{"id":"https://openalex.org/W2952087232","doi":"https://doi.org/10.1111/jcmm.14361","title":"Micro RNA \u2010301b\u20103p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4","display_name":"Micro RNA \u2010301b\u20103p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4","publication_year":2019,"publication_date":"2019-06-17","ids":{"openalex":"https://openalex.org/W2952087232","doi":"https://doi.org/10.1111/jcmm.14361","mag":"2952087232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31207037","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6653225"},"language":"en","primary_location":{"id":"doi:10.1111/jcmm.14361","doi":"https://doi.org/10.1111/jcmm.14361","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.14361","pdf_url":null,"source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/jcmm.14361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062007876","display_name":"Yang Guo","orcid":"https://orcid.org/0000-0001-5268-9645","observed_orcids":["https://orcid.org/0000-0001-5268-9645"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]},{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Guo","raw_affiliation_strings":["Graduate Department, BengBu Medical College, BengBu, Anhui Province, China","Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Department, BengBu Medical College, BengBu, Anhui Province, China","institution_ids":["https://openalex.org/I169351748"]},{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091596042","display_name":"Bowen Yao","orcid":"https://orcid.org/0000-0002-8293-0695","observed_orcids":["https://orcid.org/0000-0002-8293-0695"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bowen Yao","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016641862","display_name":"Qiaojuan Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaojuan Zhu","raw_affiliation_strings":["Department of Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059867276","display_name":"Zunqiang Xiao","orcid":"https://orcid.org/0000-0002-8521-4248","observed_orcids":["https://orcid.org/0000-0002-8521-4248"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zunqiang Xiao","raw_affiliation_strings":["Department of Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104204925","display_name":"Linjun Hu","orcid":"https://orcid.org/0000-0003-1449-9626","observed_orcids":["https://orcid.org/0000-0003-1449-9626"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linjun Hu","raw_affiliation_strings":["The Medical College of Qindao University, Qindao, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical College of Qindao University, Qindao, Shandong Province, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102982018","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0002-0480-5928","observed_orcids":["https://orcid.org/0000-0002-0480-5928"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617506","display_name":"Lijie Li","orcid":"https://orcid.org/0000-0003-4630-7692","observed_orcids":["https://orcid.org/0000-0003-4630-7692"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijie Li","raw_affiliation_strings":["Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446920","display_name":"Jiahui Wang","orcid":"https://orcid.org/0000-0002-9490-3950","observed_orcids":["https://orcid.org/0000-0002-9490-3950"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Wang","raw_affiliation_strings":["School of Basic Medical Sciences, Shandong University, Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Shandong University, Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038535866","display_name":"Qiuran Xu","orcid":"https://orcid.org/0000-0003-2171-9279","observed_orcids":["https://orcid.org/0000-0003-2171-9279"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiuran Xu","raw_affiliation_strings":["Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":"https://orcid.org/0000-0003-2171-9279","affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664945","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-5961-1469","observed_orcids":["https://orcid.org/0000-0002-5961-1469"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100599516","display_name":"Dongsheng Huang","orcid":"https://orcid.org/0000-0003-2724-9618","observed_orcids":["https://orcid.org/0000-0003-2724-9618"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongsheng Huang","raw_affiliation_strings":["Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tumour Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5038535866","https://openalex.org/A5100599516","https://openalex.org/A5100664945"],"corresponding_institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":1.656,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.82329197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"8","first_page":"5037","last_page":"5047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vgll4","display_name":"VGLL4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.734000027179718},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9419999718666077},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/3-utr-binding","display_name":"3' UTR binding","score":0.7200000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.839425802230835},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6562050580978394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6096721291542053},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5595384836196899},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5163235068321228},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.48278820514678955},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.451855331659317},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3983531892299652},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16945526003837585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16905272006988525}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/jcmm.14361","doi":"https://doi.org/10.1111/jcmm.14361","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.14361","pdf_url":null,"source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6653225","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6653225/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6653225/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:31207037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31207037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jcmm.14361","doi":"https://doi.org/10.1111/jcmm.14361","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.14361","pdf_url":null,"source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2429083759","display_name":null,"funder_award_id":"81602179","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2569708142","display_name":"Fbxw7\u901a\u8fc7Alix\u8c03\u63a7YAP\u8fdb\u5165\u5916\u6ccc\u4f53\u4ece\u800c\u5f71\u54cd\u809d\u764c\u7ec6\u80de\u589e\u6b96\u4e0e\u51cb\u4ea1\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"LY19H160036","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4437114162","display_name":null,"funder_award_id":"2017ZX09302003","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G7016528710","display_name":null,"funder_award_id":"2017ZX09302003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8913949651","display_name":null,"funder_award_id":"81874049","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952087232.pdf","grobid_xml":"https://content.openalex.org/works/W2952087232.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1604918057","https://openalex.org/W2039975023","https://openalex.org/W2055998706","https://openalex.org/W2104146736","https://openalex.org/W2117977572","https://openalex.org/W2153234291","https://openalex.org/W2201264029","https://openalex.org/W2272984102","https://openalex.org/W2336715782","https://openalex.org/W2410522613","https://openalex.org/W2464334465","https://openalex.org/W2466331987","https://openalex.org/W2472687980","https://openalex.org/W2505381768","https://openalex.org/W2570618306","https://openalex.org/W2586633598","https://openalex.org/W2616453278","https://openalex.org/W2626081362","https://openalex.org/W2782530339","https://openalex.org/W2783804618","https://openalex.org/W2797029723","https://openalex.org/W2802554845","https://openalex.org/W2809290709","https://openalex.org/W2840469152","https://openalex.org/W2885656047","https://openalex.org/W2886151061","https://openalex.org/W2889087858","https://openalex.org/W2890632252","https://openalex.org/W2891087932","https://openalex.org/W2894175986","https://openalex.org/W2897335796","https://openalex.org/W2899543731","https://openalex.org/W2902095302","https://openalex.org/W2903298719","https://openalex.org/W2918315214","https://openalex.org/W2918542186"],"related_works":["https://openalex.org/W2890632252","https://openalex.org/W1997440367","https://openalex.org/W2591797433","https://openalex.org/W2953213479","https://openalex.org/W3018261821","https://openalex.org/W4205973799","https://openalex.org/W2218963708","https://openalex.org/W3171843902","https://openalex.org/W2840469152","https://openalex.org/W2913448208"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2],"key":[3],"regulators":[4],"in":[5,25,47,61,133,166,177,212],"the":[6,32,74,90],"tumour":[7,83,129],"growth":[8,130],"and":[9,37,85,117,122,148,160,181,200,222],"metastasis":[10],"of":[11,28,35,77,100,104,120,131,141,155,184,225],"human":[12,29],"hepatocellular":[13],"carcinoma":[14],"(HCC).":[15],"Increasing":[16],"evidence":[17],"suggests":[18],"that":[19,55,73,207],"miR-301b-3p":[20,36,56,78,92,105,126,136,164,191,208,214],"functions":[21],"as":[22,41,43],"a":[23,95],"driver":[24],"various":[26],"types":[27],"cancer.":[30],"However,":[31],"expression":[33,57,154],"pattern":[34],"its":[38,151],"functional":[39],"role":[40],"well":[42],"underlying":[44],"molecular":[45],"mechanism":[46],"HCC":[48,62,101,132,167,185,194,226],"remain":[49],"poorly":[50],"known.":[51],"Our":[52],"study":[53],"found":[54],"was":[58,158],"significantly":[59],"up-regulated":[60],"tissues":[63],"compared":[64],"to":[65,110,139],"adjacent":[66],"non-tumour":[67],"tissues.":[68,168],"Clinical":[69],"association":[70],"analysis":[71],"revealed":[72],"high":[75,91],"level":[76,93,165],"closely":[79],"correlated":[80,162],"with":[81,163],"large":[82],"size":[84],"advanced":[86],"tumour-node-metastasis":[87],"stages.":[88],"Importantly,":[89],"predicted":[94],"prominent":[96],"poorer":[97],"overall":[98],"survival":[99],"patients.":[102],"Knockdown":[103],"suppressed":[106,128],"cell":[107,111,174,195,197,216,219],"proliferation,":[108,175,196,217],"led":[109],"cycle":[112,198,220],"arrest":[113,180],"at":[114],"G2/M":[115,178],"phase":[116,179],"induced":[118],"apoptosis":[119,183,201,224],"Huh7":[121],"Hep3B":[123],"cells.":[124,186],"Furthermore,":[125],"knockdown":[127,171,192],"mice.":[134],"Mechanistically,":[135],"directly":[137],"bond":[138],"3'UTR":[140],"vestigial":[142],"like":[143],"family":[144],"member":[145],"4":[146],"(VGLL4)":[147],"negatively":[149],"regulated":[150],"expression.":[152],"The":[153],"VGLL4":[156,170,188],"mRNA":[157],"down-regulated":[159],"inversely":[161],"Notably,":[169],"markedly":[172],"repressed":[173],"resulted":[176],"promoted":[182],"Accordingly,":[187],"silencing":[189],"rescued":[190],"attenuated":[193],"progression":[199,221],"resistance.":[202],"Collectively,":[203],"our":[204],"results":[205],"suggest":[206],"is":[209],"highly":[210],"expressed":[211],"HCC.":[213],"facilitates":[215],"promotes":[218],"inhibits":[223],"cells":[227],"by":[228],"repressing":[229],"VGLL4.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-06-27T00:00:00"}