{"id":"https://openalex.org/W2951717841","doi":"https://doi.org/10.1002/chin.200220209","title":"ChemInform Abstract: Design and Synthesis of a Selective EP4\u2010Receptor Agonist. Part 1. Discovery of 3,7\u2010DithiaPGE1 Derivatives and Identification of Their \u03c9 Chains.","display_name":"ChemInform Abstract: Design and Synthesis of a Selective EP4\u2010Receptor Agonist. Part 1. Discovery of 3,7\u2010DithiaPGE1 Derivatives and Identification of Their \u03c9 Chains.","publication_year":2002,"publication_date":"2002-05-21","ids":{"openalex":"https://openalex.org/W2951717841","doi":"https://doi.org/10.1002/chin.200220209","mag":"2951717841"},"language":"en","primary_location":{"id":"doi:10.1002/chin.200220209","doi":"https://doi.org/10.1002/chin.200220209","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200220209","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101981160","display_name":"Toru Maruyama","orcid":"https://orcid.org/0000-0001-6543-4377","observed_orcids":["https://orcid.org/0000-0001-6543-4377"]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Maruyama","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045914141","display_name":"Masaki Asada","orcid":"https://orcid.org/0000-0002-7117-5962","observed_orcids":["https://orcid.org/0000-0002-7117-5962"]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Asada","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112445800","display_name":"Tai Shiraishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tai Shiraishi","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021607240","display_name":"Hiromu Egashira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromu Egashira","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hideyuki Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Yoshida","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077691716","display_name":"Takayuki Maruyama","orcid":"https://orcid.org/0000-0003-2205-8310","observed_orcids":["https://orcid.org/0000-0003-2205-8310"]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Maruyama","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002066699","display_name":"Shuichi Ohuchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Ohuchida","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044537872","display_name":"Hisao Nakai","orcid":"https://orcid.org/0000-0001-9633-0255","observed_orcids":["https://orcid.org/0000-0001-9633-0255"]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Nakai","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112444965","display_name":"Kigen Kondo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kigen Kondo","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110809551","display_name":"Masaaki Toda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Toda","raw_affiliation_strings":["Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Res. Inst., Ono Pharm. Co., Ltd., Shimamoto, Osaka 618, Japan","institution_ids":["https://openalex.org/I4210112155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210112155"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38722244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ep4-receptor-agonist","display_name":"EP4 receptor agonist","score":0.9039999842643738},{"id":"https://openalex.org/keywords/prostaglandin-analogs","display_name":"prostaglandin analogues","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-synthesis","display_name":"drug synthesis","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9173517227172852},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7164949178695679},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5805073976516724},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.544951319694519},{"id":"https://openalex.org/C2780378061","wikidata":"https://www.wikidata.org/wiki/Q25351891","display_name":"Service (business)","level":2,"score":0.45327839255332947},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37166184186935425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1997186243534088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10524770617485046},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.09342479705810547},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.06623923778533936},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.058034271001815796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.200220209","doi":"https://doi.org/10.1002/chin.200220209","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.200220209","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2022611938"],"related_works":["https://openalex.org/W2952029742","https://openalex.org/W2951277807","https://openalex.org/W2022611938","https://openalex.org/W2951812433","https://openalex.org/W11454473","https://openalex.org/W2952442613","https://openalex.org/W2912071224","https://openalex.org/W2069181268","https://openalex.org/W2088536956","https://openalex.org/W2083071121"],"abstract_inverted_index":{"Abstract":[0,25],"ChemInform":[1,24],"is":[2,42],"a":[3,11,23,35],"weekly":[4],"Abstracting":[5],"Service,":[6],"delivering":[7],"concise":[8],"information":[9],"at":[10],"glance":[12],"that":[13],"was":[14,30],"extracted":[15],"from":[16],"about":[17],"100":[18],"leading":[19],"journals.":[20],"To":[21],"access":[22],"of":[26],"an":[27],"article":[28,41],"which":[29],"published":[31],"elsewhere,":[32],"please":[33],"select":[34],"\u201cFull":[36],"Text\u201d":[37],"option.":[38,47],"The":[39],"original":[40],"trackable":[43],"via":[44],"the":[45],"\u201cReferences\u201d":[46]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}
