{"id":"https://openalex.org/W2950325798","doi":"https://doi.org/10.3390/ijerph16112061","title":"Single-Cell Analysis Reveals that Chronic Silver Nanoparticle Exposure Induces Cell Division Defects in Human Epithelial Cells","display_name":"Single-Cell Analysis Reveals that Chronic Silver Nanoparticle Exposure Induces Cell Division Defects in Human Epithelial Cells","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2950325798","doi":"https://doi.org/10.3390/ijerph16112061","mag":"2950325798","pmid":"https://pubmed.ncbi.nlm.nih.gov/31212667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6603987"},"language":"en","primary_location":{"id":"doi:10.3390/ijerph16112061","doi":"https://doi.org/10.3390/ijerph16112061","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijerph16112061","pdf_url":"https://www.mdpi.com/1660-4601/16/11/2061/pdf?version=1560251437","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-4601/16/11/2061/pdf?version=1560251437","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051854954","display_name":"Ellen B. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen B. Garcia","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005325659","display_name":"Cynthia Alms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Alms","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008258836","display_name":"Albert W. Hinman","orcid":"https://orcid.org/0000-0001-6834-3796","observed_orcids":["https://orcid.org/0000-0001-6834-3796"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert W. Hinman","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Conor Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor Kelly","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adam Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Smith","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039031535","display_name":"Marina E. Vance","orcid":"https://orcid.org/0000-0003-0940-0353","observed_orcids":["https://orcid.org/0000-0003-0940-0353"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Vance","raw_affiliation_strings":["Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":"https://orcid.org/0000-0003-0940-0353","affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099758","display_name":"Jadranka Lon\u010darek","orcid":"https://orcid.org/0000-0003-1879-5473","observed_orcids":["https://orcid.org/0000-0003-1879-5473"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jadranka Loncarek","raw_affiliation_strings":["Center for Cancer Research, National Institute of Health, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research, National Institute of Health, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005962572","display_name":"Linsey C. Marr","orcid":"https://orcid.org/0000-0003-3628-6891","observed_orcids":["https://orcid.org/0000-0003-3628-6891"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linsey C. Marr","raw_affiliation_strings":["Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":"https://orcid.org/0000-0003-3628-6891","affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026937109","display_name":"Daniela Cimini","orcid":"https://orcid.org/0000-0002-4082-4894","observed_orcids":["https://orcid.org/0000-0002-4082-4894"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniela Cimini","raw_affiliation_strings":["Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026937109"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.4511,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.53492116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"11","first_page":"2061","last_page":"2061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silver-nanoparticles","display_name":"silver nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cell-division-defects","display_name":"cell division defects","score":0.953000009059906},{"id":"https://openalex.org/keywords/human-epithelial-cells","display_name":"human epithelial cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9739999771118164},{"id":"https://openalex.org/keywords/binucleated-cells","display_name":"binucleated cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.8159999847412109},{"id":"https://openalex.org/keywords/long-term-exposure","display_name":"long-term exposure","score":0.652999997138977},{"id":"https://openalex.org/keywords/alternative-toxicity-testing","display_name":"alternative toxicity testing","score":0.7080000042915344},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.6855378150939941},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.6339537501335144},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5813244581222534},{"id":"https://openalex.org/C143016879","wikidata":"https://www.wikidata.org/wiki/Q4914552","display_name":"Binucleated cells","level":5,"score":0.5433704257011414},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5365005135536194},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5006518363952637},{"id":"https://openalex.org/C127445965","wikidata":"https://www.wikidata.org/wiki/Q2518429","display_name":"Nanotoxicology","level":3,"score":0.4324783682823181},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.39061611890792847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3821815252304077},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.38033607602119446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3741339445114136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3200494050979614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2722610533237457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15930819511413574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10796988010406494},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09204944968223572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3390/ijerph16112061","doi":"https://doi.org/10.3390/ijerph16112061","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijerph16112061","pdf_url":"https://www.mdpi.com/1660-4601/16/11/2061/pdf?version=1560251437","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5597191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6603987","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6603987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6603987","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Environ Res Public Health","raw_type":"Text"},{"id":"pmid:31212667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31212667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of environmental research and public health","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:gam:jijerp:v:16:y:2019:i:11:p:2061-:d:238885","doi":null,"is_oa":false,"landing_page_url":"https://www.mdpi.com/1660-4601/16/11/2061/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a62a6f108e1c48ffae554871e39f2948","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a62a6f108e1c48ffae554871e39f2948","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Environmental Research and Public Health, Vol 16, Iss 11, p 2061 (2019)","raw_type":"article"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/90171","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/90171","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.3390/ijerph16112061","doi":"https://doi.org/10.3390/ijerph16112061","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijerph16112061","pdf_url":"https://www.mdpi.com/1660-4601/16/11/2061/pdf?version=1560251437","source":{"id":"https://openalex.org/S15239247","display_name":"International Journal of Environmental Research and Public Health","issn_l":"1660-4601","issn":["1660-4601","1661-7827"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","medline","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Environmental Research and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4695528944","display_name":"Dissecting the interplay between forces and dynamics of the mitotic apparatus and kinetochore attachments","funder_award_id":"1517506","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4794403377","display_name":null,"funder_award_id":"EF-0830093","funder_id":"https://openalex.org/F4320332167","funder_display_name":"Directorate for Biological Sciences"},{"id":"https://openalex.org/G6465338846","display_name":"Center for Environmental Implications of Nanotechnology","funder_award_id":"0830093","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7003666087","display_name":null,"funder_award_id":"EF-0830093","funder_id":"https://openalex.org/F4320332745","funder_display_name":"Center for the Environmental Implications of NanoTechnology"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332745","display_name":"Center for the Environmental Implications of NanoTechnology","ror":"https://ror.org/00py81415"},{"id":"https://openalex.org/F4320333655","display_name":"Institute for Critical Technology and Applied Science","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950325798.pdf","grobid_xml":"https://content.openalex.org/works/W2950325798.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W15532337","https://openalex.org/W130280819","https://openalex.org/W269249036","https://openalex.org/W382880255","https://openalex.org/W1160326939","https://openalex.org/W1522090640","https://openalex.org/W1543631408","https://openalex.org/W1559815414","https://openalex.org/W1851944195","https://openalex.org/W1906506906","https://openalex.org/W1929867252","https://openalex.org/W1968145208","https://openalex.org/W1968541042","https://openalex.org/W1969347970","https://openalex.org/W1970442105","https://openalex.org/W1977016073","https://openalex.org/W1991399962","https://openalex.org/W2002007973","https://openalex.org/W2008583081","https://openalex.org/W2010303079","https://openalex.org/W2011855799","https://openalex.org/W2016571415","https://openalex.org/W2016661249","https://openalex.org/W2021850614","https://openalex.org/W2024264346","https://openalex.org/W2027036579","https://openalex.org/W2037717119","https://openalex.org/W2041473955","https://openalex.org/W2050083788","https://openalex.org/W2051851983","https://openalex.org/W2056202999","https://openalex.org/W2072236397","https://openalex.org/W2087009328","https://openalex.org/W2092214136","https://openalex.org/W2094262202","https://openalex.org/W2095617425","https://openalex.org/W2104154956","https://openalex.org/W2114885607","https://openalex.org/W2115131243","https://openalex.org/W2117086129","https://openalex.org/W2117692326","https://openalex.org/W2124536696","https://openalex.org/W2126673711","https://openalex.org/W2129124130","https://openalex.org/W2131028776","https://openalex.org/W2153304690","https://openalex.org/W2155014384","https://openalex.org/W2166050577","https://openalex.org/W2171011575","https://openalex.org/W2220528754","https://openalex.org/W2303672592","https://openalex.org/W2317355101","https://openalex.org/W2333223910","https://openalex.org/W2495089965","https://openalex.org/W2503204994","https://openalex.org/W2565283972","https://openalex.org/W2606096698","https://openalex.org/W2609564974","https://openalex.org/W2611809247","https://openalex.org/W2621760894","https://openalex.org/W2738407075","https://openalex.org/W2753782648","https://openalex.org/W2769111693","https://openalex.org/W2785862171","https://openalex.org/W2786720923","https://openalex.org/W2789565357","https://openalex.org/W2790433523","https://openalex.org/W2800029424","https://openalex.org/W2800414617","https://openalex.org/W2802185561","https://openalex.org/W2886359989","https://openalex.org/W2886544667","https://openalex.org/W2896113647","https://openalex.org/W2906460811","https://openalex.org/W2909321080","https://openalex.org/W2912437910","https://openalex.org/W2913258622","https://openalex.org/W2916288088","https://openalex.org/W2922440898","https://openalex.org/W2929502893","https://openalex.org/W2938113648","https://openalex.org/W4230773480","https://openalex.org/W4234750241"],"related_works":["https://openalex.org/W3125047928","https://openalex.org/W2039322848","https://openalex.org/W2037717119","https://openalex.org/W2294685016","https://openalex.org/W757875990","https://openalex.org/W4205465531","https://openalex.org/W141797368","https://openalex.org/W2034138327","https://openalex.org/W2085361768","https://openalex.org/W2974679376"],"abstract_inverted_index":{"Multiple":[0],"organizations":[1],"have":[2],"urged":[3],"a":[4,55,70,119],"paradigm":[5],"shift":[6],"from":[7],"traditional,":[8],"whole":[9],"animal,":[10],"chemical":[11],"safety":[12],"testing":[13,28],"to":[14,53,118,169,197],"alternative":[15],"methods.":[16],"Although":[17],"these":[18],"forward-looking":[19],"methods":[20,44],"exist":[21],"for":[22,124],"risk":[23,74],"assessment":[24],"and":[25,34,42,106,143,152],"predication,":[26],"animal":[27],"is":[29],"still":[30,113],"the":[31,62,85,97,144,175,181],"preferred":[32],"method":[33],"will":[35,192],"remain":[36],"so":[37],"until":[38],"more":[39],"robust":[40],"cellular":[41],"computational":[43],"are":[45,96,112],"established.":[46],"To":[47,78],"meet":[48],"this":[49,185],"need,":[50],"we":[51,83],"aimed":[52],"develop":[54,79],"new,":[56],"cell":[57,66,135,141,162,182,189],"division-focused":[58],"approach":[59],"based":[60],"on":[61,91,140],"idea":[63],"that":[64,159,188],"defective":[65],"division":[67,142],"may":[68],"be":[69,193],"better":[71],"predictor":[72],"of":[73,87,99,121,133,146,177],"than":[75],"traditional":[76],"measurements.":[77],"such":[80],"an":[81,138,194],"approach,":[82],"investigated":[84],"toxicity":[86,110,168],"silver":[88],"nanoparticles":[89],"(AgNPs)":[90],"human":[92,170],"epithelial":[93],"cells.":[94,154],"AgNPs":[95,160],"type":[98],"nanoparticle":[100],"most":[101],"widely":[102],"employed":[103],"in":[104],"consumer":[105],"medical":[107],"products,":[108],"yet":[109],"reports":[111],"confounding.":[114],"Cells":[115],"were":[116],"exposed":[117],"range":[120],"AgNP":[122],"doses":[123],"both":[125],"short-":[126],"and-long":[127],"term":[128],"exposure":[129],"times.":[130],"The":[131],"analysis":[132,191],"treated":[134],"populations":[136],"identified":[137],"effect":[139],"emergence":[145],"abnormal":[147],"nuclear":[148],"morphologies,":[149],"including":[150],"micronuclei":[151],"binucleated":[153],"Overall,":[155],"our":[156],"results":[157],"indicate":[158],"impair":[161],"division,":[163],"not":[164],"only":[165],"further":[166],"confirming":[167],"cells,":[171],"but":[172],"also":[173],"highlighting":[174],"propagation":[176],"adverse":[178],"phenotypes":[179],"within":[180],"population.":[183],"Furthermore,":[184],"work":[186],"illustrates":[187],"division-based":[190],"important":[195],"addition":[196],"future":[198],"toxicology":[199],"studies.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}