{"id":"https://openalex.org/W2952022645","doi":"https://doi.org/10.1002/hon.9_2629","title":"MOUSE PDX AS NON\u2010CLINICAL MODELS FOR LYMPHOMA","display_name":"MOUSE PDX AS NON\u2010CLINICAL MODELS FOR LYMPHOMA","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2952022645","doi":"https://doi.org/10.1002/hon.9_2629","mag":"2952022645"},"language":"en","primary_location":{"id":"doi:10.1002/hon.9_2629","doi":"https://doi.org/10.1002/hon.9_2629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.9_2629","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030353708","display_name":"Abner Louissaint","orcid":"https://orcid.org/0000-0001-6707-917X","observed_orcids":["https://orcid.org/0000-0001-6707-917X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Louissaint","raw_affiliation_strings":["Pathology, Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030353708"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08195998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"37","issue":"S2","first_page":"40","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/in-vivo-tumor-model","display_name":"in vivo tumor model","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-immunophenotype","display_name":"tumor immunophenotype","score":0.6600000262260437},{"id":"https://openalex.org/keywords/mutational-landscape","display_name":"mutational landscape","score":0.7620000243186951},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.6869999766349792},{"id":"https://openalex.org/keywords/mhc-class-i-deficiency","display_name":"MHC class I deficiency","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tissue-tropism","display_name":"tissue tropism","score":0.6949999928474426},{"id":"https://openalex.org/keywords/preclinical-drug-testing","display_name":"preclinical drug testing","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.75}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5799076557159424},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5769233107566833},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5747910737991333},{"id":"https://openalex.org/C2779060813","wikidata":"https://www.wikidata.org/wiki/Q17143415","display_name":"Hematopathology","level":5,"score":0.5492909550666809},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.4644610285758972},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44641339778900146},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44324761629104614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4325808882713318},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.43102139234542847},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.42323383688926697},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3088744878768921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26973044872283936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25322914123535156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18593376874923706},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.12472599744796753},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.12246149778366089},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/hon.9_2629","doi":"https://doi.org/10.1002/hon.9_2629","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hon.9_2629","pdf_url":null,"source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588056411","https://openalex.org/W2577318457","https://openalex.org/W4403533098","https://openalex.org/W7135858892","https://openalex.org/W4252440788","https://openalex.org/W4307908363","https://openalex.org/W2489660615","https://openalex.org/W3181075833","https://openalex.org/W2624346540","https://openalex.org/W1501039975"],"abstract_inverted_index":{"Lymphomas":[0],"represent":[1,240],"nearly":[2,30],"70":[3],"distinct":[4],"diseases":[5],"with":[6,86,106,251,271],"unique":[7,242],"clinical":[8],"presentations,":[9],"therapeutic":[10,266],"responses":[11],"and":[12,25,42,101,116,150,163,176,198,228,247,264],"underlying":[13],"biology.":[14,45],"There":[15],"is":[16],"a":[17,70,127,213,219,241,272],"pressing":[18],"shortage":[19],"of":[20,29,32,50,72,76,159,166,173,184,189,194,208,234,274,289],"publicly":[21],"available":[22,235,281],"cell":[23],"line":[24],"in":[26,47,134,202,252],"vivo":[27,48,253],"models":[28,49,211,239,258],"all":[31],"these":[33],"diseases,":[34],"which":[35,56,131],"has":[36],"severely":[37],"hampered":[38],"efforts":[39],"to":[40,244,260],"understand":[41],"target":[43],"their":[44,177],"Most":[46],"lymphoma":[51,226],"are":[52,280],"genetically-engineered":[53],"mouse":[54],"models,":[55],"often":[57],"don't":[58],"faithfully":[59],"recapitulate":[60],"human":[61,80],"disease.":[62],"To":[63],"address":[64],"this":[65],"issue,":[66],"we":[67],"have":[68,139,156,256],"established":[69],"repository":[71],"patient-derived":[73],"xenografts":[74,179],"(PDX)":[75],"lymphomas":[77],"by":[78,110,143],"engrafting":[79],"tumors":[81,175],"into":[82],"immunodeficient":[83],"NOD/Scid/IL2rgnull":[84],"mice":[85],"or":[87],"without":[88],"an":[89],"MHC":[90],"Class":[91],"1":[92],"deficiency":[93],"(to":[94],"prevent":[95],"graft":[96],"versus":[97],"host":[98],"disease).":[99],"Blood":[100],"bone":[102],"marrow":[103],"specimens":[104,119],"involved":[105],"tumor":[107,129,195],"were":[108,120],"injected":[109],"tail":[111],"vein":[112],"injection.":[113],"Lymph":[114],"node":[115],"extranodal":[117],"biopsy":[118],"implanted":[121],"under":[122],"the":[123,133,167,203,209,231,283],"renal":[124],"capsule":[125],"as":[126],"1x1x2mm":[128],"seed,":[130],"maintains":[132],"situ":[135],"microarchitecture.":[136],"The":[137,205,268],"PDXs":[138,275],"been":[140],"extensively":[141,259],"characterized":[142],"immunohistochemistry":[144],"(IHC),":[145],"flow":[146],"cytometry,":[147],"transcriptome":[148],"sequencing":[149,216],"targeted":[151,214],"DNA":[152,215],"sequencing.":[153],"These":[154,238],"studies":[155,250],"demonstrated":[157],"retention":[158,193],"key":[160],"architectural,":[161],"cellular,":[162],"molecular":[164],"features":[165],"primary":[168,225],"tumors.":[169],"Flow":[170],"cytometric":[171],"analysis":[172],"patient":[174],"respective":[178],"revealed":[180],"highly":[181],"concordant":[182],"patterns":[183],"surface":[185],"marker":[186],"expression.":[187],"IHC":[188],"murine":[190],"tissues":[191],"confirmed":[192],"immunophenotypes,":[196],"architecture,":[197],"even":[199],"tissue":[200],"tropism":[201],"PDXs.":[204],"genetic":[206],"characterization":[207],"PDX":[210],"using":[212],"approach":[217],"showed":[218],"mutational":[220],"profile":[221],"that":[222],"clearly":[223],"matched":[224],"samples":[227],"significantly":[229],"expands":[230],"current":[232],"repertoire":[233],"pre-clinical":[236],"models.":[237,254],"opportunity":[243],"interrogate":[245,261],"biology":[246],"perform":[248],"preclinical":[249],"We":[255],"utilized":[257],"chemical,":[262],"antibody":[263],"other":[265,277],"manipulations.":[267],"lymphomas,":[269],"along":[270],"spectrum":[273],"from":[276],"hematologic":[278],"malignancies,":[279],"through":[282],"online":[284],"portal":[285],"PRoXe":[286],"(Public":[287],"Repository":[288],"Xenografts)":[290],"at":[291],"http://www.proxe.org.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-06-27T00:00:00"}