{"id":"https://openalex.org/W2951009329","doi":"https://doi.org/10.1016/s0960-894x(97)00309-0","title":"Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase","display_name":"Conformationally restricted arginine analogues as inhibitors of human nitric oxide synthase","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W2951009329","doi":"https://doi.org/10.1016/s0960-894x(97)00309-0","mag":"2951009329"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(97)00309-0","doi":"https://doi.org/10.1016/s0960-894x(97)00309-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(97)00309-0","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109986873","display_name":"Barry G. Shearer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry G. Shearer","raw_affiliation_strings":["Department of Medicinal Chemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013595829","display_name":"Shuliang Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuliang Lee","raw_affiliation_strings":["Department of Medicinal Chemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032460051","display_name":"Karl W. Franzmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl W. Franzmann","raw_affiliation_strings":["Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085523570","display_name":"Helen A.R. White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen A.R. White","raw_affiliation_strings":["Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082104559","display_name":"Daniella C.J. Sanders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniella C.J. Sanders","raw_affiliation_strings":["Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112780280","display_name":"Rachel J. Kiff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel J. Kiff","raw_affiliation_strings":["Department of Enzyme Pharmacology GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Enzyme Pharmacology GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110166075","display_name":"Edward P. Garvey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward P. Garvey","raw_affiliation_strings":["Department of Biochemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033022984","display_name":"Eric S. Furfine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric S. Furfine","raw_affiliation_strings":["Department of Biochemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry GlaxoWellcome Research and Development, Five Moore Drive, Research Triangle Park, North Carolina 27709 USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":1.4073,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82481917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"13","first_page":"1763","last_page":"1768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/arginine-analogues","display_name":"arginine analogues","score":0.8230000138282776},{"id":"https://openalex.org/keywords/conformationally-restricted-analogues","display_name":"conformationally restricted analogues","score":0.9020000100135803},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/phenyl-ring-substitution","display_name":"phenyl ring substitution","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9243879318237305},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.8037562370300293},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.674902081489563},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6476051807403564},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.594660222530365},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5611626505851746},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.5365208983421326},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.4928567409515381},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46767792105674744},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.44647490978240967},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3874671459197998},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3740368187427521},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10256195068359375},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06622633337974548}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0960-894x(97)00309-0","doi":"https://doi.org/10.1016/s0960-894x(97)00309-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(97)00309-0","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1587377302","https://openalex.org/W1599900714","https://openalex.org/W1929009802","https://openalex.org/W2007890406","https://openalex.org/W2015078180","https://openalex.org/W2025232935","https://openalex.org/W2052391094","https://openalex.org/W2068751843","https://openalex.org/W2121966508","https://openalex.org/W2135704180","https://openalex.org/W2952085478"],"related_works":["https://openalex.org/W2031353112","https://openalex.org/W2010364081","https://openalex.org/W2081165571","https://openalex.org/W1972682835","https://openalex.org/W2082839234","https://openalex.org/W2007842608","https://openalex.org/W2052433321","https://openalex.org/W2058857785","https://openalex.org/W2052846386","https://openalex.org/W2008767833"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-06-27T00:00:00"}
