{"id":"https://openalex.org/W2950428686","doi":"https://doi.org/10.1201/9781315112084-5","title":"Design and Analysis of Immunotherapy Clinical Trials","display_name":"Design and Analysis of Immunotherapy Clinical Trials","publication_year":2019,"publication_date":"2019-04-24","ids":{"openalex":"https://openalex.org/W2950428686","doi":"https://doi.org/10.1201/9781315112084-5","mag":"2950428686"},"language":"en","primary_location":{"id":"doi:10.1201/9781315112084-5","doi":"https://doi.org/10.1201/9781315112084-5","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781315112084-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306467597","display_name":"Chapman & Hall/CRC eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Textbook of Clinical Trials in Oncology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2945760132","display_name":"Textbook of Clinical Trials in Oncology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028772063","display_name":"Megan K. D. Othus","orcid":"https://orcid.org/0000-0001-8176-6371","observed_orcids":["https://orcid.org/0000-0001-8176-6371"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Megan Othus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028772063"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1322607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"87","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/trial-analysis","display_name":"trial analysis","score":0.5709999799728394},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.43617966771125793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3868892192840576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16261115670204163},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0395950973033905}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781315112084-5","doi":"https://doi.org/10.1201/9781315112084-5","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781315112084-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306467597","display_name":"Chapman & Hall/CRC eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Textbook of Clinical Trials in Oncology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2014751373"],"related_works":["https://openalex.org/W4407261931","https://openalex.org/W2915370072","https://openalex.org/W20510985","https://openalex.org/W2753127471","https://openalex.org/W2913898163","https://openalex.org/W2613158600","https://openalex.org/W2398913675","https://openalex.org/W2954600065","https://openalex.org/W17724734","https://openalex.org/W2773662158"],"abstract_inverted_index":{"Immunotherapies,":[0],"treatments":[1],"that":[2],"aim":[3],"to":[4,10],"induce":[5],"a":[6,41],"patient's":[7],"immune":[8],"system":[9],"fight":[11],"their":[12],"cancer,":[13],"have":[14,33],"been":[15],"used":[16],"with":[17],"limited":[18],"success":[19],"for":[20,63,83],"decades.":[21],"Some":[22],"newer":[23],"immunotherapy":[24],"treatments,":[25],"including":[26],"monoclonal":[27],"antibodies,":[28],"and":[29,57,76],"specifically,":[30],"checkpoint":[31],"inhibitors,":[32],"shown":[34],"much":[35],"higher":[36],"levels":[37],"of":[38,44,73],"efficacy":[39],"across":[40],"wider":[42],"range":[43],"cancers":[45],"than":[46],"prior":[47],"immunotherapies.":[48],"There":[49],"are":[50],"some":[51,72],"distinctive":[52],"characteristics":[53,59],"most":[54],"immunotherapies":[55],"share,":[56],"these":[58,74],"should":[60],"be":[61,81],"accounted":[62,82],"in":[64,84],"clinical":[65,85],"trial":[66,86],"designs.":[67],"The":[68],"chapter":[69],"following":[70],"describes":[71],"features":[75],"discusses":[77],"how":[78],"they":[79],"can":[80],"design.":[87]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-06-27T00:00:00"}
