{"id":"https://openalex.org/W2952721389","doi":"https://doi.org/10.7150/thno.33958","title":"pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance","display_name":"pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2952721389","doi":"https://doi.org/10.7150/thno.33958","mag":"2952721389","pmid":"https://pubmed.ncbi.nlm.nih.gov/31281516","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6587350"},"language":"en","primary_location":{"id":"doi:10.7150/thno.33958","doi":"https://doi.org/10.7150/thno.33958","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.33958","pdf_url":"https://www.thno.org/v09p3825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v09p3825.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101726601","display_name":"Wenjing Huang","orcid":"https://orcid.org/0000-0003-3775-3228","observed_orcids":["https://orcid.org/0000-0003-3775-3228","https://orcid.org/0009-0007-1931-0577"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjing Huang","raw_affiliation_strings":["National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007009932","display_name":"Hao Zhao","orcid":"https://orcid.org/0000-0002-5848-9457","observed_orcids":["https://orcid.org/0000-0002-5848-9457"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Zhao","raw_affiliation_strings":["National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089270650","display_name":"Jiangshan Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangshan Wan","raw_affiliation_strings":["National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029083062","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0001-6867-6443","observed_orcids":["https://orcid.org/0000-0001-6867-6443"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051582168","display_name":"Qingbo Xu","orcid":"https://orcid.org/0000-0002-1497-6288","observed_orcids":["https://orcid.org/0000-0002-1497-6288"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingbo Xu","raw_affiliation_strings":["National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101551550","display_name":"Yanbing Zhao","orcid":"https://orcid.org/0000-0002-0675-6680","observed_orcids":["https://orcid.org/0000-0002-0675-6680"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbing Zhao","raw_affiliation_strings":["Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029849389","display_name":"Xiangliang Yang","orcid":"https://orcid.org/0000-0003-0683-8763","observed_orcids":["https://orcid.org/0000-0003-0683-8763"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangliang Yang","raw_affiliation_strings":["Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012208123","display_name":"Lu Gan","orcid":"https://orcid.org/0000-0002-8785-867X","observed_orcids":["https://orcid.org/0000-0002-8785-867X","https://orcid.org/0000-0003-2138-9564","https://orcid.org/0000-0003-3486-6016","https://orcid.org/0009-0002-7156-2054"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Gan","raw_affiliation_strings":["Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007009932","https://openalex.org/A5101726601"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":2.9033,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.91333409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"13","first_page":"3825","last_page":"3839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance-reversal","display_name":"multidrug resistance reversal","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gold-nanocages","display_name":"gold nanocages","score":0.9229999780654907},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.6729999780654907},{"id":"https://openalex.org/keywords/ph-responsive-drug-delivery","display_name":"pH-responsive drug delivery","score":0.7639999985694885},{"id":"https://openalex.org/keywords/phlip","display_name":"pHLIP","score":0.6650000214576721},{"id":"https://openalex.org/keywords/thermoresponsive-polymers","display_name":"thermoresponsive polymers","score":0.8569999933242798},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/near-infrared-laser","display_name":"near-infrared laser","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-acidosis","display_name":"tumor acidosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-cell-internalization","display_name":"tumor cell internalization","score":0.6710000038146973},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.8326897025108337},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7362691164016724},{"id":"https://openalex.org/C128355301","wikidata":"https://www.wikidata.org/wiki/Q6964001","display_name":"Nanocages","level":3,"score":0.7004957795143127},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.6735153198242188},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6475390195846558},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5947275757789612},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.5587528347969055},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5507873892784119},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5408641695976257},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5348393321037292},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4952925741672516},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4844977557659149},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.42177045345306396},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4135046601295471},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3835597038269043},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3696974515914917},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3405637741088867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3134957253932953},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2810215950012207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2611919641494751},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21172365546226501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15783557295799255},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.09827136993408203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07286450266838074},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06583946943283081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7150/thno.33958","doi":"https://doi.org/10.7150/thno.33958","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.33958","pdf_url":"https://www.thno.org/v09p3825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5576393","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6587350","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6587350","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6587350","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:31281516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31281516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.33958","doi":"https://doi.org/10.7150/thno.33958","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.33958","pdf_url":"https://www.thno.org/v09p3825.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3352142131","display_name":null,"funder_award_id":"81773653","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3454951132","display_name":null,"funder_award_id":"81627901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3983260398","display_name":null,"funder_award_id":"81773653","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4067231685","display_name":null,"funder_award_id":"81627901","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6232539035","display_name":null,"funder_award_id":"2018YFA0208900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7039566399","display_name":"\u5171\u8f93\u9001\u5316\u7597\u836f\u7269/HIF\u6291\u5236\u5242\u7684\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u578b\u7eb3\u7c73\u51dd\u80f6\u8f7d\u836f\u7cfb\u7edf\u6297\u80bf\u7624\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"81672937","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7294801800","display_name":null,"funder_award_id":"2015CB931802","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7491190693","display_name":null,"funder_award_id":"2015CB931802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8788178159","display_name":null,"funder_award_id":"2018YFA0208900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338204","display_name":"Program for Changjiang Scholars and Innovative Research Team in University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952721389.pdf","grobid_xml":"https://content.openalex.org/works/W2952721389.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1534849470","https://openalex.org/W1754555893","https://openalex.org/W1809546604","https://openalex.org/W1968583232","https://openalex.org/W1982942418","https://openalex.org/W1989230986","https://openalex.org/W1999494701","https://openalex.org/W2003638618","https://openalex.org/W2029861500","https://openalex.org/W2032212875","https://openalex.org/W2036725443","https://openalex.org/W2042619042","https://openalex.org/W2044127957","https://openalex.org/W2046803956","https://openalex.org/W2062486688","https://openalex.org/W2077566437","https://openalex.org/W2079142824","https://openalex.org/W2080181785","https://openalex.org/W2095412415","https://openalex.org/W2109681676","https://openalex.org/W2112227276","https://openalex.org/W2141037581","https://openalex.org/W2154114037","https://openalex.org/W2156901760","https://openalex.org/W2169059963","https://openalex.org/W2290808634","https://openalex.org/W2314906766","https://openalex.org/W2410208054","https://openalex.org/W2522171581","https://openalex.org/W2538441272","https://openalex.org/W2550445267","https://openalex.org/W2725808895","https://openalex.org/W2756748061","https://openalex.org/W2789660273","https://openalex.org/W2899428214","https://openalex.org/W2901337024","https://openalex.org/W4246636681","https://openalex.org/W6702478978"],"related_works":["https://openalex.org/W4377939656","https://openalex.org/W2895694137","https://openalex.org/W2788610544","https://openalex.org/W4394925460","https://openalex.org/W2760920146","https://openalex.org/W2586957805","https://openalex.org/W3019707453","https://openalex.org/W7128493923","https://openalex.org/W2810005624","https://openalex.org/W3125233656"],"abstract_inverted_index":{"Reversing":[0],"multidrug":[1],"resistance":[2],"(MDR)":[3],"remains":[4],"a":[5,16,172],"big":[6],"challenge":[7],"in":[8,52,163,187,190,199],"cancer":[9,21],"therapy.Combining":[10],"the":[11,43,58,122,133,136,142,148,157,164,167,178],"hyperthermia":[12],"and":[13,42,51,97,104,116,129,171,189],"chemotherapy":[14],"is":[15],"promising":[17],"strategy":[18],"for":[19],"efficient":[20],"treatment":[22],"with":[23,184],"MDR":[24,185,198],"reversal.Gold":[25],"nanocages":[26],"(GNCs)":[27],"are":[28],"an":[29],"ideal":[30],"photothermal":[31,39,114,154],"(PTT)-chemotherapy":[32],"integration":[33],"platform":[34],"due":[35],"to":[36,86,147,177,196],"their":[37],"good":[38,113],"conversion":[40],"efficiency":[41],"unique":[44],"hollow":[45],"interiors.However,":[46],"insufficient":[47],"tumor":[48,94,101,123,127,134,144],"cell":[49,95],"internalization":[50],"vivo":[53],"premature":[54],"drug":[55,63,89,106],"leakage":[56],"restrict":[57],"anticancer":[59,88],"activity":[60],"of":[61,139,159,166,169],"GNCs-based":[62],"delivery":[64],"systems.Methods:":[65],"pH":[66],"low":[67],"insertion":[68],"peptide":[69],"(pHLIP)-and":[70],"thermoresponsive":[71,117,160],"poly(di(ethylene":[72],"glycol)":[73,77],"methyl":[74,78],"ether":[75,79],"methacrylate-co-oligo(ethylene":[76],"methacrylate)":[80],"polymer-conjugated":[81],"GNCs":[82,170],"were":[83,108],"rationally":[84],"constructed":[85],"load":[87],"doxorubicin":[90],"(DOX@pPGNCs).Tumor":[91],"acidic":[92,143],"environment-responsive":[93],"internalization,":[96],"near-infrared":[98],"(NIR)":[99],"laser-induced":[100],"accumulation,":[102],"penetration":[103],"on-demand":[105],"release":[107,176],"systematically":[109],"examined.Results:":[110],"DOX@pPGNCs":[111,131,192],"display":[112],"efficacy":[115],"property.NIR":[118],"laser":[119],"irradiations":[120],"at":[121,141],"site":[124],"significantly":[125],"enhance":[126],"accumulation":[128],"penetration.Once":[130],"reach":[132],"site,":[135],"conformational":[137],"transformation":[138],"pHLIP":[140],"microenvironment":[145],"contributes":[146],"enhanced":[149],"cellular":[150],"internalization.Furthermore,":[151],"NIR":[152],"laser-triggered":[153],"effects":[155],"induce":[156],"shrinkage":[158],"polymer,":[161],"resulting":[162],"opening":[165],"pores":[168],"rapid":[173],"intracellular":[174],"DOX":[175],"nuclei.DOX@pPGNCs":[179],"exhibit":[180],"synergistic":[181],"antitumor":[182],"effect":[183],"reversal":[186],"vitro":[188],"vivo.Conclusion:":[191],"present":[193],"strong":[194],"potential":[195],"overcome":[197],"cancer.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}
