{"id":"https://openalex.org/W2949145693","doi":"https://doi.org/10.1002/jhet.5570360502","title":"Condensation of substituted 2\u2010aminopyridine with \u03b2\u2010ketocarboxylic esters: 4H\u2010pyrido[1,2\u2010a]pyrimidin\u20104\u2010ones and pyridin\u20102\u2010ones","display_name":"Condensation of substituted 2\u2010aminopyridine with \u03b2\u2010ketocarboxylic esters: 4H\u2010pyrido[1,2\u2010a]pyrimidin\u20104\u2010ones and pyridin\u20102\u2010ones","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2949145693","doi":"https://doi.org/10.1002/jhet.5570360502","mag":"2949145693"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.5570360502","doi":"https://doi.org/10.1002/jhet.5570360502","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570360502","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110498580","display_name":"P. L. FERRARINI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pier Luigi Ferrarini","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112397436","display_name":"Claudio Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Mori","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081576364","display_name":"Clementina Manera","orcid":"https://orcid.org/0000-0002-7379-5743","observed_orcids":["https://orcid.org/0000-0002-7379-5743"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Clementina Manera","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017992138","display_name":"Filippo Mori","orcid":"https://orcid.org/0000-0001-8940-5415","observed_orcids":["https://orcid.org/0000-0001-8940-5415"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Mori","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Scienze Farmaceutiche, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008782167","display_name":"Vincenzo Calderone","orcid":"https://orcid.org/0000-0002-1441-5421","observed_orcids":["https://orcid.org/0000-0002-1441-5421"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Calderone","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110891654","display_name":"Enrica Martinotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrica Martinotti","raw_affiliation_strings":["Universita\u0300 degli Studi di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, via Bonanno, 6, 56126 Pisa Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u0300 degli Studi di Pisa, Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, via Bonanno, 6, 56126 Pisa Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.2922,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.47185759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"36","issue":"5","first_page":"1123","last_page":"1127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.15219999849796295,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13230","display_name":"Synthesis and Reactivity of Heterocycles","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-aminopyridine","display_name":"2-aminopyridine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/condensation-reactions","display_name":"condensation reactions","score":0.7149999737739563},{"id":"https://openalex.org/keywords/polyphosphoric-acid","display_name":"polyphosphoric acid","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pyridin-2-one","display_name":"pyridin-2-one","score":0.9909999966621399},{"id":"https://openalex.org/keywords/vasorelaxant-activity","display_name":"vasorelaxant activity","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9878574013710022},{"id":"https://openalex.org/C200093464","wikidata":"https://www.wikidata.org/wiki/Q166583","display_name":"Condensation","level":2,"score":0.6681265830993652},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.5675824880599976},{"id":"https://openalex.org/C2778087735","wikidata":"https://www.wikidata.org/wiki/Q2393470","display_name":"2-Aminopyridine","level":2,"score":0.5377431511878967},{"id":"https://openalex.org/C2909503537","wikidata":"https://www.wikidata.org/wiki/Q471759","display_name":"Aminopyridines","level":2,"score":0.489641010761261},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4263533353805542},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.06553813815116882},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jhet.5570360502","doi":"https://doi.org/10.1002/jhet.5570360502","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.5570360502","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:arpi.unipi.it:11568/205360","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/205360","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1963544878","https://openalex.org/W1994489962","https://openalex.org/W2049258888","https://openalex.org/W2055421076","https://openalex.org/W2068008182","https://openalex.org/W2093515087","https://openalex.org/W2327012774","https://openalex.org/W2438750847","https://openalex.org/W2953249260"],"related_works":["https://openalex.org/W2068008182","https://openalex.org/W1982897127","https://openalex.org/W1994489962","https://openalex.org/W1965532177","https://openalex.org/W1966079377","https://openalex.org/W846867910","https://openalex.org/W2045054049","https://openalex.org/W2344984522","https://openalex.org/W2155110505","https://openalex.org/W2953333176"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"report":[2],"the":[3,22,28,32],"condensation":[4],"of":[5],"substituted":[6],"2\u2010aminopyridines":[7],"5":[8],"with":[9,21],"\u03b2\u2010ketocarboxylic":[10],"esters":[11],"in":[12],"polyphosphoric":[13],"acid.":[14],"In":[15],"this":[16],"reaction":[17],"were":[18,35],"obtained":[19],"together":[20],"target":[23],"compounds,":[24],"4H\u2010pyrido[1,2\u2010a]pyrirnidin\u20104\u2010ones":[25],"6":[26],"also":[27],"pyridin\u20102\u2010ones":[29],"7.":[30],"All":[31],"compounds":[33],"7":[34],"tested":[36],"for":[37],"their":[38],"calcium\u2010antagonistic":[39],"activity":[40],"but":[41],"failed":[42],"to":[43],"evoke":[44],"any":[45],"vasorelaxant":[46],"response.":[47]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2019-06-27T00:00:00"}