{"id":"https://openalex.org/W2948979050","doi":"https://doi.org/10.2337/db19-597-p","title":"597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity","display_name":"597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2948979050","doi":"https://doi.org/10.2337/db19-597-p","mag":"2948979050"},"language":"en","primary_location":{"id":"doi:10.2337/db19-597-p","doi":"https://doi.org/10.2337/db19-597-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db19-597-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088935382","display_name":"Hisashi Yokomizo","orcid":"https://orcid.org/0000-0001-7759-2014","observed_orcids":["https://orcid.org/0000-0001-7759-2014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HISASHI YOKOMIZO","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002689577","display_name":"Kyoungmin Park","orcid":"https://orcid.org/0000-0003-0772-1217","observed_orcids":["https://orcid.org/0000-0003-0772-1217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KYOUNGMIN PARK","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073527313","display_name":"Allen C. Clermont","orcid":"https://orcid.org/0009-0000-5939-5754","observed_orcids":["https://orcid.org/0009-0000-5939-5754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALLEN CLERMONT","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056748713","display_name":"Yasutaka Maeda","orcid":"https://orcid.org/0000-0002-3259-5622","observed_orcids":["https://orcid.org/0000-0002-3259-5622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YASUTAKA MAEDA","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090972762","display_name":"Ward Fickweiler","orcid":"https://orcid.org/0000-0002-6807-2532","observed_orcids":["https://orcid.org/0000-0002-6807-2532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WARD FICKWEILER","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088284813","display_name":"Atsushi Ishikado","orcid":"https://orcid.org/0000-0001-9329-8608","observed_orcids":["https://orcid.org/0000-0001-9329-8608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ATSUSHI ISHIKADO","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340644","display_name":"Qian Li","orcid":"https://orcid.org/0000-0003-0359-5604","observed_orcids":["https://orcid.org/0000-0003-0359-5604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"QIAN LI","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043369754","display_name":"Chih\u2010Hao Wang","orcid":"https://orcid.org/0000-0003-1704-1311","observed_orcids":["https://orcid.org/0000-0003-1704-1311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHIH-HAO WANG","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068109132","display_name":"DAVID M. POBER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID M. POBER","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040787267","display_name":"I\u2010Hsien Wu","orcid":"https://orcid.org/0000-0002-2563-7505","observed_orcids":["https://orcid.org/0000-0002-2563-7505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I-HSIEN WU","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020601596","display_name":"Hillary A. Keenan","orcid":"https://orcid.org/0000-0003-4172-5537","observed_orcids":["https://orcid.org/0000-0003-4172-5537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HILLARY A. KEENAN","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042011351","display_name":"Lloyd Paul Aiello","orcid":"https://orcid.org/0000-0003-2012-3465","observed_orcids":["https://orcid.org/0000-0003-2012-3465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LLOYD P. AIELLO","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011697010","display_name":"Jennifer K. Sun","orcid":"https://orcid.org/0000-0003-0915-6303","observed_orcids":["https://orcid.org/0000-0003-0915-6303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JENNIFER K. SUN","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009528569","display_name":"George Liang King","orcid":"https://orcid.org/0000-0002-0335-5881","observed_orcids":["https://orcid.org/0000-0002-0335-5881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GEORGE L. KING","raw_affiliation_strings":["Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA, Fukuoka, Japan, Takatsuki, Japan, Cambridge, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2471,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55977648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"68","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.968999981880188},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.7450000047683716},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.968999981880188},{"id":"https://openalex.org/keywords/photoreceptors","display_name":"photoreceptors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/vitreous-body","display_name":"vitreous humor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/retinol-binding-protein-4","display_name":"retinol-binding protein 4","score":0.6499999761581421},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.6269999742507935},{"id":"https://openalex.org/keywords/retinal-endothelial-cells","display_name":"retinal endothelial cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8560000061988831},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.878000020980835},{"id":"https://openalex.org/keywords/acellular-capillaries","display_name":"acellular capillaries","score":0.671999990940094},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7587388753890991},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.7470721006393433},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6368962526321411},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6095282435417175},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.597999095916748},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5975790023803711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.594235360622406},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.5482209920883179},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5025200843811035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45211848616600037},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4400443732738495},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.4349508583545685},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4217737019062042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3376939594745636},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.20160377025604248},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.17807534337043762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16276326775550842},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09843239188194275},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/db19-597-p","doi":"https://doi.org/10.2337/db19-597-p","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db19-597-p","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2953417534","https://openalex.org/W2809050655","https://openalex.org/W3176111765","https://openalex.org/W2948836840","https://openalex.org/W3034920371","https://openalex.org/W4293073786","https://openalex.org/W4407392454","https://openalex.org/W4281845072","https://openalex.org/W4285793671","https://openalex.org/W7168173699"],"abstract_inverted_index":{"The":[0],"Joslin":[1],"Medalist":[2,42],"study":[3],"reported":[4],"that":[5,47],"after":[6],"having":[7],"type":[8],"1":[9],"diabetes":[10],"(T1D)":[11],"for":[12,214],">":[13],"50":[14],"years,":[15],"over":[16],"35%":[17],"of":[18,28,33,41,70,94,100,113,130,136,142,160,168,205,250,427],"Medalists":[19,75],"exhibit":[20],"no":[21],"to":[22,102,181,216],"mild":[23],"diabetic":[24,116],"retinopathy":[25],"(DR)":[26],"independent":[27],"glycemic":[29],"control,":[30],"suggesting":[31],"presence":[32],"endogenous":[34],"protective":[35],"factors":[36],"against":[37],"DR.":[38,62,104,253],"Proteomic":[39],"analysis":[40],"retina":[43],"and":[44,76,79,106,115,121,132,134,164,166,172,198,201,207,223,230,235,241,292,429,431],"vitreous":[45,72,84],"found":[46],"Retinol":[48],"Binding":[49],"Protein":[50],"3":[51],"(RBP3),":[52],"secreted":[53],"by":[54,67],"photoreceptors,":[55],"is":[56],"elevated":[57,92],"in":[58,111,154,183,220,252],"individuals":[59],"protected":[60],"from":[61,74],"This":[63],"finding":[64],"was":[65],"confirmed":[66],"RBP3":[68,110,144,190,215,251],"ELISA":[69],"replicate":[71],"samples":[73],"other":[77],"T1D":[78],"T2D":[80],"individuals.":[81],"In":[82],"contrast,":[83],"VEGF":[85,119,131,206,225],"concentrations":[86],"increased":[87,153],"with":[88,98],"DR":[89,242],"severity.":[90],"Thus,":[91],"ratios":[93],"intravitreous":[95],"RBP3/VEGF":[96],"correlated":[97],"lack":[99],"progression":[101],"advanced":[103],"Intervention":[105],"prevention":[107],"studies":[108],"overexpressing":[109],"retina/photoreceptors":[112],"nondiabetic":[114],"animals":[117],"inhibited":[118,151,192],"actions":[120,213],"normalized":[122],"diabetes-induced":[123,233],"retinal":[124,169,196,221,237],"capillary":[125],"permeability,":[126],"neuro-retinal":[127],"dysfunctions,":[128],"expressions":[129],"IL-6,":[133],"formation":[135],"acellular":[137],"capillaries.":[138],"Mechanistically,":[139],"physiological":[140,188],"levels":[141],"recombinant":[143],"(10-100nM),":[145],"but":[146,176],"not":[147,177],"RBP4":[148],"or":[149],"FGF,":[150],"the":[152],"VEGFR2":[155,182],"tyrosine":[156],"phosphorylation,":[157],"hyperglycemia-induced":[158],"expression":[159,204],"pro-inflammatory":[161],"cytokines":[162],"(VEGF":[163],"IL-6),":[165],"migration":[167],"endothelial":[170,197],"cells":[171,222],"M\u00fcller":[173,199],"cells.":[174],"RBP3,":[175],"RBP4,":[178],"physically":[179],"bound":[180],"cross":[184],"linkage":[185],"studies.":[186],"At":[187],"levels,":[189],"significantly":[191],"glucose":[193,218],"uptake":[194,219],"into":[195],"cells,":[200],"subsequently":[202],"decreased":[203],"IL-6.":[208],"These":[209,244],"results":[210],"suggest":[211],"novel":[212],"slow":[217],"inhibit":[224],"actions,":[226],"thereby":[227],"preventing,":[228],"delaying":[229],"even":[231],"arresting":[232],"neuro-":[234],"vascular":[236],"dysfunction,":[238],"inflammatory":[239],"abnormalities":[240],"pathologies.":[243],"findings":[245],"strongly":[246],"support":[247],"therapeutic":[248],"potential":[249],"Disclosure":[254],"H.":[255],"Yokomizo:":[256],"None.":[257,260,329,342,345,348,351],"K.":[258],"Park:":[259],"A.":[261,330],"Clermont:":[262],"Consultant;":[263,366],"Self;":[264,272,278,333,355,362,367,378,384,390,406,419],"KalVista":[265,371,379,399],"Pharmaceuticals,":[266,372,380,400],"Inc.":[267,275,335,339,381,414],"Y.":[268],"Maeda:":[269],"Research":[270,388,417],"Support;":[271,389,418],"Abbott,":[273,279],"Arkray,":[274,280],"Speaker's":[276],"Bureau;":[277],"Inc.,":[281,284,312,373,398,401,408],"Astellas":[282],"Pharma":[283,305,316],"AstraZeneca,":[285],"Daiichi":[286],"Sankyo":[287],"Company,":[288,293],"Limited,":[289],"Eli":[290],"Lilly":[291],"Kissei":[294],"Pharmaceutical":[295,321],"Co.,":[296,301,317,322],"Ltd.,":[297,302,318,323],"Kyowa":[298],"Hakko":[299],"Kirin":[300],"Mitsubishi":[303],"Tanabe":[304],"Corporation,":[306,309,396,411],"Novartis":[307,409],"Pharmaceuticals":[308,410],"Novo":[310,363,412],"Nordisk":[311,364,413],"Sanofi,":[313],"Sumitomo":[314],"Dainippon":[315],"Taisho":[319],"Toyama":[320],"Terumo":[324],"Medical":[325],"Corporation.":[326],"W.":[327],"Fickweiler:":[328],"Ishikado:":[331],"Employee;":[332,336,354],"SunStar":[334,338],"Spouse/Partner;":[337],"Q.":[340],"Li:":[341],"C.":[343],"Wang:":[344],"D.M.":[346],"Pober:":[347],"I.":[349],"Wu:":[350],"H.A.":[352],"Keenan:":[353],"Sanofi":[356],"Genzyme.":[357],"L.P.":[358],"Aiello:":[359],"Advisory":[360],"Panel;":[361],"A/S.":[365],"Decision":[368],"Resources":[369],"Group,":[370],"Mingsight,":[374],"Retinal":[375],"Solutions.":[376],"Stock/Shareholder;":[377],"Other":[382,404],"Relationship;":[383,405],"Optos.":[385],"J.K.":[386],"Sun:":[387],"Adaptive":[391],"Sensory":[392],"Technology,":[393],"Boston":[394],"Micromachines":[395],"Genentech,":[397,407],"Optovue,":[402],"Incorporated.":[403],"G.L.":[415],"King:":[416],"Sanofi.":[420],"Funding":[421],"National":[422,425],"Eye":[423],"Institute;":[424],"Institute":[426],"Diabetes":[428],"Digestive":[430],"Kidney":[432],"Diseases;":[433],"JDRF;":[434],"Thomas":[435],"J.":[436],"Beatson,":[437],"Jr.":[438],"Foundation":[439],"Inc.;":[440],"Dianne":[441],"Nunnally":[442],"Hoppes":[443],"Scholarship":[444],"Fund":[445]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-06-14T00:00:00"}