{"id":"https://openalex.org/W2949225171","doi":"https://doi.org/10.1038/s41598-017-09307-w","title":"Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes","display_name":"Extracting Intercellular Signaling Network of Cancer Tissues using Ligand-Receptor Expression Patterns from Whole-tumor and Single-cell Transcriptomes","publication_year":2017,"publication_date":"2017-08-14","ids":{"openalex":"https://openalex.org/W2949225171","doi":"https://doi.org/10.1038/s41598-017-09307-w","mag":"2949225171","pmid":"https://pubmed.ncbi.nlm.nih.gov/28821810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5562796"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-017-09307-w","doi":"https://doi.org/10.1038/s41598-017-09307-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09307-w","pdf_url":"https://www.nature.com/articles/s41598-017-09307-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-017-09307-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071371944","display_name":"Joseph Zhou","orcid":"https://orcid.org/0000-0003-3363-3720","observed_orcids":["https://orcid.org/0000-0003-3363-3720"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph X. Zhou","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058025748","display_name":"Roberto Taramelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115752224","display_name":"University of Insubria","ror":"https://ror.org/00s409261","country_code":"IT","type":"education","lineage":["https://openalex.org/I115752224"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Taramelli","raw_affiliation_strings":["Department of Biotechnology and Molecular Science, University of Insubria, Varese, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Molecular Science, University of Insubria, Varese, Italy","institution_ids":["https://openalex.org/I115752224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019398412","display_name":"Edoardo Pedrini","orcid":"https://orcid.org/0000-0002-2813-9261","observed_orcids":["https://orcid.org/0000-0002-2813-9261"]},"institutions":[{"id":"https://openalex.org/I115752224","display_name":"University of Insubria","ror":"https://ror.org/00s409261","country_code":"IT","type":"education","lineage":["https://openalex.org/I115752224"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Pedrini","raw_affiliation_strings":["Department of Biotechnology and Molecular Science, University of Insubria, Varese, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Molecular Science, University of Insubria, Varese, Italy","institution_ids":["https://openalex.org/I115752224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085788761","display_name":"Theo Knijnenburg","orcid":"https://orcid.org/0000-0001-6397-4222","observed_orcids":["https://orcid.org/0000-0001-6397-4222"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theo Knijnenburg","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019206785","display_name":"Sui Huang","orcid":"https://orcid.org/0000-0002-3545-4665","observed_orcids":["https://orcid.org/0000-0002-3545-4665"]},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sui Huang","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, USA. sui.huang@systemsbiology.org","Institute for Systems Biology, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA. sui.huang@systemsbiology.org","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019206785"],"corresponding_institution_ids":["https://openalex.org/I3148997608"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.8251,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92150247,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"8815","last_page":"8815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.10159999877214432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-cell-communication-networks","display_name":"cell-cell communication networks","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7080000042915344},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6809999942779541},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.375}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6614967584609985},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6405659914016724},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6404777765274048},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6012613773345947},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5796462893486023},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5128124356269836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4971175491809845},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4722772538661957},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.471321165561676},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4552534818649292},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45160046219825745},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4172613024711609},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3829578161239624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3624163568019867},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2856622338294983},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26971688866615295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24416831135749817}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1038/s41598-017-09307-w","doi":"https://doi.org/10.1038/s41598-017-09307-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09307-w","pdf_url":"https://www.nature.com/articles/s41598-017-09307-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/127167","doi":"https://doi.org/10.1101/127167","is_oa":true,"landing_page_url":"https://doi.org/10.1101/127167","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2017/04/13/127167.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:4459530","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5562796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5562796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5562796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:28821810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28821810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7552556a08484b418c9f1c62664e4349","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7552556a08484b418c9f1c62664e4349","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)","raw_type":"article"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/2070124","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11383/2070124","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/2070125","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11383/2070125","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-017-09307-w","doi":"https://doi.org/10.1038/s41598-017-09307-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-017-09307-w","pdf_url":"https://www.nature.com/articles/s41598-017-09307-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2699341656","display_name":"Dynamics of Non-equalibrium Cell State Transitions in Cell Populations","funder_award_id":"R01GM109964","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8969253236","display_name":"Quantitative Systems Biology","funder_award_id":"P50GM076547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949225171.pdf","grobid_xml":"https://content.openalex.org/works/W2949225171.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1016059894","https://openalex.org/W1560424863","https://openalex.org/W1569513357","https://openalex.org/W1572656384","https://openalex.org/W1963904011","https://openalex.org/W1967327758","https://openalex.org/W1974238946","https://openalex.org/W1978139448","https://openalex.org/W1978591675","https://openalex.org/W1987012261","https://openalex.org/W1987370132","https://openalex.org/W1993112045","https://openalex.org/W1996436013","https://openalex.org/W1998728654","https://openalex.org/W1999251458","https://openalex.org/W2001258296","https://openalex.org/W2001461804","https://openalex.org/W2003808152","https://openalex.org/W2009390821","https://openalex.org/W2017056838","https://openalex.org/W2017917757","https://openalex.org/W2018288777","https://openalex.org/W2022488821","https://openalex.org/W2024626836","https://openalex.org/W2030038054","https://openalex.org/W2030059329","https://openalex.org/W2030917941","https://openalex.org/W2032518018","https://openalex.org/W2041993682","https://openalex.org/W2044702943","https://openalex.org/W2046332685","https://openalex.org/W2054728198","https://openalex.org/W2062809449","https://openalex.org/W2067256262","https://openalex.org/W2072178451","https://openalex.org/W2076356973","https://openalex.org/W2078502914","https://openalex.org/W2082057045","https://openalex.org/W2083573714","https://openalex.org/W2102085111","https://openalex.org/W2106877511","https://openalex.org/W2107554353","https://openalex.org/W2114285300","https://openalex.org/W2118278569","https://openalex.org/W2123563900","https://openalex.org/W2127771118","https://openalex.org/W2127877679","https://openalex.org/W2128527767","https://openalex.org/W2131773109","https://openalex.org/W2140299974","https://openalex.org/W2141587124","https://openalex.org/W2141815918","https://openalex.org/W2145490623","https://openalex.org/W2148159408","https://openalex.org/W2158485828","https://openalex.org/W2161744213","https://openalex.org/W2165188181","https://openalex.org/W2170490448","https://openalex.org/W2171181147","https://openalex.org/W2171544336","https://openalex.org/W2171642372","https://openalex.org/W2262797342","https://openalex.org/W2332292689","https://openalex.org/W2372348799","https://openalex.org/W2401256469","https://openalex.org/W2560367415","https://openalex.org/W2586681801","https://openalex.org/W4301159569","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W4283592141","https://openalex.org/W7026482820","https://openalex.org/W7047148867","https://openalex.org/W4380370418","https://openalex.org/W2475647037","https://openalex.org/W4388756595","https://openalex.org/W3130545010","https://openalex.org/W3212976247","https://openalex.org/W4205213055","https://openalex.org/W4413795309"],"abstract_inverted_index":{"Many":[0],"behaviors":[1,44,174],"of":[2,28,37,81,108,113,129,154,172,175,188],"cancer,":[3],"such":[4],"as":[5,78,178],"progression,":[6],"metastasis":[7],"and":[8,54,63,90,110,117,192],"drug":[9],"resistance":[10],"etc.,":[11],"cannot":[12],"be":[13],"fully":[14],"understood":[15],"by":[16,58],"genetic":[17],"mutations":[18],"or":[19],"intracellular":[20],"signaling":[21,60],"alone.":[22],"Instead,":[23],"they":[24],"are":[25],"emergent":[26],"properties":[27],"the":[29,79,111,114,145,158],"cell":[30,142],"community":[31],"which":[32,141,156],"forms":[33],"a":[34,85,106,127,130,150,179,186],"tumor.":[35,146],"Studies":[36],"tumor":[38],"heterogeneity":[39],"reveal":[40],"that":[41,134],"many":[42],"cancer":[43,51,70,155,176,189],"critically":[45],"depend":[46],"on":[47],"intercellular":[48],"communication":[49,132,160],"between":[50,55,140],"cells":[52,57,177],"themselves":[53],"cancer-stromal":[56],"secreted":[59],"molecules":[61],"(ligands)":[62],"their":[64,92,118],"cognate":[65],"receptors.":[66],"We":[67,83],"analyzed":[68],"public":[69],"transcriptome":[71],"database":[72],"for":[73,105,168],"changes":[74],"in":[75,95,122,144,182],"cell-cell":[76,131,159],"interactions":[77,116],"characteristic":[80],"malignancy.":[82],"curated":[84],"list":[86],"(>2,500":[87],"ligand-receptor":[88,115],"pairs)":[89],"identified":[91],"joint":[93],"enrichment":[94],"tumors":[96],"from":[97],"TCGA":[98],"pan-cancer":[99],"data.":[100],"From":[101],"single-cell":[102],"RNA-Seq":[103],"data":[104],"case":[107],"melanoma":[109],"specificity":[112],"gene":[119],"expression":[120],"measured":[121],"individual":[123],"cells,":[124],"we":[125],"constructed":[126],"map":[128],"network":[133],"indicates":[135],"what":[136],"signal":[137],"is":[138],"exchanged":[139],"types":[143],"Such":[147],"networks":[148],"establish":[149],"new":[151,166],"formal":[152],"phenotype":[153],"captures":[157],"structure":[161],"-":[162,181],"it":[163],"may":[164,184],"open":[165],"opportunities":[167],"identifying":[169],"molecular":[170],"signatures":[171],"coordinated":[173],"population":[180],"turn":[183],"become":[185],"determinant":[187],"progression":[190],"potential":[191],"prognosis.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-06-27T00:00:00"}