{"id":"https://openalex.org/W2951535570","doi":"https://doi.org/10.1016/j.epidem.2017.12.001","title":"Modeling HIV disease progression and transmission at population-level: The potential impact of modifying disease progression in HIV treatment programs","display_name":"Modeling HIV disease progression and transmission at population-level: The potential impact of modifying disease progression in HIV treatment programs","publication_year":2017,"publication_date":"2017-12-06","ids":{"openalex":"https://openalex.org/W2951535570","doi":"https://doi.org/10.1016/j.epidem.2017.12.001","mag":"2951535570","pmid":"https://pubmed.ncbi.nlm.nih.gov/29223580","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975109"},"language":"en","primary_location":{"id":"doi:10.1016/j.epidem.2017.12.001","doi":"https://doi.org/10.1016/j.epidem.2017.12.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.epidem.2017.12.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S175543651730004X/pdf","source":{"id":"https://openalex.org/S24717195","display_name":"Epidemics","issn_l":"1755-4365","issn":["1755-4365","1878-0067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S175543651730004X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103229557","display_name":"Jennifer M. Ross","orcid":"https://orcid.org/0000-0001-5677-939X","observed_orcids":["https://orcid.org/0000-0001-5677-939X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer M. Ross","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: jross3@uw.edu","Department of Medicine, University of Washington, Seattle, WA, USA","Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: jross3@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000591201","display_name":"Roger Ying","orcid":"https://orcid.org/0000-0002-0380-3197","observed_orcids":["https://orcid.org/0000-0002-0380-3197"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Ying","raw_affiliation_strings":["Weill Cornell Medical College, Cornell University, 420 E 70th St., 12J-3, New York, NY 10021, USA. Electronic address: Rying1@gmail.com","Weill Cornell Medical College, Cornell University, 420 E 70th St., 12J-3, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, Cornell University, 420 E 70th St., 12J-3, New York, NY 10021, USA. Electronic address: Rying1@gmail.com","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Weill Cornell Medical College, Cornell University, 420 E 70th St., 12J-3, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090773831","display_name":"Connie Celum","orcid":"https://orcid.org/0000-0002-8813-3419","observed_orcids":["https://orcid.org/0000-0002-8813-3419"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie L. Celum","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: ccelum@uw.edu","Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","Department of Medicine, University of Washington, Seattle, WA, USA","Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: ccelum@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared M. Baeten","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: jbaeten@uw.edu","Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","Department of Medicine, University of Washington, Seattle, WA, USA","Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: jbaeten@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013103542","display_name":"Katherine K. Thomas","orcid":"https://orcid.org/0000-0002-7024-468X","observed_orcids":["https://orcid.org/0000-0002-7024-468X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine K. Thomas","raw_affiliation_strings":["Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA. Electronic address: kkthomas@uw.edu","Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA. Electronic address: kkthomas@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022057195","display_name":"Pamela M. Murnane","orcid":"https://orcid.org/0000-0002-3773-5831","observed_orcids":["https://orcid.org/0000-0002-3773-5831"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M. Murnane","raw_affiliation_strings":["Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco. Electronic address: pmurnane@gmail.com","Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco","Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco. Electronic address: pmurnane@gmail.com","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039461221","display_name":"Heidi van Rooyen","orcid":"https://orcid.org/0000-0002-6502-6098","observed_orcids":["https://orcid.org/0000-0002-6502-6098"]},"institutions":[{"id":"https://openalex.org/I103250015","display_name":"Human Sciences Research Council","ror":"https://ror.org/056206b04","country_code":"ZA","type":"nonprofit","lineage":["https://openalex.org/I103250015"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Heidi van Rooyen","raw_affiliation_strings":["Human Sciences Research Council, Durban, South Africa. Electronic address: hvanrooyen@hsrc.ac.za","Human Sciences Research Council, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Sciences Research Council, Durban, South Africa. Electronic address: hvanrooyen@hsrc.ac.za","institution_ids":["https://openalex.org/I103250015"]},{"raw_affiliation_string":"Human Sciences Research Council, Durban, South Africa","institution_ids":["https://openalex.org/I103250015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040963030","display_name":"James P. Hughes","orcid":"https://orcid.org/0000-0001-5034-3157","observed_orcids":["https://orcid.org/0000-0001-5034-3157"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Hughes","raw_affiliation_strings":["Department of Biostatistics, University of Washington, 1959 NE Pacific St., Box 357232, Seattle, WA 98195, USA; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jphughes@uw.edu","Department of Biostatistics, University of Washington, 1959 NE Pacific St., Box 357232, Seattle, WA 98195, USA","Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, 1959 NE Pacific St., Box 357232, Seattle, WA 98195, USA; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jphughes@uw.edu","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Biostatistics, University of Washington, 1959 NE Pacific St., Box 357232, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026481326","display_name":"Ruanne V. Barnabas","orcid":"https://orcid.org/0000-0002-1793-6003","observed_orcids":["https://orcid.org/0000-0002-1793-6003"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruanne V. Barnabas","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: rbarnaba@uw.edu","Department of Epidemiology, University of Washington, Seattle, WA, USA","Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","Department of Medicine, University of Washington, Seattle, WA, USA","Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA","Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA. Electronic address: rbarnaba@uw.edu","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Global Health, University of Washington, 325 9th Ave., Box 359927, Seattle, WA 98104-2420, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Division of Allergy and Infectious Disease, University of Washington, 1959 NE Pacific St., Box 356423, Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5103229557"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2730,"currency":"USD","value_usd":2730},"apc_paid":{"value":2730,"currency":"USD","value_usd":2730},"fwci":1.0525,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.77053755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":null,"first_page":"34","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-disease-progression","display_name":"HIV disease progression","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.906000018119812},{"id":"https://openalex.org/keywords/valacyclovir","display_name":"valacyclovir","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.5820000171661377},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9829999804496765},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.7599999904632568},{"id":"https://openalex.org/keywords/test-and-treat","display_name":"test and treat","score":0.671999990940094},{"id":"https://openalex.org/keywords/universal-treatment","display_name":"universal treatment","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.8640000224113464},{"id":"https://openalex.org/keywords/retention-in-hiv-care","display_name":"HIV care retention","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6930428147315979},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5869815945625305},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5422663688659668},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.5295019149780273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5085426568984985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39395251870155334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32221829891204834},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.29317381978034973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24992644786834717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12020695209503174},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0838766098022461}],"mesh":[{"descriptor_ui":"D000077483","descriptor_name":"Valacyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D017954","descriptor_name":"Africa South of the Sahara","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.epidem.2017.12.001","doi":"https://doi.org/10.1016/j.epidem.2017.12.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.epidem.2017.12.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S175543651730004X/pdf","source":{"id":"https://openalex.org/S24717195","display_name":"Epidemics","issn_l":"1755-4365","issn":["1755-4365","1878-0067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemics","raw_type":"journal-article"},{"id":"doi:10.1101/097337","doi":"https://doi.org/10.1101/097337","is_oa":true,"landing_page_url":"https://doi.org/10.1101/097337","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/01/06/097337.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:29223580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29223580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5511642","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5975109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5975109","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Epidemics","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8v66q0fp","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8v66q0fp","pdf_url":"https://escholarship.org/content/qt8v66q0fp/qt8v66q0fp.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2603990680ce4b859b34ebf93320981f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2603990680ce4b859b34ebf93320981f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epidemics, Vol 23, Iss , Pp 34-41 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.epidem.2017.12.001","doi":"https://doi.org/10.1016/j.epidem.2017.12.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.epidem.2017.12.001","pdf_url":"https://www.sciencedirect.com/science/article/pii/S175543651730004X/pdf","source":{"id":"https://openalex.org/S24717195","display_name":"Epidemics","issn_l":"1755-4365","issn":["1755-4365","1878-0067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epidemics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2213881162","display_name":null,"funder_award_id":"P30 AI027757","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G3534233002","display_name":"Interventions to decrease HIV infectiousness in Uganda","funder_award_id":"RC4AI092552","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3985073149","display_name":null,"funder_award_id":"AI 027757","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G5031017276","display_name":"Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRx","funder_award_id":"R01AI083034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6625095162","display_name":null,"funder_award_id":"P30 AI027757","funder_id":"https://openalex.org/F4320310094","funder_display_name":"University of Washington"},{"id":"https://openalex.org/G7791962275","display_name":null,"funder_award_id":"AI027757","funder_id":"https://openalex.org/F4320310094","funder_display_name":"University of Washington"},{"id":"https://openalex.org/G8509532979","display_name":null,"funder_award_id":"NIH P30 AI027757","funder_id":"https://openalex.org/F4320332582","funder_display_name":"Center for AIDS Research, University of Washington"},{"id":"https://openalex.org/G9000186388","display_name":null,"funder_award_id":"AI-027757","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000868680","display_name":"University of Washington/Fred Hutch Center for AIDS Research","funder_award_id":"P30AI027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000882239","display_name":"Traineeships in AIDS Prevention Studies","funder_award_id":"T32MH019105","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000895751","display_name":"Center for AIDS Prevention Studies (CAPS)","funder_award_id":"P30MH062246","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G917862342","display_name":null,"funder_award_id":"NIH P30 AI027757","funder_id":"https://openalex.org/F4320310094","funder_display_name":"University of Washington"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2951535570.pdf","grobid_xml":"https://content.openalex.org/works/W2951535570.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1588029786","https://openalex.org/W1975146800","https://openalex.org/W1991270979","https://openalex.org/W2014401391","https://openalex.org/W2029558670","https://openalex.org/W2031228067","https://openalex.org/W2055467735","https://openalex.org/W2074139927","https://openalex.org/W2074878346","https://openalex.org/W2087753903","https://openalex.org/W2098896458","https://openalex.org/W2098957040","https://openalex.org/W2100430786","https://openalex.org/W2106667886","https://openalex.org/W2113020582","https://openalex.org/W2117057469","https://openalex.org/W2119145410","https://openalex.org/W2119835296","https://openalex.org/W2122461922","https://openalex.org/W2139537135","https://openalex.org/W2147354200","https://openalex.org/W2151860060","https://openalex.org/W2152505869","https://openalex.org/W2155742166","https://openalex.org/W2159295367","https://openalex.org/W2159821675","https://openalex.org/W2160179097","https://openalex.org/W2163036286","https://openalex.org/W2166309712","https://openalex.org/W2167876918","https://openalex.org/W2169431633","https://openalex.org/W2169595126","https://openalex.org/W2173338292","https://openalex.org/W2181565919","https://openalex.org/W2293073501","https://openalex.org/W2293370508","https://openalex.org/W2314461521","https://openalex.org/W2334481472","https://openalex.org/W2352497809","https://openalex.org/W2505964812","https://openalex.org/W2595680684","https://openalex.org/W2608877821"],"related_works":["https://openalex.org/W2789730733","https://openalex.org/W2098896458","https://openalex.org/W2065936391","https://openalex.org/W2152718594","https://openalex.org/W2894236542","https://openalex.org/W433275512","https://openalex.org/W2082203834","https://openalex.org/W599338559","https://openalex.org/W2352497809","https://openalex.org/W2102384014"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Mathematical":[1],"models":[2],"that":[3,16,112,123,267],"incorporate":[4],"HIV":[5,18,49,64,73,105,115,142,155,171,208,222,241,251,269,275,290,299],"disease":[6,19,74,94,179],"progression":[7,20,75,95],"dynamics":[8],"can":[9,47],"estimate":[10],"the":[11,53,146,201,277,298],"potential":[12,147],"impact":[13,54,148],"of":[14,33,55,79,104,149,154,159,170,178,196,219,246],"strategies":[15],"delay":[17],"and":[21,84,122,162,227,234,248,254,284,295],"reduce":[22,297],"infectiousness":[23],"for":[24,188,274,280],"persons":[25,35,124],"not":[26,67],"on":[27,62,151],"antiretroviral":[28],"therapy":[29],"(ART).":[30],"Suppressive":[31],"treatment":[32,273,291],"HIV-positive":[34],"co-infected":[36],"with":[37,42,126,213,230,262],"herpes":[38],"simplex":[39],"virus-2":[40],"(HSV-2)":[41],"valacyclovir,":[43],"an":[44,214,244],"HSV-2":[45],"antiviral,":[46],"lower":[48],"viral":[50,82,116,270],"load,":[51,271],"but":[52],"partially-suppressive":[56],"valacyclovir":[57,113,127,150,163,202,236,263],"relative":[58],"to":[59,139,193],"fully-suppressive":[60],"ART":[61,90,129,161,197,232],"population":[63,108,164],"transmission":[65,106,153],"has":[66],"been":[68],"estimated.":[69],"METHODS:":[70],"We":[71,110,144],"modeled":[72],"as":[76],"a":[77,101,194,265],"function":[78],"changes":[80],"in":[81,141,156,205,238],"load":[83,117],"CD4":[85,134,182],"count":[86],"over":[87,210],"time":[88],"among":[89],"na\u00efve":[91],"persons.":[92],"The":[93,167,176],"Markov":[96],"model":[97,103],"was":[98,173,184],"nested":[99],"within":[100],"dynamic":[102],"at":[107,199,243],"level.":[109],"assumed":[111],"reduced":[114],"by":[118],"1.23":[119],"log":[120],"copies/\u03bcL,":[121],"treated":[125],"initiated":[128],"more":[130],"rapidly":[131],"when":[132,260],"their":[133],"fell":[135],"below":[136],"500":[137],"due":[138],"retention":[140],"care.":[143],"estimated":[145],"onward":[152],"three":[157],"scenarios":[158],"different":[160],"coverage.":[165],"RESULTS:":[166],"average":[168],"duration":[169,177],"infection":[172,223,252],"9.5":[174],"years.":[175],"before":[180],"reaching":[181],"200cells/\u03bcL":[183],"2.53":[185],"years":[186],"longer":[187],"females":[189],"than":[190],"males.":[191],"Relative":[192],"baseline":[195],"initiation":[198],"CD4\u2264500cells/\u03bcL,":[200],"scenario":[203,229],"resulted":[204,237],"167,000":[206],"fewer":[207,240],"infections":[209,242,283],"ten":[211],"years,":[212],"incremental":[215],"cost-effectiveness":[216],"ratio":[217],"(ICER)":[218],"$5276":[220],"per":[221,250],"averted.":[224],"A":[225],"Test":[226],"Treat":[228],"70%":[231],"coverage":[233],"no":[235],"350,000":[239],"ICER":[245],"$2822":[247],"$812":[249],"averted":[253],"QALY":[255],"gained,":[256],"respectively.":[257],"CONCLUSION:":[258],"Even":[259],"compared":[261],"suppression,":[264],"drug":[266],"reduces":[268],"universal":[272],"is":[276],"optimal":[278],"strategy":[279],"averting":[281],"new":[282],"increasing":[285],"public":[286],"health":[287],"benefit.":[288],"Universal":[289],"would":[292],"most":[293],"effectively":[294],"efficiently":[296],"burden.":[300]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}