{"id":"https://openalex.org/W2951237753","doi":"https://doi.org/10.7164/antibiotics.47.1481","title":"Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. IV. Synthesis and structure-activity relationships of matlystatin b and its stereoisomers.","display_name":"Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. IV. Synthesis and structure-activity relationships of matlystatin b and its stereoisomers.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2951237753","doi":"https://doi.org/10.7164/antibiotics.47.1481","mag":"2951237753","pmid":"https://pubmed.ncbi.nlm.nih.gov/7844043"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.47.1481","doi":"https://doi.org/10.7164/antibiotics.47.1481","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.47.1481","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/47/12/47_12_1481/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/47/12/47_12_1481/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110033371","display_name":"Kazuhiko Tamaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAZUHIKO TAMAKI","raw_affiliation_strings":["Bioscience Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan","Bioscience Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Bioscience Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111863209","display_name":"Shinwa Kurihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SHINWA KURIHARA","raw_affiliation_strings":["Bioscience Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060592500","display_name":"TETSUO OIKAWA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TETSUO OIKAWA","raw_affiliation_strings":["Bioscience Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112323991","display_name":"Kazuhiko Tanzawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAZUHIKO TANZAWA","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110620178","display_name":"Yukio Sugimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YUKIO SUGIMURA","raw_affiliation_strings":["Bioscience Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.874,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.82790412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"47","issue":"12","first_page":"1481","last_page":"1492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.2012999951839447,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8550000190734863},{"id":"https://openalex.org/keywords/stereoisomers","display_name":"stereoisomers","score":0.9380000233650208},{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.984000027179718},{"id":"https://openalex.org/keywords/metalloproteinase-inhibition","display_name":"metalloproteinase inhibition","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.8535264730453491},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6401155591011047},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6042803525924683},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.521202027797699},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4507026672363281},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39476752281188965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2568671703338623}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.47.1481","doi":"https://doi.org/10.7164/antibiotics.47.1481","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.47.1481","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/47/12/47_12_1481/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:7844043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7844043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.47.1481","doi":"https://doi.org/10.7164/antibiotics.47.1481","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.47.1481","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/47/12/47_12_1481/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2951237753.pdf","grobid_xml":"https://content.openalex.org/works/W2951237753.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1486545677","https://openalex.org/W1921315347","https://openalex.org/W1995249913","https://openalex.org/W2069993733","https://openalex.org/W2312384339","https://openalex.org/W2315943390","https://openalex.org/W2951022889","https://openalex.org/W6725471284"],"related_works":["https://openalex.org/W2089617556","https://openalex.org/W2036885411","https://openalex.org/W2320152643","https://openalex.org/W2315943390","https://openalex.org/W2953225970","https://openalex.org/W1982665625","https://openalex.org/W2949888417","https://openalex.org/W2325010361","https://openalex.org/W2050547523","https://openalex.org/W2425376057"],"abstract_inverted_index":{"The":[0],"first":[1],"total":[2],"synthesis":[3],"of":[4,13,29,36,44],"matlystatin":[5],"B":[6],"(1a),":[7],"a":[8],"low":[9],"molecular":[10],"weight":[11],"inhibitor":[12],"type":[14,40],"IV":[15,41],"collagenases,":[16],"was":[17,23,50],"accomplished,":[18],"and":[19,33,43],"its":[20],"absolute":[21],"configuration":[22],"unambiguously":[24],"determined.":[25],"Furthermore,":[26],"ten":[27],"stereoisomers":[28],"1a":[30],"were":[31],"synthesized,":[32],"the":[34,37],"inhibition":[35],"92":[38],"kDa":[39],"collagenase":[42],"other":[45],"metalloproteinases":[46],"by":[47],"each":[48],"stereoisomer":[49],"investigated.":[51]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}