{"id":"https://openalex.org/W2948676992","doi":"https://doi.org/10.1038/s41598-019-44407-9","title":"Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation","display_name":"Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation","publication_year":2019,"publication_date":"2019-06-05","ids":{"openalex":"https://openalex.org/W2948676992","doi":"https://doi.org/10.1038/s41598-019-44407-9","mag":"2948676992","pmid":"https://pubmed.ncbi.nlm.nih.gov/31165764","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6549188"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-44407-9","doi":"https://doi.org/10.1038/s41598-019-44407-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-44407-9","pdf_url":"https://www.nature.com/articles/s41598-019-44407-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-44407-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058440007","display_name":"Tadahiko Matsumoto","orcid":"https://orcid.org/0000-0002-2362-4612","observed_orcids":["https://orcid.org/0000-0002-2362-4612"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadahiko Matsumoto","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067975379","display_name":"Kotaro Shirakawa","orcid":"https://orcid.org/0000-0002-7469-1276","observed_orcids":["https://orcid.org/0000-0002-7469-1276"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Shirakawa","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010120453","display_name":"Masaru Yokoyama","orcid":"https://orcid.org/0000-0003-1641-0365","observed_orcids":["https://orcid.org/0000-0003-1641-0365"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Yokoyama","raw_affiliation_strings":["Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, 208-0011, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1641-0365","affiliations":[{"raw_affiliation_string":"Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, 208-0011, Japan","institution_ids":["https://openalex.org/I4210086300"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hirofumi Fukuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Fukuda","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066977144","display_name":"Anamaria Daniela Sarca","orcid":"https://orcid.org/0000-0002-4468-7786","observed_orcids":["https://orcid.org/0000-0002-4468-7786"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Anamaria Daniela Sarca","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4468-7786","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062554191","display_name":"Sukenao Koyabu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sukenao Koyabu","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019349961","display_name":"Hiroyuki Yamazaki","orcid":"https://orcid.org/0000-0002-5633-8997","observed_orcids":["https://orcid.org/0000-0002-5633-8997"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yamazaki","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086863267","display_name":"Yasuhiro Kazuma","orcid":"https://orcid.org/0000-0002-1046-8286","observed_orcids":["https://orcid.org/0000-0002-1046-8286"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kazuma","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048379630","display_name":"Hiroyuki Matsui","orcid":"https://orcid.org/0000-0003-1956-9603","observed_orcids":["https://orcid.org/0000-0003-1956-9603"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Matsui","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wataru Maruyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wataru Maruyama","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088500454","display_name":"Kayoko Nagata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayoko Nagata","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030145398","display_name":"Fumiko Tanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089413","display_name":"CellFree Sciences (Japan)","ror":"https://ror.org/004h24333","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210089413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiko Tanabe","raw_affiliation_strings":["CellFree Sciences Co., Ltd, Ehime, 790-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CellFree Sciences Co., Ltd, Ehime, 790-8577, Japan","institution_ids":["https://openalex.org/I4210089413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103278456","display_name":"Masayuki Kobayashi","orcid":"https://orcid.org/0000-0001-8733-8458","observed_orcids":["https://orcid.org/0000-0001-8733-8458"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Kobayashi","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8733-8458","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039959355","display_name":"Keisuke Shindo","orcid":"https://orcid.org/0000-0001-8793-8189","observed_orcids":["https://orcid.org/0000-0001-8793-8189"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Shindo","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018230010","display_name":"Ryo Morishita","orcid":"https://orcid.org/0000-0002-7763-5712","observed_orcids":["https://orcid.org/0000-0002-7763-5712"]},"institutions":[{"id":"https://openalex.org/I4210089413","display_name":"CellFree Sciences (Japan)","ror":"https://ror.org/004h24333","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210089413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Morishita","raw_affiliation_strings":["CellFree Sciences Co., Ltd, Ehime, 790-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CellFree Sciences Co., Ltd, Ehime, 790-8577, Japan","institution_ids":["https://openalex.org/I4210089413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065544054","display_name":"Hironori Sato","orcid":"https://orcid.org/0000-0002-3746-4672","observed_orcids":["https://orcid.org/0000-0002-3746-4672"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironori Sato","raw_affiliation_strings":["Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, 208-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Genomics, Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, 208-0011, Japan","institution_ids":["https://openalex.org/I4210086300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021783559","display_name":"Akifumi Takaori\u2010Kondo","orcid":"https://orcid.org/0000-0001-7678-4284","observed_orcids":["https://orcid.org/0000-0001-7678-4284"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akifumi Takaori-Kondo","raw_affiliation_strings":["Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. atakaori@kuhp.kyoto-u.ac.jp","Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7678-4284","affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. atakaori@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021783559"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":1.172,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76573205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"8307","last_page":"8307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.40139999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.09120000153779984,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apobec3b","display_name":"APOBEC3B","score":0.9769999980926514},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cytidine-deaminase","display_name":"cytidine deaminase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/c-to-t-mutations","display_name":"C>T mutations","score":0.6549999713897705},{"id":"https://openalex.org/keywords/apobec-signature","display_name":"APOBEC signature","score":0.7020000219345093},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.652999997138977},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/activation-induced-cytidine-deaminase","display_name":"activation-induced cytidine deaminase","score":0.7110000252723694},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.8679999709129333},{"id":"https://openalex.org/keywords/single-stranded-dna-binding","display_name":"single-stranded DNA binding","score":0.6389999985694885},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7110710740089417},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4673032760620117},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46503064036369324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4298166036605835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3481171131134033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34136763215065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3283729553222656},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3247007131576538}],"mesh":[{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054751","descriptor_name":"Cyclic AMP-Dependent Protein Kinase Catalytic Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-019-44407-9","doi":"https://doi.org/10.1038/s41598-019-44407-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-44407-9","pdf_url":"https://www.nature.com/articles/s41598-019-44407-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6549188","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6549188","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31165764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31165764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0004059833","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/26d482f6-bcd9-49b0-b24b-50389fa37886/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/26d482f6-bcd9-49b0-b24b-50389fa37886/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:8f7929896476490aaa3b879b65a2a978","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8f7929896476490aaa3b879b65a2a978","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)","raw_type":"article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/241722","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/241722","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/245313","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2433/245313","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoral thesis"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-44407-9","doi":"https://doi.org/10.1038/s41598-019-44407-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-44407-9","pdf_url":"https://www.nature.com/articles/s41598-019-44407-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1501512933","display_name":null,"funder_award_id":"24115004","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2137865615","display_name":null,"funder_award_id":"17fk0410204","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G4065973496","display_name":"APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers","funder_award_id":"19H03502","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5230822708","display_name":null,"funder_award_id":"16fk0410201h0102","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2948676992.pdf","grobid_xml":"https://content.openalex.org/works/W2948676992.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1609531945","https://openalex.org/W1610186027","https://openalex.org/W1966343819","https://openalex.org/W1966477735","https://openalex.org/W1970398080","https://openalex.org/W1972739934","https://openalex.org/W1976499671","https://openalex.org/W1984236815","https://openalex.org/W1996486420","https://openalex.org/W2000620255","https://openalex.org/W2001375348","https://openalex.org/W2003665515","https://openalex.org/W2015567856","https://openalex.org/W2017585121","https://openalex.org/W2019010829","https://openalex.org/W2021282819","https://openalex.org/W2023035407","https://openalex.org/W2023853884","https://openalex.org/W2035939622","https://openalex.org/W2036046527","https://openalex.org/W2041401655","https://openalex.org/W2043794217","https://openalex.org/W2054876172","https://openalex.org/W2059633603","https://openalex.org/W2059995794","https://openalex.org/W2060665625","https://openalex.org/W2073406070","https://openalex.org/W2085037886","https://openalex.org/W2085458745","https://openalex.org/W2086928171","https://openalex.org/W2087056550","https://openalex.org/W2089078314","https://openalex.org/W2092645441","https://openalex.org/W2096197897","https://openalex.org/W2102067890","https://openalex.org/W2104153021","https://openalex.org/W2104195581","https://openalex.org/W2104244040","https://openalex.org/W2106140689","https://openalex.org/W2121553505","https://openalex.org/W2127713363","https://openalex.org/W2129136620","https://openalex.org/W2130676809","https://openalex.org/W2131793664","https://openalex.org/W2134114724","https://openalex.org/W2134748364","https://openalex.org/W2136931756","https://openalex.org/W2141272547","https://openalex.org/W2144425084","https://openalex.org/W2147098985","https://openalex.org/W2152061559","https://openalex.org/W2152327707","https://openalex.org/W2154535504","https://openalex.org/W2156836754","https://openalex.org/W2157876432","https://openalex.org/W2161605421","https://openalex.org/W2177028599","https://openalex.org/W2192682263","https://openalex.org/W2268112994","https://openalex.org/W2323113674","https://openalex.org/W2402803223","https://openalex.org/W2433523887","https://openalex.org/W2517730488","https://openalex.org/W2527720111","https://openalex.org/W2533194337","https://openalex.org/W2567060579","https://openalex.org/W2578831276","https://openalex.org/W2593433491","https://openalex.org/W2605024706","https://openalex.org/W2738092767","https://openalex.org/W2754617114","https://openalex.org/W2773978309","https://openalex.org/W4232273699"],"related_works":["https://openalex.org/W2102067890","https://openalex.org/W2750193796","https://openalex.org/W3088973344","https://openalex.org/W3083648101","https://openalex.org/W2143843311","https://openalex.org/W2972990570","https://openalex.org/W3083478606","https://openalex.org/W3000379492","https://openalex.org/W2952711770","https://openalex.org/W2589646886"],"abstract_inverted_index":{"APOBEC3B":[0],"cytidine":[1,68],"deaminase":[2,72,96,115],"(A3B)":[3],"catalyzes":[4],"cytosine":[5],"into":[6],"uracil":[7],"in":[8,15,58,103,176],"single-strand":[9],"DNA":[10,17,53,100],"and":[11,55,74,91,98,111,134,145],"induces":[12],"C-to-T":[13],"mutations":[14,27,54,175],"genomic":[16],"of":[18,21,24,50,62,66,120,174],"various":[19],"types":[20],"tumors.":[22,60,179],"Accumulation":[23],"APOBEC":[25],"signature":[26],"is":[28],"correlated":[29],"with":[30,36],"a":[31,48],"worse":[32],"prognosis":[33],"for":[34],"patients":[35],"breast":[37],"cancer":[38],"or":[39],"multiple":[40],"myeloma,":[41],"suggesting":[42],"that":[43,82,106,124,154],"A3B":[44,90,108,121,158,177],"activity":[45,160],"might":[46],"be":[47],"cause":[49],"the":[51,130],"unfavorable":[52],"clonal":[56],"evolution":[57],"these":[59],"Phosphorylation":[61],"conserved":[63],"threonine":[64],"residues":[65],"other":[67],"deaminases,":[69],"activation":[70,169],"induced":[71],"(AID)":[73],"APOBEC3G,":[75],"inhibits":[76,157],"their":[77],"activity.":[78,116,150],"Here":[79],"we":[80],"show":[81],"protein":[83],"kinase":[84],"A":[85],"(PKA)":[86],"physically":[87],"binds":[88],"to":[89],"phosphorylates":[92],"Thr214.":[93],"In":[94],"vitro":[95],"assays":[97,102],"foreign":[99],"editing":[101],"cells":[104],"confirm":[105],"phosphomimetic":[107],"mutants,":[109],"T214D":[110],"T214E,":[112],"completely":[113],"lose":[114],"Molecular":[117],"dynamics":[118],"simulation":[119],"phosphorylation":[122,126,156],"reveals":[123],"Thr214":[125],"disrupts":[127],"binding":[128],"between":[129],"phospho-A3B":[131],"catalytic":[132],"core":[133],"ssDNA.":[135],"These":[136,151],"mutants":[137],"still":[138],"inhibit":[139],"retroviral":[140],"infectivity":[141],"at":[142],"least":[143],"partially,":[144],"also":[146],"retain":[147],"full":[148],"anti-retrotransposition":[149],"results":[152],"imply":[153],"PKA-mediated":[155],"mutagenic":[159],"without":[161],"destructing":[162],"its":[163],"innate":[164],"immune":[165],"functions.":[166],"Therefore,":[167],"PKA":[168],"could":[170],"reduce":[171],"further":[172],"accumulation":[173],"overexpressing":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-06-14T00:00:00"}