{"id":"https://openalex.org/W2949342485","doi":"https://doi.org/10.1002/chin.198820114","title":"ChemInform Abstract: Stereoselective Fragmentation of a Tricyclic Diester Leading to a Potent Chorismate Mutase Transition State Inhibitor.","display_name":"ChemInform Abstract: Stereoselective Fragmentation of a Tricyclic Diester Leading to a Potent Chorismate Mutase Transition State Inhibitor.","publication_year":1988,"publication_date":"1988-05-17","ids":{"openalex":"https://openalex.org/W2949342485","doi":"https://doi.org/10.1002/chin.198820114","mag":"2949342485"},"language":"en","primary_location":{"id":"doi:10.1002/chin.198820114","doi":"https://doi.org/10.1002/chin.198820114","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.198820114","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032438041","display_name":"Trafford Clarke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. CLARKE","raw_affiliation_strings":["Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023623405","display_name":"Jon D. Stewart","orcid":"https://orcid.org/0000-0003-1958-0298","observed_orcids":["https://orcid.org/0000-0003-1958-0298"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. STEWART","raw_affiliation_strings":["Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035275755","display_name":"Bruce Ganem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. GANEM","raw_affiliation_strings":["Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Chem., Baker Lab., Cornell Univ., Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2730882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.48240000009536743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.48240000009536743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.1421000063419342,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.12939999997615814,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chorismate-mutase","display_name":"chorismate mutase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/transition-state-analogue-inhibitors","display_name":"transition-state inhibitors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/1-3-cyclohexadiene","display_name":"1,3-cyclohexadiene","score":0.9259999990463257},{"id":"https://openalex.org/keywords/enol-ethers","display_name":"enol ethers","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9783680438995361},{"id":"https://openalex.org/C2778526059","wikidata":"https://www.wikidata.org/wiki/Q3693596","display_name":"Chorismate mutase","level":4,"score":0.81197190284729},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.7320665121078491},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.7160072326660156},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6179224848747253},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49520984292030334},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3207188844680786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08701416850090027},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06930175423622131},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.057935088872909546},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.198820114","doi":"https://doi.org/10.1002/chin.198820114","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.198820114","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2039738322"],"related_works":["https://openalex.org/W2039738322","https://openalex.org/W4205191948","https://openalex.org/W4236642798","https://openalex.org/W4234869322","https://openalex.org/W2398371617","https://openalex.org/W2950219452","https://openalex.org/W2346887721","https://openalex.org/W4251346310","https://openalex.org/W2952520842","https://openalex.org/W2949643829"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"siloxy\u20101,4\u2010cyclohexadienecarboxylate":[2],"(I)":[3],"is":[4,17],"coupled":[5],"with":[6],"the":[7,12,24],"bromomethylacrylate":[8],"(II)":[9],"to":[10,22],"give":[11],"1,3\u2010cyclohexadiene":[13],"derivative":[14],"(III)":[15],"which":[16],"cyclized":[18],"in":[19],"boiling":[20],"toluene":[21],"form":[23],"tricyclic":[25],"enol":[26],"ether":[27],"(IV).":[28]},"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2019-06-27T00:00:00"}