{"id":"https://openalex.org/W2951576424","doi":"https://doi.org/10.1002/chin.201238143","title":"ChemInform Abstract: Two\u2010, Three\u2010 and Four\u2010Component Coupling to Form Isoquinolones Based on Directed Metalation.","display_name":"ChemInform Abstract: Two\u2010, Three\u2010 and Four\u2010Component Coupling to Form Isoquinolones Based on Directed Metalation.","publication_year":2012,"publication_date":"2012-08-23","ids":{"openalex":"https://openalex.org/W2951576424","doi":"https://doi.org/10.1002/chin.201238143","mag":"2951576424"},"language":"en","primary_location":{"id":"doi:10.1002/chin.201238143","doi":"https://doi.org/10.1002/chin.201238143","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.201238143","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065677978","display_name":"Monika I. Antczak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monika I. Antczak","raw_affiliation_strings":["Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088196532","display_name":"Joseph M. Ready","orcid":"https://orcid.org/0000-0003-1305-9581","observed_orcids":["https://orcid.org/0000-0003-1305-9581"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Ready","raw_affiliation_strings":["Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75235, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3216005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"38","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12228","display_name":"Coordination Chemistry and Organometallics","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12228","display_name":"Coordination Chemistry and Organometallics","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.09560000151395798,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoquinolinones","display_name":"isoquinolones","score":0.9039999842643738},{"id":"https://openalex.org/keywords/directed-metalation","display_name":"directed metalation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/ortho-metalation","display_name":"ortho-metalation","score":0.949999988079071},{"id":"https://openalex.org/keywords/benzamide","display_name":"benzamide","score":0.925000011920929},{"id":"https://openalex.org/keywords/multicomponent-coupling","display_name":"multicomponent coupling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/multicomponent-reactions","display_name":"multicomponent reactions","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.97808438539505},{"id":"https://openalex.org/C2775855785","wikidata":"https://www.wikidata.org/wiki/Q2270356","display_name":"Metalation","level":2,"score":0.9606351852416992},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.6423794627189636},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5178261399269104},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3487103581428528},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3444144129753113},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3385581374168396},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33206647634506226},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.03344890475273132},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.201238143","doi":"https://doi.org/10.1002/chin.201238143","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.201238143","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2118171314"],"related_works":["https://openalex.org/W2118171314","https://openalex.org/W2127943932","https://openalex.org/W2346076164","https://openalex.org/W2042776636","https://openalex.org/W1985148714","https://openalex.org/W2952814658","https://openalex.org/W2065308825","https://openalex.org/W4241787113","https://openalex.org/W2950306596","https://openalex.org/W2050641798"],"abstract_inverted_index":{"Abstract":[0],"Benzamides":[1],"undergo":[2],"ortho\u2010metalation":[3],"with":[4,10],"magnesiate":[5],"bases":[6],"to":[7],"allow":[8],"trapping":[9],"propargylic":[11],"chlorides.":[12]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}