{"id":"https://openalex.org/W2951006908","doi":"https://doi.org/10.1002/jhet.5570380303","title":"Synthesis of 2\u2010amino\u20104h\u2010thiazolo[5,4\u2010b]indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity","display_name":"Synthesis of 2\u2010amino\u20104h\u2010thiazolo[5,4\u2010b]indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2951006908","doi":"https://doi.org/10.1002/jhet.5570380303","mag":"2951006908"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.5570380303","doi":"https://doi.org/10.1002/jhet.5570380303","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570380303","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113870933","display_name":"Jens Breinholt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens Breinholt","raw_affiliation_strings":["MedChem. Research IV, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedChem. Research IV, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066890134","display_name":"Claus Bekker Jeppesen","orcid":"https://orcid.org/0000-0003-2878-4348","observed_orcids":["https://orcid.org/0000-0003-2878-4348"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus Bekker Jeppesen","raw_affiliation_strings":["New Lead Discovery, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","New Lead Discovery, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Lead Discovery, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"New Lead Discovery, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059179785","display_name":"Sven Branner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sven Branner","raw_affiliation_strings":["Protein Biochemistry, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","Protein Biochemistry, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Biochemistry, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Protein Biochemistry, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020341109","display_name":"Carl Erik Olsen","orcid":"https://orcid.org/0000-0002-2275-0596","observed_orcids":["https://orcid.org/0000-0002-2275-0596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Erik Olsen","raw_affiliation_strings":["Chemistry Department, The Royal Veterinary and Agricultural University, DK-1871 Frederiksberg C, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, The Royal Veterinary and Agricultural University, DK-1871 Frederiksberg C, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103429263","display_name":"Niels Peter Hundahl M\u00f8ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Niels Peter Hundahl M\u00f8ller","raw_affiliation_strings":["Signal Transduction, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","Signal Transduction, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction, Novo Nordisk A/S, Novo Alle\u0301, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Signal Transduction, Novo Nordisk A/S, Novo All\u00e9, DK-2880 Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034571370","display_name":"Bjarne Hilmer Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bjarne Hilmer Nielsen","raw_affiliation_strings":["Department of Organic Chemistry, The Technical University of Denmark, DK-2800 Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, The Technical University of Denmark, DK-2800 Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102090018","display_name":"Henrik Sune Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Henrik Sune Andersen","raw_affiliation_strings":["MedChem. Research I, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedChem. Research I, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark","institution_ids":["https://openalex.org/I189090001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102090018"],"corresponding_institution_ids":["https://openalex.org/I189090001"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.7728,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67784434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"38","issue":"3","first_page":"569","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.2483000010251999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.09989999979734421,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colored-reaction-products","display_name":"colored reaction products","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase-inhibitors","display_name":"protein tyrosine phosphatase inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/n-acetyl-derivatives","display_name":"N-acetyl derivatives","score":0.7879999876022339},{"id":"https://openalex.org/keywords/oxindoles","display_name":"oxindoles","score":0.824999988079071},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9640343189239502},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.7735718488693237},{"id":"https://openalex.org/C2780083155","wikidata":"https://www.wikidata.org/wiki/Q2018788","display_name":"Oxindole","level":3,"score":0.5738131999969482},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.558694064617157},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.52732914686203},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5200592875480652},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.35263293981552124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16302573680877686},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.09242859482765198}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jhet.5570380303","doi":"https://doi.org/10.1002/jhet.5570380303","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570380303","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/05377620-a1bb-11dd-b6ae-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/05377620-a1bb-11dd-b6ae-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breinholt, J, Bekker Jeppesen, C, Branner, S, Olsen, C E, Hundahl M\u00f8ller, H P, Nielsen, B H & Andersen, H S 2001, 'Synthesis of 2-amino-4H-thiazolo[5,4-b]indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity', Journal of Heterocyclic Chemistry, vol. 38, pp. 569-577.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1496740734","https://openalex.org/W1974814154","https://openalex.org/W1979652565","https://openalex.org/W1982300319","https://openalex.org/W1990361659","https://openalex.org/W1996908796","https://openalex.org/W2005816439","https://openalex.org/W2014694962","https://openalex.org/W2036283808","https://openalex.org/W2054575721","https://openalex.org/W2072365826","https://openalex.org/W2097558464","https://openalex.org/W2099123473","https://openalex.org/W2114396018","https://openalex.org/W2123229219","https://openalex.org/W2165259997","https://openalex.org/W2949595100","https://openalex.org/W2949900542","https://openalex.org/W2950446792","https://openalex.org/W3021293958"],"related_works":["https://openalex.org/W1980928617","https://openalex.org/W2336946564","https://openalex.org/W2039684951","https://openalex.org/W2049083587","https://openalex.org/W1999461099","https://openalex.org/W2049006362","https://openalex.org/W2611547829","https://openalex.org/W2166199238","https://openalex.org/W2017060525","https://openalex.org/W2947255543"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"DMSO\u2010solution":[2],"2\u2010amino\u20104H\u2010thiazolo[5,4\u2010b]indole":[3,59],"is":[4,72],"converted":[5],"into":[6],"a":[7],"complex":[8],"mixture":[9],"of":[10,18,23,58],"colored":[11],"products.":[12],"The":[13],"three":[14],"major":[15],"conversion":[16],"end\u2010products,":[17],"which":[19],"two":[20],"are":[21],"inhibitors":[22],"protein":[24],"tyrosine":[25],"phos\u2010phatases":[26],"(PTPs),":[27],"were":[28],"isolated":[29],"by":[30,37,53],"chromatographic":[31],"methods":[32],"and":[33,42],"their":[34],"structures":[35],"characterized":[36],"spectro\u2010scopic":[38],"analysis,":[39],"including":[40],"NMR":[41],"MS":[43],"combined":[44],"with":[45],"computer":[46],"assisted":[47],"structure":[48],"elucidation,":[49],"and,":[50],"finally,":[51],"confirmed":[52],"independent":[54],"chemical":[55],"synthesis.":[56],"Synthesis":[57],"as":[60,62],"well":[61],"its":[63],"N\u2010acetyl":[64],"derivatives":[65],"prepared":[66],"from":[67],"either":[68],"oxindole":[69],"or":[70],"2\u2010bromo\u20101\u2010(2\u2010nitro\u2010phenyl)ethanone":[71],"described.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}