{"id":"https://openalex.org/W2949096701","doi":"https://doi.org/10.1021/acsabm.9b00077","title":"Effects of Aloe Vera Gel Extract in Doped Hydroxyapatite-Coated Titanium Implants onin Vivoandin VitroBiological Properties","display_name":"Effects of Aloe Vera Gel Extract in Doped Hydroxyapatite-Coated Titanium Implants onin Vivoandin VitroBiological Properties","publication_year":2019,"publication_date":"2019-06-13","ids":{"openalex":"https://openalex.org/W2949096701","doi":"https://doi.org/10.1021/acsabm.9b00077","mag":"2949096701","pmid":"https://pubmed.ncbi.nlm.nih.gov/35030764"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.9b00077","doi":"https://doi.org/10.1021/acsabm.9b00077","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.9b00077","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015385138","display_name":"Dishary Banerjee","orcid":"https://orcid.org/0000-0001-6682-9258","observed_orcids":["https://orcid.org/0000-0001-6682-9258"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dishary Banerjee","raw_affiliation_strings":["W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164-2920, United States"],"raw_orcid":"https://orcid.org/0000-0001-6682-9258","affiliations":[{"raw_affiliation_string":"W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164-2920, United States","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025156200","display_name":"Susmita Bose","orcid":"https://orcid.org/0000-0001-8601-016X","observed_orcids":["https://orcid.org/0000-0001-8601-016X"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susmita Bose","raw_affiliation_strings":["W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164-2920, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164-2920, United States","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025156200"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0274,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.72016967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"8","first_page":"3194","last_page":"3202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aloe-vera-gel-extract","display_name":"Aloe vera gel extract","score":0.921999990940094},{"id":"https://openalex.org/keywords/acemannan","display_name":"acemannan","score":1.0},{"id":"https://openalex.org/keywords/hydroxyapatite-coating","display_name":"hydroxyapatite coating","score":0.8320000171661377},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.9399999976158142},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/silver-oxide-doping","display_name":"silver oxide doping","score":0.6330000162124634},{"id":"https://openalex.org/keywords/silica-doping","display_name":"silica doping","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chitosan-coating","display_name":"chitosan coating","score":0.7900000214576721},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.859000027179718},{"id":"https://openalex.org/keywords/osteoblast-viability","display_name":"osteoblast viability","score":0.9589999914169312},{"id":"https://openalex.org/keywords/new-bone-formation","display_name":"new bone formation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5799999833106995},{"id":"https://openalex.org/keywords/antibacterial-coatings","display_name":"antibacterial coatings","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.8856594562530518},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7041105031967163},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.555378258228302},{"id":"https://openalex.org/C114874019","wikidata":"https://www.wikidata.org/wiki/Q6379013","display_name":"Simulated body fluid","level":3,"score":0.5477406978607178},{"id":"https://openalex.org/C506065880","wikidata":"https://www.wikidata.org/wiki/Q716","display_name":"Titanium","level":2,"score":0.4902203679084778},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4838344156742096},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.4251480996608734},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.3559882640838623},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.15786147117614746},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13773131370544434},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.10406419634819031},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.08922800421714783},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08399492502212524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08114275336265564},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acsabm.9b00077","doi":"https://doi.org/10.1021/acsabm.9b00077","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.9b00077","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:35030764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35030764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3372279667","display_name":"Surface modified metal implants using doped hydroxyapatite","funder_award_id":"R01AR066361","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1787136767","https://openalex.org/W1963724801","https://openalex.org/W1964249929","https://openalex.org/W1969347970","https://openalex.org/W1984734563","https://openalex.org/W1996986647","https://openalex.org/W2004891301","https://openalex.org/W2014209951","https://openalex.org/W2018613635","https://openalex.org/W2020663976","https://openalex.org/W2022729648","https://openalex.org/W2047535801","https://openalex.org/W2049436079","https://openalex.org/W2060380665","https://openalex.org/W2062900498","https://openalex.org/W2079451982","https://openalex.org/W2097935965","https://openalex.org/W2100887702","https://openalex.org/W2114977063","https://openalex.org/W2123114804","https://openalex.org/W2138166636","https://openalex.org/W2139703487","https://openalex.org/W2145548796","https://openalex.org/W2157884682","https://openalex.org/W2403776418","https://openalex.org/W2434958168","https://openalex.org/W2570028491","https://openalex.org/W2616109717","https://openalex.org/W2618781635","https://openalex.org/W2777028862","https://openalex.org/W2796837100","https://openalex.org/W2799441447","https://openalex.org/W2802395404","https://openalex.org/W2884138168","https://openalex.org/W2995230297","https://openalex.org/W3177602305"],"related_works":["https://openalex.org/W4402824595","https://openalex.org/W4406303347","https://openalex.org/W4313490820","https://openalex.org/W4413964963","https://openalex.org/W2913317871","https://openalex.org/W4387734807","https://openalex.org/W2006877588","https://openalex.org/W7110562316","https://openalex.org/W4290960128","https://openalex.org/W2460671768"],"abstract_inverted_index":{"Hydroxyapatite-coated":[0],"titanium":[1,219],"alloys":[2,102],"have":[3,33],"been":[4],"a":[5,54,80,177,206,216],"popular":[6],"choice":[7],"as":[8],"bone":[9,77,184,223],"implants":[10],"for":[11,14,43,226],"load-bearing":[12,227],"applications":[13],"the":[15,29,36,51,67,94,129,139,143,146,158,167,189,203,222],"compositional":[16],"similarity":[17],"of":[18,38,53,110,142,155,169,205,208],"hydroxyapatite":[19,30,64,89],"to":[20,35,49,103,124,137],"natural":[21,209],"bone.":[22],"The":[23,114,150],"limited":[24],"osteoinductive":[25],"properties":[26,106],"exhibited":[27],"by":[28,93,166,188],"(HA)":[31],"coatings":[32,65,90],"led":[34],"incorporation":[37,168],"growth":[39],"factor":[40],"or":[41],"dopants":[42],"improved":[44,182],"osseointegration.":[45],"This":[46],"study":[47],"aims":[48],"investigate":[50],"effects":[52,127],"naturally":[55,212],"occurring":[56,213],"aloe":[57],"vera":[58],"gel":[59],"extract,":[60],"acemannan,":[61],"in":[62,68,74,79,130,171,194,215],"doped":[63,115,217],"on":[66,100,128,221],"vitro":[69,172],"osteoblast":[70,163],"cell":[71,164],"viability":[72,165],"and":[73,87,135,181,191,211],"vivo":[75,131],"new":[76,183],"formation":[78,185],"rat":[81],"distal":[82],"femur":[83],"model.":[84],"Silver":[85],"oxide":[86],"silica-doped":[88],"were":[91],"developed":[92],"induction":[95,109],"plasma":[96],"spray":[97],"coating":[98,116,193],"method":[99],"Ti":[101],"introduce":[104],"antibacterial":[105],"along":[107],"with":[108,122,161,176],"angiogenic":[111],"properties,":[112],"respectively.":[113],"was":[117,186],"further":[118],"consecutively":[119],"dip":[120],"coated":[121],"acemannan":[123,144,156,170,190],"analyze":[125],"its":[126],"early":[132],"stage":[133],"osseointegration":[134,175],"chitosan":[136,159,192],"control":[138],"burst":[140],"release":[141,154],"from":[145,157],"calcium":[147],"phosphate":[148],"matrix.":[149],"results":[151,201],"show":[152],"controlled":[153],"coatings,":[160],"enhanced":[162],".":[173],"Improved":[174],"seamless":[178],"implant":[179,220],"interface":[180],"noted":[187],"vivo,":[195],"5":[196],"weeks":[197],"after":[198],"implantation.":[199],"Our":[200],"demonstrate":[202],"efficacy":[204],"combination":[207],"medicine":[210],"polymer":[214],"hydroxyapatite-coated":[218],"tissue":[224],"regeneration":[225],"orthopedic":[228],"applications.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-27T00:00:00"}
