{"id":"https://openalex.org/W2950198531","doi":"https://doi.org/10.1002/ajmg.b.32687","title":"Sex differences in the genetic architecture of obsessive\u2013compulsive disorder","display_name":"Sex differences in the genetic architecture of obsessive\u2013compulsive disorder","publication_year":2018,"publication_date":"2018-11-20","ids":{"openalex":"https://openalex.org/W2950198531","doi":"https://doi.org/10.1002/ajmg.b.32687","mag":"2950198531","pmid":"https://pubmed.ncbi.nlm.nih.gov/30456828","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6527502"},"language":"en","primary_location":{"id":"doi:10.1002/ajmg.b.32687","doi":"https://doi.org/10.1002/ajmg.b.32687","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32687","pdf_url":null,"source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/21/219170.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063828698","display_name":"Ekaterina A. Khramtsova","orcid":"https://orcid.org/0000-0003-4687-454X","observed_orcids":["https://orcid.org/0000-0003-4687-454X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina A. Khramtsova","raw_affiliation_strings":["Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL","Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL","Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois","Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois"],"raw_orcid":"https://orcid.org/0000-0003-4687-454X","affiliations":[{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035370019","display_name":"Raphael Soejima Correia Ramalho","orcid":"https://orcid.org/0000-0002-1267-4358","observed_orcids":["https://orcid.org/0000-0002-1267-4358"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael Heldman","raw_affiliation_strings":["University of California, Berkeley, California"],"raw_orcid":"https://orcid.org/0000-0002-1267-4358","affiliations":[{"raw_affiliation_string":"University of California, Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068110851","display_name":"Eske M. Derks","orcid":"https://orcid.org/0000-0002-6292-6883","observed_orcids":["https://orcid.org/0000-0002-6292-6883"]},"institutions":[{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Eske M. Derks","raw_affiliation_strings":["Queensland Institute of Medical Research, Brisbane, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6292-6883","affiliations":[{"raw_affiliation_string":"Queensland Institute of Medical Research, Brisbane, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070894257","display_name":"Dongmei Yu","orcid":"https://orcid.org/0000-0001-7901-4365","observed_orcids":["https://orcid.org/0000-0001-7901-4365"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongmei Yu","raw_affiliation_strings":["Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-7901-4365","affiliations":[{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157885249","display_name":"TS/OCD Psychiatric Genomics Disorders Workgroup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"TS/OCD Psychiatric Genomics Disorders Workgroup","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee","Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","Vanderbilt Genetics Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045051798","display_name":"Lea Karatheodoris Davis","orcid":"https://orcid.org/0000-0001-5143-2282","observed_orcids":["https://orcid.org/0000-0001-5143-2282"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lea K. Davis","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN","Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","Vanderbilt Genetics Institute; Vanderbilt University Medical Center, Nashville, TN","Center for Data Intensive Science, University of Chicago, Chicago, Illinois","Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois","Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois"],"raw_orcid":"https://orcid.org/0000-0001-5143-2282","affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Medical Genetics, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Genetics Institute; Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Center for Data Intensive Science, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010839205","display_name":"Barbara E. Stranger","orcid":"https://orcid.org/0000-0001-9021-7331","observed_orcids":["https://orcid.org/0000-0001-9021-7331"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara E. Stranger","raw_affiliation_strings":["Center for Data Intensive Science, University of Chicago, Chicago, IL","Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL","Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL"],"raw_orcid":"https://orcid.org/0000-0001-9021-7331","affiliations":[{"raw_affiliation_string":"Center for Data Intensive Science, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045051798","https://openalex.org/A5157885249"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I40347166","https://openalex.org/I901861585"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":8.503,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.98048525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"180","issue":"6","first_page":"351","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"genetic architecture","score":0.8999999761581421},{"id":"https://openalex.org/keywords/x-chromosome","display_name":"X chromosome","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.609000027179718},{"id":"https://openalex.org/keywords/liability-threshold-model","display_name":"liability threshold model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/grid2","display_name":"GRID2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/regulatory-variants","display_name":"regulatory variants","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gene-expression-in-brain","display_name":"brain gene expression","score":0.828000009059906},{"id":"https://openalex.org/keywords/immune-related-gene-expression","display_name":"immune gene expression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/psychiatric-genomics-consortium","display_name":"Psychiatric Genomics Consortium","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.7872986793518066},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6689028739929199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6398422122001648},{"id":"https://openalex.org/C134925867","wikidata":"https://www.wikidata.org/wiki/Q186380","display_name":"Autosome","level":4,"score":0.6295424103736877},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5724657773971558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5250111222267151},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5070319175720215},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4915347993373871},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.46988868713378906},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.30714285373687744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3003496527671814},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.28957945108413696},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22133639454841614}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017470","descriptor_name":"Receptors, Glutamate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1002/ajmg.b.32687","doi":"https://doi.org/10.1002/ajmg.b.32687","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajmg.b.32687","pdf_url":null,"source":{"id":"https://openalex.org/S2764647521","display_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","issn_l":"1552-4841","issn":["1552-4841","1552-485X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/219170","doi":"https://doi.org/10.1101/219170","is_oa":true,"landing_page_url":"https://doi.org/10.1101/219170","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/21/219170.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:30456828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30456828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6527502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6527502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Med Genet B Neuropsychiatr Genet","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/3464bfcf-a78e-4521-b7f0-81bee32326a7","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/157061168/Sex-differences-in-the-genetic-architecture-of-obsessivecompulsive-disorder.pdf","pdf_url":"https://pure.amsterdamumc.nl/ws/files/157061168/Sex-differences-in-the-genetic-architecture-of-obsessivecompulsive-disorder.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tourette Syndrome/Obsessive-Compulsive Disorder Working Group of the Psychiatric Genomics Consortium 2019, 'Sex differences in the genetic architecture of obsessive\u2013compulsive disorder', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol. 180, no. 6, pp. 351-364. https://doi.org/10.1002/ajmg.b.32687","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/458c6d47-6ed5-4e14-90ae-f8e824271760","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/sex-differences-in-the-genetic-architecture-of-obsessivecompulsive-disorder(458c6d47-6ed5-4e14-90ae-f8e824271760).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of medical genetics. Part B, Neuropsychiatric genetics, 180(6), 351 - 364. Wiley-Liss Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6x70k9gv","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6x70k9gv","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics, vol 180, iss 6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1101/219170","doi":"https://doi.org/10.1101/219170","is_oa":true,"landing_page_url":"https://doi.org/10.1101/219170","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/11/21/219170.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1022082625","display_name":null,"funder_award_id":"MH079494","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1098315437","display_name":"Developing Statistics Methods to Detect Common and Rare Genetics Variants in Human Complex Pedigrees","funder_award_id":"ZIAMH002930","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1157969529","display_name":"2/7 Psychiatric Genomics Consortium: Finding Actionable Variation","funder_award_id":"U01MH109539","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G121778103","display_name":"Translational phenomics and genomics of Gilles de la Tourette Syndrome","funder_award_id":"K23MH085057","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1600157729","display_name":null,"funder_award_id":"MH073250","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1864398734","display_name":"OCD Collaborative Genetics Association Study","funder_award_id":"R01MH071507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2048194553","display_name":null,"funder_award_id":"MH079488","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2571122742","display_name":"Identifying Intermediate Phenotypes for Compulsive Hoarding","funder_award_id":"R21MH087748","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2725772924","display_name":null,"funder_award_id":"P50-MH094267","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2772222780","display_name":"OC Foundation Genetics Collaborative Conference","funder_award_id":"R13MH073250","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2796065628","display_name":"1/7 Psychiatric Genomics Consortium: Finding actionable variation","funder_award_id":"U01MH109528","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3480170010","display_name":null,"funder_award_id":"MH002930\u201006 MH071507 MH079487 MH079488 MH079489 MH079494","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3733707689","display_name":"Re-Engineering Translational Research at the University of Chicago","funder_award_id":"UL1TR000430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4128221539","display_name":null,"funder_award_id":"MH071507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4218682071","display_name":null,"funder_award_id":"MH079487","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4258172611","display_name":null,"funder_award_id":"MH079489","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4449860107","display_name":"3/7 Psychiatric Genomics Consortium: Finding actionable variation","funder_award_id":"U01MH109536","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G471797475","display_name":"Obsessive-compulsive disorder (OCD) Collaborative Genetics Association Study","funder_award_id":"R01MH079489","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4939802854","display_name":"A Genetic Linkage Study of GTS","funder_award_id":"U01NS040024","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4990104698","display_name":"Conte Center for Computational Systems Genomics of Neuropsychiatric Phenotypes","funder_award_id":"5p50mh094267-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G520765078","display_name":"A GENETIC LINKAGE STUDY OF GTS","funder_award_id":"R01NS040024","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6375126882","display_name":"OCD Collaborative Genetics Association Study","funder_award_id":"R01MH079487","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6491617417","display_name":null,"funder_award_id":"MH002930-06","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6743951032","display_name":null,"funder_award_id":"UL1 TR000430","funder_id":"https://openalex.org/F4320309626","funder_display_name":"University of Chicago"},{"id":"https://openalex.org/G736887315","display_name":null,"funder_award_id":"MH002930","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7921968315","display_name":"OCD Collaborative Genetics Association Study","funder_award_id":"R01MH079488","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8488821259","display_name":"Obsessive-compulsive disorder (OCD) Collaborative Genetics Association Study","funder_award_id":"R01MH079494","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8631870757","display_name":null,"funder_award_id":"UL1 TR000430","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G9000108065","display_name":null,"funder_award_id":"3P50MH094267\u201004S1MH073250MH079489 MH085057MH087748S40024UL1 TR000430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000334782","display_name":null,"funder_award_id":"TR000430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000902209","display_name":"Training the Science of Child Mental Health Treatment","funder_award_id":"T32MH073517","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309371","display_name":"International OCD Foundation","ror":"https://ror.org/04f3cbh67"},{"id":"https://openalex.org/F4320309626","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950198531.pdf","grobid_xml":"https://content.openalex.org/works/W2950198531.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W149331620","https://openalex.org/W202591055","https://openalex.org/W1483881410","https://openalex.org/W1549212458","https://openalex.org/W1855058198","https://openalex.org/W1934396517","https://openalex.org/W1965563492","https://openalex.org/W1976271834","https://openalex.org/W1978116054","https://openalex.org/W1979773486","https://openalex.org/W1984127715","https://openalex.org/W1993588417","https://openalex.org/W1999966894","https://openalex.org/W2007417768","https://openalex.org/W2007850350","https://openalex.org/W2024399938","https://openalex.org/W2026884584","https://openalex.org/W2033151532","https://openalex.org/W2039153962","https://openalex.org/W2042230302","https://openalex.org/W2042305653","https://openalex.org/W2042421957","https://openalex.org/W2048339201","https://openalex.org/W2051314902","https://openalex.org/W2053005882","https://openalex.org/W2053022831","https://openalex.org/W2055742054","https://openalex.org/W2064874359","https://openalex.org/W2065692954","https://openalex.org/W2073640336","https://openalex.org/W2073715978","https://openalex.org/W2081836849","https://openalex.org/W2084233614","https://openalex.org/W2093780410","https://openalex.org/W2100825937","https://openalex.org/W2100861230","https://openalex.org/W2101280135","https://openalex.org/W2101357408","https://openalex.org/W2108356100","https://openalex.org/W2109125813","https://openalex.org/W2110846909","https://openalex.org/W2111453841","https://openalex.org/W2112631943","https://openalex.org/W2118018282","https://openalex.org/W2122161847","https://openalex.org/W2122456510","https://openalex.org/W2123106337","https://openalex.org/W2129988353","https://openalex.org/W2130410032","https://openalex.org/W2133520037","https://openalex.org/W2133887970","https://openalex.org/W2134755764","https://openalex.org/W2138198688","https://openalex.org/W2140054173","https://openalex.org/W2147102623","https://openalex.org/W2147311167","https://openalex.org/W2147774366","https://openalex.org/W2150188159","https://openalex.org/W2153860431","https://openalex.org/W2153953617","https://openalex.org/W2155276106","https://openalex.org/W2155594439","https://openalex.org/W2156536647","https://openalex.org/W2157752701","https://openalex.org/W2161028938","https://openalex.org/W2161633633","https://openalex.org/W2162426271","https://openalex.org/W2168505085","https://openalex.org/W2168646496","https://openalex.org/W2170634352","https://openalex.org/W2170684975","https://openalex.org/W2176934408","https://openalex.org/W2181632153","https://openalex.org/W2195783463","https://openalex.org/W2236290736","https://openalex.org/W2275744255","https://openalex.org/W2290796122","https://openalex.org/W2299824834","https://openalex.org/W2330978860","https://openalex.org/W2333128705","https://openalex.org/W2336993262","https://openalex.org/W2340656051","https://openalex.org/W2346626662","https://openalex.org/W2417249284","https://openalex.org/W2430433288","https://openalex.org/W2499057377","https://openalex.org/W2518536270","https://openalex.org/W2528236220","https://openalex.org/W2530651782","https://openalex.org/W2537852064","https://openalex.org/W2544485223","https://openalex.org/W2555110527","https://openalex.org/W2555566824","https://openalex.org/W2559170486","https://openalex.org/W2564431371","https://openalex.org/W2574432813","https://openalex.org/W2610359325","https://openalex.org/W2621853784","https://openalex.org/W2622693920","https://openalex.org/W2635658300","https://openalex.org/W2739834351","https://openalex.org/W2761275051","https://openalex.org/W2770092353","https://openalex.org/W2941659747","https://openalex.org/W4211038581"],"related_works":["https://openalex.org/W2950628426","https://openalex.org/W2282212096","https://openalex.org/W2090625723","https://openalex.org/W2155594439","https://openalex.org/W2073715978","https://openalex.org/W7214936892","https://openalex.org/W2021242553","https://openalex.org/W7131533324","https://openalex.org/W4407320283","https://openalex.org/W4214534792"],"abstract_inverted_index":{"Obsessive-compulsive":[0],"disorder":[1],"(OCD)":[2],"is":[3],"a":[4,21,70,107,114,127],"highly":[5],"heritable":[6],"complex":[7],"phenotype":[8],"that":[9,63,97,133,185,210],"demonstrates":[10],"sex":[11,23,67],"differences":[12,68],"in":[13,25,106,172,181,202],"age":[14],"of":[15,35,40,46,76,142,145,195,200,223],"onset":[16],"and":[17,49,84,88,120,123,175,204],"clinical":[18],"presentation,":[19],"suggesting":[20,132],"possible":[22],"difference":[24],"underlying":[26],"genetic":[27,38,98,116,146,225],"architecture.":[28],"We":[29,57,112,183],"present":[30],"the":[31,36,43,53,74,82,85,95,101,149,186,221],"first":[32],"genome-wide":[33,109,159],"characterization":[34],"sex-specific":[37,78,89,158,224],"architecture":[39],"OCD,":[41],"utilizing":[42],"largest":[44],"set":[45],"OCD":[47,122],"cases":[48],"controls":[50],"available":[51],"from":[52,139],"Psychiatric":[54],"Genomics":[55],"Consortium.":[56],"assessed":[58],"evidence":[59,125],"for":[60,126,220,228],"several":[61],"mechanisms":[62],"may":[64,103],"contribute":[65],"to":[66],"including":[69],"sex-dependent":[71,128],"liability":[72,129],"threshold,":[73],"presence":[75],"individual":[77],"risk":[79,226],"variants":[80,197],"on":[81],"autosomes":[83],"X":[86],"chromosome,":[87],"pleiotropic":[90],"effects.":[91],"Furthermore,":[92],"we":[93,152,165],"tested":[94],"hypothesis":[96],"heterogeneity":[99,147],"between":[100,118,148],"sexes":[102],"obscure":[104],"associations":[105,171],"sex-combined":[108,134],"association":[110,180],"study.":[111],"observed":[113,184],"strong":[115],"correlation":[117],"male":[119],"female":[121],"no":[124,179],"threshold":[130],"model,":[131],"analysis":[135],"does":[136],"not":[137,154],"suffer":[138],"widespread":[140],"loss":[141],"power":[143],"because":[144],"sexes.":[150],"While":[151],"did":[153,166],"detect":[155],"any":[156],"significant":[157,169],"single":[160],"nucleotide":[161],"polymorphisms":[162],"(SNP)":[163],"associations,":[164],"identify":[167],"two":[168],"gene-based":[170],"females:":[173],"GRID2":[174],"GRP135,":[176],"which":[177],"showed":[178,192],"males.":[182],"SNPs":[187],"with":[188,213],"sexually":[189],"differentiated":[190],"effects":[191],"an":[193],"enrichment":[194],"regulatory":[196],"influencing":[198],"expression":[199],"genes":[201],"brain":[203],"immune":[205],"tissues.":[206],"These":[207],"findings":[208],"suggest":[209],"future":[211],"studies":[212],"larger":[214],"sample":[215],"sizes":[216],"hold":[217],"great":[218],"promise":[219],"identification":[222],"factors":[227],"OCD.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}
