{"id":"https://openalex.org/W2949809293","doi":"https://doi.org/10.1093/gerona/glz105","title":"Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats","display_name":"Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats","publication_year":2019,"publication_date":"2019-06-10","ids":{"openalex":"https://openalex.org/W2949809293","doi":"https://doi.org/10.1093/gerona/glz105","mag":"2949809293","pmid":"https://pubmed.ncbi.nlm.nih.gov/31180116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7243593"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glz105","doi":"https://doi.org/10.1093/gerona/glz105","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glz105","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7243593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002400202","display_name":"Hilaree N. Frazier","orcid":"https://orcid.org/0000-0003-2309-2596","observed_orcids":["https://orcid.org/0000-0003-2309-2596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hilaree N Frazier","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075938872","display_name":"Adam O. Ghoweri","orcid":"https://orcid.org/0000-0003-4750-5519","observed_orcids":["https://orcid.org/0000-0003-4750-5519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam O Ghoweri","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030854991","display_name":"Emily Sudkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Sudkamp","raw_affiliation_strings":["The College of Pharmacy, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The College of Pharmacy, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050349003","display_name":"Eleanor S. Johnson","orcid":"https://orcid.org/0000-0001-9356-4339","observed_orcids":["https://orcid.org/0000-0001-9356-4339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleanor S Johnson","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022076132","display_name":"Katie L. Anderson","orcid":"https://orcid.org/0000-0002-5479-1042","observed_orcids":["https://orcid.org/0000-0002-5479-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katie L Anderson","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068863305","display_name":"Grant A Fox","orcid":"https://orcid.org/0000-0002-8932-5965","observed_orcids":["https://orcid.org/0000-0002-8932-5965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grant Fox","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032159313","display_name":"Keomany Vatthanaphone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keomany Vatthanaphone","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083569482","display_name":"Mengfan Xia","orcid":"https://orcid.org/0009-0007-6253-0049","observed_orcids":["https://orcid.org/0009-0007-6253-0049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengfan Xia","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060349635","display_name":"Ruei\u2010Lung Lin","orcid":"https://orcid.org/0000-0001-9041-284X","observed_orcids":["https://orcid.org/0000-0001-9041-284X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruei-Lung Lin","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028449319","display_name":"Kendra E Hargis-Staggs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kendra E Hargis-Staggs","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112207912","display_name":"Nada M. Porter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nada M Porter","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108347449","display_name":"James R. Pauly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R Pauly","raw_affiliation_strings":["The College of Pharmacy, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The College of Pharmacy, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031130745","display_name":"Eric M. Blalock","orcid":"https://orcid.org/0000-0001-7242-9429","observed_orcids":["https://orcid.org/0000-0001-7242-9429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric M Blalock","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101436772","display_name":"Olivier Thibault","orcid":"https://orcid.org/0000-0002-3548-3466","observed_orcids":["https://orcid.org/0000-0002-3548-3466"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olivier Thibault","raw_affiliation_strings":["Department of Pharmacology and Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Nutritional Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101436772"],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":1.8795,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84682519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"75","issue":"6","first_page":"1021","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.08669999986886978,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intranasal-insulin","display_name":"intranasal insulin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.9869999885559082},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.8100000023841858},{"id":"https://openalex.org/keywords/memory-decline","display_name":"memory decline","score":0.8370000123977661},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.7789999842643738},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8389999866485596},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tumor-suppression-genes","display_name":"tumor suppression genes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6840000152587891},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.5989999771118164},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6573506593704224},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6456478834152222},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6436519622802734},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5534774661064148},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.47387051582336426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41392844915390015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3929704427719116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35306715965270996},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24456503987312317},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.14825454354286194},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/glz105","doi":"https://doi.org/10.1093/gerona/glz105","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glz105","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7243593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7243593","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:31180116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31180116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7243593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7243593","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3921591931","display_name":"Pharmacology and Nutritional Sciences:  Multidisciplinary Approaches for Metabolic Disease","funder_award_id":"T32DK007778","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G838520318","display_name":"A healthy brain aging strategy to restore insulin signaling and Ca homeostasis","funder_award_id":"R01AG033649","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G890401152","display_name":"Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)","funder_award_id":"T32AG057461","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1527910050","https://openalex.org/W1973385255","https://openalex.org/W1976396449","https://openalex.org/W1976726492","https://openalex.org/W1981101710","https://openalex.org/W1986245376","https://openalex.org/W1997146974","https://openalex.org/W2003116578","https://openalex.org/W2003254878","https://openalex.org/W2015220759","https://openalex.org/W2021002547","https://openalex.org/W2021867559","https://openalex.org/W2023501181","https://openalex.org/W2030111077","https://openalex.org/W2039296833","https://openalex.org/W2040691151","https://openalex.org/W2044682044","https://openalex.org/W2054275187","https://openalex.org/W2056579307","https://openalex.org/W2065897200","https://openalex.org/W2070818248","https://openalex.org/W2076760455","https://openalex.org/W2084761782","https://openalex.org/W2086190854","https://openalex.org/W2087443596","https://openalex.org/W2099589415","https://openalex.org/W2103813752","https://openalex.org/W2108667319","https://openalex.org/W2119343648","https://openalex.org/W2119494733","https://openalex.org/W2120466222","https://openalex.org/W2123541107","https://openalex.org/W2127619125","https://openalex.org/W2128507030","https://openalex.org/W2136915688","https://openalex.org/W2155990560","https://openalex.org/W2156600347","https://openalex.org/W2170596893","https://openalex.org/W2184273939","https://openalex.org/W2223033079","https://openalex.org/W2313670503","https://openalex.org/W2325281074","https://openalex.org/W2346448457","https://openalex.org/W2410791621","https://openalex.org/W2531062701","https://openalex.org/W2567971507","https://openalex.org/W2586096905","https://openalex.org/W2592669355","https://openalex.org/W2602081862","https://openalex.org/W2773526606","https://openalex.org/W2904733759","https://openalex.org/W4248694092"],"related_works":["https://openalex.org/W2119494733","https://openalex.org/W2313670503","https://openalex.org/W2156600347","https://openalex.org/W4415945846","https://openalex.org/W2123541107","https://openalex.org/W1852289178","https://openalex.org/W2592669355","https://openalex.org/W7030513244","https://openalex.org/W2044355531","https://openalex.org/W1970779072"],"abstract_inverted_index":{"Intranasal":[0],"insulin":[1,46,50,66,86,101,121,138,154,183,185],"is":[2],"a":[3,48],"safe":[4],"and":[5,23,31,59,68,79,82,88,162,184,187,194],"effective":[6],"method":[7],"for":[8],"ameliorating":[9],"memory":[10,54,106],"deficits":[11],"associated":[12,56,170],"with":[13,57,171],"pathological":[14],"brain":[15,161,196],"aging.":[16],"However,":[17],"the":[18,24,32,37,85,109,124,128,160,189,195],"impact":[19],"of":[20,26,65,76,84,181,191],"different":[21],"formulations":[22],"duration":[25,193],"treatment":[27,38,62,119,192],"on":[28,108],"insulin's":[29],"efficacy":[30],"cellular":[33],"processes":[34],"targeted":[35],"by":[36,144],"remain":[39],"unclear.":[40],"Here,":[41],"we":[42],"tested":[43],"whether":[44,60],"intranasal":[45,100,145,182],"aspart,":[47],"short-acting":[49],"formulation,":[51],"could":[52],"alleviate":[53],"decline":[55],"aging":[58],"long-term":[61,97,118],"affected":[63],"regulation":[64],"receptors":[67],"other":[69],"potential":[70,179],"targets.":[71],"Outcome":[72],"variables":[73],"included":[74],"measures":[75],"spatial":[77],"learning":[78],"memory,":[80],"autoradiography":[81],"immunohistochemistry":[83],"receptor,":[87],"hippocampal":[89,132,164],"microarray":[90],"analyses.":[91],"Aged":[92],"Fischer":[93],"344":[94],"rats":[95],"receiving":[96],"(3":[98],"months)":[99],"did":[102],"not":[103,127],"show":[104],"significant":[105],"enhancement":[107],"Morris":[110],"water":[111],"maze":[112],"task.":[113],"Autoradiography":[114],"results":[115],"showed":[116],"that":[117,140],"reduced":[120],"binding":[122],"in":[123,137],"thalamus":[125],"but":[126],"hippocampus.":[129],"Results":[130],"from":[131],"immunofluorescence":[133],"revealed":[134],"age-related":[135],"decreases":[136],"immunoreactivity":[139],"were":[141],"partially":[142],"offset":[143],"administration.":[146],"Microarray":[147],"analyses":[148],"highlighted":[149],"numerous":[150],"insulin-sensitive":[151],"genes,":[152],"suggesting":[153],"aspart":[155],"was":[156],"able":[157],"to":[158],"enter":[159],"alter":[163],"RNA":[165],"expression":[166],"patterns":[167],"including":[168],"those":[169],"tumor":[172],"suppression.":[173],"Our":[174],"work":[175],"provides":[176],"insights":[177],"into":[178],"mechanisms":[180],"resistance,":[186],"highlights":[188],"importance":[190],"regions":[197],"targeted.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}
