{"id":"https://openalex.org/W2951986264","doi":"https://doi.org/10.3389/fphar.2019.00641","title":"Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis","display_name":"Optimizing Vancomycin Dosing in Chronic Kidney Disease by Deriving and Implementing a Web-Based Tool Using a Population Pharmacokinetics Analysis","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2951986264","doi":"https://doi.org/10.3389/fphar.2019.00641","mag":"2951986264","pmid":"https://pubmed.ncbi.nlm.nih.gov/31244657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6581063"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2019.00641","doi":"https://doi.org/10.3389/fphar.2019.00641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00641","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00641/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00641/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070744986","display_name":"Sreemanee Raaj Dorajoo","orcid":"https://orcid.org/0000-0002-9613-6994","observed_orcids":["https://orcid.org/0000-0002-9613-6994"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sreemanee Raaj Dorajoo","raw_affiliation_strings":["Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore","Department of Pharmacy, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]},{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022728844","display_name":"Chrystal Leandra Winata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chrystal Leandra Winata","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042883804","display_name":"Jessica Hui Fen Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jessica Hui Fen Goh","raw_affiliation_strings":["Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore","Department of Pharmacy, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]},{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104075750","display_name":"Say Tat Ooi","orcid":"https://orcid.org/0000-0003-1990-7617","observed_orcids":["https://orcid.org/0000-0003-1990-7617"]},"institutions":[{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Say Tat Ooi","raw_affiliation_strings":["Department of Medicine (Infectious Diseases), Khoo Teck Puat Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Infectious Diseases), Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078578781","display_name":"Jyoti Somani","orcid":"https://orcid.org/0000-0002-3683-4387","observed_orcids":["https://orcid.org/0000-0002-3683-4387"]},"institutions":[{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jyoti Somani","raw_affiliation_strings":["Department of Medicine (Infectious Diseases), Khoo Teck Puat Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Infectious Diseases), Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110231460","display_name":"Lee Ying Yeoh","orcid":"https://orcid.org/0000-0002-6635-8473","observed_orcids":["https://orcid.org/0000-0002-6635-8473"]},"institutions":[{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lee Ying Yeoh","raw_affiliation_strings":["Department of Medicine (Renal Medicine), Khoo Teck Puat Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Renal Medicine), Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054191132","display_name":"Siok Ying Lee","orcid":"https://orcid.org/0000-0002-7586-3316","observed_orcids":["https://orcid.org/0000-0002-7586-3316"]},"institutions":[{"id":"https://openalex.org/I2802424189","display_name":"Khoo Teck Puat Hospital","ror":"https://ror.org/05wc95s05","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802424189"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Siok Ying Lee","raw_affiliation_strings":["Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore","institution_ids":["https://openalex.org/I2802424189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054844526","display_name":"Chun Wei Yap","orcid":"https://orcid.org/0000-0002-2004-3492","observed_orcids":["https://orcid.org/0000-0002-2004-3492"]},"institutions":[{"id":"https://openalex.org/I4405257834","display_name":"National Healthcare Group","ror":"https://ror.org/05qkemg93","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4405257834"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chun Wei Yap","raw_affiliation_strings":["Health Services & Outcomes Research, National Healthcare Group, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Services & Outcomes Research, National Healthcare Group, Singapore, Singapore","institution_ids":["https://openalex.org/I4405257834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060981830","display_name":"Alexandre Chan","orcid":"https://orcid.org/0000-0003-4391-4219","observed_orcids":["https://orcid.org/0000-0003-4391-4219"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Alexandre Chan","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022293663","display_name":"Jung\u2010woo Chae","orcid":"https://orcid.org/0000-0001-6026-7063","observed_orcids":["https://orcid.org/0000-0001-6026-7063"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR","SG"],"is_corresponding":true,"raw_author_name":"Jung-woo Chae","raw_affiliation_strings":["College of Pharmacy, Chungnam National University, Daejeon, South Korea","Department of Pharmacy, National University of Singapore, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungnam National University, Daejeon, South Korea","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022293663","https://openalex.org/A5060981830"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I196345858"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.757,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.66988564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"641","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.949999988079071},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dose-prediction-model","display_name":"dose prediction model","score":0.7620000243186951},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.675000011920929},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.9110000133514404},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.3930000066757202},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7390000224113464},{"id":"https://openalex.org/keywords/clinical-implementation","display_name":"clinical implementation","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8914711475372314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.85039222240448},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7350501418113708},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6007784008979797},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5989416241645813},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5976977944374084},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.5480093359947205},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5016887187957764},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5012662410736084},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.47917380928993225},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4562784433364868},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.4448593854904175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4373205304145813},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.17203965783119202},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3389/fphar.2019.00641","doi":"https://doi.org/10.3389/fphar.2019.00641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00641","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00641/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6581063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6581063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:31244657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31244657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/206403","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/206403","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus OA2019","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/206714","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/206714","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:dc003c5dde1a4148880e341d25a7cf57","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dc003c5dde1a4148880e341d25a7cf57","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3pf9n0f4","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3pf9n0f4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in pharmacology, vol 10, iss JUN","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3pf9n0f4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3pf9n0f4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, vol 10, iss JUN","raw_type":"article"},{"id":"mag:3213350972","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/206714","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fphar.2019.00641","doi":"https://doi.org/10.3389/fphar.2019.00641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2019.00641","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2019.00641/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3732712265","display_name":null,"funder_award_id":"NRF- 2018R1C1B5085278","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2951986264.pdf","grobid_xml":"https://content.openalex.org/works/W2951986264.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1525774039","https://openalex.org/W1567187781","https://openalex.org/W1611569621","https://openalex.org/W1619915988","https://openalex.org/W1973097930","https://openalex.org/W1973795734","https://openalex.org/W1978478268","https://openalex.org/W1997009415","https://openalex.org/W2004902368","https://openalex.org/W2005918477","https://openalex.org/W2010066166","https://openalex.org/W2013981808","https://openalex.org/W2020864307","https://openalex.org/W2036129782","https://openalex.org/W2053556162","https://openalex.org/W2055111201","https://openalex.org/W2055864845","https://openalex.org/W2057605178","https://openalex.org/W2065570335","https://openalex.org/W2068489935","https://openalex.org/W2068629997","https://openalex.org/W2078727847","https://openalex.org/W2091200828","https://openalex.org/W2095033713","https://openalex.org/W2111070278","https://openalex.org/W2113095699","https://openalex.org/W2114585210","https://openalex.org/W2116331284","https://openalex.org/W2116736766","https://openalex.org/W2127473408","https://openalex.org/W2133120422","https://openalex.org/W2133948398","https://openalex.org/W2134186143","https://openalex.org/W2141994110","https://openalex.org/W2144504167","https://openalex.org/W2146105386","https://openalex.org/W2155965977","https://openalex.org/W2167433346","https://openalex.org/W2178522631","https://openalex.org/W2607031541","https://openalex.org/W2736822200","https://openalex.org/W2802097422"],"related_works":["https://openalex.org/W7203567817","https://openalex.org/W7118238323","https://openalex.org/W2951030008","https://openalex.org/W2922127687","https://openalex.org/W4414001717","https://openalex.org/W2606404614","https://openalex.org/W4399208728","https://openalex.org/W2898736682","https://openalex.org/W2921643660","https://openalex.org/W2096201962"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"kidney":[2],"disease":[3],"(CKD)":[4],"patients":[5,53,71,169],"requiring":[6],"intravenous":[7],"vancomycin":[8,20,32,48,225],"bear":[9],"considerable":[10],"risks":[11],"of":[12,70,126,128,145,151,154,211,219],"adverse":[13],"outcomes":[14],"both":[15],"from":[16,115],"the":[17,82,208],"infection":[18],"and":[19,30,81,100,106,124,131,189,235],"therapy":[21],"itself,":[22],"necessitating":[23],"especially":[24],"precise":[25],"dosing":[26,99,174,231],"to":[27,45,72,160,179,199,242],"avoid":[28],"sub-":[29],"supra-therapeutic":[31],"exposure.":[33],"Methods:":[34],"In":[35],"this":[36],"retrospective":[37],"study,":[38],"we":[39],"performed":[40],"a":[41,47,87,121,140,176,220,239],"population":[42,122,221],"pharmacokinetic":[43,78,222],"analysis":[44],"construct":[46],"dose-prediction":[49],"model":[50,62,113,136,223],"for":[51,224],"CKD":[52,227,234],"who":[54,170],"do":[55],"not":[56,206],"require":[57],"renal":[58],"replacement":[59],"therapy.":[60],"The":[61,77,95,112],"was":[63,205],"externally":[64],"validated":[65],"on":[66],"an":[67,116,157],"independent":[68],"cohort":[69,118],"assess":[73],"its":[74],"prediction":[75,143],"accuracy.":[76],"parameter":[79],"estimates":[80],"equations":[83],"were":[84,108],"productized":[85],"into":[86],"web-application":[88],"(VancApp)":[89],"subsequently":[90],"implemented":[91],"in":[92,226,233],"routine":[93],"care.":[94,201],"association":[96],"between":[97],"VancApp-based":[98,173],"time-to-target":[101],"concentration":[102],"attainment,":[103],"30-day":[104,192],"mortality":[105],"nephrotoxicity":[107],"assessed":[109],"post-implementation.":[110],"Results:":[111],"constructed":[114],"initial":[117],"(n=80)":[119],"revealed":[120],"Clearance":[123],"Volume":[125],"distribution":[127],"1.30":[129],"L/hr":[130],"1.23":[132],"L/kg,":[133],"respectively.":[134],"External":[135],"validation":[137],"(n=112)":[138],"demonstrated":[139],"mean":[141],"absolute":[142],"error":[144],"1.25":[146],"mg/L.":[147],"Following":[148],"4":[149],"months":[150],"clinical":[152,209,245],"implementation":[153,218],"VancApp":[155],"as":[156,238],"optional":[158],"alternative":[159],"usual":[161,166,200],"care":[162,167],"[VancApp":[163],"(n=22)":[164],"vs":[165,185,195],"(n=21)],":[168],"had":[171,190],"received":[172],"took":[175],"shorter":[177],"time":[178],"reach":[180],"target":[181],"concentrations":[182],"(median:":[183],"66":[184],"102":[186],"hours,":[187],"p=0.187)":[188],"fewer":[191],"mortalities":[193],"(14%":[194],"24%,":[196],"p=0.457)":[197],"compared":[198],"While":[202],"statistical":[203],"significance":[204,210],"achieved,":[207],"these":[212],"findings":[213],"appear":[214],"promising.":[215],"Conclusion:":[216],"Clinical":[217],"can":[228],"potentially":[229],"improve":[230,243],"precision":[232],"could":[236],"serve":[237],"practical":[240],"means":[241],"vital":[244],"outcomes.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}
