{"id":"https://openalex.org/W2952273776","doi":"https://doi.org/10.1016/j.molimm.2019.05.012","title":"Complement and its environmental determinants in the progression of human rheumatoid arthritis","display_name":"Complement and its environmental determinants in the progression of human rheumatoid arthritis","publication_year":2019,"publication_date":"2019-06-15","ids":{"openalex":"https://openalex.org/W2952273776","doi":"https://doi.org/10.1016/j.molimm.2019.05.012","mag":"2952273776","pmid":"https://pubmed.ncbi.nlm.nih.gov/31207549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7712508"},"language":"en","primary_location":{"id":"doi:10.1016/j.molimm.2019.05.012","doi":"https://doi.org/10.1016/j.molimm.2019.05.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2019.05.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589019300331/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0161589019300331/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071389566","display_name":"Elizabeth A. Bemis","orcid":"https://orcid.org/0000-0002-3556-3175","observed_orcids":["https://orcid.org/0000-0002-3556-3175"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Bemis","raw_affiliation_strings":["Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011886992","display_name":"Jill M. Norris","orcid":"https://orcid.org/0000-0001-8674-2598","observed_orcids":["https://orcid.org/0000-0001-8674-2598"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill M. Norris","raw_affiliation_strings":["Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091275637","display_name":"Jennifer A. Seifert","orcid":"https://orcid.org/0000-0001-5851-7246","observed_orcids":["https://orcid.org/0000-0001-5851-7246"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Seifert","raw_affiliation_strings":["Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I151808059","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015979098","display_name":"Ashley A. Frazer\u2010Abel","orcid":"https://orcid.org/0000-0002-7415-8543","observed_orcids":["https://orcid.org/0000-0002-7415-8543"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Frazer-Abel","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102016129","display_name":"Yuko Okamoto","orcid":"https://orcid.org/0000-0002-8088-1746","observed_orcids":["https://orcid.org/0000-0002-8088-1746"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuko Okamoto","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082706285","display_name":"Marie L. Feser","orcid":"https://orcid.org/0009-0003-0598-853X","observed_orcids":["https://orcid.org/0009-0003-0598-853X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie L. Feser","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045733957","display_name":"Mary Kristen Demoruelle","orcid":"https://orcid.org/0000-0002-2563-5155","observed_orcids":["https://orcid.org/0000-0002-2563-5155"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kristen Demoruelle","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011051142","display_name":"Kevin D. Deane","orcid":"https://orcid.org/0000-0003-2211-4861","observed_orcids":["https://orcid.org/0000-0003-2211-4861"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin D. Deane","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054595277","display_name":"Nirmal K. Banda","orcid":"https://orcid.org/0000-0002-5291-5136","observed_orcids":["https://orcid.org/0000-0002-5291-5136"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nirmal K. Banda","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States. Electronic address: Nirmal.Banda@ucdenver.edu","Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States. Electronic address: Nirmal.Banda@ucdenver.edu","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040063597","display_name":"Vernon Michael Holers","orcid":"https://orcid.org/0000-0002-5634-7746","observed_orcids":["https://orcid.org/0000-0002-5634-7746"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Michael Holers","raw_affiliation_strings":["Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054595277"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":5.4914,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96627029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"112","issue":null,"first_page":"256","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.902999997138977},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/anti-citrullinated-protein-antibodies","display_name":"anti-citrullinated protein antibodies","score":0.9850000143051147},{"id":"https://openalex.org/keywords/preclinical-rheumatoid-arthritis","display_name":"preclinical rheumatoid arthritis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/classical-pathway","display_name":"classical pathway","score":0.6209999918937683},{"id":"https://openalex.org/keywords/alternative-pathway","display_name":"alternative pathway","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lectin-complement-pathway","display_name":"lectin pathway","score":0.9599999785423279},{"id":"https://openalex.org/keywords/oral-contraceptive-use","display_name":"oral contraceptive use","score":0.8510000109672546},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9449999928474426},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/c2","display_name":"C2","score":0.7300000190734863},{"id":"https://openalex.org/keywords/shared-epitope","display_name":"shared epitope","score":0.8080000281333923},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5619999766349792},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7118358016014099},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7101929187774658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7011989951133728},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6801635026931763},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5620548725128174},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5257713794708252},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4762730002403259},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4442768096923828},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.439790815114975},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4318588674068451},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.43169158697128296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2600167989730835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14952638745307922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0997774600982666},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075422","descriptor_name":"Anti-Citrullinated Protein Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molimm.2019.05.012","doi":"https://doi.org/10.1016/j.molimm.2019.05.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2019.05.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589019300331/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},{"id":"pmid:31207549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31207549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7712508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7712508","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.molimm.2019.05.012","doi":"https://doi.org/10.1016/j.molimm.2019.05.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molimm.2019.05.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0161589019300331/pdf","source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1515088249","display_name":"The Role of the Lung in the Initiation of Rheumatoid Arthritis","funder_award_id":"R56AI103023","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8691188616","display_name":"Prevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid Arthritis","funder_award_id":"U01AI101981","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000222663","display_name":null,"funder_award_id":"AR\u201051749","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875420","display_name":"Complement in the Pathogenesis of Autoimmune Arthritis","funder_award_id":"R01AR051749","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320308971","display_name":"Rheumatology Research Foundation","ror":"https://ror.org/03sdr0263"},{"id":"https://openalex.org/F4320309559","display_name":"Walter S. and Lucienne Driskill Foundation","ror":"https://ror.org/00hzk1038"},{"id":"https://openalex.org/F4320311641","display_name":"University of Denver","ror":"https://ror.org/04w7skc03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332965","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952273776.pdf","grobid_xml":"https://content.openalex.org/works/W2952273776.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1019267958","https://openalex.org/W1247177501","https://openalex.org/W1499601030","https://openalex.org/W1537575434","https://openalex.org/W1543853846","https://openalex.org/W1554023045","https://openalex.org/W1599875609","https://openalex.org/W1751722025","https://openalex.org/W1831078481","https://openalex.org/W1967686288","https://openalex.org/W1973652618","https://openalex.org/W1974947707","https://openalex.org/W1980379994","https://openalex.org/W2006625417","https://openalex.org/W2009103286","https://openalex.org/W2013829757","https://openalex.org/W2017290170","https://openalex.org/W2024988150","https://openalex.org/W2031073334","https://openalex.org/W2031823694","https://openalex.org/W2037607807","https://openalex.org/W2056824071","https://openalex.org/W2076377475","https://openalex.org/W2083866706","https://openalex.org/W2092639932","https://openalex.org/W2093207947","https://openalex.org/W2097013260","https://openalex.org/W2104669609","https://openalex.org/W2104806243","https://openalex.org/W2107005433","https://openalex.org/W2118138896","https://openalex.org/W2118185093","https://openalex.org/W2121893750","https://openalex.org/W2122054964","https://openalex.org/W2122176733","https://openalex.org/W2122507029","https://openalex.org/W2124613361","https://openalex.org/W2125721476","https://openalex.org/W2131852221","https://openalex.org/W2133915381","https://openalex.org/W2137349478","https://openalex.org/W2137557789","https://openalex.org/W2143340044","https://openalex.org/W2147658712","https://openalex.org/W2149103649","https://openalex.org/W2149688542","https://openalex.org/W2151846666","https://openalex.org/W2155402987","https://openalex.org/W2157494519","https://openalex.org/W2165890913","https://openalex.org/W2168125040","https://openalex.org/W2169364567","https://openalex.org/W2172252592","https://openalex.org/W2182567877","https://openalex.org/W2256693488","https://openalex.org/W2281397941","https://openalex.org/W2325677848","https://openalex.org/W2473014308","https://openalex.org/W2589710212","https://openalex.org/W2747489820","https://openalex.org/W2756145953","https://openalex.org/W2788115780","https://openalex.org/W2789912328","https://openalex.org/W2799950849","https://openalex.org/W2800555693","https://openalex.org/W2890371891","https://openalex.org/W2900612430","https://openalex.org/W2901577946","https://openalex.org/W2906216983","https://openalex.org/W4235790631"],"related_works":["https://openalex.org/W2418488266","https://openalex.org/W2337443877","https://openalex.org/W2755959885","https://openalex.org/W2156014030","https://openalex.org/W4401173920","https://openalex.org/W1996584569","https://openalex.org/W2337376620","https://openalex.org/W6998811200","https://openalex.org/W2157869717","https://openalex.org/W7097175688"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1,106,151],"(RA)":[2],"is":[3,12,36,251],"a":[4,37,100,299],"complex":[5],"autoimmune":[6],"disease":[7,247,296],"with":[8,200,279,294,333],"an":[9,56,68],"etiology":[10],"that":[11,84,103],"not":[13,317],"yet":[14],"well":[15,352],"understood,":[16],"disproportionally":[17],"affects":[18],"women":[19],"and":[20,25,75,117,120,153,161,169,177,188,192,207,239,257,265,277],"also":[21,50],"varies":[22],"in":[23,52,108,147,221,228,328,342,348,355],"incidence":[24],"prevalence":[26],"by":[27,72,158],"population.":[28],"The":[29],"presence":[30],"of":[31,44,58,65,96,140,149,217,232,235,245,285,289,309,331],"anti-citrullinated":[32],"protein":[33],"antibodies":[34],"(ACPA)":[35],"highly":[38],"specific":[39],"biomarker":[40],"for":[41,55,137,163,345],"the":[42,53,63,93,109,125,138,174,236,243,246,262,286,322,329,339,349],"diagnosis":[43],"clinically":[45,360],"apparent":[46,361],"RA.":[47],"ACPA":[48,77,145,154,222],"are":[49,316],"present":[51],"serum":[54,144],"average":[57],"3-5":[59],"years":[60],"prior":[61],"to":[62,173,197,261,312],"onset":[64],"RA":[66,97,141,156,250,292,313,346],"during":[67,92,242,254,338],"asymptomatic":[69],"period":[70,341],"characterized":[71],"mucosal":[73,336],"inflammation":[74,256],"local":[76],"production":[78],"at":[79],"these":[80],"sites.":[81],"We":[82,129,213],"hypothesized":[83],"systemic":[85,218,233],"complement":[86,126,165,186,219,323],"activation":[87,127,170,220],"products":[88,171],"might":[89],"be":[90,198,326],"generated":[91],"pre-clinical":[94],"initiation":[95],"and/or":[98],"provide":[99],"second":[101],"hit":[102],"promotes":[104],"subsequent":[105],"development":[107,139],"joints.":[110],"In":[111,320],"addition,":[112],"we":[113],"evaluated":[114],"which":[115],"demographic":[116],"genetic":[118],"features":[119],"environmental":[121,193,266],"exposures":[122],"could":[123],"influence":[124],"process.":[128],"analyzed":[130],"plasma":[131],"from":[132],"healthy":[133],"subjects,":[134],"subjects":[135,157,224,278,293,314],"at-risk":[136,344],"based":[142],"on":[143],"positivity":[146],"absence":[148],"inflammatory":[150],"(IA),":[152],"positive":[155,223],"Multiplex":[159],"Assay":[160],"ELISA":[162],"eighteen":[164],"system":[166,324],"components,":[167],"factors":[168,194],"belonging":[172],"classical,":[175],"lectin":[176],"alternative":[178,240,287],"pathways.":[179],"By":[180],"using":[181],"regression":[182],"models,":[183],"associations":[184],"between":[185],"proteins":[187],"various":[189],"demographic,":[190,263],"genetic,":[191,264],"previously":[195],"found":[196,214,230],"associated":[199],"RA,":[201,332],"including":[202],"sex,":[203],"smoking,":[204],"shared":[205],"epitope,":[206],"oral":[208,274],"contraceptive":[209,275],"use,":[210],"were":[211],"examined.":[212],"no":[215],"evidence":[216,231],"without":[225],"IA,":[226],"but":[227,347],"contrast":[229],"involvement":[234],"both":[237],"classical":[238],"pathways":[241],"stage":[244],"where":[248],"classified":[249],"present,":[252],"(i.e.":[253],"joint":[255,350],"damage).":[258],"With":[259],"regard":[260],"variables,":[267],"females":[268],"who":[269,297,315,357],"reported":[270],"current":[271,280],"or":[272],"past":[273],"use":[276],"tobacco":[281],"exposure":[282],"demonstrated":[283,306],"alterations":[284],"pathway":[288],"complement.":[290],"Furthermore,":[291],"established":[295],"have":[298,358],"body":[300],"mass":[301],"index":[302],"categorized":[303],"as":[304,351,353],"obese":[305],"higher":[307],"levels":[308],"C2":[310],"compared":[311],"considered":[318],"obese.":[319],"sum,":[321],"may":[325],"involved":[327],"pathogenesis":[330],"only":[334],"localized":[335],"effects":[337],"preclinical":[340],"those":[343,356],"systemically":[354],"developed":[359],"arthritis.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}