{"id":"https://openalex.org/W2952261101","doi":"https://doi.org/10.1128/iai.00002-19","title":"MroQ Is a Novel Abi-Domain Protein That Influences Virulence Gene Expression in Staphylococcus aureus via Modulation of Agr Activity","display_name":"MroQ Is a Novel Abi-Domain Protein That Influences Virulence Gene Expression in Staphylococcus aureus via Modulation of Agr Activity","publication_year":2019,"publication_date":"2019-03-04","ids":{"openalex":"https://openalex.org/W2952261101","doi":"https://doi.org/10.1128/iai.00002-19","mag":"2952261101","pmid":"https://pubmed.ncbi.nlm.nih.gov/30833335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6479029"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00002-19","doi":"https://doi.org/10.1128/iai.00002-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00002-19","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/01/10/516914.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069298828","display_name":"Stephanie M Marroquin","orcid":"https://orcid.org/0000-0002-8668-2203","observed_orcids":["https://orcid.org/0000-0002-8668-2203"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Marroquin","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072434038","display_name":"Brittney D. Gimza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittney Gimza","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011383180","display_name":"Brooke R. Tomlinson","orcid":"https://orcid.org/0000-0001-6561-7931","observed_orcids":["https://orcid.org/0000-0001-6561-7931"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Tomlinson","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046951914","display_name":"Michelle Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Stein","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010900051","display_name":"Andrew Michael Frey","orcid":"https://orcid.org/0000-0002-5194-447X","observed_orcids":["https://orcid.org/0000-0002-5194-447X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Frey","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082877468","display_name":"Rebecca A. Keogh","orcid":"https://orcid.org/0000-0001-8376-2307","observed_orcids":["https://orcid.org/0000-0001-8376-2307"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Keogh","raw_affiliation_strings":["Department of Biological Sciences, Ohio University, Athens, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ohio University, Athens, Ohio, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024760048","display_name":"Rachel L. Zapf","orcid":"https://orcid.org/0000-0003-2001-5763","observed_orcids":["https://orcid.org/0000-0003-2001-5763"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Zapf","raw_affiliation_strings":["Department of Biological Sciences, Ohio University, Athens, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ohio University, Athens, Ohio, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050251759","display_name":"Daniel A. Todd","orcid":"https://orcid.org/0000-0003-2199-1029","observed_orcids":["https://orcid.org/0000-0003-2199-1029"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Todd","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of North Carolina-Greensboro, Greensboro, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina-Greensboro, Greensboro, North Carolina, USA","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034069000","display_name":"Nadja B. Cech","orcid":"https://orcid.org/0000-0001-6773-746X","observed_orcids":["https://orcid.org/0000-0001-6773-746X"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadja B. Cech","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of North Carolina-Greensboro, Greensboro, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina-Greensboro, Greensboro, North Carolina, USA","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101583926","display_name":"Ronan K. Carroll","orcid":"https://orcid.org/0000-0001-7090-3414","observed_orcids":["https://orcid.org/0000-0001-7090-3414"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronan K. Carroll","raw_affiliation_strings":["Department of Biological Sciences, Ohio University, Athens, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0001-7090-3414","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Ohio University, Athens, Ohio, USA","institution_ids":["https://openalex.org/I4210106879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016887105","display_name":"Lindsey Neil Shaw","orcid":"https://orcid.org/0000-0002-0629-8990","observed_orcids":["https://orcid.org/0000-0002-0629-8990","https://orcid.org/0000-0002-2211-0556"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lindsey N. Shaw","raw_affiliation_strings":["Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-0629-8990","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology & Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016887105"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":3.3282,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.92356017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"87","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.19789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/agr-quorum-sensing","display_name":"agr quorum sensing","score":0.7770000100135803},{"id":"https://openalex.org/keywords/virulence-gene-regulation","display_name":"virulence gene regulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8778142929077148},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8404477834701538},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8372681140899658},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7318751215934753},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44916045665740967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44136402010917664},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43755030632019043},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.43726563453674316},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.43667787313461304},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4246125817298889},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4226023554801941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35142821073532104},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13794124126434326}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.00002-19","doi":"https://doi.org/10.1128/iai.00002-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00002-19","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"doi:10.1101/516914","doi":"https://doi.org/10.1101/516914","is_oa":true,"landing_page_url":"https://doi.org/10.1101/516914","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/01/10/516914.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:6479029","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6479029","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:30833335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30833335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/516914","doi":"https://doi.org/10.1101/516914","is_oa":true,"landing_page_url":"https://doi.org/10.1101/516914","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/01/10/516914.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062342274","display_name":"Characterization of ??S in the stress & virulence responses of S. aureus","funder_award_id":"R01AI080626","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8205581542","display_name":"The Role and Regulation of Extracellular Proteases in Staphylococcus aureus","funder_award_id":"R01AI124458","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8253057211","display_name":"Strategies to Investigate Synergy in Botanical Medicines","funder_award_id":"R01AT006860","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952261101.pdf","grobid_xml":"https://content.openalex.org/works/W2952261101.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1190619119","https://openalex.org/W1531268983","https://openalex.org/W1547119536","https://openalex.org/W1716237860","https://openalex.org/W1867062643","https://openalex.org/W1892837989","https://openalex.org/W1963912540","https://openalex.org/W1966530013","https://openalex.org/W1968319760","https://openalex.org/W1970783326","https://openalex.org/W1975256163","https://openalex.org/W1984831953","https://openalex.org/W1986029743","https://openalex.org/W1987400078","https://openalex.org/W1991270869","https://openalex.org/W1992497839","https://openalex.org/W1995105203","https://openalex.org/W2001760607","https://openalex.org/W2004783061","https://openalex.org/W2005769132","https://openalex.org/W2006840128","https://openalex.org/W2007989487","https://openalex.org/W2009778318","https://openalex.org/W2011208940","https://openalex.org/W2013042266","https://openalex.org/W2014339186","https://openalex.org/W2016027535","https://openalex.org/W2021762083","https://openalex.org/W2051282756","https://openalex.org/W2053000830","https://openalex.org/W2056106906","https://openalex.org/W2062678572","https://openalex.org/W2065737889","https://openalex.org/W2067215762","https://openalex.org/W2069608343","https://openalex.org/W2069714305","https://openalex.org/W2072572024","https://openalex.org/W2078678631","https://openalex.org/W2094667070","https://openalex.org/W2096194577","https://openalex.org/W2096803605","https://openalex.org/W2101153968","https://openalex.org/W2102361871","https://openalex.org/W2106430848","https://openalex.org/W2109340370","https://openalex.org/W2109430126","https://openalex.org/W2109636459","https://openalex.org/W2122176684","https://openalex.org/W2125066910","https://openalex.org/W2125829263","https://openalex.org/W2127113854","https://openalex.org/W2131520604","https://openalex.org/W2143527951","https://openalex.org/W2144804305","https://openalex.org/W2147200488","https://openalex.org/W2152238416","https://openalex.org/W2155397502","https://openalex.org/W2155831045","https://openalex.org/W2157220975","https://openalex.org/W2163107191","https://openalex.org/W2168744931","https://openalex.org/W2169748146","https://openalex.org/W2169835725","https://openalex.org/W2176744910","https://openalex.org/W2270731344","https://openalex.org/W2284360570","https://openalex.org/W2313619242","https://openalex.org/W2346909855","https://openalex.org/W2541355695","https://openalex.org/W2573336339","https://openalex.org/W2587439443","https://openalex.org/W2791813411","https://openalex.org/W2886843504"],"related_works":["https://openalex.org/W7062761355","https://openalex.org/W2952288895","https://openalex.org/W2621227027","https://openalex.org/W3020924387","https://openalex.org/W7017852958","https://openalex.org/W7029116806","https://openalex.org/W4290725090","https://openalex.org/W4286779072","https://openalex.org/W2121030241","https://openalex.org/W4401815226"],"abstract_inverted_index":{"Abstract":[0],"Numerous":[1],"factors":[2,139],"have":[3],"to":[4,72,98,239],"date":[5],"been":[6],"identified":[7],"as":[8,44,78,104],"playing":[9],"a":[10,39,45,52,58,129,228,241],"role":[11],"in":[12,18,61,84,91,111,132,150,155,232],"the":[13,33,92,136,146,156,194,225,249],"regulation":[14],"of":[15,35,48,86,119,138,148,196,211,227],"Agr":[16,168,185],"activity":[17,113,178],"S.":[19,233],"aureus":[20,234],",":[21,235],"including":[22],"transcription":[23],"factors,":[24],"antisense":[25],"RNAs,":[26],"and":[27,64,89,125,204],"host":[28],"elements.":[29],"Herein":[30],"we":[31,56,223],"investigate":[32],"product":[34],"SAUSA300_1984":[36],"(termed":[37],"MroQ),":[38],"transmembrane":[40],"Abi-domain/M79":[41],"protease-family":[42],"protein,":[43],"novel":[46,229],"effector":[47,231],"this":[49,189],"system.":[50],"Using":[51],"USA300":[53],"mroQ":[54,93,115,124,203],"mutant":[55],"observed":[57],"drastic":[59],"reduction":[60],"proteolysis,":[62],"hemolysis":[63],"pigmentation":[65],"that":[66,160,173,202],"was":[67],"fully":[68],"complementable.":[69],"This":[70],"appears":[71],"result":[73],"from":[74],"diminished":[75,220],"agr":[76,106,126,157,205,230],"activity,":[77],"transcriptional":[79],"analysis":[80],"revealed":[81,172],"significant":[82],"decreases":[83],"expression":[85,151],"both":[87,123,207],"RNAII":[88],"RNAIII":[90],"mutant.":[94],"Such":[95],"effects":[96],"appear":[97,238],"be":[99,240],"direct,":[100],"rather":[101],"than":[102],"indirect,":[103],"known":[105,142],"effectors":[107],"demonstrated":[108,201],"limited":[109],"alterations":[110,149],"their":[112,133],"upon":[114],"disruption.":[116],"A":[117],"comparison":[118],"RNA-sequencing":[120],"datasets":[121],"for":[122,167,176,183],"mutants":[127,206],"reveal":[128],"profound":[130],"overlap":[131],"regulomes,":[134],"with":[135,248],"majority":[137],"affected":[140],"being":[141],"virulence":[143],"determinants.":[144],"Importantly,":[145],"preponderance":[147],"were":[152],"more":[153],"striking":[154],"mutant,":[158],"indicating":[159],"MroQ":[161,180],"is":[162,190],"necessary,":[163],"but":[164,214],"not":[165,191],"sufficient,":[166],"function.":[169],"Mechanism":[170],"profiling":[171],"putative":[174],"residues":[175],"metalloprotease":[177],"within":[179],"are":[181],"required":[182],"its":[184],"controlling":[186],"effect,":[187],"however":[188],"wielded":[192],"at":[193],"level":[195],"AgrD":[197],"processing.":[198],"Virulence":[199],"assessment":[200],"exhibited":[208],"increased":[209],"formation":[210],"renal":[212],"abscesses,":[213],"decreased":[215],"skin":[216],"abscess":[217],"formation,":[218],"alongside":[219],"dermonecrosis.":[221],"Collectively,":[222],"present":[224],"characterization":[226],"which":[236],"would":[237],"direct":[242],"regulator,":[243],"potentially":[244],"functioning":[245],"via":[246],"interaction":[247],"AgrC":[250],"histidine":[251],"kinase.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2019-06-27T00:00:00"}