{"id":"https://openalex.org/W2948752663","doi":"https://doi.org/10.1172/jci124099","title":"Systemic silencing of Phd2 causes reversible immune regulatory dysfunction","display_name":"Systemic silencing of Phd2 causes reversible immune regulatory dysfunction","publication_year":2019,"publication_date":"2019-06-04","ids":{"openalex":"https://openalex.org/W2948752663","doi":"https://doi.org/10.1172/jci124099","mag":"2948752663","pmid":"https://pubmed.ncbi.nlm.nih.gov/31162141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6715380"},"language":"en","primary_location":{"id":"doi:10.1172/jci124099","doi":"https://doi.org/10.1172/jci124099","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci124099","pdf_url":"http://www.jci.org/articles/view/124099/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jci.org/articles/view/124099/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103203494","display_name":"Atsushi Yamamoto","orcid":"https://orcid.org/0000-0003-0120-1982","observed_orcids":["https://orcid.org/0000-0003-0120-1982"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Atsushi Yamamoto","raw_affiliation_strings":["Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054080684","display_name":"Joanna Hester","orcid":"https://orcid.org/0000-0002-7466-3849","observed_orcids":["https://orcid.org/0000-0002-7466-3849"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna Hester","raw_affiliation_strings":["Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7466-3849","affiliations":[{"raw_affiliation_string":"Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081904410","display_name":"Philip S. Macklin","orcid":"https://orcid.org/0000-0002-7750-3242","observed_orcids":["https://orcid.org/0000-0002-7750-3242"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip S. Macklin","raw_affiliation_strings":["Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7750-3242","affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031403893","display_name":"Kento Kawai","orcid":"https://orcid.org/0000-0003-2019-7210","observed_orcids":["https://orcid.org/0000-0003-2019-7210"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kento Kawai","raw_affiliation_strings":["Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066152525","display_name":"Masateru Uchiyama","orcid":"https://orcid.org/0000-0002-7294-6706","observed_orcids":["https://orcid.org/0000-0002-7294-6706"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Masateru Uchiyama","raw_affiliation_strings":["Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110649190","display_name":"Daniel Biggs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Biggs","raw_affiliation_strings":["Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001073008","display_name":"Tammie Bishop","orcid":"https://orcid.org/0000-0003-3308-9139","observed_orcids":["https://orcid.org/0000-0003-3308-9139"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tammie Bishop","raw_affiliation_strings":["Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072903300","display_name":"Katherine R. Bull","orcid":"https://orcid.org/0000-0003-0656-0917","observed_orcids":["https://orcid.org/0000-0003-0656-0917"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katherine Bull","raw_affiliation_strings":["Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-0656-0917","affiliations":[{"raw_affiliation_string":"Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111679169","display_name":"Xiaotong Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xiaotong Cheng","raw_affiliation_strings":["Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062516284","display_name":"Eleanor Cawthorne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleanor Cawthorne","raw_affiliation_strings":["Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078351589","display_name":"Mathew L. Coleman","orcid":"https://orcid.org/0000-0001-6020-9023","observed_orcids":["https://orcid.org/0000-0001-6020-9023"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mathew L. Coleman","raw_affiliation_strings":["Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061788017","display_name":"Tanya L. Crockford","orcid":"https://orcid.org/0009-0009-2343-4841","observed_orcids":["https://orcid.org/0009-0009-2343-4841"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tanya L. Crockford","raw_affiliation_strings":["Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037395026","display_name":"Benjamin Davies","orcid":"https://orcid.org/0000-0003-3623-600X","observed_orcids":["https://orcid.org/0000-0003-3623-600X"]},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Davies","raw_affiliation_strings":["Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3623-600X","affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021011616","display_name":"Lukas E. Dow","orcid":"https://orcid.org/0000-0001-7048-1418","observed_orcids":["https://orcid.org/0000-0001-7048-1418"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukas E. Dow","raw_affiliation_strings":["Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-7048-1418","affiliations":[{"raw_affiliation_string":"Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053096526","display_name":"Robert David Goldin","orcid":"https://orcid.org/0000-0001-5184-4519","observed_orcids":["https://orcid.org/0000-0001-5184-4519"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rob Goldin","raw_affiliation_strings":["Department of Cellular Pathology, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058085497","display_name":"Kamil R. Kranc","orcid":"https://orcid.org/0000-0001-7547-4989","observed_orcids":["https://orcid.org/0000-0001-7547-4989","https://orcid.org/0009-0001-9522-6437"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kamil Kranc","raw_affiliation_strings":["MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7547-4989","affiliations":[{"raw_affiliation_string":"MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210108209","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078157114","display_name":"Hiromi Kudo","orcid":"https://orcid.org/0000-0003-4313-7165","observed_orcids":["https://orcid.org/0000-0003-4313-7165"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hiromi Kudo","raw_affiliation_strings":["Department of Cellular Pathology, Imperial College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4313-7165","affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051710302","display_name":"Hannah Lawson","orcid":"https://orcid.org/0000-0003-1450-1343","observed_orcids":["https://orcid.org/0000-0003-1450-1343","https://orcid.org/0009-0000-4129-0014"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Lawson","raw_affiliation_strings":["MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210108209","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030027454","display_name":"James McAuliffe","orcid":"https://orcid.org/0000-0002-4858-3191","observed_orcids":["https://orcid.org/0000-0002-4858-3191","https://orcid.org/0000-0002-5471-8638"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106789","display_name":"Ludwig Cancer Research","ror":"https://ror.org/01e473h50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210106789","https://openalex.org/I4210150094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James McAuliffe","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210106789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080584063","display_name":"Kate F. Milward","orcid":"https://orcid.org/0000-0003-3019-4443","observed_orcids":["https://orcid.org/0000-0003-3019-4443"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Milward","raw_affiliation_strings":["Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044637749","display_name":"Cheryl L. Scudamore","orcid":"https://orcid.org/0000-0002-7101-1714","observed_orcids":["https://orcid.org/0000-0002-7101-1714"]},"institutions":[{"id":"https://openalex.org/I4210086857","display_name":"Mary Lyon Centre at MRC Harwell","ror":"https://ror.org/0001h1y25","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210086857","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cheryl L. Scudamore","raw_affiliation_strings":["Veterinary Pathology, MRC Harwell, Mary Lyon Centre, Harwell Campus, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Pathology, MRC Harwell, Mary Lyon Centre, Harwell Campus, Oxford, United Kingdom","institution_ids":["https://openalex.org/I4210086857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062739895","display_name":"Elizabeth J. Soilleux","orcid":"https://orcid.org/0000-0002-4032-7249","observed_orcids":["https://orcid.org/0000-0002-4032-7249"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Soilleux","raw_affiliation_strings":["Department of Pathology, School of Biological Sciences, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4032-7249","affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Biological Sciences, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050961321","display_name":"Fadi Issa","orcid":"https://orcid.org/0000-0002-8279-7732","observed_orcids":["https://orcid.org/0000-0002-8279-7732"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fadi Issa","raw_affiliation_strings":["Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-8279-7732","affiliations":[{"raw_affiliation_string":"Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064727417","display_name":"Peter John Ratcliffe","orcid":"https://orcid.org/0000-0002-2853-806X","observed_orcids":["https://orcid.org/0000-0002-2853-806X"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210106789","display_name":"Ludwig Cancer Research","ror":"https://ror.org/01e473h50","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210106789","https://openalex.org/I4210150094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter J. Ratcliffe","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","The Francis Crick Institute, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2853-806X","affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210106789"]},{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023595055","display_name":"Christopher William Pugh","orcid":"https://orcid.org/0000-0002-5170-1662","observed_orcids":["https://orcid.org/0000-0002-5170-1662"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Chris W. Pugh","raw_affiliation_strings":["Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-5170-1662","affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5023595055"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5019,"currency":"EUR","value_usd":5412},"fwci":1.8565,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84176088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"129","issue":"9","first_page":"3640","last_page":"3656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolyl-hydroxylase-2","display_name":"prolyl hydroxylase 2","score":0.953000009059906},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hypoxia-signaling","display_name":"hypoxia signaling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hif-stabilization","display_name":"HIF stabilization","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7125866413116455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.672096312046051},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6364949941635132},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6295174956321716},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5959511995315552},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5241820216178894},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5054502487182617},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.46622776985168457},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.4585722088813782},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4236985743045807},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3388108015060425},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3337304890155792},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32843247056007385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2895123362541199},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.23282012343406677},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22052928805351257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21551194787025452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1491723656654358},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099162","descriptor_name":"Endothelial PAS Domain-Containing Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D064799","descriptor_name":"Hypoxia-Inducible Factor-Proline Dioxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064799","descriptor_name":"Hypoxia-Inducible Factor-Proline Dioxygenases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":15,"locations":[{"id":"doi:10.1172/jci124099","doi":"https://doi.org/10.1172/jci124099","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci124099","pdf_url":"http://www.jci.org/articles/view/124099/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6715380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6715380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:31162141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31162141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:130748","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/130748/1/124099.4-20190823124854-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/130748/1/124099.4-20190823124854-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/11550849","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Systemic_silencing_of_Phd2_causes_reversible_immune_regulatory_dysfunction/11550849","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006724899","doi":null,"is_oa":true,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2009508","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:c0a70ea4-e596-45a9-a51b-e0968051aa70","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:c0a70ea4-e596-45a9-a51b-e0968051aa70","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/10cff493-407e-4ac2-a48a-5fc21131b036","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/10cff493-407e-4ac2-a48a-5fc21131b036","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yamamoto, A, Hester, J, Macklin, P S, Kawai, K, Uchiyama, M, Biggs, D, Bishop, T, Bull, K, Cheng, X, Cawthorne, E, Coleman, M L, Crockford, T L, Davies, B, Dow, L E, Goldin, R, Kranc, K, Kudo, H, Lawson, H, McAuliffe, J, Milward, K, Scudamore, C L, Soilleux, E, Issa, F, Ratcliffe, P J & Pugh, C W 2019, 'Systemic silencing of PHD2 causes reversible immune regulatory dysfunction', Journal of Clinical Investigation, vol. 129, no. 9, 124099, pp. 3640-3656. https://doi.org/10.1172/JCI124099","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/10cff493-407e-4ac2-a48a-5fc21131b036","doi":null,"is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85067174679&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/72249","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/72249","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"3656","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/300213","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/300213","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.47286","doi":"https://doi.org/10.17863/cam.47286","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.47286","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25418/crick.11550849","doi":"https://doi.org/10.25418/crick.11550849","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.11550849","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.25418/crick.11550849.v1","doi":"https://doi.org/10.25418/crick.11550849.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.11550849.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2948499783","doi":null,"is_oa":false,"landing_page_url":"https://www.nds.ox.ac.uk/publications/1008896","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation","raw_type":null}],"best_oa_location":{"id":"doi:10.1172/jci124099","doi":"https://doi.org/10.1172/jci124099","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci124099","pdf_url":"http://www.jci.org/articles/view/124099/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080657738","display_name":null,"funder_award_id":"203141/Z/16/Z.","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G1104134325","display_name":null,"funder_award_id":"24552","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G1186624241","display_name":"Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics","funder_award_id":"203141/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G128354304","display_name":null,"funder_award_id":"AMS-SGCL11-Issa","funder_id":"https://openalex.org/F4320320241","funder_display_name":"Academy of Medical Sciences"},{"id":"https://openalex.org/G1299486252","display_name":null,"funder_award_id":"JFDKcsf1/2017","funder_id":"https://openalex.org/F4320320008","funder_display_name":"Kidney Research UK"},{"id":"https://openalex.org/G1408871713","display_name":"Therapeutic targeting of HIF prolyl hydroxylases in acute myeloid leukaemia","funder_award_id":"MR/P010008/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1925698094","display_name":null,"funder_award_id":"14633","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2167674392","display_name":null,"funder_award_id":"SF1/2014","funder_id":"https://openalex.org/F4320320008","funder_display_name":"Kidney Research UK"},{"id":"https://openalex.org/G292209363","display_name":"An investigation into the genetic and functional basis of proteinuric kidney disease","funder_award_id":"MR/R007748/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2958185063","display_name":null,"funder_award_id":"FC001501","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3049251306","display_name":null,"funder_award_id":"AMS-SGCL13-Bull","funder_id":"https://openalex.org/F4320320241","funder_display_name":"Academy of Medical Sciences"},{"id":"https://openalex.org/G3376882753","display_name":"Personalized minimization of immunosuppression after solid organ transplantation by biomarker-driven stratification of patients to improve long-term outcome and health-economic data of transplantation","funder_award_id":"305147","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3873106536","display_name":null,"funder_award_id":"203141/Z/16/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3922223068","display_name":"Defining a protein hydroxylase tumour suppressor pathway","funder_award_id":"MR/N021053/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4865929298","display_name":"Therapeutic targeting of HIF prolyl hydroxylases in acute myeloid leukaemia","funder_award_id":"MR/P010008/2","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4885137792","display_name":null,"funder_award_id":"FC001501","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5102356368","display_name":null,"funder_award_id":"CL-2013-13-005","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G5114713889","display_name":null,"funder_award_id":"FC001501","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5223915962","display_name":"Investigation of hypoxia-sensing mechanisms in immune regulation","funder_award_id":"211122/Z/18/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5403581575","display_name":"Centre for cardiovascular drug target discovery","funder_award_id":"RG/11/1/28684","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5411179404","display_name":null,"funder_award_id":"26787","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5676441087","display_name":"Defining the physiology and therapeutic potential of oxygenases as signalling enzymes.","funder_award_id":"106241/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5841612952","display_name":null,"funder_award_id":"MGU0418","funder_id":"https://openalex.org/F4320315977","funder_display_name":"Barts Charity"},{"id":"https://openalex.org/G7328908021","display_name":"Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics","funder_award_id":"203141","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8435716022","display_name":null,"funder_award_id":"FC001501","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G8538723892","display_name":null,"funder_award_id":"EU FP7","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8801296868","display_name":null,"funder_award_id":"CDP 13-005","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8871221442","display_name":null,"funder_award_id":"ACF-2013-13-018","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320311061","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846"},{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320315977","display_name":"Barts Charity","ror":"https://ror.org/0513pp416"},{"id":"https://openalex.org/F4320316261","display_name":"Universit\u00e4tsspital Basel","ror":"https://ror.org/04k51q396"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320320008","display_name":"Kidney Research UK","ror":"https://ror.org/02kx7se86"},{"id":"https://openalex.org/F4320320241","display_name":"Academy of Medical Sciences","ror":"https://ror.org/00c489v88"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320350","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41"},{"id":"https://openalex.org/F4320320658","display_name":"Jean Shanks Foundation","ror":"https://ror.org/00wf6bs47"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336051","display_name":"Oxford University Clinical Academic Graduate School","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2948752663.pdf","grobid_xml":"https://content.openalex.org/works/W2948752663.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W196688942","https://openalex.org/W1486722793","https://openalex.org/W1575585006","https://openalex.org/W1757383019","https://openalex.org/W1778788621","https://openalex.org/W1793205621","https://openalex.org/W1797434159","https://openalex.org/W1917494022","https://openalex.org/W1972187865","https://openalex.org/W1974487011","https://openalex.org/W1985458442","https://openalex.org/W1986925527","https://openalex.org/W1987802826","https://openalex.org/W1988377666","https://openalex.org/W1989354231","https://openalex.org/W1991346678","https://openalex.org/W1998146750","https://openalex.org/W1999791521","https://openalex.org/W2000809311","https://openalex.org/W2001051250","https://openalex.org/W2001740313","https://openalex.org/W2002662941","https://openalex.org/W2007868595","https://openalex.org/W2016160962","https://openalex.org/W2021947467","https://openalex.org/W2030334534","https://openalex.org/W2047793174","https://openalex.org/W2052201224","https://openalex.org/W2054170338","https://openalex.org/W2057373464","https://openalex.org/W2063261544","https://openalex.org/W2064760399","https://openalex.org/W2065779229","https://openalex.org/W2066951766","https://openalex.org/W2080274549","https://openalex.org/W2082237689","https://openalex.org/W2084476017","https://openalex.org/W2086513198","https://openalex.org/W2091041420","https://openalex.org/W2096843911","https://openalex.org/W2103119361","https://openalex.org/W2106178007","https://openalex.org/W2107770435","https://openalex.org/W2114266893","https://openalex.org/W2114412297","https://openalex.org/W2121754226","https://openalex.org/W2130456602","https://openalex.org/W2134053452","https://openalex.org/W2134591209","https://openalex.org/W2139595663","https://openalex.org/W2144598071","https://openalex.org/W2150332104","https://openalex.org/W2155662291","https://openalex.org/W2157669002","https://openalex.org/W2158715209","https://openalex.org/W2162873738","https://openalex.org/W2164164239","https://openalex.org/W2288482051","https://openalex.org/W2410984769","https://openalex.org/W2587295516","https://openalex.org/W2589709928","https://openalex.org/W2596572267","https://openalex.org/W2608519211","https://openalex.org/W2619691134","https://openalex.org/W2737785069","https://openalex.org/W2744983888","https://openalex.org/W2768129730","https://openalex.org/W2778771081","https://openalex.org/W2783442971","https://openalex.org/W2804335534"],"related_works":["https://openalex.org/W2948499783","https://openalex.org/W4220679281","https://openalex.org/W3082176517","https://openalex.org/W7214178945","https://openalex.org/W7051840181","https://openalex.org/W3092326438","https://openalex.org/W2091041420","https://openalex.org/W4415616249","https://openalex.org/W2964950870","https://openalex.org/W7070858622"],"abstract_inverted_index":{"Physiological":[0],"effects":[1,52,146,170],"of":[2,28,37,86,99,115,124,133,155,190],"cellular":[3],"hypoxia":[4],"are":[5,46,59],"sensed":[6],"by":[7,49,109],"prolyl":[8],"hydroxylase":[9],"(PHD)":[10],"enzymes":[11],"which":[12,58,77],"regulate":[13],"HIFs.":[14],"Genetic":[15],"interventions":[16],"on":[17,131],"HIF/PHD":[18,88],"pathways":[19],"reveal":[20],"multiple":[21,38],"phenotypes":[22],"that":[23,97],"extend":[24],"the":[25,83,87,134,151,183,187],"known":[26],"biology":[27],"hypoxia.":[29],"Recent":[30],"studies":[31,45],"unexpectedly":[32],"implicate":[33],"HIF":[34,100],"in":[35,102,119,171,186],"aspects":[36],"immune":[39,194],"and":[40,64,122,168,193],"inflammatory":[41],"pathways.":[42],"However":[43],"such":[44],"often":[47],"limited":[48],"systemic":[50],"lethal":[51],"and/or":[53],"use":[54],"tissue-specific":[55],"recombination":[56,114],"systems,":[57],"inherently":[60],"irreversible,":[61],"un-physiologically":[62],"restricted":[63],"difficult":[65],"to":[66],"time.":[67],"To":[68],"study":[69],"these":[70,145,163],"processes":[71],"better":[72],"we":[73],"developed":[74],"recombinant":[75],"mice":[76,104,164],"express":[78],"tetracycline-regulated":[79],"shRNAs":[80],"broadly":[81],"targeting":[82],"main":[84],"components":[85],"pathway,":[89],"permitting":[90],"timed":[91],"bi-directional":[92],"intervention.":[93],"We":[94,173],"have":[95,177],"shown":[96,178],"stabilization":[98],"levels":[101],"adult":[103],"through":[105,150],"PHD2":[106],"enzyme":[107],"silencing":[108],"RNA":[110],"interference,":[111],"or":[112],"inducible":[113],"floxed":[116],"alleles,":[117],"results":[118],"multi-lineage":[120],"leukocytosis":[121],"features":[123],"autoimmunity.":[125],"This":[126],"phenotype":[127],"was":[128,140],"rapidly":[129],"normalized":[130],"re-establishment":[132],"hypoxia-sensing":[135],"machinery":[136],"when":[137],"shRNA":[138],"expression":[139],"discontinued.":[141],"In":[142],"both":[143],"situations":[144],"were":[147],"mediated":[148],"principally":[149],"Hif2a":[152],"isoform.":[153],"Assessment":[154],"cells":[156],"bearing":[157],"regulatory":[158],"T":[159,191],"cell":[160,192],"markers":[161],"from":[162],"revealed":[165],"defective":[166],"function":[167],"pro-inflammatory":[169],"vivo.":[172],"believe":[174],"our":[175],"findings":[176],"a":[179],"new":[180],"role":[181],"for":[182],"PHD2/Hif2a":[184],"couple":[185],"reversible":[188],"regulation":[189],"activity.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-14T00:00:00"}
