{"id":"https://openalex.org/W2952068167","doi":"https://doi.org/10.1021/acs.biochem.9b00401","title":"Structure and Function of the \u03b3-Secretase Complex","display_name":"Structure and Function of the \u03b3-Secretase Complex","publication_year":2019,"publication_date":"2019-06-14","ids":{"openalex":"https://openalex.org/W2952068167","doi":"https://doi.org/10.1021/acs.biochem.9b00401","mag":"2952068167","pmid":"https://pubmed.ncbi.nlm.nih.gov/31198028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6618299"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.9b00401","doi":"https://doi.org/10.1021/acs.biochem.9b00401","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00401","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6618299","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070207434","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-5721-9092","observed_orcids":["https://orcid.org/0000-0002-5721-9092"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States"],"raw_orcid":"https://orcid.org/0000-0002-5721-9092","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070207434"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":10.1264,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.98960599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"58","issue":"27","first_page":"2953","last_page":"2966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/presenilin","display_name":"presenilin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/membrane-proteases","display_name":"membrane proteases","score":0.6980000138282776},{"id":"https://openalex.org/keywords/substrate-recognition","display_name":"substrate recognition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7459999918937683},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.6650000214576721},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.7892990112304688},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6189066171646118},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6165600419044495},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.5823537111282349},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5821704864501953},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5126675367355347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48395875096321106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.471193790435791},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.459445595741272},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.4566686451435089},{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.45251938700675964},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.44198980927467346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43086913228034973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4113556444644928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3999386727809906},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2551364302635193},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.21705636382102966},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.19864556193351746},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09583914279937744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07602018117904663},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.biochem.9b00401","doi":"https://doi.org/10.1021/acs.biochem.9b00401","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.9b00401","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:31198028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31198028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6618299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6618299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},{"id":"pmh:oai:kuscholarworks.ku.edu:1808/29732","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1808/29732","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6618299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6618299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3884118389","display_name":null,"funder_award_id":"R01 GM122894","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4751994723","display_name":null,"funder_award_id":"GM 122894","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6541807297","display_name":"University of Kansas Alzheimer's Disease Core Centers","funder_award_id":"P30AG035982","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000877962","display_name":"University of Kansas Alzheimer's Disease Research Center (KU ADRC)","funder_award_id":"P30AG072973","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W642239104","https://openalex.org/W1480987708","https://openalex.org/W1483703465","https://openalex.org/W1495136850","https://openalex.org/W1534001036","https://openalex.org/W1547581699","https://openalex.org/W1549191090","https://openalex.org/W1552188451","https://openalex.org/W1572225000","https://openalex.org/W1579606275","https://openalex.org/W1595935608","https://openalex.org/W1626267121","https://openalex.org/W1655404681","https://openalex.org/W1660631781","https://openalex.org/W1675105744","https://openalex.org/W1890431460","https://openalex.org/W1925887942","https://openalex.org/W1967237003","https://openalex.org/W1970552333","https://openalex.org/W1972706019","https://openalex.org/W1972856649","https://openalex.org/W1976230573","https://openalex.org/W1978050229","https://openalex.org/W1978281908","https://openalex.org/W1978566291","https://openalex.org/W1979432217","https://openalex.org/W1981860609","https://openalex.org/W1986199521","https://openalex.org/W1986729145","https://openalex.org/W1988601980","https://openalex.org/W1988923764","https://openalex.org/W1989725189","https://openalex.org/W1990434926","https://openalex.org/W1990668385","https://openalex.org/W1993722622","https://openalex.org/W1994453752","https://openalex.org/W1995434077","https://openalex.org/W1996310770","https://openalex.org/W1997801717","https://openalex.org/W2000582255","https://openalex.org/W2001528985","https://openalex.org/W2004305803","https://openalex.org/W2005681172","https://openalex.org/W2007773692","https://openalex.org/W2009406704","https://openalex.org/W2010117436","https://openalex.org/W2019010572","https://openalex.org/W2019556396","https://openalex.org/W2022796225","https://openalex.org/W2023628337","https://openalex.org/W2024024756","https://openalex.org/W2024668488","https://openalex.org/W2026596383","https://openalex.org/W2028310816","https://openalex.org/W2029298729","https://openalex.org/W2030446280","https://openalex.org/W2032232498","https://openalex.org/W2033796514","https://openalex.org/W2037318207","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2047680094","https://openalex.org/W2048048305","https://openalex.org/W2049451196","https://openalex.org/W2049679236","https://openalex.org/W2053328915","https://openalex.org/W2056790763","https://openalex.org/W2057709960","https://openalex.org/W2058723245","https://openalex.org/W2060579161","https://openalex.org/W2060807002","https://openalex.org/W2062688749","https://openalex.org/W2063733034","https://openalex.org/W2067521893","https://openalex.org/W2068137765","https://openalex.org/W2069523103","https://openalex.org/W2070164943","https://openalex.org/W2071367544","https://openalex.org/W2074683943","https://openalex.org/W2075175573","https://openalex.org/W2075829521","https://openalex.org/W2077196279","https://openalex.org/W2077674018","https://openalex.org/W2078528430","https://openalex.org/W2078855200","https://openalex.org/W2081569845","https://openalex.org/W2081998222","https://openalex.org/W2086163393","https://openalex.org/W2086182092","https://openalex.org/W2086324585","https://openalex.org/W2088152552","https://openalex.org/W2088569816","https://openalex.org/W2088881960","https://openalex.org/W2088989293","https://openalex.org/W2089710618","https://openalex.org/W2089824266","https://openalex.org/W2095745901","https://openalex.org/W2097750046","https://openalex.org/W2100884747","https://openalex.org/W2101077392","https://openalex.org/W2104636742","https://openalex.org/W2109550988","https://openalex.org/W2112395233","https://openalex.org/W2113166966","https://openalex.org/W2113690827","https://openalex.org/W2118330889","https://openalex.org/W2118935254","https://openalex.org/W2120396539","https://openalex.org/W2124097986","https://openalex.org/W2126070767","https://openalex.org/W2126995971","https://openalex.org/W2127113850","https://openalex.org/W2129787742","https://openalex.org/W2134365974","https://openalex.org/W2134760521","https://openalex.org/W2135198700","https://openalex.org/W2141242388","https://openalex.org/W2144417521","https://openalex.org/W2146955477","https://openalex.org/W2147154228","https://openalex.org/W2150970420","https://openalex.org/W2154196079","https://openalex.org/W2157068721","https://openalex.org/W2158354144","https://openalex.org/W2162220128","https://openalex.org/W2162588539","https://openalex.org/W2164215375","https://openalex.org/W2168087300","https://openalex.org/W2169270398","https://openalex.org/W2170313682","https://openalex.org/W2232972230","https://openalex.org/W2299685066","https://openalex.org/W2302662614","https://openalex.org/W2323386724","https://openalex.org/W2341922669","https://openalex.org/W2407449454","https://openalex.org/W2512798183","https://openalex.org/W2551395839","https://openalex.org/W2571803537","https://openalex.org/W2606115324","https://openalex.org/W2742157915","https://openalex.org/W2775777157","https://openalex.org/W2799809220","https://openalex.org/W2906429538","https://openalex.org/W2908723002","https://openalex.org/W2913658593","https://openalex.org/W4231640017","https://openalex.org/W4252175039"],"related_works":["https://openalex.org/W4224297388","https://openalex.org/W2154649244","https://openalex.org/W2957840471","https://openalex.org/W7155757780","https://openalex.org/W1890431460","https://openalex.org/W3002762550","https://openalex.org/W2042835731","https://openalex.org/W7163662369","https://openalex.org/W7165670467","https://openalex.org/W2064142228"],"abstract_inverted_index":{"\u03b3-Secretase":[0],"is":[1,29],"a":[2,137],"membrane-embedded":[3],"protease":[4,44,97],"complex,":[5],"with":[6,36],"presenilin":[7,126],"as":[8],"the":[9,17,26,34,49,54,58,91,96,115],"catalytic":[10],"component":[11],"containing":[12],"two":[13],"transmembrane":[14,55],"aspartates":[15],"in":[16,39,85,125],"active":[18],"site.":[19],"With":[20],"more":[21],"than":[22],"90":[23],"known":[24],"substrates,":[25],"\u03b3-secretase":[27,71,105],"complex":[28],"considered":[30],"\"the":[31],"proteasome":[32],"of":[33,57,70,95,102,104,117,146],"membrane\",":[35],"central":[37],"roles":[38],"biology":[40],"and":[41,73,80,120,131,149],"medicine.":[42],"The":[43],"carries":[45],"out":[46],"hydrolysis":[47],"within":[48],"lipid":[50],"bilayer":[51],"to":[52,90,107],"cleave":[53],"domain":[56],"substrate":[59,118,129],"multiple":[60],"times":[61],"before":[62],"releasing":[63],"secreted":[64],"products.":[65],"For":[66],"many":[67],"years,":[68],"elucidation":[69],"structure":[72],"function":[74],"largely":[75],"relied":[76],"on":[77],"small-molecule":[78],"probes":[79],"mutagenesis.":[81],"Recently,":[82],"however,":[83],"advances":[84],"cryo-electron":[86],"microscopy":[87],"have":[88],"led":[89],"first":[92],"detailed":[93],"structures":[94,103,135],"complex.":[98],"Two":[99],"new":[100,134],"reports":[101],"bound":[106],"membrane":[108],"protein":[109],"substrates":[110],"provide":[111],"great":[112],"insight":[113],"into":[114],"nature":[116],"recognition":[119],"how":[121],"Alzheimer's":[122,151],"disease-causing":[123,147],"mutations":[124],"might":[127],"alter":[128],"binding":[130],"processing.":[132],"These":[133],"offer":[136],"powerful":[138],"platform":[139],"for":[140],"elucidating":[141],"enzyme":[142],"mechanisms,":[143],"deciphering":[144],"effects":[145],"mutations,":[148],"advancing":[150],"disease":[152],"drug":[153],"discovery.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-06-27T00:00:00"}
