{"id":"https://openalex.org/W2952554728","doi":"https://doi.org/10.1021/jo0256890","title":"5,5-Dimethyl-1,4,2-dioxazoles as Versatile Aprotic Hydroxamic Acid Protecting Groups","display_name":"5,5-Dimethyl-1,4,2-dioxazoles as Versatile Aprotic Hydroxamic Acid Protecting Groups","publication_year":2002,"publication_date":"2002-05-29","ids":{"openalex":"https://openalex.org/W2952554728","doi":"https://doi.org/10.1021/jo0256890","mag":"2952554728","pmid":"https://pubmed.ncbi.nlm.nih.gov/12098295"},"language":"en","primary_location":{"id":"doi:10.1021/jo0256890","doi":"https://doi.org/10.1021/jo0256890","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo0256890","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073506495","display_name":"Michel A. Couturier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michel Couturier","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054283017","display_name":"John L. Tucker","orcid":"https://orcid.org/0000-0002-4535-3454","observed_orcids":["https://orcid.org/0000-0002-4535-3454"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Tucker","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009661567","display_name":"Caroline Proulx","orcid":"https://orcid.org/0000-0003-3851-793X","observed_orcids":["https://orcid.org/0000-0003-3851-793X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Proulx","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037984109","display_name":"Ghislain Boucher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghislain Boucher","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055368877","display_name":"Pascal Dub\u00e9","orcid":"https://orcid.org/0000-0002-1126-2335","observed_orcids":["https://orcid.org/0000-0002-1126-2335"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascal Dub\u00e9","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074010062","display_name":"Brian M. Andresen","orcid":"https://orcid.org/0000-0002-9645-3359","observed_orcids":["https://orcid.org/0000-0002-9645-3359"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian M. Andresen","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041773055","display_name":"Arun Kumar Ghosh","orcid":"https://orcid.org/0000-0003-2472-1841","observed_orcids":["https://orcid.org/0000-0003-2472-1841"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Ghosh","raw_affiliation_strings":["Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.9833,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.72867472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"67","issue":"14","first_page":"4833","last_page":"4838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.3483999967575073,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.3483999967575073,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14459","display_name":"Synthesis and Reactions of Organic Compounds","score":0.24560000002384186,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-functionalization","display_name":"\u03b1-functionalization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hydroxamic-acid-derivatives","display_name":"hydroxamic acid derivatives","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2776281265","wikidata":"https://www.wikidata.org/wiki/Q420327","display_name":"Hydroxamic acid","level":2,"score":0.7848206758499146},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.7095884084701538},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6683803200721741},{"id":"https://openalex.org/C2778665636","wikidata":"https://www.wikidata.org/wiki/Q412967","display_name":"Nafion","level":4,"score":0.5662846565246582},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4614594578742981},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3764854669570923},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33088722825050354},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C52859227","wikidata":"https://www.wikidata.org/wiki/Q7877","display_name":"Electrochemistry","level":3,"score":0.0},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/jo0256890","doi":"https://doi.org/10.1021/jo0256890","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo0256890","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:12098295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12098295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1560082413","https://openalex.org/W1974540339","https://openalex.org/W1976718279","https://openalex.org/W1981318026","https://openalex.org/W1987063185","https://openalex.org/W2000096348","https://openalex.org/W2010577161","https://openalex.org/W2020095635","https://openalex.org/W2020759392","https://openalex.org/W2031609935","https://openalex.org/W2032144329","https://openalex.org/W2032317157","https://openalex.org/W2033093304","https://openalex.org/W2035740951","https://openalex.org/W2044373576","https://openalex.org/W2045304092","https://openalex.org/W2047203820","https://openalex.org/W2047958515","https://openalex.org/W2048408486","https://openalex.org/W2048619557","https://openalex.org/W2049180946","https://openalex.org/W2050450378","https://openalex.org/W2055758035","https://openalex.org/W2057292401","https://openalex.org/W2060709482","https://openalex.org/W2061987340","https://openalex.org/W2066856325","https://openalex.org/W2067931161","https://openalex.org/W2068698953","https://openalex.org/W2069229327","https://openalex.org/W2069884153","https://openalex.org/W2071513872","https://openalex.org/W2072183947","https://openalex.org/W2076838398","https://openalex.org/W2077146390","https://openalex.org/W2096260527","https://openalex.org/W2101699633","https://openalex.org/W2114990684","https://openalex.org/W2117757779","https://openalex.org/W2143121617","https://openalex.org/W2313885567","https://openalex.org/W2322046268","https://openalex.org/W2327918067","https://openalex.org/W2624915007","https://openalex.org/W2950069113","https://openalex.org/W2950453920","https://openalex.org/W2950502577","https://openalex.org/W2950853344","https://openalex.org/W2951246388","https://openalex.org/W2952569267","https://openalex.org/W2952787428","https://openalex.org/W2953148376","https://openalex.org/W2953284066","https://openalex.org/W4254969751"],"related_works":["https://openalex.org/W2127836742","https://openalex.org/W3024834886","https://openalex.org/W2076838398","https://openalex.org/W2331748944","https://openalex.org/W1996528136","https://openalex.org/W2015229924","https://openalex.org/W2036024654","https://openalex.org/W1989849636","https://openalex.org/W4245278344","https://openalex.org/W2952873263"],"abstract_inverted_index":{"5,5-Dimethyl-1,4,2-dioxazoles":[0],"are":[1,15,23],"readily":[2,33],"installed":[3],"by":[4,40],"transketalization":[5],"of":[6,29,61],"2,2-diethoxypropane,":[7],"where":[8],"both":[9],"the":[10,37,59,62,66],"NH":[11],"and":[12,32,54,58],"OH":[13],"moieties":[14],"protected":[16],"in":[17,44],"a":[18,26],"nonprotic":[19],"form.":[20],"The":[21,46],"dioxazoles":[22],"stable":[24],"to":[25,36,50,65],"wide":[27],"variety":[28],"reaction":[30],"conditions":[31],"revert":[34],"back":[35],"hydroxamic":[38,56],"acid":[39],"treatment":[41],"with":[42],"Nafion-H":[43],"2-propanol.":[45],"method":[47],"is":[48],"applicable":[49],"primary,":[51],"secondary,":[52],"tertiary,":[53],"aromatic":[55],"acids,":[57],"acidity":[60],"protons":[63],"adjacent":[64],"dioxazole":[67],"allows":[68],"alpha-functionalization.":[69]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-06-27T00:00:00"}