{"id":"https://openalex.org/W2951069258","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","title":"Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain\u2013Blood Barrier and Glioblastoma Stem Cells","display_name":"Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain\u2013Blood Barrier and Glioblastoma Stem Cells","publication_year":2019,"publication_date":"2019-06-20","ids":{"openalex":"https://openalex.org/W2951069258","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","mag":"2951069258","pmid":"https://pubmed.ncbi.nlm.nih.gov/31265310"},"language":"en","primary_location":{"id":"doi:10.1021/acs.molpharmaceut.9b00018","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unito.it/bitstream/2318/1710693/2/MOL%20Pharm%20R2_submitted.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066967591","display_name":"Iris C. Salaroglio","orcid":"https://orcid.org/0000-0002-6043-3794","observed_orcids":["https://orcid.org/0000-0002-6043-3794"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Iris Chiara Salaroglio","raw_affiliation_strings":["Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064167499","display_name":"Carmen Abate","orcid":"https://orcid.org/0000-0001-9292-884X","observed_orcids":["https://orcid.org/0000-0001-9292-884X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmen Abate","raw_affiliation_strings":["Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 di Bari \u201cAldo Moro\u201d, Via Orabona 4, 70125 Bari, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9292-884X","affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 di Bari \u201cAldo Moro\u201d, Via Orabona 4, 70125 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047107350","display_name":"Barbara Rolando","orcid":"https://orcid.org/0000-0001-6138-1503","observed_orcids":["https://orcid.org/0000-0001-6138-1503"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Rolando","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, Universit\u00e0 di Torino, via Pietro Giuria 9, 10125 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6138-1503","affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, Universit\u00e0 di Torino, via Pietro Giuria 9, 10125 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035816396","display_name":"Luigi Battaglia","orcid":"https://orcid.org/0000-0002-5081-3638","observed_orcids":["https://orcid.org/0000-0002-5081-3638"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Battaglia","raw_affiliation_strings":["Dipartimento di Scienza e Tecnologia del Farmaco, Universit\u00e0 di Torino, via Pietro Giuria 9, 10125 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienza e Tecnologia del Farmaco, Universit\u00e0 di Torino, via Pietro Giuria 9, 10125 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014999187","display_name":"Elena Gazzano","orcid":"https://orcid.org/0000-0003-0939-0562","observed_orcids":["https://orcid.org/0000-0003-0939-0562"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Gazzano","raw_affiliation_strings":["Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044648942","display_name":"Elena Colombino","orcid":"https://orcid.org/0000-0002-6371-2000","observed_orcids":["https://orcid.org/0000-0002-6371-2000"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Colombino","raw_affiliation_strings":["Dipartimento di Scienze Veterinarie, Universit\u00e0 di Torino, Largo Braccini 2, 10095 Grugliasco, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Veterinarie, Universit\u00e0 di Torino, Largo Braccini 2, 10095 Grugliasco, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109236546","display_name":"Costanzo Costamagna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Costanzo Costamagna","raw_affiliation_strings":["Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040353814","display_name":"Laura Annovazzi","orcid":"https://orcid.org/0000-0002-8043-9886","observed_orcids":["https://orcid.org/0000-0002-8043-9886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Annovazzi","raw_affiliation_strings":["Centro Ricerche, Fondazione Policlinico di Monza, via Pietro Micca 29, 13100 Vercelli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Ricerche, Fondazione Policlinico di Monza, via Pietro Micca 29, 13100 Vercelli, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038819550","display_name":"Marta Mellai","orcid":"https://orcid.org/0000-0002-9139-517X","observed_orcids":["https://orcid.org/0000-0002-9139-517X"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Mellai","raw_affiliation_strings":["Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, corso Mazzini 18, 28100 Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze della Salute, Universit\u00e0 del Piemonte Orientale, corso Mazzini 18, 28100 Novara, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855380","display_name":"Francesco Berardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Berardi","raw_affiliation_strings":["Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 di Bari \u201cAldo Moro\u201d, Via Orabona 4, 70125 Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Farmacia-Scienze del Farmaco, Universit\u00e0 di Bari \u201cAldo Moro\u201d, Via Orabona 4, 70125 Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016393721","display_name":"Maria Teresa Capucchio","orcid":"https://orcid.org/0000-0002-1068-0551","observed_orcids":["https://orcid.org/0000-0002-1068-0551"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Teresa Capucchio","raw_affiliation_strings":["Dipartimento di Scienze Veterinarie, Universit\u00e0 di Torino, Largo Braccini 2, 10095 Grugliasco, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Veterinarie, Universit\u00e0 di Torino, Largo Braccini 2, 10095 Grugliasco, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011983771","display_name":"Davide Schiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Schiffer","raw_affiliation_strings":["Dipartimento di Neuroscienze, Universit\u00e0 di Torino, via Cherasco 15, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Neuroscienze, Universit\u00e0 di Torino, via Cherasco 15, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006463761","display_name":"Chiara Riganti","orcid":"https://orcid.org/0000-0001-9787-4836","observed_orcids":["https://orcid.org/0000-0001-9787-4836"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Riganti","raw_affiliation_strings":["Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9787-4836","affiliations":[{"raw_affiliation_string":"Dipartimento di Oncologia, Universit\u00e0 di Torino, via Santena 5/bis, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006463761"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.3479,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.81682998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"16","issue":"8","first_page":"3361","last_page":"3373"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein-inhibitors","display_name":"P-glycoprotein inhibitors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.7860000133514404},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.6940000057220459},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/circulating-half-life","display_name":"serum half-life","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7547128796577454},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.719778299331665},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.6671159267425537},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6586913466453552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46670055389404297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4516177177429199},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.41279205679893494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3492240309715271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3461345434188843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2728913426399231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20817327499389648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16616061329841614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15901491045951843},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15348100662231445},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.08217158913612366},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013882","descriptor_name":"Thiosemicarbazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.molpharmaceut.9b00018","doi":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.molpharmaceut.9b00018","pdf_url":null,"source":{"id":"https://openalex.org/S204562082","display_name":"Molecular Pharmaceutics","issn_l":"1543-8384","issn":["1543-8384","1543-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:31265310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31265310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/1710693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1710693","pdf_url":"https://iris.unito.it/bitstream/2318/1710693/2/MOL%20Pharm%20R2_submitted.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/232673","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/232673","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unito.it:2318/1710693","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1710693","pdf_url":"https://iris.unito.it/bitstream/2318/1710693/2/MOL%20Pharm%20R2_submitted.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1073274698","display_name":null,"funder_award_id":"IG 21408","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G793890290","display_name":null,"funder_award_id":"FARB2017","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320324143","display_name":"Fondazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2951069258.pdf","grobid_xml":"https://content.openalex.org/works/W2951069258.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1461993479","https://openalex.org/W1470598344","https://openalex.org/W1489719702","https://openalex.org/W1677499164","https://openalex.org/W1827826472","https://openalex.org/W1953042185","https://openalex.org/W1967378899","https://openalex.org/W1981063012","https://openalex.org/W1983974579","https://openalex.org/W1990171872","https://openalex.org/W2007694418","https://openalex.org/W2010697830","https://openalex.org/W2019490712","https://openalex.org/W2027568211","https://openalex.org/W2031407900","https://openalex.org/W2041413252","https://openalex.org/W2051362535","https://openalex.org/W2063916050","https://openalex.org/W2066048389","https://openalex.org/W2070613307","https://openalex.org/W2081215365","https://openalex.org/W2089700460","https://openalex.org/W2090078146","https://openalex.org/W2093904762","https://openalex.org/W2101093124","https://openalex.org/W2107798346","https://openalex.org/W2108147692","https://openalex.org/W2114594486","https://openalex.org/W2118044926","https://openalex.org/W2128610705","https://openalex.org/W2147673571","https://openalex.org/W2149744350","https://openalex.org/W2150817988","https://openalex.org/W2152368724","https://openalex.org/W2156524016","https://openalex.org/W2160396179","https://openalex.org/W2275318246","https://openalex.org/W2329199594","https://openalex.org/W2516538287","https://openalex.org/W2771736580","https://openalex.org/W2804721939","https://openalex.org/W2894355756","https://openalex.org/W4241097552"],"related_works":["https://openalex.org/W2804721939","https://openalex.org/W2949421662","https://openalex.org/W2090078146","https://openalex.org/W120778686","https://openalex.org/W2976983696","https://openalex.org/W328951983","https://openalex.org/W1979302674","https://openalex.org/W2327024117","https://openalex.org/W1668393581","https://openalex.org/W1915802091"],"abstract_inverted_index":{"P-glycoprotein":[0],"(Pgp)":[1],"is":[2,56],"highly":[3],"expressed":[4],"on":[5,14],"blood\u2013brain":[6],"barrier":[7],"(BBB)":[8],"and":[9,40,52,79,98,161,241,260],"glioblastoma":[10],"(GB)":[11],"cells,":[12],"particularly":[13],"cancer":[15],"stem":[16],"cells":[17],"(SC).":[18],"Pgp":[19,44,70],"recognizes":[20],"a":[21,63,188,226,231],"broad":[22],"spectrum":[23],"of":[24,30,43,65,85,87,123,173,192,197,205,249],"substrates,":[25],"limiting":[26],"the":[27,50,76,83,104,110,121,124,128,141,147,152,179,203,218,247,257],"therapeutic":[28],"efficacy":[29,84],"several":[31],"chemotherapeutic":[32],"drugs":[33],"in":[34,75,89,94,135,140,146,164,190,238,251],"eradicating":[35],"GB":[36,54,99,165,174,242,253],"SC.":[37,175],"Finding":[38],"effective":[39],"safe":[41],"inhibitors":[42],"that":[45,68,217],"improve":[46],"drug":[47,92,236],"delivery":[48],"across":[49],"BBB":[51,97,180,240],"target":[53],"SC":[55,143],"open":[57],"to":[58,223,263],"investigation.":[59],"We":[60],"previously":[61],"identified":[62],"series":[64],"thiosemicarbazone":[66,219],"compounds":[67,105,156,177,220],"inhibit":[69],"with":[71,137],"an":[72],"EC":[73],"50":[74],"nanomolar":[77],"range,":[78],"herein,":[80],"we":[81],"investigate":[82],"three":[86],"them":[88],"bypassing":[90],"Pgp-mediated":[91,235],"efflux":[93,237],"primary":[95],"human":[96],"cells.":[100],"At":[101],"10":[102],"nM,":[103],"were":[106],"not":[107],"cytotoxic":[108],"for":[109],"brain":[111],"microvascular":[112],"endothelial":[113],"hCMEC/D3":[114],"cell":[115],"line,":[116],"but":[117],"they":[118],"markedly":[119],"enhanced":[120],"permeability":[122],"Pgp-substrate":[125],"doxorubicin":[126,133,159,198],"through":[127],"BBB.":[129],"Thiosemicarbazone":[130],"derivatives":[131],"increased":[132,157],"uptake":[134],"GB,":[136],"greater":[138],"effects":[139],"Pgp-rich":[142],"clones":[144,149],"than":[145],"differentiated":[148],"derived":[150],"from":[151],"same":[153],"tumor.":[154],"All":[155],"intratumor":[158],"accumulation":[160],"consequent":[162],"toxicity":[163],"growing":[166],"under":[167],"competent":[168],"BBB,":[169],"producing":[170],"significant":[171],"killing":[172],"The":[176,182,195],"crossed":[178],"monolayer.":[181],"most":[183,258],"stable":[184],"derivative,":[185],"10a,":[186],"had":[187],"half-life":[189],"serum":[191],"4.2":[193],"h.":[194],"coadministration":[196],"plus":[199],"10a":[200],"significantly":[201],"reduced":[202],"growth":[204],"orthotopic":[206],"GB-SC":[207],"xenografts,":[208],"without":[209],"eliciting":[210],"toxic":[211],"side":[212],"effects.":[213],"Our":[214],"work":[215],"suggests":[216],"are":[221],"able":[222],"transform":[224],"doxorubicin,":[225],"prototype":[227],"BBB-impermeable":[228],"drug,":[229],"into":[230],"BBB-permeable":[232],"drug.":[233],"Bypassing":[234],"both":[239],"SC,":[243,254],"thiosemicarbazones":[244],"might":[245],"increase":[246],"success":[248],"chemotherapy":[250],"targeting":[252],"which":[255],"represent":[256],"aggressive":[259],"difficult":[261],"components":[262],"eradicate.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}