{"id":"https://openalex.org/W2951998010","doi":"https://doi.org/10.1002/chin.200418212","title":"The Discovery and Synthesis of Novel Adenosine Substituted 2,3\u2010Dihydro\u20101H\u2010isoindol\u20101\u2010ones: Potent Inhibitors of Poly(ADP\u2010ribose) Polymerase\u20101 (PARP\u20101).","display_name":"The Discovery and Synthesis of Novel Adenosine Substituted 2,3\u2010Dihydro\u20101H\u2010isoindol\u20101\u2010ones: Potent Inhibitors of Poly(ADP\u2010ribose) Polymerase\u20101 (PARP\u20101).","publication_year":2004,"publication_date":"2004-04-07","ids":{"openalex":"https://openalex.org/W2951998010","doi":"https://doi.org/10.1002/chin.200418212","mag":"2951998010"},"language":"en","primary_location":{"id":"doi:10.1002/chin.200418212","doi":"https://doi.org/10.1002/chin.200418212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200418212","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072865009","display_name":"Prakash G. Jagtap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash G. Jagtap","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110119843","display_name":"Garry J. Southan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry J. Southan","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067532930","display_name":"Erkan Baloglu","orcid":"https://orcid.org/0000-0002-4106-732X","observed_orcids":["https://orcid.org/0000-0002-4106-732X"]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erkan Baloglu","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895978","display_name":"Siya Ram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siya Ram","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015112375","display_name":"Jon G. Mabley","orcid":"https://orcid.org/0000-0001-9423-6230","observed_orcids":["https://orcid.org/0000-0001-9423-6230"]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon G. Mabley","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105420568","display_name":"Anita Marton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Marton","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833359","display_name":"Andrew L. Salzman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Salzman","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058049602","display_name":"Csaba Szab\u00f3","orcid":"https://orcid.org/0000-0003-3110-4235","observed_orcids":["https://orcid.org/0000-0003-3110-4235"]},"institutions":[{"id":"https://openalex.org/I4210163227","display_name":"Inotek Pharmaceuticals (United States)","ror":"https://ror.org/05x3tad86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Csaba Szabo","raw_affiliation_strings":["Inotek Pharm. Corp., Beverly, MA 01915, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inotek Pharm. Corp., Beverly, MA 01915, USA","institution_ids":["https://openalex.org/I4210163227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210163227"],"apc_list":null,"apc_paid":null,"fwci":0.1601,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6031482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-derivatives","display_name":"adenosine derivatives","score":0.7799999713897705},{"id":"https://openalex.org/keywords/parp1-inhibitors","display_name":"PARP-1 inhibitors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/isoindole-synthesis","display_name":"isoindole synthesis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37350040674209595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3280388116836548}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.200418212","doi":"https://doi.org/10.1002/chin.200418212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200418212","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2148628152"],"related_works":["https://openalex.org/W2912166368","https://openalex.org/W2254813214","https://openalex.org/W2062071114","https://openalex.org/W2949135788","https://openalex.org/W2951368511","https://openalex.org/W2016740529","https://openalex.org/W2951027377","https://openalex.org/W1770478999","https://openalex.org/W2161679104","https://openalex.org/W2023519190"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2019-06-27T00:00:00"}