{"id":"https://openalex.org/W2952485563","doi":"https://doi.org/10.1002/chin.200027210","title":"ChemInform Abstract: Yohimbine Dimers Exhibiting Binding Selectivities for Human \u03b12a\u2010 versus \u03b12b\u2010Adrenergic Receptors","display_name":"ChemInform Abstract: Yohimbine Dimers Exhibiting Binding Selectivities for Human \u03b12a\u2010 versus \u03b12b\u2010Adrenergic Receptors","publication_year":2000,"publication_date":"2000-07-04","ids":{"openalex":"https://openalex.org/W2952485563","doi":"https://doi.org/10.1002/chin.200027210","mag":"2952485563"},"language":"en","primary_location":{"id":"doi:10.1002/chin.200027210","doi":"https://doi.org/10.1002/chin.200027210","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200027210","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108745027","display_name":"Wei-ping Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiping Zheng","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110621901","display_name":"Longping Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Longping Lei","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012578707","display_name":"Shilpa G. Lalchandani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilpa Lalchandani","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026026306","display_name":"Guoping Sun","orcid":"https://orcid.org/0000-0002-4325-900X","observed_orcids":["https://orcid.org/0000-0002-4325-900X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoping Sun","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109927449","display_name":"Dennis R. Feller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis R. Feller","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016676195","display_name":"Duane D. Miller","orcid":"https://orcid.org/0000-0002-6093-0985","observed_orcids":["https://orcid.org/0000-0002-6093-0985"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane D. Miller","raw_affiliation_strings":["Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Pharm. Sci., Univ. Tenn., Memphis, TN 38163, USA","institution_ids":["https://openalex.org/I160606119","https://openalex.org/I94658018"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38398776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"27","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha2a-adrenergic-receptor","display_name":"alpha2A-adrenergic receptor","score":0.7670000195503235},{"id":"https://openalex.org/keywords/alpha2b-adrenergic-receptor","display_name":"alpha2B-adrenergic receptor","score":1.0},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.921999990940094},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9431898593902588},{"id":"https://openalex.org/C2777676773","wikidata":"https://www.wikidata.org/wiki/Q412226","display_name":"Yohimbine","level":4,"score":0.9175429940223694},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.6359460353851318},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45057162642478943},{"id":"https://openalex.org/C2780378061","wikidata":"https://www.wikidata.org/wiki/Q25351891","display_name":"Service (business)","level":2,"score":0.439360648393631},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.4318167567253113},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4085528254508972},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32064077258110046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20749437808990479},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.06487458944320679},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.200027210","doi":"https://doi.org/10.1002/chin.200027210","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200027210","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1994028083"],"related_works":["https://openalex.org/W1994028083","https://openalex.org/W2125076392","https://openalex.org/W7097671435","https://openalex.org/W2223932454","https://openalex.org/W1981423619","https://openalex.org/W2063491985","https://openalex.org/W2041331919","https://openalex.org/W2020074627","https://openalex.org/W7095782207","https://openalex.org/W2095726015"],"abstract_inverted_index":{"Abstract":[0,25],"ChemInform":[1,24],"is":[2,42],"a":[3,11,23,35],"weekly":[4],"Abstracting":[5],"Service,":[6],"delivering":[7],"concise":[8],"information":[9],"at":[10],"glance":[12],"that":[13],"was":[14,30],"extracted":[15],"from":[16],"about":[17],"100":[18],"leading":[19],"journals.":[20],"To":[21],"access":[22],"of":[26],"an":[27],"article":[28,41],"which":[29],"published":[31],"elsewhere,":[32],"please":[33],"select":[34],"\u201cFull":[36],"Text\u201d":[37],"option.":[38,47],"The":[39],"original":[40],"trackable":[43],"via":[44],"the":[45],"\u201cReferences\u201d":[46]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}