{"id":"https://openalex.org/W2952085692","doi":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","title":"PF695 ELTROMBOPAG AS SECOND LINE THERAPY IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA (ITP) IN ATTEMPT TO TREATMENT\u2010FREE REMISSION. UPDATED RESULTS OF A PHASE II PROSPECTIVE STUDY BY GIMEMA GROUP","display_name":"PF695 ELTROMBOPAG AS SECOND LINE THERAPY IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA (ITP) IN ATTEMPT TO TREATMENT\u2010FREE REMISSION. UPDATED RESULTS OF A PHASE II PROSPECTIVE STUDY BY GIMEMA GROUP","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2952085692","doi":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","mag":"2952085692"},"language":"en","primary_location":{"id":"doi:10.1097/01.hs9.0000561064.22529.7a","doi":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020570449","display_name":"Elisa Lucchini","orcid":"https://orcid.org/0000-0002-4857-8325","observed_orcids":["https://orcid.org/0000-0002-4857-8325"]},"institutions":[{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Lucchini","raw_affiliation_strings":["S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002133396","display_name":"Francesca Palandri","orcid":"https://orcid.org/0000-0001-8367-5668","observed_orcids":["https://orcid.org/0000-0001-8367-5668"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Palandri","raw_affiliation_strings":["Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007186664","display_name":"Stefano Volpetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Volpetti","raw_affiliation_strings":["Clinica Ematologica Centro Trapianti e Terapie Cellulari \u201cC. Melzi\u201d DAME Universit\u00e0 degli Studi Udine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Ematologica Centro Trapianti e Terapie Cellulari \u201cC. Melzi\u201d DAME Universit\u00e0 degli Studi Udine","institution_ids":["https://openalex.org/I129043915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045651843","display_name":"Nicola Vianelli","orcid":"https://orcid.org/0000-0001-5886-036X","observed_orcids":["https://orcid.org/0000-0001-5886-036X"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N. Vianelli","raw_affiliation_strings":["Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037355780","display_name":"Giuseppe Auteri","orcid":"https://orcid.org/0000-0001-5769-6772","observed_orcids":["https://orcid.org/0000-0001-5769-6772"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Auteri","raw_affiliation_strings":["Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d S. Orsola\u2010Malpighi Bologna University Hospital Bologna","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045957279","display_name":"Esther Diana Rossi","orcid":"https://orcid.org/0000-0003-3819-4229","observed_orcids":["https://orcid.org/0000-0003-3819-4229"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Rossi","raw_affiliation_strings":["Istituto di Ematologia Fondazione Policlinico A. Gemelli IRCCS Universit\u00e0 Cattolica Roma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ematologia Fondazione Policlinico A. Gemelli IRCCS Universit\u00e0 Cattolica Roma","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027094790","display_name":"Andrea Patriarca","orcid":"https://orcid.org/0000-0003-4415-2906","observed_orcids":["https://orcid.org/0000-0003-4415-2906"]},"institutions":[{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Patriarca","raw_affiliation_strings":["U.O. di Ematologia AOU Maggiore della Carit\u00e0 Novara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.O. di Ematologia AOU Maggiore della Carit\u00e0 Novara","institution_ids":["https://openalex.org/I4210119436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081086326","display_name":"Giuseppe Carli","orcid":"https://orcid.org/0000-0002-7078-1143","observed_orcids":["https://orcid.org/0000-0002-7078-1143"]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Carli","raw_affiliation_strings":["Hematology Department, Ospedale San Bortolo, Vicenza"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Ospedale San Bortolo, Vicenza","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535532","display_name":"Wilma Barcellini","orcid":"https://orcid.org/0000-0003-1428-9944","observed_orcids":["https://orcid.org/0000-0003-1428-9944"]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"W. Barcellini","raw_affiliation_strings":["UOC Ematologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Ematologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan","institution_ids":["https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F. Rotondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129405","display_name":"Ospedale Infermi di Rimini","ror":"https://ror.org/039bxh911","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129405"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Rotondo","raw_affiliation_strings":["Hematology Unit, Infermi Hospital, Rimini"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Unit, Infermi Hospital, Rimini","institution_ids":["https://openalex.org/I4210129405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045579010","display_name":"Ugo Consoli","orcid":"https://orcid.org/0000-0002-8305-085X","observed_orcids":["https://orcid.org/0000-0002-8305-085X"]},"institutions":[{"id":"https://openalex.org/I4210105999","display_name":"Ospedale Garibaldi","ror":"https://ror.org/01q6hrg49","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210105999"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"U. Consoli","raw_affiliation_strings":["UOC Ematologia, ARNAS Garibaldi, Catania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UOC Ematologia, ARNAS Garibaldi, Catania","institution_ids":["https://openalex.org/I4210105999"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018089906","display_name":"Federica Valeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096532","display_name":"Fondazione Ricerca Molinette","ror":"https://ror.org/01mhzrb93","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210096532"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Valeri","raw_affiliation_strings":["Regional Center for Hemorrhagic and Thrombotic Diseases Haematology Unit City of Health and Science University Hospital of Molinette Turin","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Center for Hemorrhagic and Thrombotic Diseases Haematology Unit City of Health and Science University Hospital of Molinette Turin","institution_ids":["https://openalex.org/I4210096532"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066768069","display_name":"Cristina Santoro","orcid":"https://orcid.org/0000-0002-7181-447X","observed_orcids":["https://orcid.org/0000-0002-7181-447X"]},"institutions":[{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Santoro","raw_affiliation_strings":["Department of Cellular Biotechnology and Hematology Sapienza University","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biotechnology and Hematology Sapienza University","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050651885","display_name":"Enrico Crea","orcid":"https://orcid.org/0000-0001-7503-7818","observed_orcids":["https://orcid.org/0000-0001-7503-7818"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Crea","raw_affiliation_strings":["GIMEMA Foundation Rome","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GIMEMA Foundation Rome","institution_ids":["https://openalex.org/I4210112021"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078192708","display_name":"Marco Vignetti","orcid":"https://orcid.org/0000-0003-1278-604X","observed_orcids":["https://orcid.org/0000-0003-1278-604X"]},"institutions":[{"id":"https://openalex.org/I4210112021","display_name":"Fondazione Gimema Onlus","ror":"https://ror.org/01b3n9g22","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210112021"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Vignetti","raw_affiliation_strings":["GIMEMA Foundation Rome","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GIMEMA Foundation Rome","institution_ids":["https://openalex.org/I4210112021"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067397711","display_name":"Elena Maria Boggio","orcid":"https://orcid.org/0000-0003-2700-3597","observed_orcids":["https://orcid.org/0000-0003-2700-3597"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Boggio","raw_affiliation_strings":["Laboratory of Immunology Department of Health Sciences Universit\u00e0 del Piemonte Orientale Novara","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology Department of Health Sciences Universit\u00e0 del Piemonte Orientale Novara","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030390675","display_name":"Umberto Dianzani","orcid":"https://orcid.org/0000-0001-6723-3931","observed_orcids":["https://orcid.org/0000-0001-6723-3931"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"U. Dianzani","raw_affiliation_strings":["Laboratory of Immunology Department of Health Sciences Universit\u00e0 del Piemonte Orientale Novara","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology Department of Health Sciences Universit\u00e0 del Piemonte Orientale Novara","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010658446","display_name":"Ilaria Giardini","orcid":"https://orcid.org/0000-0001-7402-6930","observed_orcids":["https://orcid.org/0000-0001-7402-6930"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Giardini","raw_affiliation_strings":["Clinical And Experimental Pharmacokinetics Lab Diagnostic Medicine Dep IRCCS Policlinico San Matteo Pavia","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical And Experimental Pharmacokinetics Lab Diagnostic Medicine Dep IRCCS Policlinico San Matteo Pavia","institution_ids":["https://openalex.org/I4210151645"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085901299","display_name":"Monica Carpenedo","orcid":"https://orcid.org/0000-0002-4355-3954","observed_orcids":["https://orcid.org/0000-0002-4355-3954"]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Carpenedo","raw_affiliation_strings":["Hematology and Transplant Dept ASST Ospedale San Gerardo Monza","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Transplant Dept ASST Ospedale San Gerardo Monza","institution_ids":["https://openalex.org/I4210110840"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013529815","display_name":"Francesco Rodeghiero","orcid":"https://orcid.org/0000-0003-2253-2502","observed_orcids":["https://orcid.org/0000-0003-2253-2502"]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]},{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Rodeghiero","raw_affiliation_strings":["Hematology Project Foundation, Vicenza Italy \u2010 affiliated to the Dept. of Hematology of the San Bortolo Hospital Vicenza Italy","S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Project Foundation, Vicenza Italy \u2010 affiliated to the Dept. of Hematology of the San Bortolo Hospital Vicenza Italy","institution_ids":["https://openalex.org/I4210152245"]},{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075720076","display_name":"Renato Fanin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129043915","display_name":"University of Udine","ror":"https://ror.org/05ht0mh31","country_code":"IT","type":"education","lineage":["https://openalex.org/I129043915"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Fanin","raw_affiliation_strings":["Clinica Ematologica Centro Trapianti e Terapie Cellulari \u201cC. Melzi\u201d DAME Universit\u00e0 degli Studi Udine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Ematologica Centro Trapianti e Terapie Cellulari \u201cC. Melzi\u201d DAME Universit\u00e0 degli Studi Udine","institution_ids":["https://openalex.org/I129043915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039006383","display_name":"Francesco F. Zaja","orcid":"https://orcid.org/0000-0003-3995-8817","observed_orcids":["https://orcid.org/0000-0003-3995-8817"]},"institutions":[{"id":"https://openalex.org/I4210164020","display_name":"Azienda Sanitaria Universitaria Integrata di Trieste","ror":"https://ror.org/05g7qp006","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210164020","https://openalex.org/I4405278440"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Zaja","raw_affiliation_strings":["S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S.C. Ematologia, Azienda Sanitaria Universitaria Integrata, Trieste","institution_ids":["https://openalex.org/I4210164020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"S1","first_page":"302","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eltrombopag","display_name":"eltrombopag","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-immune-thrombocytopenia","display_name":"primary immune thrombocytopenia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/treatment-free-remission","display_name":"treatment-free remission","score":0.8790000081062317},{"id":"https://openalex.org/keywords/thrombopoietin-receptor-agonists","display_name":"thrombopoietin receptor agonists","score":0.9549999833106995},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.5590000152587891},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.6119999885559082},{"id":"https://openalex.org/keywords/immunomodulatory-activity","display_name":"immunomodulatory activity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/persistent-itp","display_name":"persistent ITP","score":0.5659999847412109},{"id":"https://openalex.org/keywords/newly-diagnosed-itp","display_name":"newly diagnosed ITP","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2780588981","wikidata":"https://www.wikidata.org/wiki/Q411588","display_name":"Eltrombopag","level":4,"score":0.8960077166557312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8340471982955933},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8133140206336975},{"id":"https://openalex.org/C2993327898","wikidata":"https://www.wikidata.org/wiki/Q638729","display_name":"Immune thrombocytopenia","level":3,"score":0.6349487900733948},{"id":"https://openalex.org/C2776915898","wikidata":"https://www.wikidata.org/wiki/Q1235195","display_name":"Romiplostim","level":5,"score":0.6267369985580444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5880209803581238},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5809255838394165},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.567225992679596},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5075966119766235},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.48187288641929626},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.41734176874160767},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4011051058769226},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2627481520175934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.hs9.0000561064.22529.7a","doi":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1097/01.hs9.0000561064.22529.7a","doi":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.hs9.0000561064.22529.7a","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2910213359","https://openalex.org/W2952296590","https://openalex.org/W3133048368","https://openalex.org/W2563759828","https://openalex.org/W3212095802","https://openalex.org/W376014369","https://openalex.org/W4392345354","https://openalex.org/W2949513495","https://openalex.org/W2483863246","https://openalex.org/W4387382285"],"abstract_inverted_index":{"Background:":[0],"Considering":[1],"their":[2,22,29,282],"mode":[3],"of":[4,12,36,48,57,64,85,147,161,172,182,211,228,237,278,328,365,404,422,481,500],"action,":[5],"it":[6],"is":[7,52,97,513,588],"expected":[8],"that":[9,496,525],"the":[10,55,83,86,93,209,215,221,226,235,248,251,259,320,332,385,389,394,402,413,420,442,447,473,502,521,523,529,545,558,596],"efficacy":[11],"thrombopoietin":[13],"receptor\u2010agonists":[14],"(TPO\u2010RAs),":[15],"eltrombopag":[16],"(ELT)":[17],"and":[18,99,174,179,192,244,271,275,281,305,323,431,444,598],"romiplostim,":[19],"depends":[20],"on":[21],"continuous":[23],"administration.":[24],"However,":[25],"durable":[26],"remissions":[27],"after":[28,116,497],"discontinuation":[30,175],"have":[31,409],"been":[32],"described":[33],"in":[34,69,114,204,232,362,427,432,506,575],"10\u201330%":[35],"ITP":[37,110,512,576],"patients":[38],"(pts),":[39],"suggesting":[40],"a":[41,61,131,145,158,170,180,456,463,479,550,555,593],"possible":[42],"immunomodulatory":[43],"activity.":[44],"Aims:":[45],"The":[46,140,217,286,372],"aim":[47],"this":[49],"prospective":[50],"study":[51,141],"to":[53,80,129,167,198,241,273,293,458,461,504,536,557,583,591],"explore":[54],"role":[56],"ELT":[58,156,505,547],"given":[59],"for":[60],"defined":[62,196],"period":[63,146,171,181],"time":[65,403],"as":[66,554],"second\u2010line":[67],"treatment":[68,148,274],"pts":[70,154,203,229,308,317,408,416,435,438,476,507,518,541],"with":[71,82,106,120,284,450,508],"newly":[72],"diagnosed":[73],"(ND)":[74],"or":[75,108,113,126,206,510,561],"persistent":[76],"(P)":[77],"ITP,":[78],"aiming":[79],"interfere":[81],"pathogenesis":[84],"disease":[87,122],"at":[88,157,208,234,377,419,465],"an":[89,268],"early":[90,590],"stage,":[91],"when":[92],"immune":[94],"system":[95],"dysregulation":[96],"milder":[98],"reversible.":[100],"Methods:":[101],"Pts":[102,449],"aged":[103],"\u226518":[104],"years":[105,343],"ND":[107,349,509],"P":[109,511],"not":[111,410,472,572],"responsive":[112],"relapse":[115,527],"standard":[117,200],"first\u2010line":[118],"therapy,":[119,501],"active":[121],"(platelet":[123],"count":[124,133,354],"<30x109/L":[125],"steroids/IVIG":[127],"dependence":[128],"maintain":[130,544],"platelet":[132,168,353],"\u226530x109/L":[134],"and/or":[135],"avoid":[136],"bleeding)":[137],"were":[138,195,309,337,417],"included.":[139],"was":[142,220,239,291,325,341,355,367,380,425],"divided":[143],"into":[144],"(PT)":[149],"(24":[150],"weeks),":[151],"during":[152,250,441,446],"which":[153],"received":[155],"starting":[159],"dose":[160],"50":[162],"mg/day,":[163],"then":[164],"adjusted":[165],"according":[166,197],"count;":[169],"tapering":[173],"(PTD)":[176],"(week":[177,185,531],"25\u201332),":[178],"observation":[183],"(PO)":[184],"33\u201352).":[186],"Complete":[187],"response":[188,190,194,272,374,395,597],"(CR),":[189],"(R)":[191],"no":[193],"IWG":[199],"criteria.":[201],"Only":[202],"R":[205],"CR":[207,464],"end":[210,236,421],"week":[212,378,466],"24":[213,379],"entered":[214],"PTD.":[216],"primary":[218],"end\u2010point":[219],"treatment\u2010free":[222],"remission":[223,233,249],"(TFR)":[224],"i.e.":[225],"proportion":[227],"who,":[230],"being":[231],"PT,":[238],"able":[240],"taper":[242],"down":[243],"discontinue":[245],"ELT,":[246],"maintaining":[247],"PO,":[252],"without":[253],"other":[254,562],"therapies.":[255],"Secondary":[256],"objectives":[257],"included":[258],"relationship":[260],"between":[261,595],"baseline":[262,352,358,452],"TPO":[263,359,453,568,579],"serum":[264,569],"level":[265,580],"(measured":[266],"using":[267],"ELISA\u2010based":[269],"assay)":[270],"exploring":[276],"modifications":[277],"immunological":[279,599],"parameters":[280],"correlation":[283,594],"responses.":[285],"Mann":[287],"Whitney":[288],"Wilcoxon":[289],"test":[290],"used":[292,553],"determine":[294],"statistical":[295],"significance":[296],"(defined":[297],"by":[298,311],"p":[299],"<":[300],"0.05).":[301],"Results:":[302],"Between":[303],"24/02/16":[304],"05/05/2018,":[306],"55":[307],"enrolled":[310],"10":[312],"GIMEMA":[313],"Italian":[314],"Centers.":[315],"3":[316,445],"didn\u2019t":[318],"meet":[319],"inclusion":[321],"criteria":[322],"1":[324],"excluded":[326],"because":[327],"protocol":[329],"violation.":[330],"Of":[331],"51":[333],"evaluable":[334,361,418,434],"pts,":[335,366],"61%":[336],"females.":[338],"Median":[339,351,357],"age":[340],"65":[342,482],"(range":[344,370],"21\u201390).":[345],"22":[346],"(43%)":[347],"had":[348,455],"ITP.":[350],"19x109/L.":[356],"levels,":[360],"44/51":[363],"(86%)":[364],"47.6":[368],"pg/mL":[369],"31.3\u2013607.7).":[371],"overall":[373],"rate":[375],"(ORR)":[376],"67%":[381,514],"(33%":[382,515],"CR).":[383,516],"All":[384],"34":[386],"responders":[387,429],"completed":[388,411],"PTD:":[390],"17":[391,440],"(50%)":[392],"maintained":[393],"(21%":[396],"CR),":[397],"while":[398],"50%":[399],"relapsed.":[400],"At":[401],"data":[405,494],"cut\u2010off,":[406],"6/34":[407],"yet":[412],"PO.":[414,448],"28/34":[415],"PO:":[423],"TFR":[424],"observed":[426],"8/28":[428],"(29%)":[430],"8/45":[433],"(18%).":[436],"20":[437],"relapsed:":[439],"PTD":[443,530],"higher":[451,459],"levels":[454,570],"trend":[457],"probability":[460],"achieve":[462,537],"4":[467],"(p":[468],"=":[469],"0.06)":[470],"but":[471],"TFR.":[474,539,585],"23":[475],"(45%)":[477],"reported":[478],"total":[480],"adverse":[483,489],"events":[484],"(AEs),":[485],"including":[486],"15":[487],"serious":[488],"events.":[490],"Summary/Conclusion:":[491],"These":[492],"preliminary":[493],"showed":[495],"6":[498],"months":[499],"ORR":[503],"Among":[517],"who":[519,542],"started":[520],"tapering,":[522],"ones":[524],"don\u2019t":[526,543],"within":[528],"32)":[532],"are":[533,571],"more":[534],"likely":[535],"longer":[538],"For":[540],"response,":[546],"can":[548],"be":[549],"steroid\u2010sparing":[551],"agent":[552],"bridge":[556],"chronic":[559],"phase":[560],"treatments.":[563],"Differently":[564],"from":[565],"what":[566],"expected,":[567],"adequately":[573],"increased":[574],"pts.":[577],"Baseline":[578],"doesn\u2019t":[581],"seem":[582],"predict":[584],"This":[586],"analysis":[587],"too":[589],"define":[592],"parameters.":[600],"image":[601]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-06-27T00:00:00"}
