{"id":"https://openalex.org/W2949385284","doi":"https://doi.org/10.1186/s40425-019-0630-0","title":"Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma","display_name":"Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma","publication_year":2019,"publication_date":"2019-06-20","ids":{"openalex":"https://openalex.org/W2949385284","doi":"https://doi.org/10.1186/s40425-019-0630-0","mag":"2949385284","pmid":"https://pubmed.ncbi.nlm.nih.gov/31221219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585080"},"language":"en","primary_location":{"id":"doi:10.1186/s40425-019-0630-0","doi":"https://doi.org/10.1186/s40425-019-0630-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40425-019-0630-0","pdf_url":"https://jitc.bmj.com/content/jitc/7/1/155.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/7/1/155.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086339607","display_name":"Jason B. Muhitch","orcid":"https://orcid.org/0000-0002-7703-1425","observed_orcids":["https://orcid.org/0000-0002-7703-1425"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason B. Muhitch","raw_affiliation_strings":["Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Immunology","Department of Urology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013348823","display_name":"Nicholas C. Hoffend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas C. Hoffend","raw_affiliation_strings":["Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Urology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042676379","display_name":"Gissou Azabdaftari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gissou Azabdaftari","raw_affiliation_strings":["Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Pathology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091066647","display_name":"Austin Miller","orcid":"https://orcid.org/0000-0001-9739-8462","observed_orcids":["https://orcid.org/0000-0001-9739-8462"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Miller","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Biostatistics and Bioinformatics","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040346750","display_name":"Wiam Bshara","orcid":"https://orcid.org/0000-0003-3238-1664","observed_orcids":["https://orcid.org/0000-0003-3238-1664"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wiam Bshara","raw_affiliation_strings":["Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Pathology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carl D. Morrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl D. Morrison","raw_affiliation_strings":["Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Pathology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001550474","display_name":"Thomas Schwaab","orcid":"https://orcid.org/0000-0002-4042-9253","observed_orcids":["https://orcid.org/0000-0002-4042-9253"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schwaab","raw_affiliation_strings":["Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","Department of Immunology","Department of Urology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"Department of Urology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058401562","display_name":"Scott I. Abrams","orcid":"https://orcid.org/0000-0002-8742-4708","observed_orcids":["https://orcid.org/0000-0002-8742-4708"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott I. Abrams","raw_affiliation_strings":["Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA. scott.abrams@roswellpark.org","Department of Immunology","Roswell Park Comprehensive Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-8742-4708","affiliations":[{"raw_affiliation_string":"Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA. scott.abrams@roswellpark.org","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058401562"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":1.2962,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.78082512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"155","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irf8","display_name":"IRF8","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7540000081062317},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.847000002861023},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.7509999871253967},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.7857239246368408},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.7062323689460754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6831408739089966},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5328158736228943},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5061199069023132},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46993809938430786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45535942912101746},{"id":"https://openalex.org/C2779984610","wikidata":"https://www.wikidata.org/wiki/Q18028000","display_name":"IRF5","level":5,"score":0.45064103603363037},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.44005823135375977},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43299269676208496},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2948036789894104},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15339797735214233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13000568747520447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12485292553901672},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.08093482255935669},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099185","descriptor_name":"Interferon Regulatory Factor-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s40425-019-0630-0","doi":"https://doi.org/10.1186/s40425-019-0630-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40425-019-0630-0","pdf_url":"https://jitc.bmj.com/content/jitc/7/1/155.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6585080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmid:31221219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31221219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e4701ddebf774665811e8d7e4d12c060","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e4701ddebf774665811e8d7e4d12c060","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40425-019-0630-0","doi":"https://doi.org/10.1186/s40425-019-0630-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40425-019-0630-0","pdf_url":"https://jitc.bmj.com/content/jitc/7/1/155.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G520438669","display_name":"Institutional Career Development","funder_award_id":"KL2TR001413","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5654613509","display_name":"Mechanisms Underlying Functional Programs of Tumor-Associated Macrophages","funder_award_id":"R01CA172105","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7918204433","display_name":"University of Buffalo Clinical and Translational Science Institute","funder_award_id":"UL1TR001412","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306497","display_name":"Roswell Park Cancer Institute","ror":"https://ror.org/0499dwk57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949385284.pdf","grobid_xml":"https://content.openalex.org/works/W2949385284.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1966107523","https://openalex.org/W1966289807","https://openalex.org/W1985987855","https://openalex.org/W1988336550","https://openalex.org/W1989841268","https://openalex.org/W2011210685","https://openalex.org/W2028433016","https://openalex.org/W2041399091","https://openalex.org/W2068839905","https://openalex.org/W2070855360","https://openalex.org/W2076330068","https://openalex.org/W2094168446","https://openalex.org/W2107765339","https://openalex.org/W2130985618","https://openalex.org/W2148605435","https://openalex.org/W2151713361","https://openalex.org/W2151935214","https://openalex.org/W2302604202","https://openalex.org/W2551911481","https://openalex.org/W2611919322","https://openalex.org/W2614480329","https://openalex.org/W2686511444","https://openalex.org/W2796207838","https://openalex.org/W2911791951"],"related_works":["https://openalex.org/W6939447801","https://openalex.org/W2068839905","https://openalex.org/W4220998079","https://openalex.org/W2911791951","https://openalex.org/W3081443271","https://openalex.org/W4392375576","https://openalex.org/W3111353074","https://openalex.org/W4380052049","https://openalex.org/W3163597054","https://openalex.org/W4393025324"],"abstract_inverted_index":{"Tumor-associated":[0],"macrophages":[1,101,231],"have":[2,238],"been":[3],"well-characterized":[4],"in":[5,37,185],"solid":[6],"malignancies,":[7],"including":[8],"renal":[9,59,90,246],"cell":[10,58,60,89,91,247],"carcinoma":[11,61,92,248],"and":[12,27,47,216],"generally":[13],"correlate":[14],"with":[15,75,104,110,127,153,173,192,213,250],"poor":[16],"prognosis.":[17],"However,":[18],"the":[19,41,119,225],"molecular":[20],"mechanisms":[21],"which":[22,236],"govern":[23],"intratumoral":[24],"macrophage":[25,38,167,206],"behavior":[26],"patient":[28,93,160,234],"outcome":[29],"are":[30],"unclear.":[31],"Here,":[32],"we":[33,203],"investigated":[34],"whether":[35],"alterations":[36],"expression":[39,72,82,132,207,229],"of":[40,56,65,80,86,97,108,121,130,156,208,227],"transcriptional":[42],"regulator":[43],"for":[44,241,245],"myeloid":[45],"commitment":[46],"function,":[48],"interferon":[49],"regulatory":[50],"factor-8":[51],"(IRF8),":[52],"could":[53,115],"predict":[54,233],"survival":[55,139,188,220],"clear":[57,88],"patients.":[62],"Transcriptional":[63],"analysis":[64],"publicly":[66],"available":[67],"data":[68],"revealed":[69],"elevated":[70],"IRF8":[71,98,122,131,157,209,228],"was":[73],"associated":[74],"prolonged":[76,137],"disease-free":[77],"survival.":[78],"Evaluation":[79],"protein":[81],"within":[83,133,169],"histologic":[84],"sections":[85],"primary":[87,111],"samples":[94],"showed":[95],"intensity":[96],"by":[99,124,230],"CD68+":[100],"correlated":[102,212],"inversely":[103,211],"stage.":[105],"Survival":[106],"outcomes":[107],"patients":[109,152,172,191,249],"or":[112],"metastatic":[113,134,170,251],"disease":[114],"be":[116],"stratified":[117],"on":[118,166],"basis":[120],"levels":[123,129,155],"macrophages.":[125],"Patients":[126],"high":[128],"sites":[135],"had":[136,178],"overall":[138,187],"(log-rank":[140],"P":[141,198],"<":[142,199],"0.01,":[143],"HR":[144],"=":[145],"0.44,":[146],"95%":[147],"C.I.:":[148],"0.23\u20130.84)":[149],"compared":[150,189],"to":[151,190,219,232],"low":[154],"expression.":[158],"When":[159],"cohorts":[161],"were":[162],"further":[163],"separated":[164],"based":[165],"infiltration":[168],"lesions,":[171],"a":[174,179,193],"macrophagelo":[175,194],"IRF8hi":[176],"profile":[177,196],"more":[180],"than":[181],"10":[182],"year":[183],"increase":[184],"median":[186],"IRF8lo":[195],"(log-rank,":[197],"0.001).":[200],"In":[201],"summary,":[202],"report":[204],"that":[205],"is":[210],"tumor":[214],"mass":[215],"directly":[217],"related":[218],"outcome.":[221],"These":[222],"findings":[223],"support":[224],"utilization":[226],"outcome,":[235],"may":[237],"important":[239],"implications":[240],"guiding":[242],"treatment":[243],"decisions":[244],"disease.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-06-27T00:00:00"}
