{"id":"https://openalex.org/W2948757546","doi":"https://doi.org/10.3390/pharmaceutics11060265","title":"Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis","display_name":"Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis","publication_year":2019,"publication_date":"2019-06-07","ids":{"openalex":"https://openalex.org/W2948757546","doi":"https://doi.org/10.3390/pharmaceutics11060265","mag":"2948757546","pmid":"https://pubmed.ncbi.nlm.nih.gov/31181662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6631119"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics11060265","doi":"https://doi.org/10.3390/pharmaceutics11060265","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11060265","pdf_url":"https://www.mdpi.com/1999-4923/11/6/265/pdf?version=1559901401","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/11/6/265/pdf?version=1559901401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Richard G. Pearson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard G. Pearson","raw_affiliation_strings":["Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002252858","display_name":"Tahir Masud","orcid":"https://orcid.org/0000-0003-1061-2898","observed_orcids":["https://orcid.org/0000-0003-1061-2898"]},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tahir Masud","raw_affiliation_strings":["Nottingham University Hospitals NHS Trust, Queen\u2019s Med Centre, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nottingham University Hospitals NHS Trust, Queen\u2019s Med Centre, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I1334287468","https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110154543","display_name":"Elaine Blackshaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elaine Blackshaw","raw_affiliation_strings":["Radiological Sciences, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiological Sciences, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103411826","display_name":"Andrew Naylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Naylor","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112441318","display_name":"Michael Hinchcliffe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hinchcliffe","raw_affiliation_strings":["Paracelsis Ltd., BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paracelsis Ltd., BioCity Nottingham, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010554654","display_name":"Kirk Jeffery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirk Jeffery","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059069502","display_name":"Faron Jordan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faron Jordan","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047769209","display_name":"Anjumn Shabir-Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anjumn Shabir-Ahmed","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088912981","display_name":"Gareth King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth King","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew L. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146833","display_name":"Critical Pharmaceuticals (United Kingdom)","ror":"https://ror.org/04hw63k11","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210146833"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew L. Lewis","raw_affiliation_strings":["Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Pharmaceuticals Ltd., Bio City, Pennyfoot Street, Nottingham NG1 1GF, UK","institution_ids":["https://openalex.org/I4210146833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057809897","display_name":"Lisbeth Illum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisbeth Illum","raw_affiliation_strings":["Identity, 19 Cavendish Crescent North, The Park, Nottingham NG71BA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Identity, 19 Cavendish Crescent North, The Park, Nottingham NG71BA, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086810315","display_name":"Alan Christopher Perkins","orcid":"https://orcid.org/0000-0002-1054-8200","observed_orcids":["https://orcid.org/0000-0002-1054-8200"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan C. Perkins","raw_affiliation_strings":["Radiological Sciences, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK"],"raw_orcid":"https://orcid.org/0000-0002-1054-8200","affiliations":[{"raw_affiliation_string":"Radiological Sciences, School of Medicine, Queen\u2019s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1621},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1621},"fwci":1.5721,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.78475495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"6","first_page":"265","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone-1-34","display_name":"parathyroid hormone (1-34)","score":0.949999988079071},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/plasma-pharmacokinetics","display_name":"plasma pharmacokinetics","score":0.7990000247955322},{"id":"https://openalex.org/keywords/solutol-hs-15","display_name":"Solutol HS15","score":0.847000002861023},{"id":"https://openalex.org/keywords/penetration-enhancers","display_name":"penetration enhancers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/relative-bioavailability","display_name":"relative bioavailability","score":0.7149999737739563},{"id":"https://openalex.org/keywords/teriparatide","display_name":"teriparatide","score":0.9049999713897705},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nasal-spray-formulation","display_name":"nasal spray formulation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.6129999756813049},{"id":"https://openalex.org/keywords/human-volunteers","display_name":"human volunteers","score":0.47600001096725464},{"id":"https://openalex.org/keywords/peptide-absorption","display_name":"peptide absorption","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8126776218414307},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.803493082523346},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5683729648590088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5661441087722778},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4958208501338959},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.48237481713294983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4504205286502838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43289855122566223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33560365438461304},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.18348988890647888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1076275110244751}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/pharmaceutics11060265","doi":"https://doi.org/10.3390/pharmaceutics11060265","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11060265","pdf_url":"https://www.mdpi.com/1999-4923/11/6/265/pdf?version=1559901401","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5647264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6631119","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6631119","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6631119","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:31181662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31181662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:nottingham-repository.worktribe.com:2290692","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics11060265","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:2290692","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/2290692","pdf_url":"https://nottingham-repository.worktribe.com/file/2290692/1/Nasal%20Administration%20and%20Plasma%20Pharmacokinetics%20of%20Parathyroid%20Hormone%20Peptide%20PTH%201-34%20for%20the%20Treatment%20of%20Osteoporosis","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:835f2d5b3a3e42739c1270f537c2dac0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/835f2d5b3a3e42739c1270f537c2dac0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 11, Iss 6, p 265 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics11060265","doi":"https://doi.org/10.3390/pharmaceutics11060265","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics11060265","pdf_url":"https://www.mdpi.com/1999-4923/11/6/265/pdf?version=1559901401","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G59803654","display_name":null,"funder_award_id":"EP/K503800/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G611548505","display_name":"PTH nasal delivery for the treatment of osteoporosis - TSB NINTTO","funder_award_id":"EP/K502364/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7951947572","display_name":null,"funder_award_id":"17223-124195","funder_id":"https://openalex.org/F4320320098","funder_display_name":"Technology Strategy Board"}],"funders":[{"id":"https://openalex.org/F4320320098","display_name":"Technology Strategy Board","ror":"https://ror.org/05ar5fy68"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2948757546.pdf","grobid_xml":"https://content.openalex.org/works/W2948757546.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1506863052","https://openalex.org/W1963762209","https://openalex.org/W1970846552","https://openalex.org/W1975141618","https://openalex.org/W1979192533","https://openalex.org/W1981095257","https://openalex.org/W1990119473","https://openalex.org/W1994848292","https://openalex.org/W1996374439","https://openalex.org/W1998394352","https://openalex.org/W2003078882","https://openalex.org/W2037869134","https://openalex.org/W2045670750","https://openalex.org/W2063915040","https://openalex.org/W2070093255","https://openalex.org/W2078218165","https://openalex.org/W2083537472","https://openalex.org/W2095249465","https://openalex.org/W2104357139","https://openalex.org/W2123533552","https://openalex.org/W2127787997","https://openalex.org/W2132810818","https://openalex.org/W2136084437","https://openalex.org/W2138024965","https://openalex.org/W2149386903","https://openalex.org/W2154625272","https://openalex.org/W2155981252","https://openalex.org/W2377613110","https://openalex.org/W2491280414","https://openalex.org/W2570418334","https://openalex.org/W2764181784","https://openalex.org/W2796812033","https://openalex.org/W2896129998","https://openalex.org/W2898436207"],"related_works":["https://openalex.org/W2764181784","https://openalex.org/W2171359294","https://openalex.org/W3134400052","https://openalex.org/W1979936959","https://openalex.org/W2155981252","https://openalex.org/W2254617212","https://openalex.org/W1970846552","https://openalex.org/W16145474","https://openalex.org/W2799849182","https://openalex.org/W65098186"],"abstract_inverted_index":{"Nasal":[0],"delivery":[1],"of":[2,66,105,139,157,168,202,216,250,252,257,262],"large":[3],"peptides":[4,253],"such":[5],"as":[6,174,176],"parathyroid":[7],"1-34":[8,68,220],"(PTH":[9],"1-34)":[10],"can":[11],"benefit":[12],"from":[13,265],"a":[14,40,46,86,177,187],"permeation":[15,53],"enhancer":[16,54],"to":[17,36,237,268],"promote":[18],"absorption":[19],"across":[20],"the":[21,25,52,63,74,103,106,110,116,148,158,166,169,199,245,255],"nasal":[22,48,76,107,111,149,159,171,180,206],"mucosa":[23],"into":[24],"bloodstream.":[26],"Previously,":[27],"we":[28,164],"have":[29,241],"published":[30,231],"an":[31,191],"encouraging":[32],"bioavailability":[33,156,201,215],"(78%),":[34],"relative":[35,155,200],"subcutaneous":[37,93,152],"injection":[38,94,153],"in":[39,69,109,186,190,225,228,244,260],"small":[41],"animal":[42,266],"preclinical":[43,197],"model,":[44,198],"for":[45,85,147,234,247,254],"liquid":[47,75,170,203],"spray":[49,77,108,150,160,172],"formulation":[50,78,90,173,181],"containing":[51,79,183],"polyethylene":[55],"glycol":[56],"(15)-hydroxystearate":[57],"(Solutol\u00ae":[58],"HS15).":[59],"We":[60],"report":[61],"here":[62],"plasma":[64,137],"pharmacokinetics":[65,167],"PTH":[67,134,219],"healthy":[70],"human":[71,232],"volunteers":[72],"receiving":[73],"Solutol\u00ae":[80,184],"HS15.":[81],"For":[82,133],"comparison,":[83],"data":[84,233],"commercially":[87],"manufactured":[88],"teriparatide":[89,235],"delivered":[91],"via":[92,115],"pen":[95],"are":[96],"also":[97,182],"presented.":[98],"Tc-99m-DTPA":[99],"gamma":[100],"scintigraphy":[101],"monitored":[102],"deposition":[104],"cavity":[112],"and":[113,119,142,151,204,210,259],"clearance":[114,123],"inferior":[117],"meatus":[118],"nasopharynx.":[120],"The":[121,213],"50%":[122],"time":[124],"was":[125,161,208,227],"17.8":[126],"min":[127],"(minimum":[128],"10.9,":[129],"maximum":[130],"74.3":[131],"min).":[132],"1-34,":[135],"mean":[136],"Cmax":[138],"5":[140],"pg/mL":[141,144],"253":[143],"were":[145],"obtained":[146],"respectively;":[154],"\u22641%.":[162],"Subsequently,":[163],"investigated":[165],"well":[175],"dry":[178],"powder":[179,205],"HS15":[185],"crossover":[188],"study":[189],"established":[192],"ovine":[193],"model.":[194],"In":[195],"this":[196],"formulations":[207],"1.4%":[209],"1.0%":[211],"respectively.":[212],"absolute":[214],"subcutaneously":[217],"administered":[218],"(mean":[221],"77%,":[222],"range":[223],"55\u2013108%)":[224],"sheep":[226],"agreement":[229],"with":[230],"(up":[236],"95%).":[238],"These":[239],"findings":[240],"important":[242],"implications":[243],"search":[246],"alternative":[248],"routes":[249],"administration":[251],"treatment":[256],"osteoporosis,":[258],"terms":[261],"improving":[263],"translation":[264],"models":[267],"humans.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-06-14T00:00:00"}