{"id":"https://openalex.org/W2949123718","doi":"https://doi.org/10.1021/acsnano.8b07865","title":"Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment","display_name":"Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment","publication_year":2019,"publication_date":"2019-06-12","ids":{"openalex":"https://openalex.org/W2949123718","doi":"https://doi.org/10.1021/acsnano.8b07865","mag":"2949123718","pmid":"https://pubmed.ncbi.nlm.nih.gov/31187975"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.8b07865","doi":"https://doi.org/10.1021/acsnano.8b07865","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.8b07865","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/en/publications/126ad516-220f-473a-b6b7-e34b492c88c5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035082371","display_name":"John D. Martin","orcid":"https://orcid.org/0000-0002-9828-8203","observed_orcids":["https://orcid.org/0000-0002-9828-8203"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"John D. Martin","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9828-8203","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079241025","display_name":"Myrofora Panagi","orcid":"https://orcid.org/0000-0002-6256-3250","observed_orcids":["https://orcid.org/0000-0002-6256-3250"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Myrofora Panagi","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595150","display_name":"Chenyu Wang","orcid":"https://orcid.org/0009-0004-7182-2164","observed_orcids":["https://orcid.org/0009-0004-7182-2164"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyu Wang","raw_affiliation_strings":["Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073794905","display_name":"Thahomina Khan","orcid":"https://orcid.org/0000-0001-6047-6754","observed_orcids":["https://orcid.org/0000-0001-6047-6754"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Thahomina T. Khan","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090554105","display_name":"Margaret R. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Margaret R. Martin","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003082907","display_name":"Chrysovalantis Voutouri","orcid":"https://orcid.org/0000-0003-3172-9489","observed_orcids":["https://orcid.org/0000-0003-3172-9489"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Chrysovalantis Voutouri","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029551108","display_name":"Kazuko Toh","orcid":"https://orcid.org/0000-0003-1448-7131","observed_orcids":["https://orcid.org/0000-0003-1448-7131"]},"institutions":[{"id":"https://openalex.org/I4210087333","display_name":"Innovation Center of NanoMedicine","ror":"https://ror.org/000j6sc87","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087333"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuko Toh","raw_affiliation_strings":["Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan","institution_ids":["https://openalex.org/I4210087333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000014231","display_name":"Panagiotis Papageorgis","orcid":"https://orcid.org/0000-0002-7595-5616","observed_orcids":["https://orcid.org/0000-0002-7595-5616"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]},{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Panagiotis Papageorgis","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","Department of Life Sciences, Program in Biological Sciences, European University Cyprus, Nicosia 1516, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]},{"raw_affiliation_string":"Department of Life Sciences, Program in Biological Sciences, European University Cyprus, Nicosia 1516, Cyprus","institution_ids":["https://openalex.org/I201118511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040343131","display_name":"Fotios Mpekris","orcid":"https://orcid.org/0000-0002-7125-4062","observed_orcids":["https://orcid.org/0000-0002-7125-4062"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Fotios Mpekris","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085562317","display_name":"Christiana Polydorou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Christiana Polydorou","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046015782","display_name":"Genichiro Ishii","orcid":"https://orcid.org/0000-0001-8637-3323","observed_orcids":["https://orcid.org/0000-0001-8637-3323","https://orcid.org/0000-0003-4158-0286"]},"institutions":[{"id":"https://openalex.org/I4405286036","display_name":"National Cancer Center Exploratory Oncology Research & Clinical Trial Center","ror":"https://ror.org/00zwh4w61","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405286036"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Genichiro Ishii","raw_affiliation_strings":["Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan","institution_ids":["https://openalex.org/I4405286036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091260536","display_name":"Shinichiro Takahashi","orcid":"https://orcid.org/0000-0002-4828-3965","observed_orcids":["https://orcid.org/0000-0002-4828-3965"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Takahashi","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050545841","display_name":"Naoto Gotohda","orcid":"https://orcid.org/0000-0002-4468-5844","observed_orcids":["https://orcid.org/0000-0002-4468-5844"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Gotohda","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067951454","display_name":"Toshiyuki Suzuki","orcid":"https://orcid.org/0000-0002-3892-0975","observed_orcids":["https://orcid.org/0000-0002-3892-0975"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Suzuki","raw_affiliation_strings":["Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051995225","display_name":"Matthew E. Wilhelm","orcid":"https://orcid.org/0000-0002-4125-1493","observed_orcids":["https://orcid.org/0000-0002-4125-1493"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E. Wilhelm","raw_affiliation_strings":["Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016843823","display_name":"Vinicio Alejandro Melo","orcid":"https://orcid.org/0000-0002-9786-3157","observed_orcids":["https://orcid.org/0000-0002-9786-3157"]},"institutions":[{"id":"https://openalex.org/I4210087333","display_name":"Innovation Center of NanoMedicine","ror":"https://ror.org/000j6sc87","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087333"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Vinicio Alejandro Melo","raw_affiliation_strings":["Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan","institution_ids":["https://openalex.org/I4210087333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075887548","display_name":"Sabina Quader","orcid":"https://orcid.org/0000-0002-9616-7408","observed_orcids":["https://orcid.org/0000-0002-9616-7408"]},"institutions":[{"id":"https://openalex.org/I4210087333","display_name":"Innovation Center of NanoMedicine","ror":"https://ror.org/000j6sc87","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087333"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sabina Quader","raw_affiliation_strings":["Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan","institution_ids":["https://openalex.org/I4210087333"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025520499","display_name":"Jumpei Norimatsu","orcid":"https://orcid.org/0009-0009-4857-8825","observed_orcids":["https://orcid.org/0009-0009-4857-8825"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jumpei Norimatsu","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052875747","display_name":"Ryan Michael Lanning","orcid":"https://orcid.org/0000-0002-9267-519X","observed_orcids":["https://orcid.org/0000-0002-9267-519X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan M. Lanning","raw_affiliation_strings":["Department of Radiation Oncology, School of Medicine, University of Colorado, Aurora, Colorado 80045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, School of Medicine, University of Colorado, Aurora, Colorado 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084852275","display_name":"Motohiro Kojima","orcid":"https://orcid.org/0000-0002-6150-6545","observed_orcids":["https://orcid.org/0000-0002-6150-6545"]},"institutions":[{"id":"https://openalex.org/I4405286036","display_name":"National Cancer Center Exploratory Oncology Research & Clinical Trial Center","ror":"https://ror.org/00zwh4w61","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405286036"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motohiro Kojima","raw_affiliation_strings":["Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan","institution_ids":["https://openalex.org/I4405286036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041747414","display_name":"Matthew D. Stuber","orcid":"https://orcid.org/0000-0001-8435-9552","observed_orcids":["https://orcid.org/0000-0001-8435-9552"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew David Stuber","raw_affiliation_strings":["Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States"],"raw_orcid":"https://orcid.org/0000-0001-8435-9552","affiliations":[{"raw_affiliation_string":"Process Systems and Operations Research Laboratory, Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057504407","display_name":"Triantafyllos Stylianopoulos","orcid":"https://orcid.org/0000-0002-3093-1696","observed_orcids":["https://orcid.org/0000-0002-3093-1696"]},"institutions":[{"id":"https://openalex.org/I34771391","display_name":"University of Cyprus","ror":"https://ror.org/02qjrjx09","country_code":"CY","type":"education","lineage":["https://openalex.org/I34771391"]}],"countries":["CY"],"is_corresponding":false,"raw_author_name":"Triantafyllos Stylianopoulos","raw_affiliation_strings":["Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia 1678, Cyprus","institution_ids":["https://openalex.org/I34771391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015097923","display_name":"Kazunori Kataoka","orcid":"https://orcid.org/0000-0002-8591-413X","observed_orcids":["https://orcid.org/0000-0002-8591-413X"]},"institutions":[{"id":"https://openalex.org/I4210087333","display_name":"Innovation Center of NanoMedicine","ror":"https://ror.org/000j6sc87","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087333"]},{"id":"https://openalex.org/I4405286473","display_name":"Institute for Future Initiatives, The University of Tokyo","ror":"https://ror.org/028ck4741","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286473","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazunori Kataoka","raw_affiliation_strings":["Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan","Institute for Future Initiatives, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8591-413X","affiliations":[{"raw_affiliation_string":"Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821, Japan","institution_ids":["https://openalex.org/I4210087333"]},{"raw_affiliation_string":"Institute for Future Initiatives, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405286473","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056964526","display_name":"Horacio Cabral","orcid":"https://orcid.org/0000-0002-4030-2631","observed_orcids":["https://orcid.org/0000-0002-4030-2631"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Horacio Cabral","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4030-2631","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5015097923","https://openalex.org/A5056964526"],"corresponding_institution_ids":["https://openalex.org/I4210087333","https://openalex.org/I4405286473","https://openalex.org/I74801974"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":5.4376,"has_fulltext":true,"cited_by_count":138,"citation_normalized_percentile":{"value":0.98255688,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":"6","first_page":"6396","last_page":"6408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-microenvironment-normalization","display_name":"tumor microenvironment normalization","score":0.859000027179718},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.7720000147819519},{"id":"https://openalex.org/keywords/interstitial-fluid-pressure","display_name":"interstitial fluid pressure","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tissue-stiffness","display_name":"tissue stiffness","score":0.7170000076293945},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8069999814033508},{"id":"https://openalex.org/keywords/macromolecular-transport","display_name":"macromolecule transport","score":0.625},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.6710000038146973},{"id":"https://openalex.org/keywords/tumor-vasculature-normalization","display_name":"tumor vasculature normalization","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.842255175113678},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.8291356563568115},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7656744718551636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49721387028694153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4962990880012512},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4779529571533203},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4319131672382355},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.42296451330184937},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4172939956188202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3951045572757721},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3701304495334625},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3597385883331299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32856225967407227},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.24803116917610168},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2063761055469513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsnano.8b07865","doi":"https://doi.org/10.1021/acsnano.8b07865","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.8b07865","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:31187975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31187975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/126ad516-220f-473a-b6b7-e34b492c88c5","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/126ad516-220f-473a-b6b7-e34b492c88c5","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/126ad516-220f-473a-b6b7-e34b492c88c5","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/126ad516-220f-473a-b6b7-e34b492c88c5","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1019357558","display_name":"Development of a nano-pharmaceutical strategy for safely and effectively treating pregnant cancer patients","funder_award_id":"16H03179","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1585574246","display_name":null,"funder_award_id":"INFRASTRUCTURE/1216/0052","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3122727031","display_name":null,"funder_award_id":"PE14787","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G453807875","display_name":"Development of mRNA drug with RNA type aptamer conferring cell type specific translation activation function","funder_award_id":"18K19901","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5796234971","display_name":"Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy","funder_award_id":"336839","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G7216155542","display_name":null,"funder_award_id":"INFRASTRUCTURE/1216/0052","funder_id":"https://openalex.org/F4320321002","funder_display_name":"Research Promotion Foundation"},{"id":"https://openalex.org/G839548354","display_name":null,"funder_award_id":"P16731","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320321002","display_name":"Research Promotion Foundation","ror":"https://ror.org/00en9ce74"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1063491141","https://openalex.org/W1497490920","https://openalex.org/W1504011557","https://openalex.org/W1603491949","https://openalex.org/W1921704765","https://openalex.org/W1964128680","https://openalex.org/W1968583232","https://openalex.org/W1977887541","https://openalex.org/W1990954618","https://openalex.org/W1998266575","https://openalex.org/W2014282546","https://openalex.org/W2018779108","https://openalex.org/W2021883439","https://openalex.org/W2052672777","https://openalex.org/W2057327446","https://openalex.org/W2066724170","https://openalex.org/W2068881112","https://openalex.org/W2074011353","https://openalex.org/W2082589553","https://openalex.org/W2083710155","https://openalex.org/W2085759889","https://openalex.org/W2095908065","https://openalex.org/W2104300873","https://openalex.org/W2107485485","https://openalex.org/W2126163864","https://openalex.org/W2134315923","https://openalex.org/W2293660651","https://openalex.org/W2320560945","https://openalex.org/W2555713683","https://openalex.org/W2555883270","https://openalex.org/W2562398320","https://openalex.org/W2589726211","https://openalex.org/W2591572678","https://openalex.org/W2597588035","https://openalex.org/W2606343471","https://openalex.org/W2764334703","https://openalex.org/W2766971652","https://openalex.org/W2793869682","https://openalex.org/W2884616676"],"related_works":["https://openalex.org/W4386026136","https://openalex.org/W2605655413","https://openalex.org/W4409253153","https://openalex.org/W3012934060","https://openalex.org/W4229453655","https://openalex.org/W4406269654","https://openalex.org/W1601131774","https://openalex.org/W2055430648","https://openalex.org/W4220783622","https://openalex.org/W2057327446"],"abstract_inverted_index":{"Dexamethasone":[0,44],"is":[1,75],"a":[2,139],"glucocorticoid":[3],"steroid":[4],"with":[5,141,150],"anti-inflammatory":[6],"properties":[7],"used":[8],"to":[9],"treat":[10],"many":[11],"diseases,":[12],"including":[13],"cancer,":[14],"in":[15,38,85],"which":[16,71,136],"it":[17],"helps":[18],"manage":[19],"various":[20],"side":[21],"effects":[22,35],"of":[23,36,65,80,105,117,128],"chemo-,":[24],"radio-,":[25],"and":[26,47,58,67,82,115,131,161],"immunotherapies.":[27],"Here,":[28],"we":[29],"investigate":[30],"the":[31,48,63,101,106,112],"tumor":[32,113],"microenvironment":[33],"(TME)-normalizing":[34],"dexamethasone":[37,89,110,151],"metastatic":[39],"murine":[40,126],"breast":[41],"cancer":[42],"(BC).":[43],"normalizes":[45],"vessels":[46],"extracellular":[49],"matrix,":[50],"thereby":[51],"reducing":[52,100],"interstitial":[53,95],"fluid":[54,81],"pressure,":[55],"tissue":[56],"stiffness,":[57],"solid":[59],"stress.":[60],"In":[61],"turn,":[62],"penetration":[64,92],"13":[66],"32":[68],"nm":[69,119],"dextrans,":[70],"represent":[72],"nanocarriers":[73],"(NCs),":[74],"increased.":[76],"A":[77],"mechanistic":[78],"model":[79],"macromolecule":[83],"transport":[84],"tumors":[86,160],"predicts":[87],"that":[88,148],"increases":[90,111],"NC":[91,153],"by":[93],"increasing":[94],"hydraulic":[96],"conductivity":[97],"without":[98],"significantly":[99],"effective":[102],"pore":[103],"diameter":[104],"vessel":[107],"wall.":[108],"Also,":[109],"accumulation":[114],"efficacy":[116,157],"\u223c30":[118],"polymeric":[120],"micelles":[121],"containing":[122],"cisplatin":[123],"(CDDP/m)":[124],"against":[125,158],"models":[127],"primary":[129,159],"BC":[130,133],"spontaneous":[132],"lung":[134],"metastasis,":[135],"also":[137],"feature":[138],"TME":[140],"abnormal":[142],"mechanical":[143],"properties.":[144],"These":[145],"results":[146],"suggest":[147],"pretreatment":[149],"before":[152],"administration":[154],"could":[155],"increase":[156],"metastases.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":26},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}