{"id":"https://openalex.org/W2952776887","doi":"https://doi.org/10.1093/ndt/gfz103.sp710","title":"SP710RESISTANCE OF T FOLLICULAR HELPER CELLS TO MOUSE ANTI-THYMOCYTE GLOBULIN","display_name":"SP710RESISTANCE OF T FOLLICULAR HELPER CELLS TO MOUSE ANTI-THYMOCYTE GLOBULIN","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2952776887","doi":"https://doi.org/10.1093/ndt/gfz103.sp710","mag":"2952776887"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfz103.sp710","doi":"https://doi.org/10.1093/ndt/gfz103.sp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfz103.sp710","pdf_url":"https://academic.oup.com/ndt/article-pdf/34/Supplement_1/gfz103.SP710/28822891/gfz103.sp710.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ndt/article-pdf/34/Supplement_1/gfz103.SP710/28822891/gfz103.sp710.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068810672","display_name":"Mar\u00eda Jos\u00e9 P\u00e9rez\u2010S\u00e1ez","orcid":"https://orcid.org/0000-0002-8601-2699","observed_orcids":["https://orcid.org/0000-0002-8601-2699"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jos\u00e9 P\u00e9rez-S\u00e1ez","raw_affiliation_strings":["Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083488593","display_name":"Naoka Murakami","orcid":"https://orcid.org/0000-0001-8168-5811","observed_orcids":["https://orcid.org/0000-0001-8168-5811"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoka Murakami","raw_affiliation_strings":["Brigham and Women's Hospital, BOSTON, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, BOSTON, United States of America","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003943728","display_name":"Thiago J. Borges","orcid":"https://orcid.org/0000-0002-6554-0169","observed_orcids":["https://orcid.org/0000-0002-6554-0169"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thiago Borges","raw_affiliation_strings":["Brigham and Women's Hospital, BOSTON, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, BOSTON, United States of America","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071002542","display_name":"Dolores Redondo\u2010Pach\u00f3n","orcid":"https://orcid.org/0000-0002-0458-0052","observed_orcids":["https://orcid.org/0000-0002-0458-0052"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Redondo Dolores","raw_affiliation_strings":["Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045529984","display_name":"Marta Crespo","orcid":"https://orcid.org/0000-0001-6992-6379","observed_orcids":["https://orcid.org/0000-0001-6992-6379","https://orcid.org/0000-0002-1852-2259"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Crespo","raw_affiliation_strings":["Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090121520","display_name":"Julio Pascual","orcid":"https://orcid.org/0000-0002-4735-7838","observed_orcids":["https://orcid.org/0000-0002-4735-7838"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julio Pascual","raw_affiliation_strings":["Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonardo Riella","raw_affiliation_strings":["Brigham and Women's Hospital, BOSTON, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, BOSTON, United States of America","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06395326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.23319999873638153,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.890999972820282},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.8180000185966492},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.847000002861023},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8657662272453308},{"id":"https://openalex.org/C2780882860","wikidata":"https://www.wikidata.org/wiki/Q584065","display_name":"Anti-thymocyte globulin","level":3,"score":0.8180975914001465},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.55597984790802},{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.5532068610191345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4882548153400421},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.45578330755233765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22864356637001038},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.14270877838134766},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.057752519845962524}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfz103.sp710","doi":"https://doi.org/10.1093/ndt/gfz103.sp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfz103.sp710","pdf_url":"https://academic.oup.com/ndt/article-pdf/34/Supplement_1/gfz103.SP710/28822891/gfz103.sp710.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ndt/gfz103.sp710","doi":"https://doi.org/10.1093/ndt/gfz103.sp710","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfz103.sp710","pdf_url":"https://academic.oup.com/ndt/article-pdf/34/Supplement_1/gfz103.SP710/28822891/gfz103.sp710.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952776887.pdf","grobid_xml":"https://content.openalex.org/works/W2952776887.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221076448","https://openalex.org/W2590403265","https://openalex.org/W2000605953","https://openalex.org/W2810208447","https://openalex.org/W2037813506","https://openalex.org/W2592069947","https://openalex.org/W2070674901","https://openalex.org/W2912445847","https://openalex.org/W4390078544","https://openalex.org/W3007838104"],"abstract_inverted_index":{"INTRODUCTION:":[0],"T":[1,11,246],"follicular":[2],"helper":[3],"(Tfh)":[4],"cells":[5,12,25,201,247,299],"are":[6,26],"a":[7,41,81,275],"subset":[8],"of":[9,44,59,65,104,278,284,292,304],"CD4+":[10],"that":[13],"specialize":[14],"in":[15,37,53,195,208,244,249,296],"providing":[16],"help":[17,233],"for":[18,289],"germinal":[19],"center":[20],"(GC)":[21],"reactions":[22],"where":[23],"B":[24],"activated,":[27],"differentiate":[28,231],"and":[29,72,112,132,157,165,178,182,198,206,222,232,252,268],"produce":[30],"high-affinity":[31],"antibodies.In":[32],"addition":[33],"to":[34,100,230,257,260,300],"those":[35],"residing":[36],"lymph":[38,175],"nodes":[39,176],"(rTfh),":[40],"small":[42],"percentage":[43],"Tfhcells":[45],"called":[46],"circulating":[47,113,197],"Tfh":[48,96,183,226,255,298],"(cTfh)":[49],"can":[50],"be":[51],"found":[52],"peripheral":[54,250],"blood.":[55],"In":[56],"the":[57,102,234,282,290,302],"setting":[58],"kidney":[60],"transplantation":[61],"(KT),":[62],"higher":[63],"percentages":[64],"cTfh":[66,204],"have":[67],"been":[68],"associated":[69],"with":[70,122,137,152],"donor-specific-antibodies":[71],"chronic":[73],"antibody":[74],"mediated":[75],"rejection.":[76],"Anti-thymocyte":[77],"globulin":[78],"(ATG)":[79],"is":[80,90,242,274,287],"widely":[82],"used":[83],"potent":[84],"depleting":[85,196,245],"induction":[86],"therapy,":[87],"however,":[88],"little":[89],"known":[91],"about":[92],"its":[93,261],"effect":[94,103],"on":[95,108,159,171,188,219],"population.":[97],"We":[98,116],"aimed":[99],"analyze":[101],"mouse":[105,128],"ATG":[106],"(mATG)":[107],"both":[109,248],"secondary":[110],"lymphoid-resident":[111],"Tfh.":[114],"METHODS:":[115],"generated":[117],"mATG":[118,144,167,192,216,241],"by":[119,135],"immunizing":[120],"rabbits":[121],"splenocytes":[123],"retrieved":[124],"from":[125],"three":[126],"different":[127],"strains":[129],"(DBA/B,":[130],"C3H":[131],"SJL)":[133],"followed":[134],"purification":[136],"ammonium":[138],"sulfate":[139],"precipitation.":[140],"To":[141],"examine":[142],"if":[143],"could":[145],"deplete":[146],"\u201cformed\u201d":[147],"Tfh,":[148],"mice":[149],"were":[150,180,211,227],"immunized":[151],"NP-Ova":[153],"(100":[154],"mcg/mouse,":[155,169],"s.c.)":[156],"CFA":[158],"day":[160,172,189,220],"0":[161,221],"(GC":[162],"formation,":[163],"Fig1A),":[164],"received":[166],"(500":[168],"i.p.)":[170],"7.":[173],"Draining":[174],"(dLNs)":[177],"blood":[179,251],"harvested":[181],"population":[184],"(CD4+CXCR5+PD-1+)":[185],"was":[186,193,217],"examined":[187],"9.":[190],"While":[191],"effective":[194,243,294],"resident":[199],"non-Tfh":[200],">90%":[202],"(Fig1B-1C),":[203],"(Fig1B)":[205],"rTfh":[207],"LN":[209],"(Fig1C)":[210],"relatively":[212],"spared.":[213],"Furthermore,":[214],"when":[215],"given":[218],"4":[223],"after":[224],"immunization,":[225],"still":[228],"able":[229],"GC":[235],"reaction":[236],"(Fig":[237],"1D).":[238],"RESULTS:":[239],"CONCLUSIONS:":[240],"SLOs.":[253],"However,":[254],"seem":[256],"show":[258],"resistance":[259,286],"effect.":[262],"The":[263],"mechanisms":[264],"involved":[265],"remain":[266],"uncertain":[267],"require":[269],"further":[270],"investigation.":[271],"Since":[272],"ABMR":[273],"dominant":[276],"cause":[277],"graft":[279],"failure,":[280],"investigating":[281],"mechanism":[283],"this":[285],"crucial":[288],"development":[291],"more":[293],"therapies":[295],"restraining":[297],"prevent":[301],"production":[303],"donor-specific":[305],"antibodies.":[306]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-06-27T00:00:00"}
