{"id":"https://openalex.org/W2952014132","doi":"https://doi.org/10.1016/j.exer.2017.12.013","title":"Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse","display_name":"Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse","publication_year":2018,"publication_date":"2018-02-03","ids":{"openalex":"https://openalex.org/W2952014132","doi":"https://doi.org/10.1016/j.exer.2017.12.013","mag":"2952014132","pmid":"https://pubmed.ncbi.nlm.nih.gov/29421330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5939594"},"language":"en","primary_location":{"id":"doi:10.1016/j.exer.2017.12.013","doi":"https://doi.org/10.1016/j.exer.2017.12.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2017.12.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483517306607/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0014483517306607/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054191294","display_name":"Felix L. Struebing","orcid":"https://orcid.org/0000-0002-9436-6294","observed_orcids":["https://orcid.org/0000-0002-9436-6294"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix L. Struebing","raw_affiliation_strings":["Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA"],"raw_orcid":"https://orcid.org/0000-0002-9436-6294","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077663520","display_name":"Rebecca King","orcid":"https://orcid.org/0000-0003-0874-0102","observed_orcids":["https://orcid.org/0000-0003-0874-0102"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca King","raw_affiliation_strings":["Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051524591","display_name":"Jessica N. Cooke Bailey","orcid":"https://orcid.org/0000-0002-4001-8702","observed_orcids":["https://orcid.org/0000-0002-4001-8702"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica N. Cooke Bailey","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086641481","display_name":"Janey L. Wiggs","orcid":"https://orcid.org/0000-0003-1890-3278","observed_orcids":["https://orcid.org/0000-0003-1890-3278"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janey L. Wiggs","raw_affiliation_strings":["Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045113631","display_name":"Eldon E. Geisert","orcid":"https://orcid.org/0000-0003-0787-4416","observed_orcids":["https://orcid.org/0000-0003-0787-4416"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eldon E. Geisert","raw_affiliation_strings":["Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. Electronic address: egeiser@emory.edu","Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. Electronic address: egeiser@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045113631"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":{"value":4010,"currency":"USD","value_usd":4010},"fwci":1.757,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83755027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"169","issue":null,"first_page":"61","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.9409999847412109},{"id":"https://openalex.org/keywords/elevated-intraocular-pressure","display_name":"intraocular pressure elevation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/glaucoma-risk","display_name":"glaucoma risk","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bxd-recombinant-inbred-strains","display_name":"BXD recombinant inbred mice","score":0.8740000128746033},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.7799999713897705},{"id":"https://openalex.org/keywords/aldh7a1","display_name":"ALDH7A1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/magnetic-beads","display_name":"magnetic beads","score":0.671999990940094},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.7457059621810913},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.6498594284057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6446568965911865},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5852639079093933},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.5767017006874084},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5668261051177979},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.5535569190979004},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5472958087921143},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5401161909103394},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5029460787773132},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.46788328886032104},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.444938063621521},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4386240839958191},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34957242012023926},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32383203506469727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2936026453971863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19798541069030762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15588703751564026},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.12453150749206543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009901","descriptor_name":"Optic Nerve Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.exer.2017.12.013","doi":"https://doi.org/10.1016/j.exer.2017.12.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2017.12.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483517306607/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},{"id":"doi:10.1101/212753","doi":"https://doi.org/10.1101/212753","is_oa":true,"landing_page_url":"https://doi.org/10.1101/212753","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/01/212753.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:29421330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29421330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental eye research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4859234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5939594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5939594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5939594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Exp Eye Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.exer.2017.12.013","doi":"https://doi.org/10.1016/j.exer.2017.12.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2017.12.013","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483517306607/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1385659940","display_name":null,"funder_award_id":"R01EY178841","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2118613836","display_name":null,"funder_award_id":"P30EY06360","funder_id":"https://openalex.org/F4320306811","funder_display_name":"Research to Prevent Blindness"},{"id":"https://openalex.org/G2481449490","display_name":"Long Noncoding RNA lncLOXL1 and Exfoliation Syndrome.","funder_award_id":"R21EY028671","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3671246162","display_name":null,"funder_award_id":"PO30EY014104","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3821350855","display_name":null,"funder_award_id":"EY022305","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4579318641","display_name":"Modulators of Retinal Injury","funder_award_id":"R01EY017841","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5561405880","display_name":null,"funder_award_id":"PO30EY014104","funder_id":"https://openalex.org/F4320306709","funder_display_name":"Glaucoma Research Foundation"},{"id":"https://openalex.org/G5732525105","display_name":"Molecular Genetics of Norma Tension Glaucoma","funder_award_id":"R01EY023512","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G767331861","display_name":null,"funder_award_id":"P30EY06360","funder_id":"https://openalex.org/F4320306709","funder_display_name":"Glaucoma Research Foundation"},{"id":"https://openalex.org/G8365442528","display_name":null,"funder_award_id":"R01 EY022305","funder_id":"https://openalex.org/F4320306709","funder_display_name":"Glaucoma Research Foundation"},{"id":"https://openalex.org/G9000858529","display_name":"P30 Core Grant for Vision Research","funder_award_id":"P30EY014104","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000860143","display_name":"P30-Core Grant for Vision Research","funder_award_id":"P30EY006360","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000881234","display_name":"NEIGHBORHOOD Consortium for POAG Genetics","funder_award_id":"R01EY022305","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306709","display_name":"Glaucoma Research Foundation","ror":"https://ror.org/05ez53b31"},{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952014132.pdf","grobid_xml":"https://content.openalex.org/works/W2952014132.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1129919997","https://openalex.org/W1562714951","https://openalex.org/W1599235209","https://openalex.org/W1960721561","https://openalex.org/W1974273434","https://openalex.org/W1979464604","https://openalex.org/W1989399186","https://openalex.org/W1991677561","https://openalex.org/W2013859310","https://openalex.org/W2017702277","https://openalex.org/W2032124492","https://openalex.org/W2045269704","https://openalex.org/W2050065221","https://openalex.org/W2061404823","https://openalex.org/W2065969837","https://openalex.org/W2067341924","https://openalex.org/W2072669203","https://openalex.org/W2079224601","https://openalex.org/W2087647596","https://openalex.org/W2099955914","https://openalex.org/W2135114355","https://openalex.org/W2135930638","https://openalex.org/W2145908472","https://openalex.org/W2147122728","https://openalex.org/W2157890401","https://openalex.org/W2165756541","https://openalex.org/W2257300821","https://openalex.org/W2265638154","https://openalex.org/W2499240546","https://openalex.org/W2520667824","https://openalex.org/W2524796157","https://openalex.org/W2549574097","https://openalex.org/W2568000928","https://openalex.org/W2623499978","https://openalex.org/W2626606138","https://openalex.org/W6635786941","https://openalex.org/W6684350457"],"related_works":["https://openalex.org/W2949949104","https://openalex.org/W2021384712","https://openalex.org/W1486289153","https://openalex.org/W3011382181","https://openalex.org/W2915789757","https://openalex.org/W2617737588","https://openalex.org/W1967857249","https://openalex.org/W2342156798","https://openalex.org/W2080782177","https://openalex.org/W1984266077"],"abstract_inverted_index":{"The":[0,53,132,147],"present":[1],"study":[2],"was":[3,31,55,102,138,160,204,239,264],"designed":[4],"to":[5,17,50,167,206,285],"identify":[6],"genomic":[7,281],"loci":[8],"modulating":[9,236],"the":[10,23,38,43,59,99,111,114,141,154,200,231,257,269],"susceptibility":[11,284],"of":[12,150,268],"retinal":[13],"ganglion":[14],"cells":[15],"(RGC)":[16],"elevated":[18,32,130,175],"intraocular":[19],"pressure":[20],"(IOP)":[21],"in":[22,89,117,153,171,245,256,290],"BXD":[24,119],"recombinant":[25],"inbred":[26],"mouse":[27,246],"strain":[28,137],"set.":[29],"IOP":[30,54,66,77],"by":[33],"injecting":[34],"magnetic":[35],"microspheres":[36],"into":[37,145],"anterior":[39],"chamber":[40],"and":[41,98,113,125,140,225,288],"blocking":[42],"trabecular":[44],"meshwork":[45],"using":[46],"a":[47,82,180,189,208],"handheld":[48],"magnet":[49],"impede":[51],"drainage.":[52],"then":[56],"measured":[57],"over":[58],"next":[60],"21":[61],"days.":[62],"Only":[63],"animals":[64,172],"with":[65,129,173,188,254,274],"greater":[67],"than":[68],"25":[69],"mmHg":[70,80],"for":[71,104,109,135,185,235],"two":[72],"consecutive":[73],"days":[74],"or":[75],"an":[76,291],"above":[78],"30":[79],"on":[81,195,220],"single":[83],"day":[84,93],"after":[85],"microsphere-injection":[86],"were":[87,96,107,143,250],"used":[88,205],"this":[90,229,262],"study.":[91],"On":[92],"21,":[94],"mice":[95],"sacrificed":[97],"optic":[100,155],"nerve":[101,156],"processed":[103],"histology.":[105],"Axons":[106],"counted":[108],"both":[110,186],"injected":[112],"control":[115],"eye":[116],"49":[118],"strains,":[120],"totaling":[121],"181":[122],"normal":[123,151],"counts":[124,127],"191":[126],"associated":[128,253,273],"IOP.":[131,176],"axon":[133,202,237],"loss":[134,203,238],"each":[136],"calculated":[139],"data":[142],"entered":[144],"genenetwork.org.":[146],"average":[148],"number":[149],"axons":[152],"across":[157],"all":[158],"strains":[159],"54,788":[161],"\u00b1":[162,169],"16%":[163],"(SD),":[164],"which":[165],"dropped":[166],"49,545":[168],"20%":[170],"artificially":[174],"Interval":[177],"mapping":[178],"demonstrated":[179,242],"relatively":[181],"similar":[182],"genome-wide":[183,209],"map":[184],"conditions":[187],"suggestive":[190],"Quantitative":[191],"Trait":[192],"Locus":[193],"(QTL)":[194],"proximal":[196],"Chromosome":[197,221],"3.":[198],"When":[199],"relative":[201],"generate":[207],"interval":[210],"map,":[211],"we":[212],"identified":[213,265],"one":[214],"significant":[215],"QTL":[216],"(p":[217],"<":[218],"0.05)":[219],"18":[222],"between":[223],"53.6":[224],"57":[226],"Mb.":[227],"Within":[228],"region,":[230],"best":[232],"candidate":[233],"gene":[234],"Aldh7a1.":[240],"Immunohistochemistry":[241],"ALDH7A1":[243,248],"expression":[244],"RGCs.":[247],"variants":[249],"not":[251],"significantly":[252],"glaucoma":[255,275,293],"NEIGHBORHOOD":[258],"GWAS":[259],"dataset,":[260],"but":[261],"enzyme":[263],"as":[266],"part":[267],"butanoate":[270],"pathway":[271],"previously":[272],"risk.":[276],"Our":[277],"results":[278],"suggest":[279],"that":[280],"background":[282],"influences":[283],"RGC":[286],"degeneration":[287],"death":[289],"inducible":[292],"model.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2019-06-27T00:00:00"}
