{"id":"https://openalex.org/W2949569889","doi":"https://doi.org/10.3390/ijms20122916","title":"Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo","display_name":"Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo","publication_year":2019,"publication_date":"2019-06-14","ids":{"openalex":"https://openalex.org/W2949569889","doi":"https://doi.org/10.3390/ijms20122916","mag":"2949569889","pmid":"https://pubmed.ncbi.nlm.nih.gov/31207966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6628290"},"language":"en","primary_location":{"id":"doi:10.3390/ijms20122916","doi":"https://doi.org/10.3390/ijms20122916","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20122916","pdf_url":"https://www.mdpi.com/1422-0067/20/12/2916/pdf?version=1560517295","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/20/12/2916/pdf?version=1560517295","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103090895","display_name":"Jana Riegger","orcid":"https://orcid.org/0000-0003-0048-5047","observed_orcids":["https://orcid.org/0000-0003-0048-5047"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Riegger","raw_affiliation_strings":["Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm 89081, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077143344","display_name":"Frank Leucht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Leucht","raw_affiliation_strings":["Department of Orthopedics, University of Ulm, Ulm 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University of Ulm, Ulm 89081, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074288160","display_name":"Hans\u2010Georg Palm","orcid":"https://orcid.org/0000-0002-1100-8820","observed_orcids":["https://orcid.org/0000-0002-1100-8820"]},"institutions":[{"id":"https://openalex.org/I4210158087","display_name":"Bundeswehrkrankenhaus Ulm","ror":"https://ror.org/05qz2jt34","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210158087"]},{"id":"https://openalex.org/I4387152969","display_name":"Bundeswehr","ror":"https://ror.org/00nmgny79","country_code":"DE","type":"government","lineage":["https://openalex.org/I4387152969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Georg Palm","raw_affiliation_strings":["Department of Orthopedics and Trauma Surgery, German Armed Forces Hospital Ulm, Ulm 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Trauma Surgery, German Armed Forces Hospital Ulm, Ulm 89081, Germany","institution_ids":["https://openalex.org/I4210158087","https://openalex.org/I4387152969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065496991","display_name":"Anita A. Ignatius","orcid":"https://orcid.org/0000-0002-4782-1979","observed_orcids":["https://orcid.org/0000-0002-4782-1979"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anita Ignatius","raw_affiliation_strings":["Institute of Orthopedic Research and Biomechanics, University of Ulm, Ulm 89081, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4782-1979","affiliations":[{"raw_affiliation_string":"Institute of Orthopedic Research and Biomechanics, University of Ulm, Ulm 89081, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061132766","display_name":"Rolf Erwin Brenner","orcid":"https://orcid.org/0000-0002-5730-9792","observed_orcids":["https://orcid.org/0000-0002-5730-9792"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rolf E. Brenner","raw_affiliation_strings":["Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm 89081, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061132766"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1205,"currency":"EUR","value_usd":1299},"fwci":0.8449,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71891716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"12","first_page":"2916","last_page":"2916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bone-morphogenetic-protein-7","display_name":"bone morphogenetic protein-7","score":0.8709999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7049999833106995},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.8510000109672546},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/cartilage-damage","display_name":"cartilage damage","score":0.6240000128746033},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7503078579902649},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6940774917602539},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6563530564308167},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.6539685726165771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6118504405021667},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.5848702788352966},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5162984728813171},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.47014763951301575},{"id":"https://openalex.org/C96646087","wikidata":"https://www.wikidata.org/wiki/Q978198","display_name":"Condyle","level":2,"score":0.4353224039077759},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.41272640228271484},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3981747031211853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33919399976730347},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32471033930778503},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2700839042663574},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26730096340179443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21816617250442505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17806673049926758},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.1730571687221527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10076102614402771},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09550800919532776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014949","descriptor_name":"Wounds, Nonpenetrating","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014949","descriptor_name":"Wounds, Nonpenetrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms20122916","doi":"https://doi.org/10.3390/ijms20122916","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20122916","pdf_url":"https://www.mdpi.com/1422-0067/20/12/2916/pdf?version=1560517295","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:31207966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31207966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6628290","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6628290/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9fa114052e6041b6a3ed5c6e43e50d70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9fa114052e6041b6a3ed5c6e43e50d70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 20, Iss 12, p 2916 (2019)","raw_type":"article"},{"id":"pmh:oai:oparu.uni-ulm.de:123456789/35205","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-35205-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400353","display_name":"OPen Access Repositorium der Universit\u00e4t Ulm (OPARU) (Ulm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I196349391","host_organization_name":"Universit\u00e4t Ulm","host_organization_lineage":["https://openalex.org/I196349391"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"doi:10.18725/oparu-35143","doi":"https://doi.org/10.18725/oparu-35143","is_oa":true,"landing_page_url":"https://doi.org/10.18725/oparu-35143","pdf_url":null,"source":{"id":"https://openalex.org/S7407052964","display_name":"Universit\u00e4t Ulm, Kommunikations- und Informationszentrum (kiz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.3390/ijms20122916","doi":"https://doi.org/10.3390/ijms20122916","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms20122916","pdf_url":"https://www.mdpi.com/1422-0067/20/12/2916/pdf?version=1560517295","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324890","display_name":"Ministry of Defense","ror":"https://ror.org/04wxm6g36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949569889.pdf","grobid_xml":"https://content.openalex.org/works/W2949569889.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1848620583","https://openalex.org/W1997111185","https://openalex.org/W2005037358","https://openalex.org/W2014982468","https://openalex.org/W2024959837","https://openalex.org/W2028082525","https://openalex.org/W2044924856","https://openalex.org/W2065937508","https://openalex.org/W2086771075","https://openalex.org/W2125415219","https://openalex.org/W2274125837","https://openalex.org/W2425593468","https://openalex.org/W2489163603","https://openalex.org/W2523595403","https://openalex.org/W2552475067","https://openalex.org/W2750091852","https://openalex.org/W2786048393","https://openalex.org/W2891411097"],"related_works":["https://openalex.org/W2750091852","https://openalex.org/W2489163603","https://openalex.org/W7117702366","https://openalex.org/W2796630558","https://openalex.org/W2086771075","https://openalex.org/W4410258374","https://openalex.org/W7099357558","https://openalex.org/W4404310456","https://openalex.org/W2114954785","https://openalex.org/W2995845124"],"abstract_inverted_index":{"Joint":[0],"injuries":[1],"are":[2],"highly":[3],"associated":[4],"with":[5,29,93],"the":[6,48,94,115,166,169],"development":[7],"of":[8,18,53,96,117,149,171,188],"post-traumatic":[9],"osteoarthritis.":[10],"Previous":[11],"studies":[12],"revealed":[13],"cell-":[14],"and":[15,50,56,81,114,122,130,154,162],"matrix-protective":[16],"effects":[17],"N-acetylcysteine":[19],"(NAC)":[20],"after":[21,177],"ex":[22],"vivo":[23,63],"cartilage":[24,64,179],"trauma,":[25],"while":[26],"chondroanabolic":[27,57],"stimulation":[28],"bone":[30],"morphogenetic":[31],"protein":[32],"7":[33],"(BMP7)":[34],"enhanced":[35,159],"type":[36],"II":[37],"collagen":[38],"(COL2)":[39],"expression.":[40],"Here,":[41],"as":[42],"a":[43,60,97],"next":[44],"step,":[45],"we":[46],"investigated":[47],"combined":[49],"individual":[51],"efficacy":[52,170],"intra-articular":[54],"antioxidative":[55],"treatment":[58],"in":[59,62,136,160,183],"rabbit":[61],"trauma":[65,76,105,180],"model.":[66],"Animals":[67],"were":[68,91,134,158],"randomly":[69],"divided":[70],"into":[71],"group":[72,82],"A":[73],"(right":[74,84],"joint:":[75,79,85,88],"(T);":[77],"left":[78,87],"T+BMP7)":[80],"B":[83],"T+NAC;":[86],"T+BMP7+NAC).":[89],"Condyles":[90],"impacted":[92],"use":[95],"spring-loaded":[98],"impact":[99],"device":[100],"to":[101,195],"ensure":[102],"defined,":[103],"single":[104],"administration.":[106],"After":[107],"12":[108],"weeks,":[109],"histopathological":[110],"analysis":[111],"was":[112,124,181,190],"performed":[113],"presence":[116],"matrix":[118],"metalloproteinase":[119],"13":[120],"(MMP-13)":[121],"COL2":[123,150],"assessed.":[125],"Trauma-induced":[126],"hypocellularity,":[127],"MMP-13":[128],"expression,":[129],"cell":[131],"cluster":[132,144],"formation":[133],"reduced":[135],"NAC-treated":[137],"animals.":[138],"In":[139],"contrast,":[140],"BMP7":[141,189],"further":[142],"increased":[143],"formation.":[145],"Moreover,":[146],"synovial":[147],"concentrations":[148],"carboxy":[151],"propeptide":[152],"(CPII)":[153],"proteoglycan":[155],"staining":[156],"intensities":[157],"NAC-":[161],"NAC+BMP7-treated":[163],"joints.":[164],"For":[165],"first":[167],"time,":[168],"NAC":[172,196],"regarding":[173],"early":[174],"harm":[175],"reduction":[176],"blunt":[178],"demonstrated":[182],"vivo.":[184],"However,":[185],"parallel":[186],"administration":[187],"not":[191],"significantly":[192],"superior":[193],"compared":[194],"alone.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-06-27T00:00:00"}
