{"id":"https://openalex.org/W2949396808","doi":"https://doi.org/10.1111/bpa.12759","title":"Cerebrovascular miRNAs correlate with the clearance of A\u03b2 through perivascular route in younger 3xTg\u2010AD mice","display_name":"Cerebrovascular miRNAs correlate with the clearance of A\u03b2 through perivascular route in younger 3xTg\u2010AD mice","publication_year":2019,"publication_date":"2019-06-17","ids":{"openalex":"https://openalex.org/W2949396808","doi":"https://doi.org/10.1111/bpa.12759","mag":"2949396808","pmid":"https://pubmed.ncbi.nlm.nih.gov/31206909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018084"},"language":"en","primary_location":{"id":"doi:10.1111/bpa.12759","doi":"https://doi.org/10.1111/bpa.12759","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bpa.12759","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045170572","display_name":"Lijuan Fu","orcid":"https://orcid.org/0000-0003-4890-9304","observed_orcids":["https://orcid.org/0000-0003-4890-9304"]},"institutions":[{"id":"https://openalex.org/I4210102009","display_name":"California Medical Innovations Institute","ror":"https://ror.org/0156zyn36","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210102009"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lijuan Fu","raw_affiliation_strings":["California Medical Innovations Institute San Diego USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Medical Innovations Institute San Diego USA","institution_ids":["https://openalex.org/I4210102009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110447098","display_name":"Ge Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102009","display_name":"California Medical Innovations Institute","ror":"https://ror.org/0156zyn36","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210102009"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Jiang","raw_affiliation_strings":["California Medical Innovations Institute San Diego USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Medical Innovations Institute San Diego USA","institution_ids":["https://openalex.org/I4210102009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084591354","display_name":"Hope Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102009","display_name":"California Medical Innovations Institute","ror":"https://ror.org/0156zyn36","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210102009"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope Weng","raw_affiliation_strings":["California Medical Innovations Institute San Diego USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Medical Innovations Institute San Diego USA","institution_ids":["https://openalex.org/I4210102009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038570981","display_name":"Gregory M. Dick","orcid":"https://orcid.org/0000-0003-1444-6436","observed_orcids":["https://orcid.org/0000-0003-1444-6436"]},"institutions":[{"id":"https://openalex.org/I4210102009","display_name":"California Medical Innovations Institute","ror":"https://ror.org/0156zyn36","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210102009"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Dick","raw_affiliation_strings":["California Medical Innovations Institute San Diego USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Medical Innovations Institute San Diego USA","institution_ids":["https://openalex.org/I4210102009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082533047","display_name":"Yan-Zhong Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94611258","display_name":"Hebei Normal University","ror":"https://ror.org/004rbbw49","country_code":"CN","type":"education","lineage":["https://openalex.org/I94611258"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanzhong Chang","raw_affiliation_strings":["Laboratory of Molecular Iron Metabolism, College of Life Science Hebei Normal University Shijiazhuang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Iron Metabolism, College of Life Science Hebei Normal University Shijiazhuang China","institution_ids":["https://openalex.org/I94611258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081782138","display_name":"Ghassan S. Kassab","orcid":"https://orcid.org/0000-0001-7126-1484","observed_orcids":["https://orcid.org/0000-0001-7126-1484"]},"institutions":[{"id":"https://openalex.org/I4210102009","display_name":"California Medical Innovations Institute","ror":"https://ror.org/0156zyn36","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210102009"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ghassan S. Kassab","raw_affiliation_strings":["California Medical Innovations Institute San Diego USA"],"raw_orcid":"https://orcid.org/0000-0001-7126-1484","affiliations":[{"raw_affiliation_string":"California Medical Innovations Institute San Diego USA","institution_ids":["https://openalex.org/I4210102009"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045170572","https://openalex.org/A5081782138"],"corresponding_institution_ids":["https://openalex.org/I4210102009"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.005,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74460413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"1","first_page":"92","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.16590000689029694,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.875},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7179999947547913},{"id":"https://openalex.org/keywords/perivascular-clearance","display_name":"perivascular clearance","score":0.7940000295639038},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.5860000252723694},{"id":"https://openalex.org/keywords/3xtg-ad-mice","display_name":"3xTg-AD mice","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pericyte-coverage","display_name":"pericyte coverage","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vascular-activation","display_name":"vascular activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6626453399658203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5235571265220642},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49211686849594116},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.450603723526001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3383725881576538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28206872940063477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08266916871070862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06054505705833435}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bpa.12759","doi":"https://doi.org/10.1111/bpa.12759","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bpa.12759","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8018084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018084","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},{"id":"pmid:31206909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31206909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain pathology (Zurich, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8018084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018084","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W195933567","https://openalex.org/W1462966185","https://openalex.org/W1509604932","https://openalex.org/W1533514205","https://openalex.org/W1575882738","https://openalex.org/W1594119953","https://openalex.org/W1616471316","https://openalex.org/W1767010801","https://openalex.org/W1965306643","https://openalex.org/W1966067381","https://openalex.org/W1967464880","https://openalex.org/W1970830035","https://openalex.org/W1972161622","https://openalex.org/W1973276273","https://openalex.org/W1977604869","https://openalex.org/W1978494744","https://openalex.org/W1979322303","https://openalex.org/W1988194907","https://openalex.org/W1994183414","https://openalex.org/W2003727694","https://openalex.org/W2006035554","https://openalex.org/W2015967842","https://openalex.org/W2017129209","https://openalex.org/W2019780808","https://openalex.org/W2020430203","https://openalex.org/W2020497815","https://openalex.org/W2021135219","https://openalex.org/W2031762899","https://openalex.org/W2033379465","https://openalex.org/W2034275438","https://openalex.org/W2041851050","https://openalex.org/W2047243884","https://openalex.org/W2075481535","https://openalex.org/W2080125561","https://openalex.org/W2091910339","https://openalex.org/W2098613848","https://openalex.org/W2100258988","https://openalex.org/W2100314515","https://openalex.org/W2103904206","https://openalex.org/W2107233754","https://openalex.org/W2109290881","https://openalex.org/W2114789645","https://openalex.org/W2115565175","https://openalex.org/W2119324011","https://openalex.org/W2122290210","https://openalex.org/W2125039506","https://openalex.org/W2129994868","https://openalex.org/W2130411480","https://openalex.org/W2130550747","https://openalex.org/W2142177110","https://openalex.org/W2156676300","https://openalex.org/W2163115168","https://openalex.org/W2163294226","https://openalex.org/W2163607988","https://openalex.org/W2206677774","https://openalex.org/W2207861280","https://openalex.org/W2258063978","https://openalex.org/W2298163613","https://openalex.org/W2337947575","https://openalex.org/W2344971244","https://openalex.org/W2408972675","https://openalex.org/W2411901770","https://openalex.org/W2508875112","https://openalex.org/W2518673348","https://openalex.org/W2520061116","https://openalex.org/W2595097811","https://openalex.org/W2596717566","https://openalex.org/W2613148122","https://openalex.org/W2742236243","https://openalex.org/W2752167770","https://openalex.org/W2753636297","https://openalex.org/W2754025821","https://openalex.org/W2774117551"],"related_works":["https://openalex.org/W3167662738","https://openalex.org/W3213776375","https://openalex.org/W4378649216","https://openalex.org/W4384297753","https://openalex.org/W3123867917","https://openalex.org/W2094113864","https://openalex.org/W2067766876","https://openalex.org/W2983989986","https://openalex.org/W2106914633","https://openalex.org/W2518485355"],"abstract_inverted_index":{"The":[0,50,241],"\"two-hit":[1],"vascular":[2,106,207],"hypothesis":[3,12],"for":[4,252,259],"Alzheimer's":[5],"disease":[6],"(AD)\"":[7],"and":[8,45,72,111,162,190,209,236],"amyloid-\u03b2":[9],"(A\u03b2)":[10],"oligomer":[11,167],"suggest":[13],"that":[14,60,77,143],"impaired":[15],"soluble":[16],"A\u03b2":[17,34,94,103,128,152,166,179,195,210,229],"oligomers":[18,35,180,230],"clearance":[19,168],"through":[20,169,231],"the":[21,30,42,82,91,96,126,145,170,204,232,253],"cerebral":[22,216],"vasculature":[23],"may":[24,80,219,247],"be":[25],"an":[26],"initial":[27],"step":[28],"of":[29,84,93,130,148,156,178,187,203,228,243,255],"AD":[31,97,132,149,239,260],"process.":[32],"Soluble":[33],"are":[36,67],"driven":[37],"into":[38],"perivascular":[39,102,171,233],"spaces":[40],"from":[41],"brain":[43,85,244],"parenchyma":[44],"toward":[46],"peripheral":[47],"blood":[48,86],"flow.":[49],"underlying":[51],"vascular-based":[52],"mechanism,":[53],"however,":[54],"has":[55],"not":[56],"been":[57],"defined.":[58],"Given":[59],"microRNAs":[61],"(miRNAs),":[62],"emerging":[63],"as":[64],"novel":[65],"modulators,":[66],"involved":[68],"in":[69,95,136,174,200],"numerous":[70],"physiological":[71],"pathological":[73],"processes,":[74],"we":[75],"hypothesized":[76],"cerebrovascular":[78],"miRNAs":[79,114,189,208,246],"regulate":[81],"activities":[83],"vessels,":[87],"which":[88],"further":[89,201],"affects":[90],"concentration":[92],"brain.":[98],"In":[99],"this":[100],"study,":[101],"deposits,":[104],"higher":[105,154],"activation,":[107],"increased":[108,191],"pericyte":[109,160,192],"coverage":[110,193],"up-regulated":[112],"capillaries":[113],"at":[115,144,181,197],"6":[116],"months":[117],"old":[118],"(6":[119],"mo)":[120,135],"were":[121],"found":[122],"to":[123,225,238],"correlate":[124],"with":[125],"lower":[127],"levels":[129],"middle":[131],"stage":[133,147],"(9":[134],"3xTg-AD":[137],"(3xTg)":[138],"mice.":[139],"It":[140],"is":[141],"implicated":[142],"early":[146],"when":[150],"intracellular":[151],"appeared,":[153],"expression":[155],"vessel-specific":[157,245],"miRNAs,":[158],"elevated":[159],"coverage,":[161],"activated":[163,223],"endothelium":[164],"facilitate":[165],"route,":[172],"resulting":[173],"a":[175,215,249],"transient":[176],"reduction":[177],"9":[182,198],"mo.":[183],"Additionally,":[184],"ghrelin-induced":[185],"upregulation":[186],"capillary":[188],"attenuated":[194],"burden":[196],"mo,":[199],"support":[202],"relationship":[205],"between":[206],"clearance.":[211],"This":[212],"work":[213],"suggests":[214],"microvessel":[217],"miRNA":[218],"boost":[220],"endothelial":[221],"highly":[222],"phenotypes":[224],"promote":[226],"elimination":[227],"drainage":[234],"pathway":[235],"contribute":[237],"progression.":[240],"targeting":[242],"provide":[248],"new":[250],"rationale":[251],"development":[254],"innovative":[256],"therapeutic":[257],"strategies":[258],"treatment.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}