{"id":"https://openalex.org/W2949572122","doi":"https://doi.org/10.1186/s13059-018-1493-2","title":"Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons","display_name":"Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons","publication_year":2018,"publication_date":"2018-08-15","ids":{"openalex":"https://openalex.org/W2949572122","doi":"https://doi.org/10.1186/s13059-018-1493-2","mag":"2949572122","pmid":"https://pubmed.ncbi.nlm.nih.gov/30111345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6092797"},"language":"en","primary_location":{"id":"doi:10.1186/s13059-018-1493-2","doi":"https://doi.org/10.1186/s13059-018-1493-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-018-1493-2","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1493-2","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1493-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088902928","display_name":"Yuan Yuan","orcid":"https://orcid.org/0000-0002-2718-8301","observed_orcids":["https://orcid.org/0000-0002-2718-8301"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-2718-8301","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111661085","display_name":"Shirley Xie","orcid":"https://orcid.org/0009-0002-0195-9179","observed_orcids":["https://orcid.org/0009-0002-0195-9179"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley Xie","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676801","display_name":"Jennifer Cordes Darnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C. Darnell","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-5134-8088","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065494336","display_name":"Andrew Darnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Darnell","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089346436","display_name":"Yuhki Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhki Saito","raw_affiliation_strings":["Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA*","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA*","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137397235","display_name":"Hemali P. Phatnani","orcid":"https://orcid.org/0000-0002-6571-3891","observed_orcids":["https://orcid.org/0000-0002-6571-3891"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hemali Phatnani","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York NY 10032, USA","New York Genome Center, 101 Avenue of the Americas, NY, NY 10013 USA*","New York Genome Center, 101 Avenue of the Americas, New York, NY, 10013, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, 101 Avenue of the Americas, NY, NY 10013 USA*","institution_ids":["https://openalex.org/I4210151462"]},{"raw_affiliation_string":"New York Genome Center, 101 Avenue of the Americas, New York, NY, 10013, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110763952","display_name":"Elisabeth A. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth Murphy","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043128989","display_name":"Chaolin Zhang","orcid":"https://orcid.org/0000-0002-0013-5314","observed_orcids":["https://orcid.org/0000-0002-0013-5314"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaolin Zhang","raw_affiliation_strings":["Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA","Department of Biochemistry and Molecular Biophysics, Columbia University, New York NY 10032, USA","Department of Systems Biology, Columbia University, New York, NY, 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-0013-5314","affiliations":[{"raw_affiliation_string":"Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091116725","display_name":"Tom Maniatis","orcid":"https://orcid.org/0000-0002-2722-8633","observed_orcids":["https://orcid.org/0000-0002-2722-8633"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Maniatis","raw_affiliation_strings":["Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA","Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-2722-8633","affiliations":[{"raw_affiliation_string":"Center for Motor Neuron Biology and Disease, Columbia University, New York NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035034609","display_name":"Robert B. Darnell","orcid":"https://orcid.org/0000-0002-5134-8088","observed_orcids":["https://orcid.org/0000-0002-5134-8088"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B. Darnell","raw_affiliation_strings":["Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA*","Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","New York Genome Center, 101 Avenue of the Americas, NY, NY 10013 USA*","Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA*","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Ave. NY, NY 10065 USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"New York Genome Center, 101 Avenue of the Americas, NY, NY 10013 USA*","institution_ids":["https://openalex.org/I4210151462"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave., New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035034609"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210151462","https://openalex.org/I83399316"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":0.5239,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.61735022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nova","display_name":"nova","score":0.9610000252723694},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/alternative-rna-processing","display_name":"alternative RNA processing","score":0.7839999794960022},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.8259999752044678},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.8130000233650208},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.8339999914169312},{"id":"https://openalex.org/keywords/protein-palmitoylation","display_name":"palmitoylation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.9660000205039978},{"id":"https://openalex.org/keywords/clip","display_name":"CLIP","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8708418607711792},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6467489004135132},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5074848532676697},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.49533334374427795},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47803956270217896},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4772591292858124},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.47669312357902527},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4280104339122772},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36206406354904175},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.204889178276062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19210517406463623}],"mesh":[{"descriptor_ui":"D000090682","descriptor_name":"Neuro-Oncological Ventral Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022202","descriptor_name":"Chromosomes, Artificial, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054878","descriptor_name":"Lipoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058112","descriptor_name":"Septins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13059-018-1493-2","doi":"https://doi.org/10.1186/s13059-018-1493-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-018-1493-2","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1493-2","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"doi:10.1101/237347","doi":"https://doi.org/10.1101/237347","is_oa":true,"landing_page_url":"https://doi.org/10.1101/237347","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/01/08/237347.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5044682","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6092797","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6092797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6092797","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:30111345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30111345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cb685f73162747c5a46387f6f24edeab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cb685f73162747c5a46387f6f24edeab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)","raw_type":"article"},{"id":"doi:10.7916/d8hd9ckd","doi":"https://doi.org/10.7916/d8hd9ckd","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d8hd9ckd","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13059-018-1493-2","doi":"https://doi.org/10.1186/s13059-018-1493-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-018-1493-2","pdf_url":"https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1493-2","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2892338632","display_name":"CLIP Tool Kit (CTK): pipeline, user interface and tutorials for CLIP data analysis","funder_award_id":"R03HG009528","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3030965158","display_name":"New York Center for Collaborative Research in Common Disease Genomics","funder_award_id":"UM1HG008901","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3223075604","display_name":"RNA Dysregulation in ALS","funder_award_id":"RC2NS069473","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5395448260","display_name":"RNA regulatory networks in motor neuron development and function","funder_award_id":"R01NS089676","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6207683964","display_name":"Cell-specific RNA Targets of the Fragile X Mental Retardation Protein Family","funder_award_id":"R01HD040647","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6842922247","display_name":"Single-nucleotide resolution mapping of allelic protein-RNA interactions and splicing-regulatory variants","funder_award_id":"R01GM124486","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8070025138","display_name":"Combining New Molecular and Informatic Strategies to Find Hidden Ways to Treat Brain Disease","funder_award_id":"R35NS097404","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949572122.pdf","grobid_xml":"https://content.openalex.org/works/W2949572122.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1496738545","https://openalex.org/W1542694382","https://openalex.org/W1545888483","https://openalex.org/W1846146953","https://openalex.org/W1969289230","https://openalex.org/W1969651353","https://openalex.org/W1971147333","https://openalex.org/W1975958907","https://openalex.org/W1981898947","https://openalex.org/W1987332330","https://openalex.org/W1988476536","https://openalex.org/W1993981485","https://openalex.org/W2002177759","https://openalex.org/W2003629016","https://openalex.org/W2008150634","https://openalex.org/W2014216846","https://openalex.org/W2014405654","https://openalex.org/W2014893821","https://openalex.org/W2018110972","https://openalex.org/W2018863540","https://openalex.org/W2021699617","https://openalex.org/W2023823207","https://openalex.org/W2026364178","https://openalex.org/W2026671856","https://openalex.org/W2029979788","https://openalex.org/W2030457340","https://openalex.org/W2031873527","https://openalex.org/W2033593485","https://openalex.org/W2036583346","https://openalex.org/W2038963685","https://openalex.org/W2040356728","https://openalex.org/W2044117548","https://openalex.org/W2047247191","https://openalex.org/W2051808752","https://openalex.org/W2052326665","https://openalex.org/W2054275187","https://openalex.org/W2057759463","https://openalex.org/W2058704339","https://openalex.org/W2060501484","https://openalex.org/W2060945204","https://openalex.org/W2065819397","https://openalex.org/W2076211723","https://openalex.org/W2076398196","https://openalex.org/W2076712912","https://openalex.org/W2082628132","https://openalex.org/W2085073283","https://openalex.org/W2089178885","https://openalex.org/W2091735806","https://openalex.org/W2094336451","https://openalex.org/W2096911942","https://openalex.org/W2100148098","https://openalex.org/W2101033679","https://openalex.org/W2110289399","https://openalex.org/W2111147277","https://openalex.org/W2111355677","https://openalex.org/W2112159040","https://openalex.org/W2112813983","https://openalex.org/W2113596954","https://openalex.org/W2114104545","https://openalex.org/W2114893730","https://openalex.org/W2115155255","https://openalex.org/W2117333689","https://openalex.org/W2118823143","https://openalex.org/W2119655833","https://openalex.org/W2121098824","https://openalex.org/W2123051989","https://openalex.org/W2124940469","https://openalex.org/W2124976615","https://openalex.org/W2131636181","https://openalex.org/W2145859343","https://openalex.org/W2146152985","https://openalex.org/W2149258280","https://openalex.org/W2150626351","https://openalex.org/W2150829331","https://openalex.org/W2157290643","https://openalex.org/W2274689446","https://openalex.org/W2298545792","https://openalex.org/W2325580275","https://openalex.org/W2345850272","https://openalex.org/W2403981087","https://openalex.org/W2411301486","https://openalex.org/W2431193407","https://openalex.org/W2512648537","https://openalex.org/W2537007468","https://openalex.org/W2580545098","https://openalex.org/W2588562184","https://openalex.org/W2755381547"],"related_works":["https://openalex.org/W6977633842","https://openalex.org/W6939513007","https://openalex.org/W6902366560","https://openalex.org/W2792472871","https://openalex.org/W2909498090","https://openalex.org/W2053998703","https://openalex.org/W7099578169","https://openalex.org/W2048518974","https://openalex.org/W2073654740","https://openalex.org/W2626510008"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alternative":[1],"RNA":[2,27,69,106,150,165],"processing":[3,28,166],"plays":[4],"an":[5],"essential":[6],"role":[7,114],"in":[8,14,29,34,70,98,117,121,137],"shaping":[9],"cell":[10,31,38,148,170],"identity":[11],"and":[12,51,56,59,68,159],"connectivity":[13],"the":[15,71,94,128,132,161],"central":[16],"nervous":[17],"system.":[18],"This":[19,100],"is":[20,152],"believed":[21],"to":[22,61,85,91,103,109],"involve":[23],"differential":[24,105],"regulation":[25,41,107,151,167],"of":[26,37,81,93,131,163],"various":[30],"types.":[32],"However,":[33],"vivo":[35],"study":[36,145],"type-specific":[39,149],"post-transcriptional":[40],"has":[42],"been":[43],"a":[44,49,79,112],"challenge.":[45],"Here,":[46],"we":[47],"describe":[48],"sensitive":[50],"stringent":[52],"method":[53],"combining":[54],"genetics":[55],"CLIP":[57,84],"(crosslinking":[58],"immunoprecipitation)":[60],"globally":[62],"identify":[63],"regulatory":[64],"interactions":[65,89,120],"between":[66],"NOVA":[67,116,125],"mouse":[72],"spinal":[73,96],"cord":[74,97],"motoneurons.":[75,122],"RESULTS:":[76],"We":[77],"developed":[78],"means":[80],"undertaking":[82],"motoneuron-specific":[83,87],"explore":[86],"protein-RNA":[88],"relative":[90],"studies":[92],"whole":[95],"mouse.":[99],"allowed":[101],"us":[102],"pinpoint":[104],"specific":[108],"motoneurons,":[110,138],"revealing":[111],"major":[113],"for":[115,154],"regulating":[118],"cytoskeleton":[119,133],"In":[123],"particular,":[124],"specifically":[126],"promotes":[127],"palmitoylated":[129],"isoform":[130],"protein":[134],"Septin":[135],"8":[136],"which":[139],"enhances":[140],"dendritic":[141],"arborization.":[142],"CONCLUSIONS:":[143],"Our":[144],"demonstrates":[146],"that":[147],"important":[153],"fine":[155],"tuning":[156],"motoneuron":[157],"physiology":[158],"highlights":[160],"value":[162],"defining":[164],"at":[168],"single":[169],"type":[171],"resolution.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}