{"id":"https://openalex.org/W2952044437","doi":"https://doi.org/10.1002/cjoc.201100305","title":"Catalytic Asymmetric Hydrogenation of Ethyl 2\u2010(Benzo[b]thiophen\u20105\u2010yl)\u20102\u2010oxoacetate with Ru\u2010SunPhos in the Formal Synthesis of T\u2010588","display_name":"Catalytic Asymmetric Hydrogenation of Ethyl 2\u2010(Benzo[b]thiophen\u20105\u2010yl)\u20102\u2010oxoacetate with Ru\u2010SunPhos in the Formal Synthesis of T\u2010588","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2952044437","doi":"https://doi.org/10.1002/cjoc.201100305","mag":"2952044437"},"language":"en","primary_location":{"id":"doi:10.1002/cjoc.201100305","doi":"https://doi.org/10.1002/cjoc.201100305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cjoc.201100305","pdf_url":null,"source":{"id":"https://openalex.org/S112006741","display_name":"Chinese Journal of Chemistry","issn_l":"1001-604X","issn":["1001-604X","1614-7065"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaoming Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Li","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108239560","display_name":"Xin Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Ma","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068975119","display_name":"Wanfang Li","orcid":"https://orcid.org/0000-0002-2544-1756","observed_orcids":["https://orcid.org/0000-0002-2544-1756"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanfang Li","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087298250","display_name":"Xiaoming Tao","orcid":"https://orcid.org/0000-0002-2406-0695","observed_orcids":["https://orcid.org/0000-0002-2406-0695"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Tao","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078866836","display_name":"Qinghua Meng","orcid":"https://orcid.org/0000-0002-5522-9852","observed_orcids":["https://orcid.org/0000-0002-5522-9852"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghua Meng","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weizheng Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizheng Fan","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063288717","display_name":"Zhaoguo Zhang","orcid":"https://orcid.org/0000-0003-3270-6617","observed_orcids":["https://orcid.org/0000-0003-3270-6617"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112946","display_name":"Shanghai Institute of Organic Chemistry","ror":"https://ror.org/01y3hvq34","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaoguo Zhang","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","Shanghai Isntitute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Isntitute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063288717"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I4210112946"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.1926,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61843911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"29","issue":"12","first_page":"2581","last_page":"2583"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12240","display_name":"Nanomaterials for catalytic reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asymmetric-hydrogenation","display_name":"asymmetric hydrogenation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/nootropics","display_name":"nootropic drugs","score":0.6320000290870667},{"id":"https://openalex.org/keywords/benzo-b-thiophene","display_name":"benzo[b]thiophene","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hydroxylation","display_name":"hydroxylation","score":0.41100001335144043},{"id":"https://openalex.org/keywords/recrystallization","display_name":"recrystallization","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9588764905929565},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.7803394794464111},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.5457183718681335},{"id":"https://openalex.org/C195702682","wikidata":"https://www.wikidata.org/wiki/Q623318","display_name":"Recrystallization (geology)","level":2,"score":0.5381895303726196},{"id":"https://openalex.org/C197356162","wikidata":"https://www.wikidata.org/wiki/Q4812077","display_name":"Asymmetric hydrogenation","level":4,"score":0.47921448945999146},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.43085089325904846},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.40392225980758667},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.39230024814605713},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.360342413187027},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/cjoc.201100305","doi":"https://doi.org/10.1002/cjoc.201100305","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cjoc.201100305","pdf_url":null,"source":{"id":"https://openalex.org/S112006741","display_name":"Chinese Journal of Chemistry","issn_l":"1001-604X","issn":["1001-604X","1614-7065"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.5199999809265137,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1984832858","https://openalex.org/W2007639332","https://openalex.org/W2017637631","https://openalex.org/W2022407069","https://openalex.org/W2039069312","https://openalex.org/W2052279706","https://openalex.org/W2072053169","https://openalex.org/W2079073711","https://openalex.org/W2081786334","https://openalex.org/W2127391340","https://openalex.org/W2130451496","https://openalex.org/W2157359173","https://openalex.org/W2313599598","https://openalex.org/W2316338341","https://openalex.org/W2912432751","https://openalex.org/W2952704045"],"related_works":["https://openalex.org/W1998801350","https://openalex.org/W2410776758","https://openalex.org/W2117365805","https://openalex.org/W2118647742","https://openalex.org/W2950553453","https://openalex.org/W2950174046","https://openalex.org/W2010402968","https://openalex.org/W2951999596","https://openalex.org/W2111064869","https://openalex.org/W2150742977"],"abstract_inverted_index":{"Abstract":[0],"Application":[1],"of":[2,6,13,26,61],"catalytic":[3],"asymmetric":[4],"hydrogenation":[5,20],"ethyl":[7],"2\u2010(benzo[b]thiophen\u20105\u2010yl)\u20102\u2010oxoacetate":[8],"for":[9],"the":[10,24,55,59],"formal":[11],"synthesis":[12,60],"cognitive":[14],"enhancer":[15],"T\u2010588":[16],"is":[17],"described.":[18],"The":[19],"was":[21,35],"conducted":[22],"under":[23],"catalysis":[25],"Ru\u2010SunPhos":[27],"system":[28],"with":[29,37],"HCl":[30],"as":[31,54],"additive.":[32],"Ethyl":[33],"2\u2010(benzo[b]thiophen\u20105\u2010yl)\u20102\u2010hydroxy\u2010acetate":[34],"obtained":[36],"98.6%":[38],"ee,":[39],"which":[40],"could":[41],"be":[42],"easily":[43],"upgraded":[44],"to":[45],"99.5%":[46],"ee":[47],"after":[48],"a":[49],"simple":[50],"recrystallization":[51],"and":[52],"served":[53],"key":[56],"intermediate":[57],"in":[58],"T\u2010588.":[62]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2019-06-27T00:00:00"}