{"id":"https://openalex.org/W2950534331","doi":"https://doi.org/10.1038/s41467-019-10497-2","title":"Modeling microcephaly with cerebral organoids reveals a WDR62\u2013CEP170\u2013KIF2A pathway promoting cilium disassembly in neural progenitors","display_name":"Modeling microcephaly with cerebral organoids reveals a WDR62\u2013CEP170\u2013KIF2A pathway promoting cilium disassembly in neural progenitors","publication_year":2019,"publication_date":"2019-06-13","ids":{"openalex":"https://openalex.org/W2950534331","doi":"https://doi.org/10.1038/s41467-019-10497-2","mag":"2950534331","pmid":"https://pubmed.ncbi.nlm.nih.gov/31197141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6565620"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-019-10497-2","doi":"https://doi.org/10.1038/s41467-019-10497-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-10497-2","pdf_url":"https://www.nature.com/articles/s41467-019-10497-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-019-10497-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100637188","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-9179-236X","observed_orcids":["https://orcid.org/0000-0002-9179-236X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089248350","display_name":"Si-Lu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Si-Lu Yang","raw_affiliation_strings":["Department of Genetics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050029251","display_name":"Mei Yang","orcid":"https://orcid.org/0000-0001-9988-8991","observed_orcids":["https://orcid.org/0000-0001-9988-8991"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Yang","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023782278","display_name":"Stephanie A. Herrlinger","orcid":"https://orcid.org/0000-0002-6049-0246","observed_orcids":["https://orcid.org/0000-0002-6049-0246"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Herrlinger","raw_affiliation_strings":["Department of Genetics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079814205","display_name":"Qiang Shao","orcid":"https://orcid.org/0000-0001-5307-8264","observed_orcids":["https://orcid.org/0000-0001-5307-8264"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Shao","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA"],"raw_orcid":"https://orcid.org/0000-0001-5307-8264","affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020830629","display_name":"John L. Collar","orcid":"https://orcid.org/0000-0001-9679-2601","observed_orcids":["https://orcid.org/0000-0001-9679-2601"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Collar","raw_affiliation_strings":["Department of Genetics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":"https://orcid.org/0000-0001-9679-2601","affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028766250","display_name":"Edgar Fierro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgar Fierro","raw_affiliation_strings":["Department of Genetics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632209","display_name":"Yanhong Shi","orcid":"https://orcid.org/0000-0002-3938-5839","observed_orcids":["https://orcid.org/0000-0002-3938-5839"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhong Shi","raw_affiliation_strings":["Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698831","display_name":"Aimin Liu","orcid":"https://orcid.org/0000-0003-0099-0879","observed_orcids":["https://orcid.org/0000-0003-0099-0879"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aimin Liu","raw_affiliation_strings":["Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA, 16802, USA"],"raw_orcid":"https://orcid.org/0000-0003-0099-0879","affiliations":[{"raw_affiliation_string":"Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, PA, 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004561389","display_name":"Hui L\u00fc","orcid":"https://orcid.org/0000-0003-2336-2170","observed_orcids":["https://orcid.org/0000-0003-2336-2170"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Lu","raw_affiliation_strings":["Department of Pharmacology and Physiology, The George Washington University, Washington, DC, 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, The George Washington University, Washington, DC, 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066863619","display_name":"Bruce E. Herring","orcid":"https://orcid.org/0000-0002-6974-5911","observed_orcids":["https://orcid.org/0000-0002-6974-5911"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce E. Herring","raw_affiliation_strings":["Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA"],"raw_orcid":"https://orcid.org/0000-0002-6974-5911","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006168167","display_name":"Ming\u2010Lei Guo","orcid":"https://orcid.org/0000-0003-2969-0802","observed_orcids":["https://orcid.org/0000-0003-2969-0802"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming-Lei Guo","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053649150","display_name":"Shilpa J. Buch","orcid":"https://orcid.org/0000-0002-3103-6685","observed_orcids":["https://orcid.org/0000-0002-3103-6685"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilpa Buch","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723428","display_name":"Zhen Zhao","orcid":"https://orcid.org/0000-0001-8967-5570","observed_orcids":["https://orcid.org/0000-0001-8967-5570"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zhao","raw_affiliation_strings":["Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041162076","display_name":"Jian Xu","orcid":"https://orcid.org/0000-0002-8162-889X","observed_orcids":["https://orcid.org/0000-0002-8162-889X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Xu","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090682121","display_name":"Zhipeng Lu","orcid":"https://orcid.org/0000-0001-5124-7546","observed_orcids":["https://orcid.org/0000-0001-5124-7546"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhipeng Lu","raw_affiliation_strings":["Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":null,"display_name":"Jian-Fu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian-Fu Chen","raw_affiliation_strings":["Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA. Jianfu@usc.edu","Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA. Jianfu@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Center for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":11.839,"has_fulltext":true,"cited_by_count":196,"citation_normalized_percentile":{"value":0.99245667,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"2612","last_page":"2612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0966000035405159,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-microcephaly","display_name":"primary microcephaly","score":0.8989999890327454},{"id":"https://openalex.org/keywords/wdr62","display_name":"WDR62","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cep170","display_name":"CEP170","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kif2a","display_name":"KIF2A","score":1.0},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/outer-radial-glia","display_name":"outer radial glia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.7319999933242798},{"id":"https://openalex.org/keywords/centrosomal-proteins","display_name":"centrosomal proteins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.6809999942779541},{"id":"https://openalex.org/keywords/neural-progenitor-cell-proliferation","display_name":"neural progenitor proliferation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/premature-differentiation","display_name":"premature differentiation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/microtubule-depolymerization","display_name":"microtubule depolymerization","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.819853663444519},{"id":"https://openalex.org/C2776395126","wikidata":"https://www.wikidata.org/wiki/Q431643","display_name":"Microcephaly","level":2,"score":0.6730791926383972},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.6561244130134583},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5394322276115417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5361179709434509},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5054450035095215},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5042785406112671},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4702664315700531},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.45348164439201355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20621293783187866},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18948635458946228}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008831","descriptor_name":"Microcephaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008831","descriptor_name":"Microcephaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-019-10497-2","doi":"https://doi.org/10.1038/s41467-019-10497-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-10497-2","pdf_url":"https://www.nature.com/articles/s41467-019-10497-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5555269","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6565620","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31197141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31197141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6565620","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6565620/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10497-2","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-019-10497-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8e30b728f07d4663b6d200b978527e82","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8e30b728f07d4663b6d200b978527e82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:fe809d4eaad64cd5995ce2a720fd1c05","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fe809d4eaad64cd5995ce2a720fd1c05","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-019-10497-2","doi":"https://doi.org/10.1038/s41467-019-10497-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-10497-2","pdf_url":"https://www.nature.com/articles/s41467-019-10497-2.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1125503657","display_name":"mRNA Translation Dysregulation in Neurodevelopmental and Neurodegenerative Diseases (Stephanie Herrlinger)","funder_award_id":"F99NS105187","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2291199618","display_name":null,"funder_award_id":"R01NS097231","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2798364454","display_name":"Correlating physiology and transcription during learning in a model for the 22q11.2 deletion","funder_award_id":"K00MH121382","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3452128553","display_name":"Genetic analysis of a microRNA pathway regulating neural tube closure","funder_award_id":"R01NS096176","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5047665993","display_name":"Methylation signaling in periodontal health and disease","funder_award_id":"R01DE026468","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5541964005","display_name":"Mechanisms regulating neural progenitor expansion in the developing brain","funder_award_id":"R01NS097231","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6490713460","display_name":null,"funder_award_id":"R01NS097231","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"},{"id":"https://openalex.org/G7411236662","display_name":null,"funder_award_id":"R01NS096176","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8362590946","display_name":"Zika Virus Capsid Protein Mediated Blockage of host microRNA machinery","funder_award_id":"R01NS110687","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8718567843","display_name":null,"funder_award_id":"R01NS096176","funder_id":"https://openalex.org/F4320308668","funder_display_name":"University of Southern California"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950534331.pdf","grobid_xml":"https://content.openalex.org/works/W2950534331.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1963944756","https://openalex.org/W1977120293","https://openalex.org/W1977709885","https://openalex.org/W1986166279","https://openalex.org/W1987529702","https://openalex.org/W1991103421","https://openalex.org/W1992444794","https://openalex.org/W2000345419","https://openalex.org/W2000766568","https://openalex.org/W2002500862","https://openalex.org/W2007991122","https://openalex.org/W2008996257","https://openalex.org/W2018286352","https://openalex.org/W2020343730","https://openalex.org/W2026143081","https://openalex.org/W2028617035","https://openalex.org/W2032141866","https://openalex.org/W2034665038","https://openalex.org/W2035009696","https://openalex.org/W2036253239","https://openalex.org/W2045926445","https://openalex.org/W2051785391","https://openalex.org/W2072479339","https://openalex.org/W2072710787","https://openalex.org/W2073555909","https://openalex.org/W2094074562","https://openalex.org/W2101266961","https://openalex.org/W2107767405","https://openalex.org/W2113260757","https://openalex.org/W2123700457","https://openalex.org/W2124843892","https://openalex.org/W2131999768","https://openalex.org/W2143417289","https://openalex.org/W2153686100","https://openalex.org/W2159243681","https://openalex.org/W2159720471","https://openalex.org/W2169449091","https://openalex.org/W2169786878","https://openalex.org/W2257475384","https://openalex.org/W2290993632","https://openalex.org/W2291971412","https://openalex.org/W2341041396","https://openalex.org/W2472442334","https://openalex.org/W2543622711","https://openalex.org/W2576459186","https://openalex.org/W2593500419","https://openalex.org/W2609844460","https://openalex.org/W2626358192","https://openalex.org/W2745959028","https://openalex.org/W2766990747"],"related_works":["https://openalex.org/W2020343730","https://openalex.org/W2995602340","https://openalex.org/W6884905222","https://openalex.org/W2007991122","https://openalex.org/W3042476686","https://openalex.org/W4379375658","https://openalex.org/W2593500419","https://openalex.org/W3086095517","https://openalex.org/W1976231145","https://openalex.org/W2043493961"],"abstract_inverted_index":{"Primary":[0],"microcephaly":[1,19,131],"is":[2],"caused":[3],"by":[4],"mutations":[5],"in":[6,37,40,123],"genes":[7],"encoding":[8],"centrosomal":[9],"proteins":[10],"including":[11,57],"WDR62":[12,34,62,86,109],"and":[13,26,46,71,80,89,116,126,135],"KIF2A.":[14],"However,":[15],"mechanisms":[16],"underlying":[17],"human":[18,27],"remain":[20],"elusive.":[21],"By":[22],"creating":[23],"mutant":[24],"mice":[25,136],"cerebral":[28,133],"organoids,":[29],"here":[30],"we":[31],"found":[32],"that":[33],"deletion":[35],"resulted":[36],"a":[38,138],"reduction":[39],"the":[41,50,94],"size":[42],"of":[43,52,83,97,145],"mouse":[44],"brains":[45],"organoids":[47,134],"due":[48],"to":[49,65,77,93,106,148],"disruption":[51,144],"neural":[53],"progenitor":[54],"cells":[55],"(NPCs),":[56],"outer":[58],"radial":[59],"glia":[60],"(oRG).":[61],"ablation":[63],"led":[64],"retarded":[66],"cilium":[67,124,142],"disassembly,":[68,143],"long":[69],"cilium,":[70,99],"delayed":[72],"cell":[73],"cycle":[74],"progression":[75],"leading":[76],"decreased":[78],"proliferation":[79],"premature":[81],"differentiation":[82],"NPCs.":[84],"Mechanistically,":[85],"interacts":[87],"with":[88,132],"promotes":[90],"CEP170's":[91],"localization":[92],"basal":[95,113],"body":[96,114],"primary":[98],"where":[100],"CEP170":[101],"recruits":[102],"microtubule-depolymerizing":[103],"factor":[104],"KIF2A":[105,118],"disassemble":[107],"cilium.":[108],"depletion":[110],"reduced":[111],"KIF2A's":[112],"localization,":[115],"enhanced":[117],"expression":[119],"partially":[120],"rescued":[121],"deficits":[122],"length":[125],"NPC":[127],"proliferation.":[128],"Thus,":[129],"modeling":[130],"reveals":[137],"WDR62-CEP170-KIF2A":[139],"pathway":[140],"promoting":[141],"which":[146],"contributes":[147],"microcephaly.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":36},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-27T00:00:00"}