{"id":"https://openalex.org/W2952050394","doi":"https://doi.org/10.1038/s41598-019-45209-9","title":"PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1","display_name":"PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1","publication_year":2019,"publication_date":"2019-06-19","ids":{"openalex":"https://openalex.org/W2952050394","doi":"https://doi.org/10.1038/s41598-019-45209-9","mag":"2952050394","pmid":"https://pubmed.ncbi.nlm.nih.gov/31217499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6584570"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-45209-9","doi":"https://doi.org/10.1038/s41598-019-45209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45209-9","pdf_url":"https://www.nature.com/articles/s41598-019-45209-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-45209-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023436702","display_name":"Haihong Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Haihong Guo","raw_affiliation_strings":["Clinic for Neuropathlogy, Medical School, RWTH Aachen University, 52074, Aachen, Germany","Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Neuropathlogy, Medical School, RWTH Aachen University, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053983781","display_name":"Fabian Treude","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Treude","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049942833","display_name":"Oliver Holger Kr\u00e4mer","orcid":"https://orcid.org/0000-0003-3973-045X","observed_orcids":["https://orcid.org/0000-0003-3973-045X"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver H. Kr\u00e4mer","raw_affiliation_strings":["Department of Toxicology, University Medical Center, 55131, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, University Medical Center, 55131, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041462448","display_name":"Bernhard L\u00fcscher","orcid":"https://orcid.org/0000-0002-9622-8709","observed_orcids":["https://orcid.org/0000-0002-9622-8709"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard L\u00fcscher","raw_affiliation_strings":["Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084106145","display_name":"J\u00f6rg Hartkamp","orcid":"https://orcid.org/0000-0002-6863-9228","observed_orcids":["https://orcid.org/0000-0002-6863-9228"]},"institutions":[{"id":"https://openalex.org/I4210138726","display_name":"Biofrontera (Germany)","ror":"https://ror.org/03vtebn72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210138726"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00f6rg Hartkamp","raw_affiliation_strings":["Biofrontera Bioscience GmbH, 51377, Leverkusen, Germany. jhartkamp@gmx.de","Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany. jhartkamp@gmx.de","Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biofrontera Bioscience GmbH, 51377, Leverkusen, Germany. jhartkamp@gmx.de","institution_ids":["https://openalex.org/I4210138726"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany. jhartkamp@gmx.de","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084106145"],"corresponding_institution_ids":["https://openalex.org/I4210138726","https://openalex.org/I887968799"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":1.0255,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.73451744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"8755","last_page":"8755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/par-4","display_name":"Par-4","score":0.968999981880188},{"id":"https://openalex.org/keywords/ciap1","display_name":"cIAP1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.824999988079071},{"id":"https://openalex.org/keywords/caspase-8-activation","display_name":"caspase-8 activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dna-damage-induced-apoptosis","display_name":"DNA damage-induced apoptosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/smac-mimetics","display_name":"IAP antagonists","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lcl161","display_name":"LCL161","score":0.968999981880188},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8140000104904175},{"id":"https://openalex.org/keywords/iap-proteins","display_name":"IAP proteins","score":0.6480000019073486},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6679680347442627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6386299729347229},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5939952731132507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.478561669588089},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.47152552008628845},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4565770626068115},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.45271480083465576},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.4424746334552765},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44176873564720154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4084553122520447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38677746057510376},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1751222014427185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10753872990608215}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018179","descriptor_name":"Receptors, Thrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018179","descriptor_name":"Receptors, Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-45209-9","doi":"https://doi.org/10.1038/s41598-019-45209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45209-9","pdf_url":"https://www.nature.com/articles/s41598-019-45209-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:31217499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31217499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6584570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6584570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f6ba8008decc4242941ae011a7bff3d8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f6ba8008decc4242941ae011a7bff3d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-45209-9","doi":"https://doi.org/10.1038/s41598-019-45209-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-45209-9","pdf_url":"https://www.nature.com/articles/s41598-019-45209-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8217181791","display_name":null,"funder_award_id":"DFG HA 6337/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324232","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34"},{"id":"https://openalex.org/F4320335386","display_name":"Medizinische Fakult\u00e4t, RWTH Aachen University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952050394.pdf","grobid_xml":"https://content.openalex.org/works/W2952050394.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1596394435","https://openalex.org/W1948838904","https://openalex.org/W1970934195","https://openalex.org/W1979946545","https://openalex.org/W1982273641","https://openalex.org/W1986532652","https://openalex.org/W1999866543","https://openalex.org/W2000888772","https://openalex.org/W2006309229","https://openalex.org/W2012224485","https://openalex.org/W2034269086","https://openalex.org/W2040193443","https://openalex.org/W2042421692","https://openalex.org/W2051073953","https://openalex.org/W2053274595","https://openalex.org/W2070228077","https://openalex.org/W2071126343","https://openalex.org/W2071630684","https://openalex.org/W2078361177","https://openalex.org/W2082318061","https://openalex.org/W2085012901","https://openalex.org/W2088573055","https://openalex.org/W2091269867","https://openalex.org/W2097255042","https://openalex.org/W2114428213","https://openalex.org/W2123183032","https://openalex.org/W2123496677","https://openalex.org/W2127492785","https://openalex.org/W2139015981","https://openalex.org/W2139597854","https://openalex.org/W2141393790","https://openalex.org/W2143296225","https://openalex.org/W2153961526","https://openalex.org/W2161334764","https://openalex.org/W2166921147","https://openalex.org/W2170554156","https://openalex.org/W2170602872","https://openalex.org/W2288109457","https://openalex.org/W2299234014","https://openalex.org/W2524835388","https://openalex.org/W2549185756","https://openalex.org/W2605995955","https://openalex.org/W2626111643","https://openalex.org/W2782903404","https://openalex.org/W2887885653","https://openalex.org/W4214918874"],"related_works":["https://openalex.org/W2612058412","https://openalex.org/W2050643539","https://openalex.org/W2766893287","https://openalex.org/W2039643947","https://openalex.org/W2027979933","https://openalex.org/W2612444362","https://openalex.org/W2161334764","https://openalex.org/W7042475005","https://openalex.org/W7167458272","https://openalex.org/W3111044342"],"abstract_inverted_index":{"Most":[0],"deaths":[1],"from":[2,6],"breast":[3,29,90],"cancer":[4,30,91],"result":[5],"tumour":[7,19],"recurrence,":[8],"which":[9],"is":[10,26],"typically":[11],"an":[12,47],"incurable":[13],"disease.":[14],"Down-regulation":[15],"of":[16,41,52,64,75,85,104,108,118,124,134,142,162,176],"the":[17,39,73,125,135],"pro-apoptotic":[18],"suppressor":[20],"protein":[21],"prostate":[22],"apoptosis":[23,100],"response-4":[24],"(PAR-4)":[25],"required":[27],"for":[28,50,191],"recurrence":[31],"and":[32,67,101,128,144,164,178,186],"resistance":[33,96],"to":[34,97,140],"chemotherapy.":[35],"Recent":[36],"advances":[37],"in":[38,87,194],"analysis":[40],"apoptotic":[42],"signalling":[43],"networks":[44],"have":[45],"uncovered":[46],"important":[48,173],"role":[49],"activation":[51,70,103],"caspase-8":[53,69,119,146,166],"following":[54],"DNA":[55,60,98,111],"damage":[56,61],"by":[57,71,120,160],"genotoxic":[58,187],"drugs.":[59],"induces":[62],"depletion":[63,141],"IAP":[65],"proteins":[66],"causes":[68],"promoting":[72],"formation":[74],"a":[76],"cytosolic":[77],"cell":[78,92],"death":[79],"complex.":[80],"We":[81],"demonstrate":[82,130],"that":[83,131,182],"loss":[84,107,161],"PAR-4":[86,109,115,137,163,177],"triple":[88],"negative":[89],"lines":[93],"(TNBC)":[94],"mediates":[95],"damage-induced":[99,112],"prevents":[102,110],"caspase-8.":[105],"Moreover,":[106],"cIAP1":[113,143,150,171],"depletion.":[114],"functions":[116],"downstream":[117,174],"cleavage-induced":[121],"nuclear":[122,132],"translocation":[123,133],"C-terminal":[126,136],"part":[127],"we":[129,179],"fragment":[138],"leads":[139],"subsequent":[145],"activation.":[147,167],"Specifically":[148],"targeting":[149],"with":[151],"RNAi":[152],"or":[153],"Smac":[154,184],"mimetics":[155,185],"(LCL161)":[156],"overcomes":[157],"chemo-resistance":[158],"induced":[159],"restores":[165],"Our":[168],"data":[169],"identify":[170],"as":[172],"mediator":[175],"provide":[180],"evidence":[181],"combining":[183],"drugs":[188],"creates":[189],"vulnerability":[190],"synthetic":[192],"lethality":[193],"TNBC":[195],"cells":[196],"lacking":[197],"PAR-4.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-27T00:00:00"}