{"id":"https://openalex.org/W2952697985","doi":"https://doi.org/10.1002/chin.201619176","title":"ChemInform Abstract: Flueggether A and Virosinine A, anti\u2010HIV Alkaloids from Flueggea virosa.","display_name":"ChemInform Abstract: Flueggether A and Virosinine A, anti\u2010HIV Alkaloids from Flueggea virosa.","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2952697985","doi":"https://doi.org/10.1002/chin.201619176","mag":"2952697985"},"language":"en","primary_location":{"id":"doi:10.1002/chin.201619176","doi":"https://doi.org/10.1002/chin.201619176","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.201619176","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100408705","display_name":"Hua Zhang","orcid":"https://orcid.org/0000-0002-5959-6473","observed_orcids":["https://orcid.org/0000-0002-5959-6473","https://orcid.org/0000-0001-6626-1842"]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102803157","display_name":"Kongkai Zhu","orcid":"https://orcid.org/0000-0003-2293-3568","observed_orcids":["https://orcid.org/0000-0003-2293-3568"]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kong\u2010Kai Zhu","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059224619","display_name":"Ying\u2010Shan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying\u2010Shan Han","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024637740","display_name":"Cheng Luo","orcid":"https://orcid.org/0000-0003-3864-8382","observed_orcids":["https://orcid.org/0000-0003-3864-8382"]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Luo","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mark A. Wainberg","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040928944","display_name":"Jian\u2010Min Yue","orcid":"https://orcid.org/0000-0002-4053-4870","observed_orcids":["https://orcid.org/0000-0002-4053-4870"]},"institutions":[{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian\u2010Min Yue","raw_affiliation_strings":["State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Lab. Drug Res., Shanghai Inst. Mater. Med., Chin. Acad. Sci., Shanghai 201203, Peop. Rep. China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33218482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"19","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.09309999644756317,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flueggea-virosa","display_name":"Flueggea virosa","score":0.9890000224113464},{"id":"https://openalex.org/keywords/securinega-alkaloids","display_name":"Securinega alkaloids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/anti-hiv-activity","display_name":"anti-HIV activity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ether-bridge","display_name":"ether bridge","score":0.9309999942779541},{"id":"https://openalex.org/keywords/heterocyclic-alkaloids","display_name":"heterocyclic alkaloids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9734805822372437},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6164276599884033},{"id":"https://openalex.org/C2780407432","wikidata":"https://www.wikidata.org/wiki/Q103230","display_name":"Ether","level":2,"score":0.5708283185958862},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.5571621060371399},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5317507982254028},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29294106364250183},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.03536638617515564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.201619176","doi":"https://doi.org/10.1002/chin.201619176","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.201619176","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2441739980"],"related_works":["https://openalex.org/W2441739980","https://openalex.org/W2951888136","https://openalex.org/W1968580173","https://openalex.org/W2192788148","https://openalex.org/W2295933227","https://openalex.org/W2950314077","https://openalex.org/W2911243935","https://openalex.org/W2042367713","https://openalex.org/W2950263924","https://openalex.org/W2334713445"],"abstract_inverted_index":{"Abstract":[0],"Flueggether":[1],"A":[2,17],"(I),":[3],"the":[4],"first":[5],"example":[6],"of":[7],"Securinega":[8],"alkaloid":[9],"oligomers":[10],"with":[11],"an":[12],"ether":[13],"bridge,":[14],"and":[15],"virosinine":[16],"(II),":[18],"possessing":[19],"a":[20],"novel":[21],"heterocyclic":[22],"backbone,":[23],"exhibit":[24],"weak":[25],"in":[26],"vitro":[27],"anti\u2010HIV":[28],"activity.":[29]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-06-27T00:00:00"}