{"id":"https://openalex.org/W2949848879","doi":"https://doi.org/10.1021/jm990327e","title":"N2-Aroylanthranilamide Inhibitors of Human Factor Xa","display_name":"N2-Aroylanthranilamide Inhibitors of Human Factor Xa","publication_year":2000,"publication_date":"2000-02-12","ids":{"openalex":"https://openalex.org/W2949848879","doi":"https://doi.org/10.1021/jm990327e","mag":"2949848879","pmid":"https://pubmed.ncbi.nlm.nih.gov/10715154"},"language":"en","primary_location":{"id":"doi:10.1021/jm990327e","doi":"https://doi.org/10.1021/jm990327e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm990327e","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026100293","display_name":"Ying K. Yee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ying K. Yee","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007099393","display_name":"Ann Louise Tebbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Louise Tebbe","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080952947","display_name":"Jared H. Linebarger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared H. Linebarger","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055799305","display_name":"Douglas W. Beight","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Beight","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090777392","display_name":"Trelia J. Craft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trelia J. Craft","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027548267","display_name":"Donetta S. Gifford\u2010Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donetta Gifford-Moore","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062998654","display_name":"Theodore G. Goodson III","orcid":"https://orcid.org/0000-0003-2453-2290","observed_orcids":["https://orcid.org/0000-0003-2453-2290"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Goodson","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065742359","display_name":"David K. Herron","orcid":"https://orcid.org/0000-0001-8750-3150","observed_orcids":["https://orcid.org/0000-0001-8750-3150"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Herron","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020958766","display_name":"Valentine J. Klimkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentine J. Klimkowski","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042224883","display_name":"Jeffrey A. Kyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Kyle","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110170278","display_name":"J. Scott Sawyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Scott Sawyer","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456269","display_name":"Gerald F. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald F. Smith","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083376789","display_name":"Jennifer M. Tinsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Tinsley","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105358002","display_name":"Richard D. Towner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Towner","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043438192","display_name":"Leonard C. Weir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Weir","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":null,"display_name":"Michael R. Wiley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Wiley","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026100293"],"corresponding_institution_ids":["https://openalex.org/I168537998"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6886,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.90477426,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"43","issue":"5","first_page":"873","last_page":"882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.6850000023841858},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9331246614456177},{"id":"https://openalex.org/C104264131","wikidata":"https://www.wikidata.org/wiki/Q898637","display_name":"Isopropyl","level":2,"score":0.7871010303497314},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.778203010559082},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7554386854171753},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7519848346710205},{"id":"https://openalex.org/C2778327999","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Carboxamide","level":2,"score":0.4109601080417633},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.21982598304748535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06794950366020203},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05275195837020874}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015951","descriptor_name":"Factor Xa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D065427","descriptor_name":"Factor Xa Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm990327e","doi":"https://doi.org/10.1021/jm990327e","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm990327e","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:10715154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10715154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W317133381","https://openalex.org/W2005619410","https://openalex.org/W2032028280","https://openalex.org/W2051623598","https://openalex.org/W2162166182","https://openalex.org/W2333088363","https://openalex.org/W2949634541"],"related_works":["https://openalex.org/W2089680191","https://openalex.org/W1993489302","https://openalex.org/W2949634541","https://openalex.org/W2084303941","https://openalex.org/W2107226701","https://openalex.org/W2915461860","https://openalex.org/W2951636204","https://openalex.org/W2084651707","https://openalex.org/W4292364275","https://openalex.org/W2028503370"],"abstract_inverted_index":{"Reversal":[0],"of":[1,20,31,54,75],"the":[2,32,46,51,67,72,92,96,104,110],"A-ring":[3,47],"amide":[4],"link":[5],"in":[6,45,66,109],"1,2-dibenzamidobenzene":[7],"1":[8],"(fXa":[9],"K(ass)":[10,116],"=":[11,117,123],"0.81":[12],"x":[13,119],"10(6)":[14,120],"L/mol)":[15],"led":[16],"to":[17,50,69],"a":[18,82],"series":[19,113],"human":[21],"factor":[22],"Xa":[23],"(hfXa)":[24],"inhibitors":[25],"based":[26],"on":[27],"N(2)-aroylanthranilamide":[28,111],"4.":[29],"Expansion":[30],"SAR":[33],"around":[34],"4":[35,112],"showed":[36],"that":[37],"only":[38],"small":[39],"planar":[40],"substituents":[41],"could":[42],"be":[43],"accommodated":[44],"for":[48],"binding":[49],"S1":[52],"site":[53,74],"hfXa.":[55,76],"Bulky":[56],"groups":[57],"such":[58],"as":[59],"4-isopropyl,":[60],"4-tert-butyl,":[61],"and":[62,98],"4-dimethylamino":[63],"were":[64],"favored":[65],"B-ring":[68],"interact":[70],"with":[71,114],"S4":[73],"The":[77],"central":[78],"(C)":[79],"ring":[80],"containing":[81],"5-methanesulfonamido":[83],"group":[84],"yielded":[85],"greater":[86],"activity":[87],"than":[88],"carbamoyl":[89],"groups.":[90],"Combining":[91],"beneficial":[93],"features":[94],"from":[95],"B-":[97],"C-ring":[99],"SAR,":[100],"compound":[101],"55":[102],"represents":[103],"most":[105],"potent":[106],"hfXa":[107,115],"inhibitor":[108],"58":[118],"L/mol":[121],"(K(i)":[122],"11.5":[124],"nM).":[125]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}
