{"id":"https://openalex.org/W2950265181","doi":"https://doi.org/10.1109/cdc.2018.8619371","title":"Extrinsic Noise Suppression in Micro RNA Mediated Incoherent Feedforward Loops","display_name":"Extrinsic Noise Suppression in Micro RNA Mediated Incoherent Feedforward Loops","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2950265181","doi":"https://doi.org/10.1109/cdc.2018.8619371","mag":"2950265181"},"language":"en","primary_location":{"id":"doi:10.1109/cdc.2018.8619371","doi":"https://doi.org/10.1109/cdc.2018.8619371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619371","pdf_url":null,"source":{"id":"https://openalex.org/S4210221977","display_name":"IEEE Conference on Decision and Control (CDC)","issn_l":"0191-2216","issn":["0191-2216"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/09/20/422394.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079275765","display_name":"Alberto Carignano","orcid":"https://orcid.org/0000-0003-3306-9365","observed_orcids":["https://orcid.org/0000-0003-3306-9365"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alberto Carignano","raw_affiliation_strings":["A.Carignano is with the Department of Electrical & Computer Engineering, University of Washington, Seattle, WA 98915, USA","Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6532-3343","affiliations":[{"raw_affiliation_string":"A.Carignano is with the Department of Electrical & Computer Engineering, University of Washington, Seattle, WA 98915, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075692191","display_name":"Sumit Mukherjee","orcid":"https://orcid.org/0000-0001-6532-3343","observed_orcids":["https://orcid.org/0000-0001-6532-3343"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sumit Mukherjee","raw_affiliation_strings":["S.Mukherjee is with the Department of Electrical & Computer, Engineering, University of Washington, Seattle, WA 98915, USA","Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S.Mukherjee is with the Department of Electrical & Computer, Engineering, University of Washington, Seattle, WA 98915, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Electrical & Computer Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838","observed_orcids":["https://orcid.org/0000-0002-1451-2838"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":["A.Singh is with the Center for Bioinformatics and Computational, Biology, University of Delaware, Newark, DE 19701, USA","Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A.Singh is with the Center for Bioinformatics and Computational, Biology, University of Delaware, Newark, DE 19701, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021731745","display_name":"Georg Seelig","orcid":"https://orcid.org/0000-0002-3163-8782","observed_orcids":["https://orcid.org/0000-0002-3163-8782"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Georg Seelig","raw_affiliation_strings":["G.Seelig is with the Paul G. Allen School of Computer Science, & Engineering, University of Washington, Seattle, WA 98915, USA","Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3163-8782","affiliations":[{"raw_affiliation_string":"G.Seelig is with the Paul G. Allen School of Computer Science, & Engineering, University of Washington, Seattle, WA 98915, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021731745","https://openalex.org/A5022267407","https://openalex.org/A5075692191","https://openalex.org/A5079275765"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":9.4743,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.9817682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"4353","last_page":"4359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/incoherent-feedforward-loop","display_name":"incoherent feedforward loop","score":0.8389999866485596},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9229999780654907},{"id":"https://openalex.org/keywords/extrinsic-noise","display_name":"extrinsic noise","score":0.8560000061988831},{"id":"https://openalex.org/keywords/noise-buffering","display_name":"noise buffering","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.9769999980926514},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-regulatory-circuits","display_name":"gene regulatory circuits","score":0.3230000138282776},{"id":"https://openalex.org/keywords/noise-amplification","display_name":"noise amplification","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C38858127","wikidata":"https://www.wikidata.org/wiki/Q5441228","display_name":"Feed forward","level":2,"score":0.7465139627456665},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6461133360862732},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.640634298324585},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.577486515045166},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5130959749221802},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43342238664627075},{"id":"https://openalex.org/C2987345804","wikidata":"https://www.wikidata.org/wiki/Q583234","display_name":"Noise suppression","level":3,"score":0.43306785821914673},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3441891670227051},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.34224772453308105},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3343769609928131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32219767570495605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24219265580177307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15750399231910706},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.15482932329177856},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1278863251209259},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.12509089708328247},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10617455840110779},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08844822645187378},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08650901913642883},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.08399680256843567},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0641196072101593},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cdc.2018.8619371","doi":"https://doi.org/10.1109/cdc.2018.8619371","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cdc.2018.8619371","pdf_url":null,"source":{"id":"https://openalex.org/S4210221977","display_name":"IEEE Conference on Decision and Control (CDC)","issn_l":"0191-2216","issn":["0191-2216"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE Conference on Decision and Control (CDC)","raw_type":"proceedings-article"},{"id":"doi:10.1101/422394","doi":"https://doi.org/10.1101/422394","is_oa":true,"landing_page_url":"https://doi.org/10.1101/422394","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/09/20/422394.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/422394","doi":"https://doi.org/10.1101/422394","is_oa":true,"landing_page_url":"https://doi.org/10.1101/422394","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/09/20/422394.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950265181.pdf","grobid_xml":"https://content.openalex.org/works/W2950265181.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1519953847","https://openalex.org/W1669686402","https://openalex.org/W1753309339","https://openalex.org/W1972206112","https://openalex.org/W1973339647","https://openalex.org/W1973960290","https://openalex.org/W1977905073","https://openalex.org/W1978402873","https://openalex.org/W1983907180","https://openalex.org/W2020596227","https://openalex.org/W2030362521","https://openalex.org/W2032446791","https://openalex.org/W2043564861","https://openalex.org/W2043946672","https://openalex.org/W2045958909","https://openalex.org/W2072893505","https://openalex.org/W2073094004","https://openalex.org/W2077336113","https://openalex.org/W2099551708","https://openalex.org/W2117298796","https://openalex.org/W2127793379","https://openalex.org/W2133297762","https://openalex.org/W2134543131","https://openalex.org/W2135541516","https://openalex.org/W2147556100","https://openalex.org/W2150055571","https://openalex.org/W2155202381","https://openalex.org/W2156534285","https://openalex.org/W2158341634","https://openalex.org/W2159579373","https://openalex.org/W2267017199","https://openalex.org/W2314232199","https://openalex.org/W2314564135","https://openalex.org/W2402827159","https://openalex.org/W2727980082","https://openalex.org/W4232123484"],"related_works":["https://openalex.org/W2323205418","https://openalex.org/W2043946672","https://openalex.org/W2001078617","https://openalex.org/W2971823165","https://openalex.org/W2083550659","https://openalex.org/W2950705934","https://openalex.org/W4399129809","https://openalex.org/W2004995323","https://openalex.org/W3029019180","https://openalex.org/W2000271119"],"abstract_inverted_index":{"Abstract":[0],"MicroRNA":[1],"mediated":[2,84],"incoherent":[3],"feed":[4,51,85,150,195],"forward":[5,52,86,151,196],"loops":[6],"(IFFLs)":[7],"are":[8,41,61,167],"recurrent":[9],"network":[10,87],"motifs":[11],"in":[12,144,182,204],"mammalian":[13],"cells":[14],"and":[15,26,40,98,105,164,190],"have":[16],"been":[17,57],"a":[18,148,154],"topic":[19],"of":[20,94,119,132,140,147,157,180],"study":[21],"for":[22,82],"their":[23],"noise":[24,45,66,80,103,111,134,143],"rejection":[25,81,139],"buffering":[27],"properties.":[28],"Previous":[29],"work":[30,71],"showed":[31],"that":[32,59,76,125,175],"IFFLs":[33],"can":[34,128,198],"adapt":[35],"to":[36,44,78,187],"varying":[37],"promoter":[38],"activity":[39],"less":[42],"prone":[43],"than":[46,67],"similar":[47],"circuits":[48],"without":[49],"the":[50,73,92,107,117,130,145,158,162,178,183,188,194],"loop.":[53],"Furthermore,":[54],"it":[55],"has":[56],"shown":[58],"microRNAs":[60],"better":[62],"at":[63],"rejecting":[64],"extrinsic":[65,79,102,121,133,142,184],"intrinsic":[68],"noise.":[69],"This":[70],"studies":[72],"biological":[74],"mechanisms":[75],"lead":[77],"microRNA":[83,163,191],"motifs.":[88],"Specifically,":[89],"we":[90,123,173],"compare":[91],"effects":[93],"microRNA-induced":[95],"mRNA":[96,166,189],"degradation":[97],"translational":[99,126],"inhibition":[100,127],"on":[101,177],"rejection,":[104],"identify":[106],"parameter":[108],"regimes":[109],"where":[110,161],"is":[112],"most":[113],"efficiently":[114],"rejected.":[115],"In":[116],"case":[118,146,156],"static":[120],"noise,":[122],"find":[124],"expand":[129],"regime":[131],"rejection.":[135],"We":[136],"then":[137],"analyze":[138],"dynamic":[141],"single-gene":[149],"loop":[152,197],"(sgFFL),":[153],"special":[155,171],"IFFL":[159],"motif":[160],"target":[165],"co-expressed.":[168],"For":[169],"this":[170],"case,":[172],"demonstrate":[174],"depending":[176],"time-scale":[179],"fluctuations":[181,203],"variable":[185],"compared":[186],"decay":[192],"rates,":[193],"both":[199],"buffer":[200],"or":[201],"amplify":[202],"gene":[205],"product":[206],"copy":[207],"numbers.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2019-06-27T00:00:00"}
