{"id":"https://openalex.org/W2949039012","doi":null,"title":"Reliable biomarkers for clinical forms of multiple sclerosis: development of personalized strategies based on IFN type I immnue signature.","display_name":"Reliable biomarkers for clinical forms of multiple sclerosis: development of personalized strategies based on IFN type I immnue signature.","publication_year":2013,"publication_date":"2013-04-10","ids":{"openalex":"https://openalex.org/W2949039012","mag":"2949039012"},"language":"en","primary_location":{"id":"pmh:oai:dnet:eprintscompl::ae354dd4d6e0b54461c67ca05b926854","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","pdf_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076256234","display_name":"Marta Tejera\u2010Alhambra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marta Tejera Alhambra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076256234"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.9179999828338623},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7379999756813049},{"id":"https://openalex.org/keywords/interferon-therapy-response","display_name":"interferon therapy response","score":0.5989999771118164},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.7099999785423279},{"id":"https://openalex.org/keywords/clinical-disability","display_name":"clinical disability","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8690000176429749},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.748058021068573},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5956205129623413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5889959931373596},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.5342122316360474},{"id":"https://openalex.org/C110015553","wikidata":"https://www.wikidata.org/wiki/Q5009623","display_name":"CCL3","level":5,"score":0.44290050864219666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4425995647907257},{"id":"https://openalex.org/C2780590879","wikidata":"https://www.wikidata.org/wiki/Q5009606","display_name":"CCL11","level":5,"score":0.4403200149536133},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4273117780685425},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42091548442840576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41988372802734375},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41794317960739136},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.3708103895187378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22976145148277283},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1931881308555603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:eprintscompl::ae354dd4d6e0b54461c67ca05b926854","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","pdf_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/517800","doi":null,"is_oa":false,"landing_page_url":"http://eprints.ucm.es/22340/1/T34632.pdf","pdf_url":"http://eprints.ucm.es/22340/1/T34632.pdf","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.ucm.es:22340","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ucm.es/22340/1/T34632.pdf","pdf_url":"https://eprints.ucm.es/22340/1/T34632.pdf","source":{"id":"https://openalex.org/S4377196321","display_name":"Docta Complutense (Universidad Complutense de Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121748325","host_organization_name":"Universidad Complutense de Madrid","host_organization_lineage":["https://openalex.org/I121748325"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2949039012","doi":null,"is_oa":false,"landing_page_url":"https://eprints.ucm.es/id/eprint/22340/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:eprintscompl::ae354dd4d6e0b54461c67ca05b926854","doi":null,"is_oa":true,"landing_page_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","pdf_url":"https://eprints.ucm.es/id/eprint/22340/1/T34632.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7052323766","https://openalex.org/W2193966886","https://openalex.org/W7100566869","https://openalex.org/W2509248415","https://openalex.org/W25256083","https://openalex.org/W2519972260","https://openalex.org/W2066629315","https://openalex.org/W2099906640","https://openalex.org/W3010374237","https://openalex.org/W3032082124"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3],"a":[4,54,150],"highly":[5],"heterogeneous":[6],"disease":[7],"and":[8,40,63,77,95,109,119,121,133,147,149],"to":[9,16,74,137],"date":[10],"reliable":[11],"plasma":[12,68,145],"biomarkers":[13,33],"that":[14,44,91],"enable":[15],"distinguish":[17],"among":[18],"the":[19,67,92],"different":[20,123],"clinical":[21,83,94],"forms":[22,98],"of":[23,58,69,104,129,144,154],"MS":[24,38,70,97],"are":[25,99],"lacking.":[26],"The":[27],"present":[28],"work":[29],"has":[30],"identified":[31],"blood":[32],"in":[34,66,86,127],"182":[35],"subjects":[36],"(129":[37],"patients":[39,71,130,136],"53":[41],"healthy":[42,75],"controls)":[43],"were":[45],"consecutively":[46],"recruited":[47],"as":[48],"two":[49],"independent":[50],"cohorts.":[51],"We":[52],"found":[53],"significant":[55],"lower":[56],"expression":[57,125,152],"dipeptydil":[59],"peptidase":[60],"4":[61],"(DPP4)":[62],"DPP":[64,78],"activity":[65,79],"with":[72,82,101,122],"respect":[73],"controls":[76],"correlated":[80],"inversely":[81],"disability":[84],"score":[85],"MS.":[87],"Our":[88],"results":[89],"demonstrate":[90],"divergent":[93],"histology-based":[96],"associated":[100],"distinct":[102],"profiles":[103],"circulating":[105],"biomarkers,":[106],"mostly":[107],"chemokines":[108],"growth/angiogenic":[110],"factors":[111],"(HGF,":[112],"Eotaxin/CCL11,":[113],"MCP-1/CCL2,":[114],"Rantes/CCL5,":[115],"EGF,":[116],"MIP-1\u03b2/CCL4,":[117],"VEGF":[118],"FGFb);":[120],"gene":[124],"levels":[126,143],"PBMCs":[128],"(CLU,":[131],"IRF2":[132],"LDLR).":[134],"Responder":[135],"type":[138],"I":[139],"IFN":[140,155],"displayed":[141],"high":[142],"IP10":[146],"MCP-1,":[148],"specific":[151],"pattern":[153],"stimulated":[156],"genes.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-14T00:00:00"}