","https://openalex.org/W2128323824","https://openalex.org/W2134757533","https://openalex.org/W2144762955","https://openalex.org/W2144893575","https://openalex.org/W2151887741","https://openalex.org/W2152573681","https://openalex.org/W2152995125","https://openalex.org/W2157156822","https://openalex.org/W2158230102","https://openalex.org/W2166066623","https://openalex.org/W2168912452","https://openalex.org/W2169436065","https://openalex.org/W2169947310","https://openalex.org/W2173518071","https://openalex.org/W2174114678","https://openalex.org/W2193953711","https://openalex.org/W2195558355","https://openalex.org/W2215005393","https://openalex.org/W2296319761","https://openalex.org/W2331911623","https://openalex.org/W2338807579","https://openalex.org/W2339766289","https://openalex.org/W2379594833","https://openalex.org/W2905068988","https://openalex.org/W4236670782","https://openalex.org/W4239648059","https://openalex.org/W4295837538"],"related_works":["https://openalex.org/W4376110128","https://openalex.org/W4407135048","https://openalex.org/W3021243554","https://openalex.org/W2744336424","https://openalex.org/W1943048093","https://openalex.org/W2133204396","https://openalex.org/W2563318491","https://openalex.org/W2144762955","https://openalex.org/W4409710917","https://openalex.org/W7136078805"],"abstract_inverted_index":{"The":[0],"characterization":[1],"of":[2,5,25,29,31,51,66,79,98,106,124,142,149,167,180,184,214,221],"the":[3,26,48,52,58,62,70,96,100,104,122,125,128,135,140,147,150,162,165,168,181,194,198,215,222],"distribution":[4],"mutational":[6],"effects":[7,28,55],"is":[8,152],"a":[9,43,190,218,229],"key":[10],"goal":[11],"in":[12,42],"evolutionary":[13],"biology.":[14],"Recently":[15],"developed":[16],"deep-sequencing":[17,90],"approaches":[18],"allow":[19,174],"for":[20,87,175,192,197,212,228,232,237],"accurate":[21],"and":[22,64,69,82,103,158,164,173,177],"simultaneous":[23],"estimation":[24],"fitness":[27,54],"hundreds":[30],"engineered":[32],"mutations":[33,67],"by":[34],"monitoring":[35],"their":[36],"relative":[37],"abundance":[38],"across":[39],"time":[40,108,117,156],"points":[41,118,157],"single":[44],"bulk":[45,91],"competition.":[46],"Naturally,":[47],"achievable":[49,129],"resolution":[50],"estimated":[53],"depends":[56],"on":[57,95],"specific":[59,238],"experimental":[60,171,223],"setup,":[61,224],"organism":[63],"type":[65],"studied,":[68],"sequencing":[71,101,136],"technology":[72],"utilized,":[73],"among":[74],"other":[75],"factors.":[76],"By":[77],"means":[78],"analytical":[80,111],"approximations":[81],"simulations,":[83],"we":[84,188,203],"provide":[85,189],"guidelines":[86],"optimizing":[88],"time-sampled":[89],"competition":[92],"experiments,":[93],"focusing":[94],"number":[97,105,141],"mutants,":[99],"depth,":[102],"sampled":[107],"points.":[109],"Our":[110],"results":[112],"show":[113],"that":[114],"sampling":[115,154],"more":[116,155],"together":[119],"with":[120,133],"extending":[121],"duration":[123,148],"experiment":[126,151,169],"improves":[127],"precision":[130,220],"disproportionately":[131],"compared":[132],"increasing":[134],"depth":[137],"or":[138],"reducing":[139],"competing":[143],"mutants.":[144],"Even":[145],"if":[146],"fixed,":[153],"clustering":[159],"these":[160],"at":[161],"beginning":[163],"end":[166],"increase":[170],"power":[172],"efficient":[176],"precise":[178],"assessment":[179],"entire":[182],"range":[183],"selection":[185,239],"coefficients.":[186],"Finally,":[187],"formula":[191],"calculating":[193],"95%-confidence":[195],"interval":[196],"measurement":[199],"error":[200],"estimate,":[201],"which":[202],"implement":[204],"as":[205,225,227],"an":[206],"interactive":[207],"web":[208],"tool.":[209],"This":[210],"allows":[211],"quantification":[213],"maximum":[216],"expected":[217],"priori":[219],"well":[226],"statistical":[230],"threshold":[231],"determining":[233],"deviations":[234],"from":[235],"neutrality":[236],"coefficient":[240],"estimates.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-27T00:00:00"}
